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Showing 1-30 of 726 results for "A5376" within Papers
Gerasimos Siasos et al.
International journal of cardiology, 177(1), 192-196 (2014-12-17)
In the present study, we evaluated the association of platelet reactivity with vascular function in patients after percutaneous coronary intervention receiving clopidogrel treatment. We enrolled 150 patients with stable CAD receiving clopidogrel regimen (75 mg/d), 1 month after percutaneous coronary
Jui-Pin Wu et al.
Environmental toxicology and pharmacology, 39(2), 898-905 (2015-03-25)
Pain relief medications commonly occur in the aquatic environment at measurable levels. While the neurotoxicity of pain relievers to higher vertebrates is currently known, little is known about their effects on aquatic animals. This study investigated the neurotoxicity of pain
Chunyu Li et al.
European journal of medicinal chemistry, 46(11), 5598-5608 (2011-10-11)
High anti-thrombotic activity of aminoacid modified tetrahydro-β-carbolines was generally correlated with a small proximity of the side chain of the aminoacid residue to the carboline-cycle. This paper explored that the aromatization of the tetrahydro-β-carboline-cycle of N-(1-methyl-β-tetrahydrocarboline-3-carbonyl)-N'-(aminoacid-acyl)-hydrazines leaded to N-(1-methyl-β-carboline-3-carbonyl)-N'-(aminoacid-acyl)-hydrazines and
Margarita Gutiérrez et al.
Platelets, 25(4), 234-238 (2013-07-12)
Abstract Nine synthetic isoxazoles were evaluated as antiplatelet agents and studied the possible mechanism of more active compound. The initial screening was evaluating all compounds against platelet aggregation assays. The most active compound was isoxazole 8 showing an inhibition of
Kazuhiro Iguchi et al.
Oncology letters, 7(5), 1665-1668 (2014-04-26)
Prostate cancer occurs more frequently among older males and such elderly individuals often have chronic underlying disorders for which various drugs are administered for treatment. The levels of prostate-specific antigen (PSA), a widely used prostate cancer marker, are influenced by
Sarpogrelate- another new antiplatelet agent?
Quratulain Shaikh et al.
JPMA. The Journal of the Pakistan Medical Association, 62(11), 1253-1253 (2013-07-23)
Yinjian Zhou et al.
Bioorganic & medicinal chemistry, 18(6), 2165-2172 (2010-02-24)
To discover analgesics for treating chronic pain 17 novel Schiff's bases, N,N'-(Z-allylidene-1,3-diyl)bisamino acid methyl esters were prepared from 1,1,3,3,-tetramethoxypropane and amino acid methyl esters. On tail-flick mouse model 20 micromol/kg of these Schiff's bases were orally administered, the analgesic action
Phedias Diamandis et al.
Nature chemical biology, 3(5), 268-273 (2007-04-10)
The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways that governs the
Weighing the risks of perioperative aspirin.
John Serak et al.
World neurosurgery, 82(6), 928-929 (2014-10-15)
Jitendra Kumar Mishra et al.
Bioorganic & medicinal chemistry letters, 20(1), 244-247 (2009-11-26)
A diverse group of novel medium ring heterocycles derived from naturally abundant proteinogenic amino acids were evaluated for their potency towards antithrombotic activity. The more potent benzofused oxazepine and oxazocine scaffolds were diversified by incorporating different amino acids at the
Thirada Thongbai
Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 96(11), 1423-1427 (2014-01-17)
Aspirin is a widely used medication for primary and secondary prevention of cardiovascular and cerebrovascular events. The gastrointestinal risks of aspirin are well known, but the frequency of gastroduodenal mucosal injuries in aspirin users in Thailand is currently unknown. The
Esra Bayram et al.
Bioorganic & medicinal chemistry, 16(20), 9101-9105 (2008-09-30)
The inhibition of two human cytosolic carbonic anhydrase (hCA, EC 4.2.1.1) isozymes, hCA I and II, with a series of salicylic acid derivatives was investigated by using the esterase method with 4-nitrophenyl acetate as substrate. IC(50) values for sulfasalazine, diflunisal
Pei-Yuan He et al.
Chinese medical journal, 128(5), 638-643 (2015-02-24)
The impact of body mass index (BMI) on the clinical outcomes after percutaneous coronary intervention (PCI) in patients ≥ 75 years old remained unclear. A total of 1098 elderly patients undergoing PCI with stent implantation were recruited. Patients were divided
C C N Chong et al.
Alimentary pharmacology & therapeutics, 41(2), 199-208 (2014-11-22)
The effect of antiviral therapy on the post-hepatectomy long-term survival in patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) remains uncertain. To evaluate the effect of antiviral therapy on post-hepatectomy survival and recurrence in patients with HBV-related HCC. This
Eli I Lev et al.
Journal of the American College of Cardiology, 47(1), 27-33 (2006-01-03)
We evaluated the response to clopidogrel among aspirin-resistant versus aspirin-sensitive patients undergoing elective coronary stenting. Patients (n = 150) treated with aspirin but not clopidogrel had blood samples drawn at baseline and 24 h after clopidogrel loading. Depending on the
Sinan Demirtas et al.
The Kaohsiung journal of medical sciences, 31(3), 115-122 (2015-03-07)
The aim of this study was to investigate whether anticoagulant and antiaggregant agents have protective effects against oxidative damage induced by peripheral ischemia-reperfusion (I/R). Groups were created as follows: control group, I/R group (sham group), I/R plus acetylsalicylic acid (Group
Peter Hamilton et al.
The Analyst, 137(1), 118-125 (2011-11-10)
Analysis of needle-shaped particles of cellobiose octaacetate (COA) obtained from vacuum agitated drying experiments was performed using three particle size analysis techniques: laser diffraction (LD), focused beam reflectance measurements (FBRM) and dynamic image analysis. Comparative measurements were also made for
Mai Ramadan et al.
Journal of natural products, 69(7), 1041-1045 (2006-07-29)
Chamazulene carboxylic acid (1) is a natural profen with anti-inflammatory activity and a degradation product of proazulenic sesquiterpene lactones, e.g., matricin. Both 1 and proazulenes occur in chamomile (Matricaria recutita), yarrow (Achillea millefolium), and a few other Asteraceae species. It
Norbert Handler et al.
Bioorganic & medicinal chemistry, 15(18), 6109-6118 (2007-07-03)
Resveratrol ((E)-3,4',5-trihydroxy-stilbene), a phytoalexin found in various plants, shows non-selective cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) inhibition. In order to find more selective COX inhibitors a series of bridged stilbene derivatives was synthesized and evaluated for their ability to inhibit both
NSAID-associated gastrointestinal bleeding: assessing the role of concomitant medications.
Loren Laine
Gastroenterology, 147(4), 730-733 (2014-08-30)
Chisa Matsumoto et al.
The American journal of clinical nutrition, 101(2), 362-367 (2015-02-04)
Previous studies reported beneficial effects of cocoa or chocolate on insulin resistance, oxidative stress, and inflammation, which are important risk factors of type 2 diabetes mellitus (DM). However, it is unclear whether chocolate consumption is associated with risk of DM.
Guoyong Yu et al.
Food chemistry, 194, 577-586 (2015-10-17)
Bioactive compounds present in foods could have beneficial effects on human health. In this study, we report the capacity of peptides released from oat, highland barley, and buckwheat proteins after enzymatic digestion to inhibit platelet aggregation in vitro. All hydrolysates
Jing Li et al.
Journal of ethnopharmacology, 155(1), 285-292 (2014-06-01)
Vinegar has been used as both a common seasoning and a traditional Chinese medicine. Sorghum vinegar is an excellent source of physiological substances with multiple health benefits. To evaluate the antiplatelet aggregation activity of alditols and monosaccharides extracted from sorghum
Eva-Luise Hobl et al.
European journal of clinical investigation, 45(1), 13-17 (2014-11-18)
This study describes the implications of the pharmacokinetics of low-dose chewable aspirin for acute coronary syndromes. Current guidelines recommend the administration of 162-325 mg aspirin chewing tablets for the treatment of acute myocardial infarction. Although aspirin is widely used and a
Shu-Zhen Mu et al.
Journal of natural products, 71(4), 564-569 (2008-02-22)
Four new Daphniphyllum alkaloids, daphnioldhanines H-K ( 1- 4), along with 34 known alkaloids, were isolated from Daphniphyllum oldhami. The known alkaloid dehydrodaphnigraciline ( 5) is now reported as a natural product. Their structures were elucidated by spectroscopic methods, especially
Aspirin may prevent blood clots in the legs from recurring.
Harvard heart letter : from Harvard Medical School, 23(6), 8-8 (2013-07-24)
Scot H Simpson et al.
The American journal of medicine, 127(1), 95-95 (2014-01-05)
Randomized controlled trials have shown that ≤ 100 mg aspirin daily is not effective for primary prevention of cardiovascular events in diabetes; however, clinical and pharmacologic evidence suggests these patients need >100 mg for adequate antiplatelet activity. Although high on-treatment
Prophylaxis against venous thromboembolism after arthroplasty: establishing value requires more than one perspective. Commentary on an article by John T. Schousboe, MD, PhD, and Gregory A. Brown, MD, PhD: "Cost-effectiveness of low-molecular-weight heparin compared with aspirin for prophylaxis against venous thromboembolism after total joint arthroplasty".
Adolph J Yates
The Journal of bone and joint surgery. American volume, 95(14), e102 1-e102 2 (2013-07-19)
Kadriye Orta Kilickesmez et al.
Coronary artery disease, 26(1), 37-41 (2014-09-18)
Spontaneous reperfusion (SR) was associated with better clinical outcomes and lower incidence of major adverse cardiovascular events. Endothelin-1 (ET-1) is a potent endothelium-derived vasoconstrictor peptide and elevated systemic ET-1 levels predict a poor prognosis in patients with ST-segment elevation myocardial
Laura Mauri et al.
The New England journal of medicine, 371(23), 2155-2166 (2014-11-18)
Dual antiplatelet therapy is recommended after coronary stenting to prevent thrombotic complications, yet the benefits and risks of treatment beyond 1 year are uncertain. Patients were enrolled after they had undergone a coronary stent procedure in which a drug-eluting stent
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