917796

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Which polymers can make nanoparticulate drug carriers long-circulating?

Torchilin V P, et al.

Advanced Drug Delivery Reviews, 16, 141-155 (1995)

Protein adsorption is required for stealth effect of poly(ethylene glycol)- and poly(phosphoester)-coated nanocarriers.

Susanne Schöttler et al.

Nature nanotechnology, 11(4), 372-377 (2016-02-16)

The current gold standard to reduce non-specific cellular uptake of drug delivery vehicles is by covalent attachment of poly(ethylene glycol) (PEG). It is thought that PEG can reduce protein adsorption and thereby confer a stealth effect. Here, we show that

PLGA-based nanoparticles: an overview of biomedical applications.

Fabienne Danhier et al.

Journal of controlled release : official journal of the Controlled Release Society, 161(2), 505-522 (2012-02-23)

Poly(lactic-co-glycolic acid) (PLGA) is one of the most successfully developed biodegradable polymers. Among the different polymers developed to formulate polymeric nanoparticles, PLGA has attracted considerable attention due to its attractive properties: (i) biodegradability and biocompatibility, (ii) FDA and European Medicine

FDA-approved poly(ethylene glycol)−protein conjugate drugs.

Polym. Chem., 2, 1442-1448 (2011)

Synthesis and Assembly of Click-Nucleic-Acid-Containing PEG-PLGA Nanoparticles for DNA Delivery.

Albert Harguindey et al.

Advanced materials (Deerfield Beach, Fla.), 29(24) (2017-04-12)

Co-delivery of both chemotherapy drugs and siRNA from a single delivery vehicle can have a significant impact on cancer therapy due to the potential for overcoming issues such as drug resistance. However, the inherent chemical differences between charged nucleic acids

Biodegradable PLGA-b-PEG polymeric nanoparticles: synthesis, properties, and nanomedical applications as drug delivery system.

Locatelli E, et al

Journal of Nanoparticle Research, 14, 1316-1316 (2012)

PLGA-based nanoparticles as cancer drug delivery systems.

Fatemeh Sadat Tabatabaei Mirakabad et al.

Asian Pacific journal of cancer prevention : APJCP, 15(2), 517-535 (2014-02-27)

Poly (lactic-co-glycolic acid) (PLGA) is one of the most effective biodegradable polymeric nanoparticles (NPs). It has been approved by the US FDA to use in drug delivery systems due to controlled and sustained- release properties, low toxicity, and biocompatibility with

Technical aspects of preparing PEG-PLGA nanoparticles as carrier for chemotherapeutic ‎agents by nanoprecipitation method.

Hassan A Almoustafa et al.

International journal of pharmaceutics, 533(1), 275-284 (2017-09-26)

Nanoprecipitation is a simple and increasingly trending method for nanoparticles preparation. The self-assembly feature of poly (ethylene glycol)-poly (lactide-co-glycolic acid) (PEG-PLGA) amphiphilic copolymer into a nanoparticle and its versatile structure makes nanoprecipitation one of the best methods for its preparation.

Functional PLGA NPs for oral drug delivery: recent strategies and developments.

L Martin-Banderas et al.

Mini reviews in medicinal chemistry, 13(1), 58-69 (2012-09-15)

This article presents the potential of PLGA nanoparticles for the oral administration of drugs. Different strategies are used to improve oral absorption of these nanoparticles. These strategies are based on modification of nanoparticle surface properties. They can be achieved either

PEGylated PLGA nanoparticles as protein carriers: synthesis, preparation and biodistribution in rats.

Y Li et al.

Journal of controlled release : official journal of the Controlled Release Society, 71(2), 203-211 (2001-03-29)

The aim of the present work was to assess the merits of PEGylated poly(lactic-co-glycolic acid) (PEG-PLGA) nanoparticles as protein and peptide drugs (PPD) carriers. PEG-PLGA copolymer, which could be used to prepare the stealth nanoparticles or long-circulating nanoparticles, was synthesized

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