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A4034
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Showing 1-30 of 233 results for "A4034" within Papers
K E Hwang et al.
Poultry science, 92(12), 3244-3250 (2013-11-16)
We investigated the inhibition of lipid oxidation of raw chicken patties by the antioxidants ascorbic acid (Aa), ganghwayakssuk extracts (GE), and their combination (Aa + GE). All antioxidant combinations were effective at delaying lipid oxidation compared with the control or
Scott B Swarbreck et al.
The Journal of surgical research, 191(2), 432-440 (2014-05-13)
Sepsis, a potential risk associated with surgery, leads to a systemic inflammatory response including the plugging of capillary beds. This plugging may precipitate organ failure and subsequent death. We have shown that capillary plugging can be reversed rapidly within 1
X Yang et al.
Poultry science, 93(4), 898-905 (2014-04-08)
The study was conducted to determine the effects of low ambient temperature (LAT) and a vitamin C (VC) dietary supplement on the growth performance, blood parameters, and antioxidant capacity of 21-d-old broilers. A total of 400 one-day-old male Cobb broilers
Gábor Bánhegyi et al.
Biochimica et biophysica acta, 1843(9), 1909-1916 (2014-06-08)
Beyond its general role as antioxidant, specific functions of ascorbate are compartmentalized within the eukaryotic cell. The list of organelle-specific functions of ascorbate has been recently expanded with the epigenetic role exerted as a cofactor for DNA and histone demethylases
Jing Hao et al.
The EMBO journal, 34(15), 2096-2110 (2015-06-18)
The replisome is important for DNA replication checkpoint activation, but how specific components of the replisome coordinate with ATR to activate Chk1 in human cells remains largely unknown. Here, we demonstrate that And-1, a replisome component, acts together with ATR
Michael DiPrima et al.
Molecular oncology, 13(11), 2441-2459 (2019-09-24)
Advanced colorectal carcinoma is currently incurable, and new therapies are urgently needed. We report that phosphotyrosine-dependent Eph receptor signaling sustains colorectal carcinoma cell survival, thereby uncovering a survival pathway active in colorectal carcinoma cells. We find that genetic and biochemical
Rajaa Sebaa et al.
Molecular metabolism, 25, 35-49 (2019-05-08)
Brown adipose tissue (BAT) is important for thermoregulation in many mammals. Uncoupling protein 1 (UCP1) is the critical regulator of thermogenesis in BAT. Here we aimed to investigate the deacetylation control of BAT and to investigate a possible functional connection
Nafees B Baig et al.
Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus, 19(5), 455-461 (2015-10-22)
To compare the in vitro characteristics of Tenon's capsule fibroblasts from children and adults that may be relevant to filtration surgery success. Fibroblast cell lines derived from 5 young (median patient age, 2.4 years) and 7 old (median patient age
Jiangnan Zheng et al.
Journal of chromatography. A, 1358, 29-38 (2014-07-22)
Selective enrichment of glycopeptides from complex biological samples is essential for MS-based glycoproteomics, but challenges still remain. In this work, glucose-functionalized magnetic mesoporous nanoparticles (MMNs), which hold the attractive features of well-defined core/shell structure, high specific surface area (324m(2)/g), narrow
Emily G McDermott et al.
Journal of medical entomology, 56(5), 1359-1367 (2019-05-28)
Attractive toxic sugar baits (ATSBs) can be an effective vector control tool, especially in areas where aerial or aquatic applications of pesticides are undesirable or impractical. In general, there is a need to develop novel or alternative insecticides for vector
Annlia Paganini-Hill et al.
American journal of epidemiology, 181(2), 120-126 (2015-01-01)
To assess the relationship between antioxidant vitamin intake and all-cause mortality in older adults, we examined these associations using data from the Leisure World Cohort Study, a prospective study of residents of the Leisure World retirement community in Laguna Hills
Matthew Allan et al.
Food chemistry, 195, 2-10 (2015-11-18)
Deliquescence points (RH0, RH0mix) of ionic crystalline food ingredients and blends thereof were determined using water activity and moisture sorption techniques. Measured RH0mix values of ingredient blends with and without a common ion were compared to Ross equation predictions of
Pedro Cisternas et al.
Journal of neurochemistry, 129(4), 663-671 (2014-01-28)
Vitamin C is an essential factor for neuronal function and survival, existing in two redox states, ascorbic acid (AA), and its oxidized form, dehydroascorbic acid (DHA). Here, we show uptake of both AA and DHA by primary cultures of rat
Vijayalakshmi Thamilselvan et al.
BJU international, 114(1), 140-150 (2014-01-28)
To test our hypothesis that physiological levels of urinary oxalate induce oxidative renal cell injury, as studies to date have shown that oxalate causes oxidative injury only at supra-physiological levels. To study the combined effect of α-tocopherol and ascorbic acid
Sang Hun Lee et al.
Neuron, 108(4), 676-690 (2020-09-07)
Amyloid precursor protein (APP) is associated with both familial and sporadic forms of Alzheimer's disease. Despite its importance, the role of APP family in neuronal function and survival remains unclear because of perinatal lethality exhibited by knockout mice lacking all
Branden J Stansley et al.
Psychopharmacology, 232(17), 3203-3213 (2015-06-04)
L-dopa, the main therapeutic for Parkinson's disease (PD), has been shown to increase brain dopamine concentrations that are necessary for proper motor control; however, PD patients experience non-motor symptoms that are not improved or could be exacerbated by L-dopa. The
Sasmita Tripathy et al.
Journal of lipid research, 55(7), 1448-1464 (2014-05-13)
Nonalcoholic fatty liver disease is a major public health concern in the obese and type 2 diabetic populations. The high-fat lard diet induces obesity and fatty liver in C57BL/6J mice and suppresses expression of the PPAR-target gene, FA elongase 5
Jungwoo Wren Kim et al.
Cell stem cell, 27(4), 633-645 (2020-08-28)
The G2019S mutation in leucine-rich repeat kinase 2 (LRRK2) is a common cause of familial Parkinson's disease (PD). This mutation results in dopaminergic neurodegeneration via dysregulated protein translation, although how alterations in protein synthesis contribute to neurodegeneration in human neurons
David L Choveaux et al.
Experimental parasitology, 148, 30-39 (2014-12-03)
Copper is an essential micronutrient for all living organisms as an important catalytic co-factor for key enzymes. In higher eukaryotes intracellular copper is distributed by copper metallochaperones. Copper chelators such as neocuproine and tetrathiomolybdate inhibit Plasmodium falciparum erythrocytic development, indicating
Paul F Kramer et al.
eLife, 9 (2020-09-02)
Axons of dopaminergic neurons innervate the striatum where they contribute to movement and reinforcement learning. Past work has shown that striatal GABA tonically inhibits dopamine release, but whether GABA-A receptors directly modulate transmission or act indirectly through circuit elements is
Dominique Leitner et al.
Stem cell research, 41, 101617-101617 (2019-11-16)
Parkinson's disease is associated with the loss of dopaminergic neurons in the midbrain. Clinical studies investigating replacement of these neurons with in vitro-generated neurons are currently underway. However, this approach has been limited by difficulties in scaling up on-demand production
Marta Soler et al.
Inorganic chemistry, 54(22), 10542-10558 (2015-10-28)
The conjugation of redox-active complexes that can function as chemical nucleases to cationic tetrapeptides is pursued in this work in order to explore the expected synergistic effect between these two elements in DNA oxidative cleavage. Coordination complexes of biologically relevant
Uwe Gröber et al.
Medizinische Monatsschrift fur Pharmazeuten, 36(4), 133-143 (2013-05-10)
Many patients receiving cancer treatment use micronutrient supplements, with the intention to complement their cancer treatment, or help them cope with the therapy- and disease-associated side-effects. Up to 90% of the cancer patients are adding antioxidants without the knowledge of
Junitsu Ito et al.
Life sciences, 95(1), 1-8 (2013-12-21)
Aldehyde reductase (AKR1A), a member of the aldo-keto reductase superfamily, is highly expressed in the liver and is involved in both the detoxification of carbonyl compounds and ascorbic acid biosynthesis. By comparison with wild-type mice, Akr1a-knockout (Akr1a(-/-)) mice and human
Senlian Hong et al.
Cell chemical biology, 27(9), 1140-1150 (2020-07-11)
Wnt/β-catenin signaling regulates critical, context-dependent transcription in numerous physiological events. Among the well-documented mechanisms affecting Wnt/β-catenin activity, modification of N-glycans by L-fucose is the newest and the least understood. Using a combination of Chinese hamster ovary cell mutants with different
Recombinant spider silk protein eADF4(C16)-RGD coatings are suitable for cardiac tissue engineering.
Johannes P M Kramer et al.
Scientific reports, 10(1), 8789-8789 (2020-05-31)
Cardiac tissue engineering is a promising approach to treat cardiovascular diseases, which are a major socio-economic burden worldwide. An optimal material for cardiac tissue engineering, allowing cardiomyocyte attachment and exhibiting proper immunocompatibility, biocompatibility and mechanical characteristics, has not yet emerged.
Zilan Zhou et al.
International journal of pharmaceutics, 487(1-2), 81-90 (2015-04-14)
A dual functional nano-scaled drug carrier, comprising of a targeting ligand and pH sensitivity, has been made in order to increase the specificity and efficacy of the drug delivery system. The nanoparticles are made of a tri-block copolymer, poly(d,l lactide-co-glycolide)
Ulrich Moser
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 82(5), 327-332 (2013-06-26)
Deficiencies of essential nutrients have been responsible for many epidemic outbreaks of deficiency diseases in the past. Large observational studies point at possible links between nutrition and chronic diseases. Low intake of antioxidant vitamins e. g. have been correlated to
Amit Kumar Mishra et al.
Indian journal of biochemistry & biophysics, 50(2), 139-149 (2013-06-01)
The effects of elevated CO2 and O3, singly and in combination were investigated on various physiological, biochemical and yield parameters of two locally grown wheat (Triticum aestivum L.) cultivars (HUW-37 and K-9107) in open top chambers (OTCs). Elevated CO2 stimulated
Eman Al-Sayed et al.
Pharmaceutical biology, 52(12), 1581-1590 (2014-09-23)
Liver disease is a serious problem. Polyphenolic compounds have marked antioxidant effect and can prevent the liver damage caused by free radicals. In vitro studies have revealed the strong antioxidant activity of an ellagitannin-rich plant, namely, Melaleuca styphelioides Sm. (Myrtaceae).
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