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Showing 61-68 of 68 results for "a6419" within Papers

Paclitaxel Enhances the Innate Immunity by Promoting NLRP3 Inflammasome Activation in Macrophages.

Qiong-Zhen Zeng et al.

Frontiers in immunology, 10, 72-72 (2019-02-15)

Microtubules play critical roles in regulating the activation of NLRP3 inflammasome and microtubule-destabilizing agents such as colchicine have been shown to suppress the activation of this inflammasome. However, it remains largely unknown whether paclitaxel, a microtubule-stabilizing agent being used in

Altered inflammasome machinery as a key player in the perpetuation of Rett syndrome oxinflammation.

Alessandra Pecorelli et al.

Redox biology, 28, 101334-101334 (2019-10-14)

Rett syndrome (RTT) is a progressive neurodevelopmental disorder mainly caused by mutations in the X-linked MECP2 gene. RTT patients show multisystem disturbances associated with an oxinflammatory status. Inflammasomes are multi-protein complexes, responsible for host immune responses against pathogen infections and

Distinct Mechanisms of Resistance to a CENP-E Inhibitor Emerge in Near-Haploid and Diploid Cancer Cells.

Rudolf Pisa et al.

Cell chemical biology, 27(7), 850-857 (2020-05-23)

Aberrant chromosome numbers in cancer cells may impose distinct constraints on the emergence of drug resistance-a major factor limiting the long-term efficacy of molecularly targeted therapeutics. However, for most anticancer drugs we lack analyses of drug-resistance mechanisms in cells with

Protective effect of kaempferol on LPS plus ATP-induced inflammatory response in cardiac fibroblasts.

Xi-Lan Tang et al.

Inflammation, 38(1), 94-101 (2014-09-06)

Inflammatory response is an important mechanism in the pathogenesis of cardiovascular diseases. Cardiac fibroblasts play a crucial role in cardiac inflammation and might become a potential therapeutic target in cardiovascular diseases. Kaempferol, a flavonoid commonly existing in many edible fruits

Chromatin integration labeling for mapping DNA-binding proteins and modifications with low input.

Tetsuya Handa et al.

Nature protocols, 15(10), 3334-3360 (2020-08-19)

Cell identity is determined by the selective activation or silencing of specific genes via transcription factor binding and epigenetic modifications on the genome. Chromatin immunoprecipitation (ChIP) has been the standard technique for mapping the sites of transcription factor binding and

Nipun S Basrur et al.

eLife, 9 (2020-12-08)

The Aedesaegypti mosquito shows extreme sexual dimorphism in feeding. Only females are attracted to and obtain a blood-meal from humans, which they use to stimulate egg production. The fruitless gene is sex-specifically spliced and encodes a BTB zinc-finger transcription factor

Cannabidiol protects livers against nonalcoholic steatohepatitis induced by high-fat high cholesterol diet via regulating NF-κB and NLRP3 inflammasome pathway.

Yuanling Huang et al.

Journal of cellular physiology, 234(11), 21224-21234 (2019-04-30)

Cannabidiol (CBD), an abundant nonpsychoactive constituent of marijuana, has been reported previously to protect against hepatic steatosis. In this study, we studied further the functions and mechanisms of CBD on liver inflammation induced by HFC diet. Mice feeding an HFC

Quinone-induced protein handling changes: implications for major protein handling systems in quinone-mediated toxicity.

Rui Xiong et al.

Toxicology and applied pharmacology, 280(2), 285-295 (2014-08-26)

Para-quinones such as 1,4-Benzoquinone (BQ) and menadione (MD) and ortho-quinones including the oxidation products of catecholamines, are derived from xenobiotics as well as endogenous molecules. The effects of quinones on major protein handling systems in cells; the 20/26S proteasome, the

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