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Showing 1-30 of 82 results for "A3785" within Papers
Shireen A Mazroa et al.
International journal of experimental pathology, 96(3), 172-182 (2015-04-22)
Polypropylene mesh is commonly used in the treatment of abdominal hernia. Different approaches were addressed to improve their tissue integration and consequently reduce long-term complications. This study aimed to investigate the effect of alpha-lipoic acid (ALA) co-administration on structural and
Eric M Kercher et al.
Journal of biomedical optics, 25(6), 1-13 (2020-04-17)
Commercial lasers, lamps, and light-emitting diode (LED) light sources have stimulated the clinical translation of photodynamic therapy (PDT). Yet, the continued exploration of new photosensitizers (PSs) for PDT often requires separate activation wavelengths for each agent being investigated. Customized light
Hidetoshi Takahashi et al.
The Journal of dermatology, 41(8), 729-731 (2014-08-08)
Photodynamic therapy (PDT) is useful for superficial skin tumors such as actinic keratosis and Bowen disease. Although PDT is non-surgical and easily-performed treatment modality, irradiation apparatus is large and expensive. Using 7, 12-dimethylbenz[a]anthracene (DMBA) and 12-ο-tetradecanoylphorbol-13-acetate (TPA)-induced mouse skin papilloma
Conditional expression of PfAP2-G for controlled massive sexual conversion in Plasmodium falciparum.
Oriol Llorà-Batlle et al.
Science advances, 6(24), eaaz5057-eaaz5057 (2020-06-25)
Malaria transmission requires that some asexual parasites convert into sexual forms termed gametocytes. The initial stages of sexual development, including sexually committed schizonts and sexual rings, remain poorly characterized, mainly because they are morphologically identical to their asexual counterparts and
Yasushi Nakai et al.
Photodiagnosis and photodynamic therapy, 12(2), 282-288 (2015-01-18)
We evaluated the feasibility of photodynamic diagnosis of bladder cancer by spectrophotometric analysis of voided urine samples after extracorporeal treatment with 5-aminolevulinic acid (ALA). Sixty-one patients with bladder cancer, confirmed histologically after the transurethral resection of a bladder tumor, were
Minami Nishikiori et al.
Journal of chromatographic science, 53(4), 537-541 (2014-07-19)
It has been suggested that serum concentrations of polyunsaturated essential fatty acids correlate with the symptoms or severity of various diseases, including depression and Alzheimer-type dementia, and that determination of serum fatty acids might be important for disease diagnosis. Thus
C L Sherry et al.
Prostaglandins, leukotrienes, and essential fatty acids, 95, 63-69 (2015-02-24)
This study investigated the effects of docosahexaenoic acid (DHA) supplementation on the fatty acid composition of breast milk and plasma concentrations in lactating women and their infants. Eighty-nine lactating women 4-6 weeks post-partum received placebo, 200 mg or 400 mg
Breann L Brown et al.
Structure (London, England : 1993), 26(4), 580-589 (2018-03-20)
5-Aminolevulinic acid synthase (ALAS) catalyzes the first step in heme biosynthesis. We present the crystal structure of a eukaryotic ALAS from Saccharomyces cerevisiae. In this homodimeric structure, one ALAS subunit contains covalently bound cofactor, pyridoxal 5'-phosphate (PLP), whereas the second
Carla S Santos et al.
Plants (Basel, Switzerland), 8(9) (2019-09-22)
Iron deficiency chlorosis (IDC) is an abiotic stress often experienced by soybean, owing to the low solubility of iron in alkaline soils. Here, soybean lines with contrasting Fe efficiencies were analyzed to test the hypothesis that the Fe efficiency trait
Amrita Khaire et al.
Reproduction, fertility, and development, 27(2), 341-350 (2013-12-21)
Maternal vitamin B12 deficiency leads to an adverse pregnancy outcome and increases the risk for developing diabetes and metabolic syndrome in mothers in later life. Our earlier studies have demonstrated that vitamin B12 and n-3 polyunsaturated fatty acids (PUFA) are
Floor A Harms et al.
Journal of clinical monitoring and computing, 29(4), 509-519 (2014-11-13)
The recently developed technique for measuring cutaneous mitochondrial oxygen tension (mitoPO2) by means of the Protoporphyrin IX-Triplet State Lifetime Technique (PpIX-TSLT) provides new opportunities for assessing mitochondrial function in vivo. The aims of this work were to study whether cutaneous
Jonathan M Fahey et al.
Nitric oxide : biology and chemistry, 49, 47-55 (2015-06-13)
Employing an in vitro model for 5-aminolevulinic acid (ALA)-based photodynamic therapy (PDT), we recently reported that human prostate cancer PC3 cells rapidly and persistently overexpressed inducible nitric oxide synthase (iNOS) and nitric oxide (NO) after a moderate ALA/light challenge. The
Ashleigh K A Wiggins et al.
Experimental cell research, 333(1), 147-154 (2015-03-10)
Heterogeneity of breast cancer (BC) subtypes makes BC treatment difficult. α-linolenic acid (ALA), rich in flaxseed oil, has been shown to reduce growth and increase apoptosis in several BC cell lines, but the mechanism of action needs further understanding. Four
Chengcheng Zhang et al.
PloS one, 10(4), e0123256-e0123256 (2015-04-18)
Colorectal cancer is common. Polyunsaturated fatty acids (PUFAs) exert growth-inhibitory and pro-apoptotic effects on colon cancer cells. Metabolites of PUFAs such as prostaglandins (PGs), leukotrienes (LTs) and lipoxins (LXs) play a significant role in colon cancer. Human colon cancer LoVo
Aleksandra Kawczyk-Krupka et al.
Photodiagnosis and photodynamic therapy, 12(1), 27-35 (2015-01-17)
Photodynamic therapy (PDT) reveals immune modulatory effect. The aim of the study was to evaluate the influence of 5-aminolevulinic acid (ALA) mediated photodynamic effect on secretory activity (MIF, MCP-1) of colon cancer cells in vitro both in normoxia and in
Konrad Teodor Sawicki et al.
Journal of the American Heart Association, 4(8), e002272-e002272 (2015-08-02)
Heme is an essential iron-containing molecule for cardiovascular physiology, but in excess it may increase oxidative stress. Failing human hearts have increased heme levels, with upregulation of the rate-limiting enzyme in heme synthesis, δ-aminolevulinic acid synthase 2 (ALAS2), which is
Xue Yang et al.
Photochemistry and photobiology, 91(4), 923-930 (2015-03-27)
Aminolevulinic acid (ALA)-mediated protoporphyrin IX (PpIX) production is being explored for tumor fluorescence imaging and photodynamic therapy (PDT). As a prodrug, ALA is converted in heme biosynthesis pathway to PpIX with fluorescent and photosensitizing properties. To better understand the role
Shigeru Kato et al.
The Journal of surgical research, 176(2), 430-436 (2012-01-10)
Lymph node metastasis is one of the most critical prognostic factors in patients with colorectal cancer. Although regional lymph nodes should be surgically resected and pathologically examined, techniques for the intraoperative diagnosis of lymph node metastasis remain to be well
Sofía Mira-Martínez et al.
Antimicrobial agents and chemotherapy, 63(5) (2019-02-21)
During the intraerythrocytic asexual cycle malaria parasites acquire nutrients and other solutes through a broad selectivity channel localized at the membrane of the infected erythrocyte termed the plasmodial surface anion channel (PSAC). The protein product of the Plasmodium falciparum clonally
N Neittaanmäki-Perttu et al.
The British journal of dermatology, 171(5), 1172-1180 (2014-08-12)
Daylight-mediated photodynamic therapy (DL-PDT) using methyl-5-aminolaevulinate (MAL) is effective for thin, grade I, actinic keratoses (AK). There are no published studies of other photosensitizers used in DL-PDT. To compare the efficacy and adverse effects of 5-aminolaevulinic acid nanoemulsion (BF-200 ALA)
Wuting Wei et al.
Neurochemistry international, 87, 85-91 (2015-06-10)
Alpha lipoic acid (ALA) is a powerful antioxidant that has proven protective effects against brain damage following a traumatic brain injury (TBI) in rats. However, the molecular mechanisms underlying these effects are not well understood. This study investigated the effect
Lucia La Sala et al.
Acta diabetologica, 52(3), 505-512 (2014-11-16)
High glucose-induced oxidative stress has been suggested as one of the mediators of endothelial damage in diabetes. The major endothelial protein, endoglin, has been found overexpressed in the vessels during pathological situations, but little is known about its relation to
Venkareddy Lalith Kumar et al.
Neurochemical research, 39(12), 2501-2515 (2014-10-18)
Epidemiological evidence has shown higher susceptibility of Children to the adverse effects of lead (Pb) exposure. However, experimental studies on Pb-induced neurotoxicity in prepubertal (PP) rats are limited. The present study aimed to examine the propensity of ferulic acid (FA)
N Guelzim et al.
Prostaglandins, leukotrienes, and essential fatty acids, 91(5), 203-211 (2014-08-31)
The hypothesis that n-3 polyunsaturated fatty acids (PUFA) could contribute to maintain muscle mass during energy restriction aiming to weight loss was tested in the rat, with special attention paid to insulin signalling. After 10 weeks on a diet rich
Eric G Hernández et al.
PloS one, 10(5), e0126195-e0126195 (2015-05-06)
Amebiasis is an endemic disease and a public health problem throughout Mexico, although the incidence rates of amebic liver abscess (ALA) vary among the geographic regions of the country. Notably, incidence rates are high in the northwestern states (especially Sonora
Wai Wing So et al.
Nutrients, 7(8), 6956-6973 (2015-08-22)
Omega-3 (n-3) fatty acids are dietary long-chain fatty acids with an array of health benefits. Previous research has demonstrated the growth-inhibitory effect of n-3 fatty acids on different cancer cell lines in vitro, yet their anti-tumor effects and underlying action
Alexander Persoskie et al.
Social science & medicine (1982), 141, 46-55 (2015-08-08)
In addition to their primary goal of protecting nonsmokers from secondhand smoke, smoke-free air laws may also encourage intentions to quit smoking, quit attempts, and cessation among smokers. However, laws may not encourage quitting if smokers feel threatened by them
Daniel J Ham et al.
The Journal of nutrition, 145(5), 900-906 (2015-03-06)
Increasing arginine (Arg) availability reduces atrophy in cultured skeletal muscle cells. Supplementation with its metabolic precursor citrulline (Cit) is more effective at improving skeletal muscle Arg concentrations. We tested the hypothesis that Cit supplementation would attenuate skeletal muscle atrophy and
A A Philchenkov et al.
Experimental oncology, 36(4), 241-245 (2014-12-30)
Photodynamic therapy (PDT) is considered as a possible alternative approach to overcoming multidrug resistance (MDR). Analysis of cross-resistance to PDT in cells with different MDR pathways and resistance levels seems to be advantageous for elucidating the general mechanisms of cancer
Pritpal Kaur et al.
PloS one, 16(11), e0260400-e0260400 (2021-11-23)
Heme is an essential cofactor for enzymes of the electron transport chain (ETC) and ATP synthesis in mitochondrial oxidative phosphorylation (OXPHOS). Heme also binds to and destabilizes Bach1, a transcription regulator that controls expression of several groups of genes important
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