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Showing 1-30 of 726 results for "A5376" within Papers
A Anil Timur et al.
Thrombosis research, 134(1), 96-104 (2014-05-24)
Poor response to antiplatelet drugs is associated with adverse outcomes. We assessed platelet inhibition and its stability and tested correlation and agreement between platelet function assays. Peripheral blood from 58 patients on both aspirin and clopidogrel who underwent percutaneous coronary
Antiplatelet therapy and anticoagulants.
Bartosz Hudzik et al.
Lancet (London, England), 382(9886), 24-24 (2013-07-09)
Nivedita Priya et al.
Bioorganic & medicinal chemistry, 18(11), 4085-4094 (2010-05-08)
We have studied earlier a membrane bound novel enzyme Acetoxy Drug: protein transacetylase identified as Calreticulin Transacetylase (CRTAase) that catalyzes the transfer of acetyl groups from polyphenolic acetates (PAs) to the receptor proteins and thus modulating their biological activities. In
Yulia S Chistyachenko et al.
Drug delivery, 22(3), 400-407 (2014-02-13)
Inclusion complexes of salicylic acid (SA) and acetylsalicylic acid (aspirin, ASA) with polysaccharide arabinogalactan (AG) from larch wood Larix sibirica and Larix gmelinii were synthesized using mechanochemical technology. In the present study, we have investigated physicochemical properties of the synthesized
Christoph J Konrad et al.
Journal of clinical anesthesia, 18(1), 12-17 (2006-03-07)
The aim of the study was to determine the duration and effects of aspirin on platelet function. Prospective investigation. Blood samples from volunteers. PATIENTS AND MONITORING: Ten healthy male volunteers took part in this investigation. After having measured baseline hemostatic
Romain A Colas et al.
American journal of physiology. Cell physiology, 307(1), C39-C54 (2014-04-04)
Resolution of acute inflammation is an active process locally controlled by a novel genus of specialized pro-resolving mediators (SPM) that orchestrate key resolution responses. Hence, it is of general interest to identify individual bioactive mediators and profile their biosynthetic pathways
V Khanna et al.
Journal of thrombosis and haemostasis : JTH, 13(6), 920-930 (2015-03-27)
Dual-antiplatelet therapy (DAPT) with aspirin and a P2Y12 inhibitor, mostly clopidogrel, is the default therapy in both acute coronary syndrome (ACS) and after intracoronary stents. It is well established that responses to antiplatelet therapy (APT), particularly clopidogrel, are subject to
Bogdan Januś et al.
Kardiologia polska, 73(5), 323-330 (2014-11-28)
In patients with acute ST segment elevation myocardial infarction (STEMI), primary percutaneous coronary intervention (PCI) is the preferred reperfusion method over fibrinolysis, if it is performed in a timely fashion by an experienced team in a centre with on-site primary
Sean Ekins et al.
Drug metabolism and disposition: the biological fate of chemicals, 38(12), 2302-2308 (2010-09-17)
Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predictive in vivo, in vitro, and in silico models to identify compounds
Alejandro M S Mayer et al.
Bioorganic & medicinal chemistry, 20(1), 279-282 (2011-12-14)
The effects of five Hymeniacidon sp. amphilectane metabolites (1-5) and two semi-synthetic analogs (6 and 7) on thromboxane B(2) (TXB(2)) and superoxide anion (O(2)(-)) generation from Escherichia coli LPS-activated rat brain microglia were investigated. All Hymeniacidon sp. metabolites and analogs
Immune thrombocytopenic purpura and myocardial infarction: a dilemma of management.
Ghassan Zaid et al.
The Israel Medical Association journal : IMAJ, 15(12), 775-776 (2014-01-24)
[Serious organ damage and intractable clinical conditions in rheumatic and connective tissue disease--progress in pathophysiology and treatment. Topics: II. Clinical conditions special attention needed to be paid to; 2. Antiphospholipid syndrome].
Shinsuke Yasuda
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 102(10), 2621-2630 (2014-01-10)
Nauder Faraday et al.
The American journal of cardiology, 98(6), 774-779 (2006-09-05)
Resistance to inhibition of platelet function by aspirin may contribute to future myocardial infarction and stroke. Adverse cardiovascular outcomes have been associated with aspirin resistance on several different platelet function assays, including the level of urinary 11-dehydro thromboxane B2 (Tx-M)
Smoking status and the effects of antiplatelet drugs.
Michael M Hirschl
BMJ (Clinical research ed.), 347, f5909-f5909 (2014-01-30)
H Yang et al.
Cell death & disease, 6, e1786-e1786 (2015-06-13)
High-mobility group box 1 (HMGB1) is an inflammatory molecule that has a critical role in the initiation and progression of malignant mesothelioma (MM). Aspirin (acetylsalicylic acid, ASA) is the most widely used nonsteroidal anti-inflammatory drug that reduces the incidence, metastatic
Arshad Mehmood Abbasi et al.
International journal of molecular sciences, 16(6), 13507-13527 (2015-06-16)
Mango (Mangifera indica L.), also called "the king of fruits", is one of the most popular fruits in tropical regions. Pulp and peel samples of mango cultivars were analyzed to estimate total phenolic, total flavonoid and total anthocyanin contents. Phenolic
Mariana Martins Gomes Pinheiro et al.
PloS one, 10(3), e0121063-e0121063 (2015-03-26)
Choisya ternata Kunth (Rutaceae) is native to North America where it is popularly known as "Mexican orange". In this study, the anti-inflammatory effects of the essential oil (EO) obtained from the leaves of C. ternata, one of its minor components
Vasileios I Sakellariou et al.
The Journal of arthroplasty, 30(9), 1618-1622 (2015-04-22)
We retrospectively reviewed 110 patients who underwent two-stage revision surgery in order to identify potential risk factors for recurrence of periprosthetic infection. We found that patients with inflammatory arthritis (P=0.0125), perioperative hematoma formation (P=0.0422), wound dehiscence (P=0.042), and those who
Hoa L Nguyen et al.
PloS one, 9(10), e108998-e108998 (2014-10-04)
Cardiovascular disease is one of the leading causes of morbidity and mortality in Vietnam. We conducted a pilot study of Hanoi residents hospitalized with a first acute myocardial infarction (AMI) at the Vietnam National Heart Institute in Hanoi for purposes
Subhash Reddy et al.
The American surgeon, 80(10), 975-978 (2014-09-30)
Antiplatelet and anticoagulant medication increases the risk of intracranial hemorrhage (ICH) after a fall in geriatric patients. We sought to determine whether there were differences in ICH rates and outcomes based on type of anticoagulant or antiplatelet agent after a
Vijay Kunadian et al.
The American journal of cardiology, 114(12), 1823-1829 (2014-12-03)
There are limited data on the impact of anemia on clinical outcomes in unstable angina and non-ST-segment elevation myocardial infarction treated with an early invasive strategy. We sought to determine the short- and long-term clinical events among patients with and
Levent Ozturk et al.
BMC anesthesiology, 15, 104-104 (2015-07-22)
The goal of this study was to compare the influence of an interscalene brachial plexus block (ISB) performed with either bupivacaine or levobupivacaine in conjunction with general anaesthesia (GA) on desflurane consumption, which was titrated to maintain the recovery profiles
L-B Guo et al.
European review for medical and pharmacological sciences, 19(19), 3643-3648 (2015-10-28)
To evaluate the factors that may have an impact on the prognosis of ischemic stroke. The study included 973 patients who were diagnosed with an ischemic stroke. The patients were divided into 6 groups according their eosinophil counts' level and
Kevin Shih et al.
Journal of plastic, reconstructive & aesthetic surgery : JPRAS, 68(11), 1610-1615 (2015-09-18)
Age has been shown to be an independent predictor of complications in general surgery patients. In contrast, the effect of age on outcomes after plastic surgery has yet to be confirmed or refuted. The objective of the current investigation was
Mangesh A Thorat et al.
Current oncology reports, 15(6), 533-540 (2013-10-12)
Since its first synthesis in 1897, several medicinal roles and mechanisms of action of aspirin have become apparent; the latest among these being its role in cancer prevention and treatment. A large body of evidence supports aspirin's effect in reducing
Loretta Lazzarato et al.
Journal of medicinal chemistry, 52(16), 5058-5068 (2010-06-22)
A series of (nitrooxyacyloxy)methyl esters of aspirin were synthesized and evaluated as new NO-donor aspirins. Different amounts of aspirin were released in serum from these products according to the nature of nitrooxyacyloxy moiety present. In the aromatic series, there is
LOAD: a pilot study of the safety of loading of aspirin & clopidogrel in acute ischaemic stroke and transient ischaemic attack. Is the loading dose of aspirin and clopidogrel a good alternative for patients with acute ischaemic stroke and TIA? How this will impact our clinical practice?
Fauzia Nomani et al.
JPMA. The Journal of the Pakistan Medical Association, 63(10), 1316-1316 (2014-01-08)
Guadalupe Ortiz-Muñoz et al.
Blood, 124(17), 2625-2634 (2014-08-22)
Evidence is emerging that platelets are major contributors to innate immune responses in conditions such as acute lung injury (ALI). Platelets form heterotypic aggregates with neutrophils, and we hypothesized that lipoxin mediators regulate formation of neutrophil-platelet aggregates (NPA) and that
Morten Würtz et al.
PloS one, 9(10), e111816-e111816 (2014-11-02)
Platelet aggregation during aspirin treatment displays considerable inter-individual variability. A genetic etiology likely exists, but it remains unclear to what extent genetic polymorphisms determine platelet aggregation in aspirin-treated individuals. To identify platelet-related single nucleotide polymorphisms (SNPs) influencing platelet aggregation during
Suresh Khode et al.
European journal of medicinal chemistry, 44(4), 1682-1688 (2008-11-07)
A novel series of 5-(substituted)aryl-3-(3-coumarinyl)-1-phenyl-2-pyrazolines (3a-l) were synthesized by reacting various substituted 3-aryl-1-(3-coumarinyl)propan-1-ones (2a-l) with phenylhydrazine in the presence of hot pyridine. Structures of all new synthesized compounds were characterized on the basis of elemental analysis and spectral data (IR
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