CN
Search Within
A0326
Applied Filters:
Keyword:'A0326'
Showing 1-30 of 54 results for "A0326" within Papers
Yongli Chang et al.
Neurochemistry international, 122, 85-93 (2018-11-19)
The GABAergic rostromedial tegmental nucleus (RMTg) has reciprocal connections with the dopaminergic ventral tegmental area and substantia nigra pars compacta (SNc), and is involved in inhibitory control of monoaminergic nuclei. At present, it is not clear whether unilateral 6-hydroxydopamine lesions
Ligand recognition in glutamate receptors: insights from mutagenesis of the soluble alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-binding domain of glutamate receptor type D (GluR-D).
K Keinänen et al.
Biochemical Society transactions, 25(3), 835-838 (1997-08-01)
Wolfgang Wagner et al.
Cell reports, 28(1), 11-20 (2019-07-04)
Myosin VI is an actin-based cytoskeletal motor implicated in various steps of membrane trafficking. Here, we investigated whether this myosin is crucial for synaptic function and plasticity in neurons. We find that myosin VI localizes at cerebellar parallel fiber to
Hideki Toyota et al.
Neuroscience letters, 526(2), 128-132 (2012-09-04)
Topical FGLM-NH(2) (Phenylalanine-Glycine-Leucine-Methionine-Amide) plus SSSR (Serine-Serine-Serine-Arginine) facilitates recovery from vestibular disorders induced by (±)-α-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) in guinea pigs and might offer a treatment strategy for patients with peripheral vestibular disorders. The tetrapeptide FGLM-NH(2) derived from substance P (SP) can
Pei-Yu Shih et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(29), 9789-9802 (2014-07-18)
Neuronal nAChRs in the medial habenula (MHb) to the interpeduncular nucleus (IPN) pathway are key mediators of nicotine's aversive properties. In this paper, we report new details regarding nAChR anatomical localization and function in MHb and IPN. A new group
Tao Liu et al.
Molecular pain, 9, 16-16 (2013-03-30)
Proinflammatory cytokine interleukin-1β (IL-1β) released from spinal microglia plays an important role in the maintenance of acute and chronic pain states. However, the cellular basis of this action remains poorly understood. Using whole-cell patch-clamp recordings, we examined the action of
Mado Lemieux et al.
The Journal of cell biology, 198(6), 1055-1073 (2012-09-12)
The processing of excitatory synaptic inputs involves compartmentalized dendritic Ca(2+) oscillations. The downstream signaling evoked by these local Ca(2+) transients and their impact on local synaptic development and remodeling are unknown. Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is an important decoder
Roland Bock et al.
Nature neuroscience, 16(5), 632-638 (2013-04-02)
A hallmark of addiction is the loss of control over drug intake, which is seen in only a fraction of those exposed to stimulant drugs such as cocaine. The cellular mechanisms underlying vulnerability or resistance to compulsive drug use remain
Vincent Pascoli et al.
Nature, 509(7501), 459-464 (2014-05-23)
Nucleus accumbens neurons serve to integrate information from cortical and limbic regions to direct behaviour. Addictive drugs are proposed to hijack this system, enabling drug-associated cues to trigger relapse to drug seeking. However, the connections affected and proof of causality
Masahito Wakita et al.
Brain research bulletin, 118, 34-45 (2015-09-08)
We evaluated the effects of N2O on synaptic transmission using a preparation of mechanically dissociated rat hippocampal CA3 neurons that allowed assays of single bouton responses evoked from native functional nerve endings. We studied the effects of N2O on GABAA
Xin Yang et al.
Annals of neurology, 75(4), 492-507 (2013-11-19)
Hypoglycemia is a common adverse event and can injure central nervous system (CNS) white matter (WM). We determined whether glutamate receptors were involved in hypoglycemic WM injury. Mouse optic nerves (MON), CNS WM tracts, were maintained at 37°C with oxygenated
J E Hawkinson et al.
European journal of pharmacology, 329(2-3), 213-221 (1997-06-25)
AMPA receptors can be labeled using the agonist radioligands [3H](R,S)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid ([3H](R,S)-AMPA), [3H](S)-AMPA or [3H](S)-5-fluorowillardiine. In the presence of KSCN, [3H](R,S)-AMPA and [3H](S)-AMPA bind to a single population of sites in rat brain membranes, whereas [3H](S)-5-fluorowillardiine binds with two affinity
Frederic Lanore et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(49), 17882-17893 (2012-12-12)
The grik2 gene, coding for the kainate receptor subunit GluK2 (formerly GluR6), is associated with autism spectrum disorders and intellectual disability. Here, we tested the hypothesis that GluK2 could play a role in the appropriate maturation of synaptic circuits involved
Hidenobu Mizuno et al.
Neuron, 82(2), 365-379 (2014-04-02)
Thalamocortical (TC) connectivity is reorganized by thalamic inputs during postnatal development; however, the dynamic characteristics of TC reorganization and the underlying mechanisms remain unexplored. We addressed this question using dendritic refinement of layer 4 (L4) stellate neurons in mouse barrel cortex
Shunhui Wei et al.
Journal of neurochemistry, 124(4), 478-489 (2012-11-24)
Heterozygosity for missense mutations in Seipin, namely N88S and S90L, leads to a broad spectrum of motor neuropathy, while a number of loss-of-function mutations in Seipin are associated with the Berardinelli-Seip congenital generalized lipodystrophy type 2 (CGL2, BSCL2), a condition
Stuti J Jaiswal et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(6), 2616-2625 (2013-02-09)
Developmental nicotine exposure (DNE) impacts central respiratory control in neonates born to smoking mothers. We previously showed that DNE enhances the respiratory motor response to bath application of AMPA to the brainstem, although it was unclear which brainstem respiratory neurons
Seth L Shipman et al.
Neuron, 76(2), 309-316 (2012-10-23)
At neuronal excitatory synapses, two major subtypes of the synaptic adhesion molecule neuroligin are present. These subtypes, neuroligin 1 and neuroligin 3, have roles in synaptogenesis and synaptic maintenance that appear largely overlapping. In this study, we combine electrophysiology with
Joonwoo Lee et al.
Biological & pharmaceutical bulletin, 36(3), 331-338 (2013-03-02)
Various effects of acorn extract have been reported including antioxidant activity, cytotoxicity against cancer cells, and the levels of acetylcholine and its related enzyme activities in the dementia mouse models. However, it is unclear whether acorn extract inhibits glutamate-induced calcium
H Kylin
Chemosphere, 90(6), 1821-1828 (2012-10-10)
Environmental monitoring of pesticide residues in surface water is often done with time-integrated sampling where a specified volume is sampled each hour during, e.g., a week, thus avoiding at momentary high or low extreme concentrations. However, sampling over an extended
Cristina Limatola
Cerebellum (London, England), 3(1), 2-10 (2004-04-10)
AMPA-type glutamate receptors may transduce both neurotoxic and neurotrophic signals, basically depending on receptor subunit composition and on the extent of receptor activation. While a great deal of data are available on the mechanisms underlying the neurotoxic effects induced by
Aase Frandsen et al.
Neurochemical research, 28(10), 1495-1499 (2003-10-23)
Glutamate-induced neurodegeneration is the result of excessive stimulation of the different subtypes of glutamate receptors. With regard to the AMPA ((RS)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionate) receptors it has been clear from numerous studies that in addition to the Ca2+ permeability of the receptor complexes
Ahmed H Ahmed et al.
The Journal of biological chemistry, 287(49), 41007-41013 (2012-10-19)
Glutamate receptors mediate the majority of excitatory synaptic transmission in the central nervous system, and excessive stimulation of these receptors is involved in a variety of neurological disorders and neuronal damage from stroke. The development of new subtype-specific antagonists would
Timm Schubert et al.
Neuron, 78(1), 124-137 (2013-04-16)
Presynaptic inhibition onto axons regulates neuronal output, but how such inhibitory synapses develop and are maintained in vivo remains unclear. Axon terminals of glutamatergic retinal rod bipolar cells (RBCs) receive GABAA and GABAC receptor-mediated synaptic inhibition. We found that perturbing GABAergic
Kari R Nations et al.
Journal of psychopharmacology (Oxford, England), 26(12), 1525-1539 (2012-09-08)
Org 26576 acts by modulating ionotropic AMPA-type glutamate receptors to enhance glutamatergic neurotransmission. The aim of this Phase 1b study (N=54) was to explore safety, tolerability, pharmacokinetics, and pharmacodynamics of Org 26576 in depressed patients. Part I (N=24) evaluated the
Pierre Francotte et al.
Journal of medicinal chemistry, 56(20), 7838-7850 (2013-10-05)
On the basis of the results obtained in previous series of AMPA potentiators belonging to 3,4-dihydro-2H-benzo- and 3,4-dihydro-2H-pyrido-1,2,4-thiadiazine 1,1-dioxides, the present work focuses on the design of original isosteric 3,4-dihydro-2H-thieno-1,2,4-thiadiazine 1,1-dioxides. Owing to the sulfur position, three series of compounds
Is mTOR involved in the mechanisms of the fast-acting antidepressant effects of AMPA receptor agonists?
Yimin Hu et al.
Amino acids, 44(3), 1093-1093 (2012-10-12)
Tine Bryan Stensbøl et al.
Current pharmaceutical design, 8(10), 857-872 (2002-04-12)
It is generally agreed that (S)-glutamic acid (Glu) receptors are involved in the development of a number of diseases in the central nervous system (CNS), and ligands that interact with these receptors are of significant interest. Selective ligands are indispensable
Jun Wang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(43), 15124-15132 (2012-10-27)
We found previously that acute ex vivo as well as repeated cycles of in vivo ethanol exposure and withdrawal, including excessive voluntary consumption of ethanol, produces a long-lasting increase in the activity of NR2B-containing NMDA receptors (NR2B-NMDARs) in the dorsomedial
Interneuron Diversity series: Fast in, fast out-temporal and spatial signal processing in hippocampal interneurons
Jonas P, et al.
Trends in Neurosciences, 27(1), 30-40 (2004)
Sheyla Mejia-Gervacio
The Journal of physiology, 590(19), 4663-4671 (2012-08-15)
A cholinergic synaptic input has been highlighted in recent years as an important modulator of motoneuron excitability. In the present study, it was examined whether, as in other regions, the cholinergic inputs on spinal motoneurons modulate the glutamatergic synaptic activity
Page 1 of 2