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Showing 31-60 of 68 results for "a6419" within Papers
Teresa Obis et al.
Molecular brain, 8(1), 80-80 (2015-12-03)
Various protein kinase C (PKC) isoforms contribute to the phosphorylating activity that modulates neurotransmitter release. In previous studies we showed that nPKCε is confined in the presynaptic site of the neuromuscular junction and its presynaptic function is activity-dependent. Furthermore, nPKCε
Butaek Lim et al.
Sensors (Basel, Switzerland), 15(8), 17977-17989 (2015-07-28)
We report a simple detection of protein kinase activity using Zn(II)-mediated fluorescent resonance energy transfer (FRET) between quantum dots (QDs) and dye-tethered peptides. With neither complex chemical ligands nor surface modification of QDs, Zn(II) was the only metal ion that
Ambre M Bertholet et al.
Frontiers in physiology, 11, 326-326 (2020-05-01)
Mitochondria convert the chemical energy of metabolic substrates into adenosine triphosphate (ATP) and heat. Although ATP production has become a focal point of research in bioenergetics, mitochondrial thermogenesis is also crucial for energy metabolism. Mitochondria generate heat due to H+
Kajal Hamidzadeh et al.
Blood advances, 4(21), 5460-5472 (2020-11-10)
Stimulated macrophages are potent producers of inflammatory mediators. This activity is highly regulated, in part, by resolving molecules to prevent tissue damage. In this study, we demonstrate that inflammation induced by Toll-like receptor stimulation is followed by the upregulation of
Marco Buscetta et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(1), 1819-1832 (2020-01-10)
The NLRP3 inflammasome is formed by the sensor NLRP3, the adaptor ASC, and pro-caspase-1. Assembly and activation of the inflammasome trigger caspase-1-dependent cleavage of pro-IL-1β and pro-IL-18 into their secreted forms. Cigarette smoke is a risk factor for chronic inflammatory
Jingbo Jiang et al.
Journal of the American Heart Association, 8(16), e012385-e012385 (2019-08-20)
Background α Carboxyl terminus 1 (αCT1) is a 25-amino acid therapeutic peptide incorporating the zonula occludens-1 (ZO-1)-binding domain of connexin 43 (Cx43) that is currently in phase 3 clinical testing on chronic wounds. In mice, we reported that αCT1 reduced
Daniele Ferrante et al.
Cell reports, 35(11), 109248-109248 (2021-06-17)
Loss-of-function mutations in proline-rich transmembrane protein-2 (PRRT2) cause paroxysmal disorders associated with defective Ca2+ dependence of glutamatergic transmission. We find that either acute or constitutive PRRT2 deletion induces a significant decrease in the amplitude of evoked excitatory postsynaptic currents (eEPSCs)
Conditional knockdown of proteins using auxin-inducible degron (AID) fusions in Toxoplasma gondii
Brown KM, et al.
Bio-protocol, 8(4), 245-253 (2018)
Pharmacology of adenosine receptors and their signaling role in immunity and inflammation
Pharmacology & Therapeutics, 21(3), 245-253 (2014)
Trafficking of cholesterol to the ER is required for NLRP3 inflammasome activation
de la Roche M, et al.
The Journal of Cell Biology, 217(10), 3560-3576 (2018)
Nora Grahl et al.
PLoS pathogens, 11(8), e1005133-e1005133 (2015-09-01)
Candida albicans is both a major fungal pathogen and a member of the commensal human microflora. The morphological switch from yeast to hyphal growth is associated with disease and many environmental factors are known to influence the yeast-to-hyphae switch. The
Monika Bambouskova et al.
Cell reports, 34(10), 108756-108756 (2021-03-11)
Itaconate is a unique regulatory metabolite that is induced upon Toll-like receptor (TLR) stimulation in myeloid cells. Here, we demonstrate major inflammatory tolerance and cell death phenotypes associated with itaconate production in activated macrophages. We show that endogenous itaconate is
Srabani Mitra et al.
Purinergic signalling, 15(1), 119-123 (2018-12-14)
The pro-inflammatory cytokine IL-1β is a secreted protein that is cleaved by caspase-1 during inflammasome activation upon recognition of internal and external insults to cells. Purinergic receptor P2X7 has been described to be involved in the release pathway of bioactive
Ning-Ning Liu et al.
mBio, 11(2) (2020-03-19)
The Candida albicans high-affinity phosphate transporter Pho84 is required for normal Target of Rapamycin (TOR) signaling, oxidative stress resistance, and virulence of this fungal pathogen. It also contributes to C. albicans' tolerance of two antifungal drug classes, polyenes and echinocandins.
Claudia Espinosa-Garcia et al.
International journal of molecular sciences, 21(11) (2020-05-30)
NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome inhibition and autophagy induction attenuate inflammation and improve outcome in rodent models of cerebral ischemia. However, the impact of chronic stress on NLRP3 inflammasome and autophagic response to ischemia remains unknown. Progesterone
Teneale A Stewart et al.
ACS pharmacology & translational science, 3(1), 63-75 (2020-04-08)
An essential process in predicting the in vivo pharmacological activity of a candidate molecule involves the evaluation of target responses using established model systems. While these models largely comprise immortalized cells, which are often serially passaged as monolayers on uniformly
In Young Lee et al.
Molecular cell, 73(6), 1138-1149 (2019-03-23)
The nuclear factor (NF)-κB pathway plays a central role in inflammatory and immune responses, with aberrant activation of NF-κB signaling being implicated in various human disorders. Here, we show that mammalian ste20-like kinase 1 (MST1) is a previously unrecognized component
Ambre M Bertholet et al.
Nature, 571(7766), 515-520 (2019-07-26)
The mitochondrial ADP/ATP carrier (AAC) is a major transport protein of the inner mitochondrial membrane. It exchanges mitochondrial ATP for cytosolic ADP and controls cellular production of ATP. In addition, it has been proposed that AAC mediates mitochondrial uncoupling, but
Nipun S Basrur et al.
eLife, 9 (2020-12-08)
The Aedesaegypti mosquito shows extreme sexual dimorphism in feeding. Only females are attracted to and obtain a blood-meal from humans, which they use to stimulate egg production. The fruitless gene is sex-specifically spliced and encodes a BTB zinc-finger transcription factor
Rui Xiong et al.
Toxicology and applied pharmacology, 280(2), 285-295 (2014-08-26)
Para-quinones such as 1,4-Benzoquinone (BQ) and menadione (MD) and ortho-quinones including the oxidation products of catecholamines, are derived from xenobiotics as well as endogenous molecules. The effects of quinones on major protein handling systems in cells; the 20/26S proteasome, the
Yuanling Huang et al.
Journal of cellular physiology, 234(11), 21224-21234 (2019-04-30)
Cannabidiol (CBD), an abundant nonpsychoactive constituent of marijuana, has been reported previously to protect against hepatic steatosis. In this study, we studied further the functions and mechanisms of CBD on liver inflammation induced by HFC diet. Mice feeding an HFC
Changliang He et al.
International immunopharmacology, 71, 328-335 (2019-04-06)
Pyroptosis is a different type of proinflammatory and lytic mode of cell death from apoptosis and necrosis, which play a killer and cleaner to the pathogenic microorganisms as an immune response when the host is infected by pathogenic microorganisms. Ketone
Alessandra Pecorelli et al.
Redox biology, 28, 101334-101334 (2019-10-14)
Rett syndrome (RTT) is a progressive neurodevelopmental disorder mainly caused by mutations in the X-linked MECP2 gene. RTT patients show multisystem disturbances associated with an oxinflammatory status. Inflammasomes are multi-protein complexes, responsible for host immune responses against pathogen infections and
Hoseok Choi et al.
Biosensors & bioelectronics, 73, 93-99 (2015-06-09)
We report a simple method for analyzing sequential phosphorylation by protein kinases using fluorescent peptide substrates and microfluidic isoelectric focusing (μIEF) electrophoresis. When a dye-labeled peptide substrate was sequentially phosphorylated by two consecutive protein kinases (mitogen-activated protein kinase (MAPK) and
Moumita Basu et al.
Journal of cell science, 133(7) (2020-02-23)
Intracellular survival of Leishmania donovani demands rapid production of host ATP for its sustenance. However, a gradual decrease in intracellular ATP in spite of increased glycolysis suggests ATP efflux during infection. Accordingly, upon infection, we show here that ATP is
Yvette Wooff et al.
Scientific reports, 10(1), 2263-2263 (2020-02-12)
Activation of the inflammasome is involved in the progression of retinal degenerative diseases, in particular, in the pathogenesis of Age-Related Macular Degeneration (AMD), with NLRP3 activation the focus of many investigations. In this study, we used genetic and pharmacological approaches
Tetsuya Handa et al.
Nature protocols, 15(10), 3334-3360 (2020-08-19)
Cell identity is determined by the selective activation or silencing of specific genes via transcription factor binding and epigenetic modifications on the genome. Chromatin immunoprecipitation (ChIP) has been the standard technique for mapping the sites of transcription factor binding and
Weerachat Sompong et al.
PloS one, 10(6), e0129495-e0129495 (2015-06-09)
Ferulic acid (FA) is the ubiquitous phytochemical phenolic derivative of cinnamic acid. Experimental studies in diabetic models demonstrate that FA possesses multiple mechanisms of action associated with anti-hyperglycemic activity. The mechanism by which FA prevents diabetes-associated vascular damages remains unknown.
Brent Asrican et al.
STAR protocols, 2(1), 100335-100335 (2021-02-23)
The transition from quiescence to activation in radial neural stem cells (rNSCs) is a key first step in the process of adult neurogenesis, which can be monitored in the context of circuit activation in live tissue by whole-cell patch-clamp recording
Ajay Dixit et al.
American journal of physiology. Gastrointestinal and liver physiology, 317(4), G463-G475 (2019-08-23)
In the current study, we explored the role of extracellular ATP (eATP) in promoting systemic inflammation during development of acute pancreatitis (AP). Release of extracellular (e)ATP was evaluated in plasma and bronchoalveolar lavage fluid (BALF) of mice with experimental acute
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