Martin Spickenreither et al.
Bioorganic & medicinal chemistry letters, 16(20), 5313-5316 (2006-08-16)
Previously, we identified ascorbic acid 6-O-hexadecanoate as an up to 1500 times more potent inhibitor of bacterial and bovine hyaluronidases than the parent compound, vitamin C, and determined a crystal structure of hyaluronidase from Streptococcus pneumoniae in complex with the