93829

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Showing 1-30 of 311 results for "93829" within Papers

The survival and differentiation of pro-B and pre-B cells in the bone marrow is dependent on IL-7Rα Tyr449.

Daniel T Patton et al.

Journal of immunology (Baltimore, Md. : 1950), 193(7), 3446-3455 (2014-08-22)

IL-7 is critical for murine T and B cell development and survival and plays a significant role in lymphoblastic leukemia in both humans and mice. We evaluated the role of the IL-7Rα Tyr(449) cytoplasmic SH2-binding motif in IL-7-mediated B cell

Flexibility of cold- and heat-adapted subtilisin-like serine proteinases evaluated with fluorescence quenching and molecular dynamics.

Asta Rós Sigtryggsdóttir et al.

Biochimica et biophysica acta, 1844(4), 705-712 (2014-02-25)

The subtilisin-like serine proteinases, VPR, from a psychrotrophic Vibrio species and aqualysin I (AQUI) from the thermophile Thermus aquaticus, are structural homologues, but differ significantly with respect to stability and catalytic properties. It has been postulated that the higher catalytic

Three-phase molecularly imprinted sol-gel based hollow fiber liquid-phase microextraction combined with liquid chromatography-tandem mass spectrometry for enrichment and selective determination of a tentative lung cancer biomarker.

Mohammad Mahdi Moein et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 995-996, 38-45 (2015-05-30)

In the present study, the modification of a polysulfone hollow fiber membrane with in situ molecularly imprinted sol-gel process (as a novel and one-step method) was prepared and investigated. 3-(propylmethacrylate)trimethoxysilane (3PMTMOS) as an inorganic precursor was used for preparation of

Femtosecond dynamics of short-range protein electron transfer in flavodoxin.

Ting-Fang He et al.

Biochemistry, 52(51), 9120-9128 (2013-12-03)

Intraprotein electron transfer (ET) in flavoproteins is important for understanding the correlation of their redox, configuration, and reactivity at the active site. Here, we used oxidized flavodoxin as a model system and report our complete characterization of a photoinduced redox

Development of radioiodine-labeled 4-hydroxyphenylcysteamine for specific diagnosis of malignant melanoma.

Masato Kobayashi et al.

Nuclear medicine and biology, 42(6), 536-540 (2015-03-07)

A specific diagnosis for melanoma is strongly desired because malignant melanoma has poor prognosis. In a previous study, although radioiodine-125-labeled 4-hydroxyphenyl-L-cysteine ((125)I-L-PC) was found to have good substrate affinity for tyrosinase enzyme in the melanin metabolic pathway, (123/131)I-L-PC had insufficient

Differential in vitro inhibition studies of some cerium vanadate derivatives on xanthine oxidase.

Mustafa Oğuzhan Kaya et al.

Journal of enzyme inhibition and medicinal chemistry, 30(2), 286-289 (2014-06-26)

In this preliminary study, a new series of some cerium vanadate derivatives have been investigated as new type of inhibitors of xanthine oxidase (XO; E.C 1.17.3.2). XO is a superoxide-producing enzyme found normally in serum and the lungs, and its

Comparison of serum and urinary levels of modified nucleoside, 1-methyladenosine, in cancer patients using a monoclonal antibody-based inhibition ELISA.

S Ishiwata et al.

The Tohoku journal of experimental medicine, 176(1), 61-68 (1995-05-01)

To evaluate the clinical usefulness of serum 1-methyladenosine, several modifications have been made in our previously established inhibition ELISA system. Horseradish peroxidase (HRP) labeled anti-mouse IgG and 3,3',5,5'-tetramethylbenzidine (TMBZ) were used as a secondary antibody and a substrate, respectively. The

Proton-coupled electron transfer: Free radicals under control.

Bridgette A Barry

Nature chemistry, 6(5), 376-377 (2014-04-24)

Formal reduction potential of 3,5-difluorotyrosine in a structured protein: insight into multistep radical transfer.

Kanchana R Ravichandran et al.

Biochemistry, 52(49), 8907-8915 (2013-11-16)

The reversible Y-O•/Y-OH redox properties of the α3Y model protein allow access to the electrochemical and thermodynamic properties of 3,5-difluorotyrosine. The unnatural amino acid has been incorporated at position 32, the dedicated radical site in α3Y, by in vivo nonsense

Recessively inherited L-DOPA-responsive dystonia caused by a point mutation (Q381K) in the tyrosine hydroxylase gene.

P M Knappskog et al.

Human molecular genetics, 4(7), 1209-1212 (1995-07-01)

Tyrosine hydroxylase (TH) catalyzes the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-DOPA), the rate-limiting step in the biosynthesis of dopamine. Recently, we described a point mutation in hTH (Q381K) in a family of two siblings suffering from progressive L-DOPA-responsive dystonia (DRD)

Self-recognition behavior of a helix-loop-helix domain by a fragment scan.

Michael Beisswenger et al.

Biochimica et biophysica acta, 1844(9), 1675-1683 (2014-07-02)

The inhibitors of DNA binding Id1-4 are helix-loop-helix (HLH) proteins that exert their biological function by interacting with members of the basic-HLH (bHLH) transcription-factor family. The HLH domains of the Id and bHLH proteins allow both self- and hetero-association. Due

Nemaline myopathy in a newborn infant: a rare muscle disorder.

O Olukman et al.

Neurologia i neurochirurgia polska, 47(5), 493-498 (2013-10-30)

Nemaline myopathy (NM) is a genetically and clinically heterogeneous muscle disorder, defined by the presence of characteristic nemaline bodies on muscle biopsy. The disease has a wide spectrum of phenotypes, ranging from forms with neonatal onset and fatal outcome to

Design and evaluation of hydroxamate derivatives as metal-mediated inhibitors of a protein tyrosine kinase.

Xianfeng Gu et al.

Journal of medicinal chemistry, 49(25), 7532-7539 (2006-12-08)

Protein tyrosine kinases use two Mg(2+) ions as cofactors in catalysis, one as the ATP-Mg complex (M1) and the other as an essential activator (M2). The M2-binding site has high affinity for transition metal cations such as cobalt and zinc.

Role of O-(2-18F-fluoroethyl)-L-tyrosine PET as a diagnostic tool for detection of malignant progression in patients with low-grade glioma.

Norbert Galldiks et al.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 54(12), 2046-2054 (2013-10-26)

In patients with low-grade glioma (LGG) of World Health Organization (WHO) grade II, early detection of progression to WHO grade III or IV is of high clinical importance because the initiation of a specific treatment depends mainly on the WHO

The osmopressor response is linked to upregulation of aquaporin-1 tyrosine phosphorylation on red blood cell membranes.

You Hsiang Chu et al.

Hypertension (Dallas, Tex. : 1979), 62(1), 197-202 (2013-05-22)

Studies in patients with an impaired efferent baroreflex led us to discover that ingesting water induces a robust increase in blood pressure and vascular resistance. This response was also present in healthy subjects with intact baroreflexes, described as osmopressor response.

Pentosidine and N(epsilon)-(carboxymethyl)-lysine in Alzheimer's disease and vascular dementia.

K J Bär et al.

Neurobiology of aging, 24(2), 333-338 (2002-12-25)

Increasing evidence suggests an interaction of oxidative stress and the formation of advanced glycation end products (AGE) in the onset and progression of Alzheimer's disease. We studied levels of pentosidine and N(epsilon)-(carboxymethyl)-lysine (CML) in serum and cerebrospinal fluid (CSF) of

Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines.

Anthony Bertucci et al.

Bioorganic & medicinal chemistry, 18(6), 2300-2303 (2010-02-24)

The activity of the coral Stylophora pystillata secretory carbonic anhydrase STPCA has been tested in presence of amino acids and amines. All the investigated compounds showed a positive, activating effect on k(cat) and have been separated in weak (K(A) in

Differential 12C-/13C-isotope dansylation labeling and fast liquid chromatography/mass spectrometry for absolute and relative quantification of the metabolome.

Kevin Guo et al.

Analytical chemistry, 81(10), 3919-3932 (2009-03-25)

We report a new quantitative metabolome profiling technique based on differential (12)C-/(13)C-isotope dansylation labeling of metabolites, fast liquid chromatography (LC) separation and electrospray ionization Fourier-transform ion cyclotron resonance mass spectrometry (ESI-FTICR MS) detection. An isotope reagent, (13)C-dansyl chloride, can be

Rational and efficient site-directed mutagenesis of adenylation domain alters relative yields of luminmide derivatives in vivo.

Xiaoying Bian et al.

Biotechnology and bioengineering, 112(7), 1343-1353 (2015-02-17)

Cloning and engineering of natural product biosynthetic pathways followed by heterologous expression in a tractable host is a widely used approach for expression and genetic modification of microbial secondary metabolites. Herein, we employed ccdB counterselection combined with oligonucleotide-mediated recombineering to

Acute tryptophan depletion reduces kynurenine levels: implications for treatment of impaired visuospatial memory performance in irritable bowel syndrome.

Paul J Kennedy et al.

Psychopharmacology, 232(8), 1357-1371 (2014-10-24)

A visuospatial episodic memory impairment has recently been identified in irritable bowel syndrome. Increased tryptophan metabolism along the kynurenine pathway has also been reported in irritable bowel syndrome, which may play a role in altered cognitive performance as peripheral kynurenine

Monitoring conformational changes in peroxisome proliferator-activated receptor α by a genetically encoded photoamino acid, cross-linking, and mass spectrometry.

Rico Schwarz et al.

Journal of medicinal chemistry, 56(11), 4252-4263 (2013-05-04)

Chemical cross-linking combined with an enzymatic digestion and mass spectrometric analysis of the reaction products has evolved into an alternative strategy to structurally resolve protein complexes. We investigated conformational changes in peroxisome proliferator-activated receptor α (PPARα) upon ligand binding. Using

Tyrosine-1 and threonine-4 phosphorylation marks complete the RNA polymerase II CTD phospho-code.

Martin Heidemann et al.

RNA biology, 9(9), 1144-1146 (2012-09-11)

Eukaryotic RNA polymerase II (RNAP II) has evolved an array of heptad repeats with the consensus sequence Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7 at the carboxy-terminal domain (CTD) of its largest subunit (Rpb1). Dynamic phosphorylation of Ser2, Ser5 and Ser7 residues orchestrates the binding of

Minced beef is more rapidly digested and absorbed than beef steak, resulting in greater postprandial protein retention in older men.

Bart Pennings et al.

The American journal of clinical nutrition, 98(1), 121-128 (2013-05-03)

Older individuals generally experience a reduced food-chewing efficiency. As a consequence, food texture may represent an important factor that modulates dietary protein digestion and absorption kinetics and the subsequent postprandial protein balance. We assessed the effect of meat texture on

Discriminating ability of (18)F-FET PET for several cerebral neoplastic lesions.

Tomoyuki Kawada

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 55(1), 176-176 (2013-11-08)

FET-PET-based reirradiation and chloroquine in patients with recurrent glioblastoma: first tolerability and feasibility results.

Angelika Bilger et al.

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 190(10), 957-961 (2014-06-15)

Treatment of recurrent glioblastoma (rGBM) remains an unsolved clinical problem. Reirradiation (re-RT) can be used to treat some patients with rGBM, but as a monotherapy it has only limited efficacy. Chloroquine (CQ) is an anti-malaria and immunomodulatory drug that may

Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines.

Daniela Vullo et al.

Bioorganic & medicinal chemistry letters, 17(15), 4107-4112 (2007-06-02)

An activation study of the human carbonic anhydrase (hCA, EC 4.2.1.1) isozymes VII and XIV using a small library of natural/non-natural amino acids and aromatic/heterocyclic amines is reported. hCA VII was efficiently activated by L-/D-His, dopamine and serotonin (K(A)s of

Continuous low-level glial cell line-derived neurotrophic factor delivery using recombinant adeno-associated viral vectors provides neuroprotection and induces behavioral recovery in a primate model of Parkinson's disease.

Andisheh Eslamboli et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 25(4), 769-777 (2005-01-28)

The therapeutic potential of glial cell line-derived neurotrophic factor (GDNF) for Parkinson's disease is likely to depend on sustained delivery of the appropriate amount to the target areas. Recombinant adeno-associated viral vectors (rAAVs) expressing GDNF may be a suitable delivery

Impact of hydration state and molecular oxygen on the chemical stability of levothyroxine sodium.

Mazen Lee Hamad et al.

Pharmaceutical development and technology, 20(3), 314-319 (2013-12-04)

Levothyroxine sodium is an important medication used primarily for treating patients with hypothyroidism. Levothyroxine sodium tablets have been recalled many times since their 1955 introduction to the US market. These recalls resulted from the failure of lots to meet their

Site-specific nitration of apolipoprotein A-I at tyrosine 166 is both abundant within human atherosclerotic plaque and dysfunctional.

Joseph A DiDonato et al.

The Journal of biological chemistry, 289(15), 10276-10292 (2014-02-22)

We reported previously that apolipoprotein A-I (apoA-I) is oxidatively modified in the artery wall at tyrosine 166 (Tyr(166)), serving as a preferred site for post-translational modification through nitration. Recent studies, however, question the extent and functional importance of apoA-I Tyr(166)

Second-sphere interactions between the C93-Y157 cross-link and the substrate-bound Fe site influence the O₂ coupling efficiency in mouse cysteine dioxygenase.

Wei Li et al.

Biochemistry, 52(51), 9104-9119 (2013-11-28)

Cysteine dioxygenase (CDO) is a non-heme iron enzyme that catalyzes the O₂-dependent oxidation of l-cysteine (l-Cys) to produce cysteinesulfinic acid (CSA). Adjacent to the Fe site of CDO is a covalently cross-linked cysteine-tyrosine pair (C93-Y157). While several theories have been

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