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Showing 1-30 of 455 results for "93352" within Papers
Adriana Lizbeth Juárez-Rojas et al.
Systems biology in reproductive medicine, 61(4), 211-221 (2015-04-14)
Testicular apoptosis is activated by stress, but it is not clear which signaling pathway is activated in response to stress. The aim of this study was to investigate whether intrinsic, extrinsic, or both apoptotic signaling pathways are activated by acute
Maria Sol Degese et al.
The Biochemical journal, 467(1), 77-90 (2015-01-15)
Mitogen-activated protein kinase (MAPK) pathways constitute key regulatory elements linking extracellular stimuli to nuclear gene expression. Immediate-early responsive genes (IEGs) of the activator protein 1 (AP-1) family, such as fos, achieve peak expression levels shortly after cells are stimulated with
M Lorena Cortez et al.
Bioelectrochemistry (Amsterdam, Netherlands), 105, 117-122 (2015-06-22)
In this work the effects of the self-assembly solvent on the structure and electrochemical behavior of redox-active polyelectrolyte–surfactant complexes cast on electrode supports from aqueous and DMF solutions are presented. The complex studied is formed by complexation of osmium complex-modified
Xinru Li et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 76, 95-101 (2015-04-29)
The purpose of this work was to demonstrate the advantages of a folate modified pH sensitive micelle system (HPPF) on reducing the systemic toxicity of antitumor drug doxorubicin (DOX) as well as increasing the antitumor efficacy on multi-drug resistant tumor.
Duraisamy Ponnusamy et al.
Infection and immunity, 83(5), 2065-2081 (2015-03-11)
The identification of new virulence factors in Yersinia pestis and understanding their molecular mechanisms during an infection process are necessary in designing a better vaccine or to formulate an appropriate therapeutic intervention. By using a high-throughput, signature-tagged mutagenic approach, we
Blanca V Rodriguez et al.
Analytical biochemistry, 492, 69-75 (2015-09-30)
High-quality chromosomal DNA is a requirement for many biochemical and molecular biological techniques. To isolate cellular DNA, standard protocols typically lyse cells and separate nucleic acids from other biological molecules using a combination of chemical and physical methods. After a
Sui Ching Phung et al.
Analytical and bioanalytical chemistry, 407(23), 6995-7002 (2015-07-06)
Counter-pressure was used to extend the duration of field-amplified sample injection in isotachophoresis (FASI-ITP) in order to improve the detection of bacterial cells. Using 0.51-μm negatively charged encapsulated fluorescent beads as a model, the counter-pressure, injection and separation voltages, and
C Brooks Mobley et al.
Journal of the International Society of Sports Nutrition, 12, 32-32 (2015-08-19)
Phosphatidic acid (PA) is a diacyl-glycerophospholipid that acts as a signaling molecule in numerous cellular processes. Recently, PA has been proposed to stimulate skeletal muscle protein accretion, but mechanistic studies are lacking. Furthermore, it is unknown whether co-ingesting PA with
Qi-Bin Zhang et al.
Nature communications, 6, 8062-8062 (2015-08-22)
The South Asian Monsoon and mid-latitude Westerlies are two important controls on Tibetan Plateau (TP) fresh water resources. Understanding their interaction requires long-term information on spatial patterns in moisture variability on the TP. Here we develop a network of 23
Jia-Hui Lin et al.
Physical chemistry chemical physics : PCCP, 17(23), 15124-15130 (2015-03-31)
This study describes the synthesis of fluorescent polydopamine dots (PDs) through hydroxyl radical-induced degradation of polydopamine nanoparticles. The decomposition of polydopamine nanoparticles to fluorescent PDs was confirmed using transmission electron microscopy and dark-field microscopy. The analysis of PDs by using
Piyasi Mukhopadhyay et al.
International journal of biological macromolecules, 72, 640-648 (2014-09-23)
Chitosan-alginate (CS/ALG) nanoparticles were prepared by formation of an ionotropic pre-gelation of an alginate (ALG) core entrapping insulin, followed by chitosan (CS) polyelectrolyte complexation, for successful oral insulin administration. Mild preparation process without harsh chemicals is aimed at improving insulin
Martina Sandberg Abelius et al.
Journal of reproductive immunology, 106, 100-109 (2014-07-23)
The immunological milieu in the placenta may be crucial for priming the developing foetal immune system. Early imbalances may promote the establishment of immune-mediated diseases in later life, including allergies. The initial exposure to allergens seems to occur in utero
Roger A Vaughan et al.
Journal of physiology and biochemistry, 71(4), 679-689 (2015-09-25)
Exercise offers several benefits for health, including increased lean body mass and heightened energy expenditure, which may be partially attributable to secretory factors known as myokines. Irisin, a recently identified myokine, was shown to increase metabolic rate and mitochondrial content
Sebastian Fiedler et al.
Biophysical journal, 109(10), 2079-2089 (2015-11-21)
Cyclic lipopeptides act against a variety of plant pathogens and are thus highly efficient crop-protection agents. Some pesticides contain Bacillus subtilis strains that produce lipopeptide families, such as surfactins (SF), iturins (IT), and fengycins (FE). The antimicrobial activity of these
Cyril Lafon et al.
Ultrasound in medicine & biology, 31(10), 1383-1389 (2005-10-15)
An optically transparent phantom was developed for use in high-intensity focused ultrasound (US), or HIFU, dosimetry studies. The phantom is composed of polyacrylamide hydrogel, embedded with bovine serum albumin (BSA) that becomes optically opaque when denatured. Acoustic and optical properties
Olivia Larne et al.
Carcinogenesis, 36(8), 858-866 (2015-05-15)
Androgen signalling through the androgen receptor (AR) is essential for prostate cancer initiation, progression and transformation to the lethal castration-resistant state. The aim of this study was to characterize the mechanisms by which miR-145 deregulation contribute to prostate cancer progression.
Xuefei Yin et al.
Proteomics, 14(17-18), 2008-2016 (2014-07-22)
In this paper, we demonstrate a rapid and reproducible 1D LC-MS/MS workflow for fast quantitative proteomic research. We have optimized the LC-MS/MS conditions, including digestion and gradient conditions, sample loading amount, and MS parameter settings. As a result, we were
Ivan Sanchez-De Melo et al.
Journal of proteomics, 127(Pt B), 225-233 (2015-04-25)
The pharmaceutical market has entered an era in which the production of new therapeutics is being often replaced by "biosimilars", copies of already commercialized products waiting for the patents to expire in order to be distributed in a more competitive
Alessandro Bertucci et al.
Biosensors & bioelectronics, 63, 248-254 (2014-08-12)
Microstructured optical fibers containing microchannels and Bragg grating inscribed were internally functionalized with a peptide nucleic acid (PNA) probe specific for a gene tract of the genetically modified Roundup Ready soy. These fibers were used as an optofluidic device for
Audrey J Majeske et al.
Journal of immunology (Baltimore, Md. : 1950), 193(11), 5678-5688 (2014-10-31)
Immune systems in animals rely on fast and efficient responses to a wide variety of pathogens. The Sp185/333 gene family in the purple sea urchin, Strongylocentrotus purpuratus, consists of an estimated 50 (±10) members per genome that share a basic
Jill A Madden et al.
Toxicological sciences : an official journal of the Society of Toxicology, 141(2), 441-452 (2014-07-30)
The anti-neoplastic prodrug, cyclophosphamide, requires biotransformation to phosphoramide mustard (PM), which partitions to volatile chloroethylaziridine (CEZ). PM and CEZ are ovotoxicants, however their ovarian biotransformation remains ill-defined. This study investigated PM and CEZ metabolism mechanisms through the utilization of cultured
Erica Dorigatti de Avila et al.
Biomaterials, 67, 84-92 (2015-07-27)
Bacterial biofilm infections remain prevalent reasons for implant failure. Dental implant placement occurs in the oral environment, which harbors a plethora of biofilm-forming bacteria. Due to its trans-mucosal placement, part of the implant structure is exposed to oral cavity and
Manuel J Barbanoj Rodríguez et al.
Expert review of neurotherapeutics, 8(11), 1625-1640 (2008-11-07)
Since the last review about the safety and efficacy of dexketoprofen trometamol, new clinical evidence supporting its advantages has been published. Concerning the oral formulation, studies about its pharmacokinetics in special populations and efficacy studies in various pain conditions are
Min-Beom Kim et al.
Phytotherapy research : PTR, 29(3), 434-443 (2015-01-15)
Several studies have demonstrated that deregulated activation of signal transducer and activator of transcription 3 (STAT3) has been associated with survival, proliferation, chemoresistance and angiogenesis of tumour cells. Thus, inhibition of STAT3 expression could be a potent therapeutic approach for
Nerea Fernández-Iglesias et al.
Nanoscale, 7(34), 14324-14331 (2015-08-06)
Once nanoparticles enter a biological system, it is known that their surface is instantly covered by the biomolecules present with preference to proteins. This protein corona has been a subject of numerous studies in order to reveal its composition. Besides
Corey A Baron et al.
Magnetic resonance in medicine, 73(3), 1075-1084 (2014-04-12)
An acquisition method that does not increase scan time or specific absorption rate is investigated for reducing the deleterious effects of cerebrospinal fluid (CSF) partial volume effects on diffusion tensor imaging (DTI) tractography. It is based on using a shorter
Xuepei Zhang et al.
Journal of chromatography. A, 1359, 84-90 (2014-07-30)
A new approach for proteome-wide profiling drug binding proteins by using monolithic capillary affinity chromatography in combination with HPLC-MS/MS is reported. Two immunosuppresive drugs, namely FK506 and cyclosporin A, were utilized as the experimental models for proof-of-concept. The monolithic capillary
Mohammad Dahrouj et al.
Experimental eye research, 137, 50-56 (2015-06-14)
Diabetic macular edema (DME) is a major cause of visual impairment. Although DME is generally believed to be a microvascular disease, dysfunction of the retinal pigment epithelium (RPE) can also contribute to its development. Advanced glycation end-products (AGE) are thought
Xia-Bing Fu et al.
Dalton transactions (Cambridge, England : 2003), 43(23), 8721-8737 (2014-04-29)
Two new water-soluble copper(ii)-dipeptide complexes: [Cu(glygly)(PyTA)]ClO4·1.5H2O (1) and [Cu(glygly)(PzTA)]ClO4·1.5H2O (2) (glygly = glycylglycine anion, PyTA = 2,4-diamino-6-(2'-pyridyl)-1,3,5-triazine and PzTA = 2,4-diamino-6-(2'-pyrazino)-1,3,5-triazine), utilizing two interrelated DNA base-like ligands (PyTA and PzTA), have been synthesized and characterized. The structure elucidation for 1
Guang-Lin Yang et al.
Oncology reports, 33(4), 2045-2051 (2015-01-28)
Gastric cancer cell are not particularly sensitive to Ara-C, a deoxycytidine analog that affects DNA synthesis. In the present study, AGS and MKN-45 gastric cancer cell lines were treated with Ara-C to determine its role in cell prolife-ration and apoptosis.
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