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Showing 1-30 of 168 results for "95-71-6" within Papers
Axel Maurice-Szamburski et al.
JAMA, 313(9), 916-925 (2015-03-04)
Sedative premedication is widely administered before surgery, but little clinical evidence supports its use. To assess the efficacy of sedative premedication on perioperative patient experience. A randomized clinical trial, the PremedX study, enrolled 1062 adult patients who were younger than
Mark J Mentrikoski et al.
American journal of clinical pathology, 143(3), 430-436 (2015-02-20)
Even with adequate history, the distinction of cutaneous metastatic breast carcinoma from primary sweat gland carcinoma can be difficult. Although previous studies have attempted to separate these tumors with various immunohistochemical panels, those series have been limited by small numbers
Mingquan Chen et al.
Anesthesia and analgesia, 118(4), 863-868 (2014-03-22)
In this study, we sought to determine the median effective dose (ED50) for motor block of intrathecally administered plain bupivacaine in adults (20-80 years) and to assess the effect of age on ED50 required for motor block. This study was
Bankole A Johnson et al.
JAMA psychiatry, 70(12), 1338-1346 (2013-10-18)
No medication has been established as an efficacious treatment for cocaine dependence. We hypothesized that dual modulation of the mesocorticolimbic dopamine system by topiramate-a glutamate receptor antagonist and γ-aminobutyric acid receptor agonist-would result in efficacious treatment for cocaine dependence compared
Dong-Mei An et al.
Epilepsy research, 92(2-3), 226-230 (2010-11-13)
Antiepileptic drugs including lamotrigine (LTG) and carbamazepine (CBZ) are among the most common causes of cutaneous adverse reactions (cADRs). Human leukocyte antigen (HLA)-B*1502 has been strongly associated with CBZ-induced Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). To investigate this relationship, we performed
Sabine Spiegl-Kreinecker et al.
Neuro-oncology, 12(1), 28-36 (2010-02-13)
O(6)-Methylguanine DNA methyltransferase (MGMT) is implicated as a major predictive factor for treatment response to alkylating agents including temozolomide (TMZ) of glioblastoma multiforme (GBM) patients. However, whether the MGMT status in GBM patients should be detected at the level of
Raphael N'Guessan et al.
PloS one, 11(11), e0165925-e0165925 (2016-11-17)
Malaria control through use of long-lasting insecticidal nets (LN) is threatened by the selection of anopheline mosquitoes strongly resistant to pyrethroid insecticides. To sustain future effectiveness it is essential to identify and evaluate novel insecticides suitable for nets. Mixtures of
Ana Antonic et al.
International journal of stroke : official journal of the International Stroke Society, 9(5), 544-552 (2014-01-08)
Hypothermia provides neuroprotection after cardiac arrest, hypoxic-ischemic encephalopathy, and in animal models of ischemic stroke. However, as drug development for stroke has been beset by translational failure, we sought additional evidence that hypothermia protects human neurons against ischemic injury. Human
M Pehlivan et al.
Platelets, 22(8), 588-595 (2011-05-20)
Immune thrombocytopenic purpura (ITP) is an autoimmune disease characterized by the presence of autoantibodies developing against thrombocyte membrane glycoproteins (GPs), such as GPIIa/IIIa and GPIb/IX. Single nucleotide polymorphisms (SNPs) of inflammatory cytokine genes were investigated in 71 patients with chronic
Anthony M Sammel et al.
Arthritis & rheumatology (Hoboken, N.J.), 71(8), 1319-1328 (2019-03-09)
Positron emission tomography/computed tomography (PET/CT) has not been well studied as a first-line test for giant cell arteritis (GCA), due, in part, to historical limitations in visualizing the cranial arteries. The Giant Cell Arteritis and PET Scan (GAPS) study was
Shilpa Grover et al.
JAMA, 308(5), 485-492 (2012-08-02)
Patients with multiple colorectal adenomas may carry germline mutations in the APC or MUTYH genes. To determine the prevalence of pathogenic APC and MUTYH mutations in patients with multiple colorectal adenomas who had undergone genetic testing and to compare the
R Hui et al.
Annals of oncology : official journal of the European Society for Medical Oncology, 28(4), 874-881 (2017-02-09)
Pembrolizumab improved survival as first- and second-line therapy compared with chemotherapy in patients with highly programmed death ligand 1 (PD-L1) expressing advanced non-small cell lung cancer (NSCLC). We report the long-term safety and clinical activity of pembrolizumab as first-line therapy
Nicole Berwald et al.
The American journal of emergency medicine, 32(7), 768-771 (2014-05-06)
The benefit of antibiotic prophylaxis for simple hand lacerations (lacerations that do not involve special structures) has not been adequately studied. To assess the feasibility of a randomized controlled trial to determine the role of antibiotic prophylaxis in emergency department
Eva-Katrin Bentz et al.
Reproductive sciences (Thousand Oaks, Calif.), 14(7), 705-709 (2007-11-15)
The relation between genetic variation of the androgen metabolism and transsexualism is unknown. In a case-control study of 100 male-to-female (MtF) transsexuals, 47 female-to-male (FtM) transsexuals, and 1670 controls, the authors assess allele and genotype frequencies of the steroid 5-alpha
Valerie C Cluzet et al.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 60(10), 1489-1496 (2015-02-05)
The duration of colonization and factors associated with clearance of methicillin-resistant Staphylococcus aureus (MRSA) after community-onset MRSA skin and soft-tissue infection (SSTI) remain unclear. We conducted a prospective cohort study of patients with acute MRSA SSTI presenting to 5 adult
Petros Christopoulos et al.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 18(9), 1430-1437 (2012-03-21)
Total body irradiation has been the mainstay of conditioning since the inception of allogeneic hematopoietic cell transplantation, but toxicity often precludes its use. For less-fit patients with acute lymphoblastic leukemia and other hematologic malignancies frequently affecting the central nervous system
Takara L Stanley et al.
JAMA, 312(4), 380-389 (2014-07-20)
Among patients infected with human immunodeficiency virus (HIV), visceral adiposity is associated with metabolic dysregulation and ectopic fat accumulation. Tesamorelin, a growth hormone-releasing hormone analog, specifically targets visceral fat reduction but its effects on liver fat are unknown. To investigate
F Ghodratnama et al.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 28(1), 12-15 (1999-01-16)
There has recently been renewed interest in the possible role of viruses in recurrent aphthous stomatitis (RAS). In this study, sera from 22 patients with RAS, 24 patients with oral lichen planus (OLP) and 15 healthy controls were screened for
Stijn Crobach et al.
The Journal of molecular diagnostics : JMD, 17(2), 193-200 (2014-12-30)
Differentiating primary endometrioid or mucinous ovarian tumors from secondary ovarian tumors can be challenging. We compared somatic mutation profiles of primary and secondary ovarian cancers to investigate if these profiles can help diagnose ovarian tumors. Cancer-related genes (n = 115)
X Yang et al.
The Journal of biological chemistry, 274(50), 35434-35440 (1999-12-10)
Diphosphoinositol polyphosphate phosphohydrolase (DIPP) hydrolyzes diadenosine 5',5"'-P(1),P(6)-hexaphosphate (Ap(6)A), a Nudix (nucleoside diphosphate attached-moiety "x") substrate, and two non-Nudix compounds: diphosphoinositol pentakisphosphate (PP-InsP(5)) and bis-diphosphoinositol tetrakisphosphate ((PP)(2)-InsP(4)). Guided by multiple sequence alignments, we used site-directed mutagenesis to obtain new information concerning
Mary E Cooley et al.
Journal of pain and symptom management, 49(1), 13-26 (2014-06-01)
Distressing symptoms interfere with the quality of life in patients with lung cancer. Algorithm-based clinical decision support (CDS) to improve evidence-based management of isolated symptoms seems promising, but no reports yet address multiple symptoms. This study examined the feasibility of
Reginald F Frye et al.
Clinical pharmacology and therapeutics, 80(3), 235-245 (2006-09-06)
The liver plays a significant role in drug metabolism; thus it would be expected that liver disease may have a detrimental effect on the activity of cytochrome P450 (CYP) enzymes. The extent to which the presence and severity of liver
Vappu Rantalaiho et al.
Annals of the rheumatic diseases, 73(11), 1954-1961 (2013-08-03)
To study whether adding initial infliximab to remission-targeted initial combination-DMARD treatment improves the long-term outcomes in patients with early rheumatoid arthritis (RA). Ninety-nine patients with early, DMARD-naïve RA were treated with a triple combination of DMARDs, starting with methotrexate (max
Rasha Mazen Al Khaldi et al.
Disease markers, 30(4), 197-212 (2011-06-23)
The aims of this study are to (1) study the influence of polymorphisms in adiponectin gene on adiponectin levels and potential associations with breast, prostate and colon cancer; (2) investigate the associations of adiponectin levels with other adipokines and breast
Walking and running produce similar reductions in cause-specific disease mortality in hypertensives.
Paul T Williams
Hypertension (Dallas, Tex. : 1979), 62(3), 485-491 (2013-08-14)
To test prospectively in hypertensives whether moderate and vigorous exercise produces equivalent reductions in mortality, Cox-proportional hazard analyses were applied to energy expenditure (metabolic equivalents hours/d [METh/d]) in 6973 walkers and 3907 runners who used hypertensive medications at baseline. A
Feng-Cai Zhu et al.
Lancet (London, England), 381(9882), 2024-2032 (2013-06-04)
A vaccine for enterovirus 71 (EV71) is needed to address the high burden of disease associated with infection. We assessed the efficacy, safety, immunogenicity, antibody persistence, and immunological correlates of an inactivated alum-adjuvant EV71 vaccine. We did a randomised, double-blind
Jin-Wei Cheng et al.
Clinical therapeutics, 30(4), 622-632 (2008-05-24)
This meta-analysis was performed to evaluate the efficacy and tolerability of bimatoprost compared with latanoprost in reducing intraocular pressure (IOP). Pertinent studies were identified through searches of PubMed, EMBASE, the Chinese Biomedicine Database, and the Cochrane Controlled Trials Register up
Jan-Yow Chen et al.
PloS one, 7(1), e29951-e29951 (2012-01-14)
It is well known that familial sick sinus syndrome (SSS) is caused by functional alterations of ion channels and gap junction. Limited information is available on the mechanism of age-related non-familial SSS. Although evidence shows a close link between arrhythmia
Ingrid Hansen-Pupp et al.
Pediatric research, 64(2), 183-188 (2008-04-09)
Preterm birth carries a risk for impaired developmental outcome. We have previously described an association between increased levels of proinflammatory cytokines during the first 72 postnatal hours and cerebral damage as detected by ultrasound in a cohort of 74 very
Z Suo et al.
Histopathology, 23(1), 45-54 (1993-07-01)
The expression of cytokeratins (CK) 1, 4, 5/6, 8, 13, 18, 19 and 20 and involucrin in 42 cases of squamous cell carcinomas from various locations was examined. The tumours expressed CK5/6 in 55%, CK8 in 76%, CK13 in 43%
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