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Showing 1-30 of 104 results for "A6410" within Papers
Bo Huo et al.
Cell calcium, 47(3), 234-241 (2010-01-12)
To investigate the roles of intercellular gap junctions and extracellular ATP diffusion in bone cell calcium signaling propagation in bone tissue, in vitro bone cell networks were constructed by using microcontact printing and self-assembled monolayer technologies. In the network, neighboring
Amber N Murray et al.
Protein science : a publication of the Protein Society, 19(4), 836-846 (2010-02-18)
The formation of amyloid, a cross-beta-sheet fibrillar aggregate, is associated with a variety of aging-associated degenerative diseases. Herein, we report the existence of a mammalian amyloid disaggregase activity that is present in all tissues and cell types tested. Homogenates from
CD39: a new surface marker of mouse regulatory γδ T cells.
Atsushi Otsuka et al.
The Journal of allergy and clinical immunology, 132(6), 1448-1451 (2013-07-23)
Autoimmune hepatitis: 50 Years of (slow) progress.
M Eric Gershwin et al.
Hepatology (Baltimore, Md.), 59(3), 754-756 (2014-04-09)
Mehwish Younas et al.
Journal of immunology (Baltimore, Md. : 1950), 191(6), 3161-3168 (2013-08-24)
The heterogeneity of human regulatory T cells (Tregs) may explain the discrepancies between studies on Tregs in physiology and pathology. Contrasting effects of IL-7 on the expansion and survival of human Tregs were reported. Therefore, we investigated the effects of
L Geys et al.
Journal of thrombosis and haemostasis : JTH, 16(1), 150-163 (2017-11-10)
Essentials Obesity is a potential risk factor for development of thrombotic thrombocytopenic purpura (TTP). Obese ADAMTS-13-deficient mice were triggered with von Willebrand factor (VWF). Depletion of hepatic and splenic macrophages protects against thrombocytopenia in this model. VWF enhances phagocytosis of
Cristina Gontan et al.
The Journal of cell biology, 185(1), 27-34 (2009-04-08)
SRY and other Sox-type transcription factors are important developmental regulators with various implications in human disease. In this study, we identified Exp4 (exportin 4) as an interaction partner of Sox2 in mouse embryonic stem cells and neural progenitors. We show
Inga Scheller et al.
Haematologica, 105(6), 1667-1676 (2019-10-05)
Platelet aggregate formation is a multistep process involving receptor-mediated, as well as biomechanical, signaling cascades, which are highly dependent on actin dynamics. We have previously shown that actin depolymerizing factor (ADF)/n-cofilin and Twinfilin 2a, members of the ADF homology (ADF-H)
Ravisha R Weerasinghe et al.
FEBS letters, 583(15), 2521-2526 (2009-07-15)
Amongst the many stimuli orienting the growth of plant roots, of critical importance are the touch signals generated as roots explore the mechanically complex soil environment. However, the molecular mechanisms behind these sensory events remain poorly defined. We report an
Absence of Pear1 does not affect murine platelet function in vivo
Criel M, et al.
Thrombosis Research, 146, 76-83 (2016)
M M Imanguli et al.
Leukemia, 28(10), 2016-2027 (2014-03-01)
Activation and migration of regulatory T cells (Treg) into tissue is critical in control of inflammation, but has not been examined extensively in chronic graft versus host disease (cGVHD). In parallel studies of tissues and blood, we determined that FoxP3(+)
Chindu Govindaraj et al.
Clinical immunology (Orlando, Fla.), 149(1), 97-110 (2013-08-21)
Ovarian cancer is a prevalent gynecological malignancy with potent immune-suppression capabilities; regulatory T cells (Tregs) are significant contributors to this immune-suppression. As ovarian cancer patients present with high levels of TNF and Tregs expressing TNFR2 are associated with maximal suppressive
Zenichiro Saze et al.
Blood, 122(1), 9-18 (2013-05-17)
Antibody-independent role of B cells in modulating T-cell responses is incompletely understood. Freshly isolated or cultured B cells isolated from the peripheral blood of 30 normal donors were evaluated for CD39 and CD73 coexpression, the ability to produce adenosine 5'-monophosphate
Xiao-Wei Gu et al.
Science signaling, 13(646) (2020-08-28)
Embryo implantation involves a sterile inflammatory reaction that is required for the invasion of the blastocyst into the decidua. Adenosine triphosphate (ATP) released from stressed or injured cells acts as an important signaling molecule to regulate many key physiological events
Sören Backhaus et al.
Journal of lipid research, 58(6), 1055-1066 (2017-04-14)
Interleukin (IL)-1β is a potent pro-inflammatory cytokine of innate immunity involved in host defense. High systemic IL-1β levels, however, cause life-threatening inflammatory diseases, including systemic inflammatory response syndrome. In response to various danger signals, the pro-form of IL-1β is synthesized
Naresh Kumar et al.
Neurochemistry international, 61(8), 1276-1279 (2012-10-20)
Our electrophysiological studies have shown that both purinergic and glutamatergic receptors are involved in central sensitization of nociceptive neurons in the medullary dorsal horn (MDH). Here we assessed the effects of intrathecal administration of apyrase (a nucleotide degrading enzyme of
Jessica Herrath et al.
European journal of immunology, 44(10), 2979-2989 (2014-07-06)
Treg cells are important for the maintenance of self-tolerance and are implicated in autoimmunity. Despite enrichment of Treg cells in joints of rheumatoid arthritis (RA) patients, local inflammation persists. As expression of the ATP-hydrolyzing enzymes CD39 and CD73 and the
Ivan D Mascanfroni et al.
Nature immunology, 14(10), 1054-1063 (2013-09-03)
Dendritic cells (DCs) control the balance between effector T cells and regulatory T cells in vivo. Hence, the study of DCs might identify mechanisms of disease pathogenesis and guide new therapeutic approaches for disorders mediated by the immune system. We
CD39 target practice.
Debra K Newman
Blood, 121(16), 3061-3062 (2013-04-20)
Jing Wu et al.
Investigative ophthalmology & visual science, 53(11), 7142-7148 (2012-09-22)
To investigate the mechanisms for endogenous production of extracellular adenosine in trabecular meshwork (TM) cells and evaluate its physiological relevance to the regulation of aqueous humor outflow facility. Extra-cellular levels of adenosine monophosphate (AMP) and adenosine in porcine trabecular meshwork
Matthias Zebisch et al.
Acta crystallographica. Section F, Structural biology and crystallization communications, 69(Pt 3), 257-262 (2013-03-23)
Nucleoside triphosphate diphosphohydrolases (NTPDases) are a large class of nucleotidases that hydrolyze the (γ/β)- and (β/α)-anhydride bonds of nucleoside triphosphates and diphosphates, respectively. NTPDases are found throughout the eukaryotic domain. In addition, a very small number of members can be
Heather B Cohen et al.
Blood, 122(11), 1935-1945 (2013-08-03)
Sepsis is a highly fatal disease caused by an initial hyperinflammatory response followed by a state of profound immunosuppression. Although it is well appreciated that the initial production of proinflammatory cytokines by macrophages accompanies the onset of sepsis, it remains
David W Rooklin et al.
Journal of the American Chemical Society, 134(37), 15595-15603 (2012-08-30)
Human soluble calcium-activated nucleotidase 1 (hSCAN-1) represents a new family of apyrase enzymes that catalyze the hydrolysis of nucleotide di- and triphosphates, thereby modulating extracellular purinergic and pyrimidinergic signaling. Among well-characterized phosphoryl transfer enzymes, hSCAN-1 is unique not only in
Austin L Hughes
Gene, 527(1), 123-130 (2013-06-25)
Phylogenetic analyses of three families of arthropod apyrases were used to reconstruct the evolutionary relationships of salivary-expressed apyrases, which have an anti-coagulant function in blood-feeding arthropods. Members of the 5'nucleotidase family were recruited for salivary expression in blood-feeding species at
Simon Stritt et al.
Haematologica (2022-06-01)
Vascular homeostasis is impaired in various diseases thereby contributing to the progression of their underlying pathologies. The endothelial immediate early gene Apolipoprotein L domain-containing 1 (APOLD1) helps regulate endothelial function. However, its precise role in endothelial cell (EC) biology remains
Martina Nowak-Machen et al.
American journal of respiratory cell and molecular biology, 48(5), 601-609 (2013-01-26)
Critically ill patients are routinely exposed to high concentrations of supplemental oxygen for prolonged periods of time, which can be life-saving in the short term, but such exposure also causes severe lung injury and increases mortality. To address this therapeutic
Activation of endothelial NO synthase and P2X7 receptor modification mediates the cholinergic control of ATP-induced interleukin-1I? release by mononuclear phagocytes.
Richter, et al.
Frontiers in Immunology, 14, 1140592-1140592 (2023)
François Martin et al.
Trends in molecular medicine, 18(12), 742-749 (2012-10-23)
The immune system has important roles in limiting the spread of cancer and shaping the tumor microenvironment. Although the contributions of T helper 17 (Th17) cells (a subtype of CD4(+) T lymphocytes) to autoimmunity and allergy response are well known
Inga Scheller et al.
Haematologica (2021-08-06)
Coordinated rearrangements of the actin cytoskeleton are pivotal for platelet biogenesis from megakaryocytes (MKs) but also orchestrate key functions of peripheral platelets in hemostasis and thrombosis, such as granule release, the formation of filopodia and lamellipodia, or clot retraction. Along
Fátima Husein Abdalla et al.
Molecular and cellular biochemistry, 381(1-2), 1-8 (2013-06-26)
This study investigated the effect of quercetin on nucleoside triphosphate diphosphohydrolase (NTP-Dase), 50-nucleotidase, adenosine deaminase (ADA), and acetylcholinesterase (AChE) activities in synaptosomes from cerebral cortex of adult rats exposed to cadmium (Cd). Rats were exposed to Cd (2.5 mg/Kg) and
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