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Showing 1-30 of 231 results for "A5533" within Papers
Sai Krishna Srimadh Bhagavatham et al.
Scientific reports, 11(1), 15129-15129 (2021-07-25)
Rheumatoid Arthritis (RA) is a chronic autoimmune disease associated with inflammation and joint remodeling. Adenosine deaminase (ADA), a risk factor in RA, degrades adenosine, an anti-inflammatory molecule, resulting in an inflammatory bias. We present an integrative analysis of clinical data
Ignacio Fernández et al.
Animals : an open access journal from MDPI, 11(3) (2021-03-04)
Skeletal deformities reduce fish viability, growth, wellbeing, and feed efficiency but also degrade the consumer's perception of aquaculture products. Herein, the skeletal development and the incidence of skeletal deformities in tench (Tinca tinca) reared in semi-extensive conditions has been described
Ayman A Gouda et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 105, 488-496 (2013-01-29)
Rapid, sensitive and validated spectrophotometric methods for the determination of two antiepileptics (gabapentin (GAB) and pregabalin (PRG)) in pure forms and in pharmaceutical formulations was developed. The method is based on the formation of charge transfer complex between drug and
Hidehiro Ogata et al.
Dental materials journal, 31(1), 92-97 (2012-01-27)
The aim of this study was to investigate mineralizing ability of a premixed calcium phosphate cement (premixed-CPC) compared to mineral trioxide aggregate (MTA) and zinc oxide eugenol cement (SuperEBA) in ROS17/2.8 cells. The measurements of cell proliferation, alkaline phosphatase (ALPase)
Liang-Yin Chou et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(4), 5767-5781 (2020-03-05)
Chondrocytes in growth plates are responsible for longitudinal growth in long bones during endochondral ossification. Discoidin domain receptor 1 (Ddr1) is expressed in chondrocytes, but the molecular mechanisms by which DDR1 regulates chondrocyte behaviors during the endochondral ossification process remain
Fernando Ezquer et al.
PloS one, 6(1), e16566-e16566 (2011-02-10)
Type 1 diabetes mellitus (T1D) is due to autoimmune destruction of pancreatic beta-cells. Previously, we have shown that intravenously administered bone marrow-derived multipotent mesenchymal stromal cells (MSCs) allows pancreatic islet recovery, improves insulin secretion and reverts hyperglycemia in low doses
Zhanguang Chen et al.
Talanta, 99, 774-779 (2012-09-13)
In this study, a new type of rapid, label-free fluorescence turn-on assay for detection of tiopronin using Alizarin Red S (ARS)/copper ion ensemble is developed. ARS is high fluorescence in BR buffer solution. But, the fluorescence of ARS can be
Li Hong Zhang et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 97, 639-647 (2012-08-04)
Rhodamine S could emit strong and stable room temperature phosphorescence (RTP) on polyamide membrane (PAM) in the presence of heavy atom perturber Pb(2+). When Rhodamine S-piperidine solution was dropped on PAM, the red (Rhod.S)(n)-P-SOR (Rhod.S, (Rhod.S)(n), P and SOR refer
Katarina Lopusna et al.
The Journal of biological chemistry, 296, 100285-100285 (2021-01-16)
DNA methylation regulates gene transcription and is involved in various physiological processes in mammals, including development and hematopoiesis. It is catalyzed by DNA methyltransferases including Dnmt1, Dnmt3a, and Dnmt3b. For Dnmt3b, its effects on transcription can result from its own
S An et al.
Journal of periodontal research, 47(3), 374-382 (2011-12-06)
A number of bone-filling materials containing calcium (Ca(2+) ) and phosphate (P) ions have been used in the repair of periodontal bone defects; however, the effects that local release of Ca(2+) and P ions has on biological reactions are not
L Henry Goodnough et al.
JBMR plus, 4(10), e10398-e10398 (2020-10-27)
Delayed union or nonunion are relatively rare complications after fracture surgery, but when they do occur, they can result in substantial morbidity for the patient. In many cases, the etiology of impaired fracture healing is uncertain and attempts to determine
Christian L Bonatto Paese et al.
Developmental dynamics : an official publication of the American Association of Anatomists, 250(9), 1358-1367 (2021-02-20)
The naturally occurring chicken mutant talpid2 (ta2 ), best known for its limb and craniofacial defects, has long served as a valuable tool for developmental biologists studying growth and patterning of craniofacial structures and the limb. The mutant provides a
Matthew J Carr et al.
Cell stem cell, 24(2), 240-256 (2018-12-07)
Peripheral innervation plays an important role in regulating tissue repair and regeneration. Here we provide evidence that injured peripheral nerves provide a reservoir of mesenchymal precursor cells that can directly contribute to murine digit tip regeneration and skin repair. In
Impaired marrow osteogenesis is associated with reduced endocortical bone formation but does not impair periosteal bone formation in long bones of SAMP6 mice.
Silva MJ, et al.
Journal of Bone and Mineral Research, 20, 419-419 (2005)
Sayantani Sinha et al.
Cell reports, 31(4), 107570-107570 (2020-04-30)
Bone morphogenic protein (BMP)/transforming growth factor β (TGF-β) signaling determines mesenchymal-stromal-cell (MSC) osteolineage commitment and tissue identity. However, molecular integration of developmental signaling with MSC-intrinsic chromatin regulation remains incompletely understood. SWI/SNF-(BAF) is an ATP-dependent chromatin remodeler implicated in multi-cellular development.
Jun Ying et al.
JCI insight, 5(3) (2020-02-14)
We previously established that DNA methyltransferase 3b (Dnmt3b) is the sole Dnmt responsive to fracture repair and that Dnmt3b expression is induced in progenitor cells during fracture repair. In the current study, we confirmed that Dnmt3b ablation in mesenchymal progenitor
Lidan Luo et al.
Stem cell research, 48, 101990-101990 (2020-09-21)
Induced mesenchymal stromal cells (iMSCs) derived from human pluripotent stem cells (PSCs) are attractive cells for regenerative medicine. However, the transcriptome of iMSCs and signature genes that can distinguish MSCs from fibroblasts and other cell types are rarely explored. In
Luciana S Carmo et al.
Arteriosclerosis, thrombosis, and vascular biology, 39(2), 200-211 (2018-12-26)
Objective- We hypothesized that ob/ob mice develop expansive vascular remodeling associated with calcification. Approach and Results- We quantified and investigated mechanisms of vascular remodeling and vascular calcification in ob/ob mice after vitamin D3(VD) stimulation or PBS (control), compared with C57BL/6
Yangwu Chen et al.
Science advances, 6(18), eaay9526-eaay9526 (2020-06-05)
Heterotopic ossification (HO) in connective tissues like tendons and ligaments severely damages tissue structure. The pathogenesis of HO remains unclear but may involve mTOR. The results presented here indicate that tendon stem/progenitor cells do not undergo osteochondrogenic differentiation when mTOR
Haixia Liu et al.
Phytotherapy research : PTR, 35(1), 424-441 (2020-08-06)
Fructus Ligustri Lucidi (FLL) has been preclinically and clinically used to treat musculoskeletal diseases. However, whether and how FLL affect the canonical Wnt/β-catenin signaling in the management of osteoporosis remains largely unknown. To this end, ovariectomized (OVX) rats and primary
Qing Yao et al.
Developmental cell, 49(5), 748-763 (2019-05-21)
Oxygen (O2) is both an indispensable metabolic substrate and a regulatory signal that controls the activity of Hypoxia-Inducible Factor 1α (Hif1a), a mediator of the cellular adaptation to low O2 tension (hypoxia). Hypoxic cells require Hif1a to survive. Additionally, Hif1a
Erwin A van Vliet et al.
Neurobiology of disease, 145, 105080-105080 (2020-09-13)
Traumatic brain injury (TBI) causes 10-20% of acquired epilepsy, which typically develops within 2 years post-injury with poorly understood mechanisms. We investigated the location, severity, evolution and persistence of blood-brain barrier (BBB) dysfunction and associated neuroinflammation after TBI, and their contribution
Matthew Anderson-Baron et al.
Frontiers in bioengineering and biotechnology, 8, 572356-572356 (2021-01-21)
Human nasal septal chondrocytes (NC) are a promising minimally invasive derivable chondrogenic cell source for cartilage repair. However, the quality of NC-derived cartilage is variable between donors. Coculture of NC with mesenchymal stem cells (MSCs) mitigates the variability but with
Yuko Katoh-Fukui et al.
Bone, 120, 219-231 (2018-11-06)
A set of key developmental genes is essential for skeletal growth from multipotent progenitor cells at weaning. Polycomb group proteins, which regulate such genes contributes to the cell lineage commitment and subsequent differentiation via epigenetic chromatin modification and remodeling. However
Jeske J Smink et al.
The EMBO journal, 28(12), 1769-1781 (2009-05-15)
Disequilibrium between bone-forming osteoblasts and bone-resorbing osteoclasts is central to many bone diseases. Here, we show that dysregulated expression of translationally controlled isoforms of CCAAT/enhancer-binding protein beta (C/EBPbeta) differentially affect bone mass. Alternative translation initiation that is controlled by the
Rong Fu et al.
Nature communications, 11(1), 460-460 (2020-01-25)
Recent interest in the control of bone metabolism has focused on a specialized subset of CD31hiendomucinhi vessels, which are reported to couple angiogenesis with osteogenesis. However, the underlying mechanisms that link these processes together remain largely undefined. Here we show
Da-Yo Yuh et al.
The Journal of biological chemistry, 295(21), 7261-7273 (2020-04-14)
The integrin-binding secreted protein developmental endothelial locus-1 (DEL-1) is involved in the regulation of both the initiation and resolution of inflammation in different diseases, including periodontitis, an oral disorder characterized by inflammatory bone loss. Here, using a mouse model of
Xiaoming Yang et al.
Cell & bioscience, 10, 103-103 (2020-09-19)
Long bones of limbs are formed through endochondral bone formation, which depends on the coordinated development of growth plates. Our previous studies have demonstrated that dysfunction of mitogen-activated protein kinase 7 (MAPK7) can cause skeletal dysplasia. However, little is known
Andrew J Kim et al.
Circulation, 141(2), 132-146 (2020-01-14)
Myxomatous valve degeneration (MVD) involves the progressive thickening and degeneration of the heart valves, leading to valve prolapse, regurgitant blood flow, and impaired cardiac function. Leukocytes composed primarily of macrophages have recently been detected in myxomatous valves, but the timing
Paola Romina Amable et al.
PloS one, 9(8), e104662-e104662 (2014-08-15)
Platelet-rich plasma (PRP) is increasingly used as a cell culture supplement, in order to reduce the contact of human cells with animal-derived products during in vitro expansion. The effect of supplementation changes on cell growth and protein production is not
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