Search Within
92817
Applied Filters:
Keyword:'92817'
Showing 1-30 of 144 results for "92817" within Papers
Kyung-Eui Park et al.
Bioscience, biotechnology, and biochemistry, 78(6), 981-988 (2014-07-19)
Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC), the most abundant phospholipids of plasma membrane, resulting in the production of choline and phosphatidic acid (PA). Choline is a precursor of the neurotransmitter acetylcholine, whereas PA functions as an intracellular
Renate Wagner et al.
Oncotarget, 8(7), 11600-11613 (2017-01-14)
Receptor-PI3K-mTORC1 signaling and fatty acid synthase (FASN)-regulated lipid biosynthesis harbor numerous drug targets and are molecularly connected. We hypothesize that unraveling the mechanisms of pathway cross-talk will be useful for designing novel co-targeting strategies for ovarian cancer (OC). The impact
Amanda C Gentry et al.
Nucleic acids research, 39(3), 1014-1022 (2010-09-22)
Human topoisomerase I plays an important role in removing positive DNA supercoils that accumulate ahead of replication forks. It also is the target for camptothecin-based anticancer drugs that act by increasing levels of topoisomerase I-mediated DNA scission. Evidence suggests that
Moumita Paul et al.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 16(5), 735-743 (2011-04-06)
In this study, the detailed DNA sequence specificity of four acridine Pt complexes was examined and compared with that of cisplatin. The DNA sequence specificity was determined in a telomere-containing DNA sequence using a polymerase stop assay, with a fluorescent
Gabriela Petroselli et al.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 11(6), 1062-1068 (2012-03-24)
A group of nitrogen heterocyclic aromatic compounds used, among others, as UV-MALDI matrices was studied. By using spectroscopic, luminescence and photoacoustic techniques, as well as time resolved phosphorescence for singlet oxygen production determination, the behaviour of 9-aminoacridine (9AA), 3-aminoquinoline (3AQ)
Thao Bich Nguyen et al.
Applied and environmental microbiology, 84(9) (2018-03-04)
In streptomycetes, autoregulators are important signaling compounds that trigger secondary metabolism, and they are regarded as Streptomyces hormones based on their extremely low effective concentrations (nM) and the involvement of specific receptor proteins. Our previous distribution study revealed that butenolide-type
Hwi Won Seo et al.
Journal of ginseng research, 41(4), 595-601 (2017-10-13)
Red ginseng oil (RGO) is produced by supercritical CO2 extraction of secondary products derived from Korean Red Ginseng extract. As the use of RGO has increased, product safety concerns have become more important. In the present study, the subacute oral
Tetsuya Sakurai et al.
Science signaling, 11(541) (2018-08-02)
Although immune responses are essential to protect the body from infection, they can also harm tissues. Certain tissues and organs, including the eye, constitute specialized microenvironments that locally inhibit immune reactivity. Dedicator of cytokinesis protein 2 (DOCK2) is a Rac-specific
Mandy Eibisch et al.
Rapid communications in mass spectrometry : RCM, 25(8), 1100-1106 (2011-04-01)
Phospholipids (PLs) are increasingly analyzed by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry (MS) and imaging MS. Different classes of PLs are preferentially detectable either as positive or negative ions depending on the charges of their headgroups. Sphingomyelin (SM) and
Asuka Takumi et al.
Regulatory toxicology and pharmacology : RTP, 107, 104399-104399 (2019-06-04)
In response to the lack of authenticated mutagenicity/genotoxicity studies on MSG monohydrate, a series of genotoxicity studies conducted under GLP and according to globally accepted test guidelines (e.g., OECD) was performed. A bacterial reverse mutation test using Salmonella typhimurium (TA100
Gang Sun et al.
Analytical chemistry, 80(19), 7576-7585 (2008-09-05)
A matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) based approach was developed for the rapid analyses of cellular glycerophospholipids. Through multiplexed solvent-enabled optimization of analyte-matrix interactions during the crystallization process, over a 30-fold increase in S/N was achieved using
Jenny Leopold et al.
Biomolecules, 8(4) (2018-12-16)
Matrix-assisted laser desorption/ionization (MALDI) is one of the most successful "soft" ionization methods in the field of mass spectrometry and enables the analysis of a broad range of molecules, including lipids. Although the details of the ionization process are still
Jianing Wang et al.
Analytica chimica acta, 1061, 28-41 (2019-03-31)
The mainstream of lipidomics involves mass spectrometry-based, systematic, and large-scale studies of the structure, composition, and quantity of lipids in biological systems such as organs, cells, and body fluids. As increasingly more researchers in broad fields are beginning to pay
Katia G Samper et al.
Dalton transactions (Cambridge, England : 2003), 41(1), 300-306 (2011-11-18)
The interaction of a novel Pt complex, [Pt(dmba)(N9-9AA)(PPh(3))](+)1 (dmba = N,N-dimethylbenzylamine-κN,κC; 9AA = 9-aminoacridine), which exhibits anti-tumor activity, with certain key proteins has been monitored by ESI-MS. Also, the interaction of 1 with a designed double-stranded oligonucleotide containing the GG
Tatiana E Samatadze et al.
Scientific reports, 9(1), 9155-9155 (2019-06-27)
The morphological, meiotic and chromosomal variability were studied in two cultivars of Calendula officinalis L. and their mutant lines obtained though chemical mutagenesis using diethyl sulphate (DES) (0.04%, 0.08%) and dimethyl sulphate (DMS) (0.025%, 0.05%). The studied cultivars displayed different
Russell T Sapio et al.
Scientific reports, 7(1), 9041-9041 (2017-08-24)
The p53-mediated nucleolar stress response associated with inhibition of ribosomal RNA transcription was previously shown to potentiate killing of tumor cells. Here, we asked whether targeting of ribosome biogenesis can be used as the basis for selective p53-dependent cytoprotection of
Marianna Halasi et al.
The Journal of biological chemistry, 291(1), 142-148 (2015-11-13)
The oncogenic transcription factor FOXM1 is overexpressed in the majority of human cancers, and it is a potential target for anticancer therapy. We identified proteasome inhibitors as the first type of drugs that target FOXM1 in cancer cells. Here we
Wei Ju et al.
Retrovirology, 11, 43-43 (2014-06-04)
Adult T-cell leukemia/lymphoma (ATL) is an aggressive malignancy of CD4+CD25+ lymphocytes caused by human T-cell lymphotropic virus type 1. While much progress has been made in understanding the mechanisms of cellular dysregulation, the prognosis for aggressive ATL still remains poor.
Thomas Kunzke et al.
Oncotarget, 8(40), 68012-68025 (2017-10-06)
Glycosylation in cancer is a highly dynamic process that has a significant impact on tumor biology. Further, the attachment of aberrant glycan forms is already considered a hallmark of the disease state. Mass spectrometry has become a prominent approach to
Elvira Sondo et al.
American journal of physiology. Cell physiology, 301(4), C872-C885 (2011-07-15)
The F508del mutation, the most frequent in cystic fibrosis (CF), impairs the maturation of the CFTR chloride channel. The F508del defect can be partially overcome at low temperature (27°C) or with pharmacological correctors. However, the efficacy of correctors on the
Daria Fleyshman et al.
Cell cycle (Georgetown, Tex.), 15(3), 455-470 (2015-12-24)
The realization, that the androgen receptor (AR) is essential for prostate cancer (PC) even after relapse following androgen deprivation therapy motivated the search for novel types of AR inhibitors. We proposed that targeting AR expression versus its function would work
Nadezhda L Bolsheva et al.
PloS one, 10(4), e0122015-e0122015 (2015-04-04)
The wide variation in chromosome number found in species of the genus Linum (2n = 16, 18, 20, 26, 28, 30, 32, 36, 42, 72, 84) indicates that chromosomal mutations have played an important role in the speciation of this
Paul Baldrick et al.
Regulatory toxicology and pharmacology : RTP, 108, 104441-104441 (2019-08-20)
PQ Birch represents an allergen-specific immunotherapy for the treatment of birch pollinosis. It consists of native birch pollen extract chemically modified with glutaldehyde adsorbed to L-tyrosine in its microcrystalline form with addition of the adjuvant Monophosphoryl Lipid A (MPL®). A
C Manivannan et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 95, 685-692 (2012-05-16)
The fluorescence quenching of 9-Aminoacridine (9-AA) by various dyes were probed in aqueous medium using steady state and time resolved fluorescence spectroscopic techniques. From these techniques, we had rationalized the interaction of 9-AA with various dyes via ground state complex
David H Bechtel
Regulatory toxicology and pharmacology : RTP, 70 Suppl 2, S131-S142 (2014-12-17)
Four versions of esterified propoxylated glycerols (EPGs) were evaluated for potential genotoxicity using a range of in vitro and in vivo assays. H-EPG-05 HR/SO 9:1, H-EPG-05 soyate, and H-EPG-14 soyate were non-mutagenic in reverse mutation assays (maximum concentration 1000 μg/plate)
Zoë A E Waller et al.
Biochemical and biophysical research communications, 447(1), 128-132 (2014-04-05)
The transcription factor nuclear factor (erythroid-derived 2)-like 2 (Nrf2) regulates multiple antioxidants, Phase II detoxification enzymes and other cytoprotective enzymes in cells. Activation of Nrf2 is recognised as being of potential therapeutic benefit in inflammatory-diseases whereas more recently, it has
C Manivannan et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 103, 18-24 (2012-12-22)
9-Aminoacridine (9-AA) is an important attractive pharmaceutical drug employed as chemotheraptic agent for wound dressings. However, 9-AA possesses limited solubility and rapid metabolic decomposition renders this potential drug to limit its applications. Here we propose cyclodextrins (CDs) as a drug
Stephan R Fagerer et al.
European journal of mass spectrometry (Chichester, England), 19(1), 39-47 (2013-07-12)
Matrix-assisted laser desorption/ionization (MALDI) has been shown to be highly sensitive for analyzing low-mass compounds such as metabolites if the right matrix is used. 9-aminoacridine (9AA) is the most commonly employed matrix for negative mode MALDI-MS in metabolomics. However, matrix
Mindong Ren et al.
The Journal of cell biology, 218(5), 1491-1502 (2019-03-28)
Mitochondria contain cardiolipin (CL), an organelle-specific phospholipid that carries four fatty acids with a strong preference for unsaturated chains. Unsaturation is essential for the stability and for the function of mitochondrial CL. Surprisingly, we found tetrapalmitoyl-CL (TPCL), a fully saturated
William J Perry et al.
Journal of mass spectrometry : JMS, 55(4), e4491-e4491 (2019-12-21)
The specific matrix used in matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) can have an effect on the molecules ionized from a tissue sample. The sensitivity for distinct classes of biomolecules can vary when employing different MALDI matrices. Here
Page 1 of 5