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Showing 1-30 of 115 results for "A6535" within Papers
Moritz Schmelzle et al.
Transplantation, 95(1), 63-69 (2012-12-13)
We have previously demonstrated that CD133 and CD39 are expressed by hematopoietic stem cells (HSC), which are mobilized after liver injury and target sites of injury, limit vascular inflammation, and boost hepatic regeneration. Plasma microparticles (MP) expressing CD39 can block
David Riewe et al.
Plant physiology, 147(3), 1092-1109 (2008-05-16)
Apyrases hydrolyze nucleoside triphosphates and diphosphates and are found in all eukaryotes and a few prokaryotes. Although their enzymatic properties have been well characterized, relatively little is known regarding their subcellular localization and physiological function in plants. In this study
Ya-Dong Gao et al.
The Journal of asthma : official journal of the Association for the Care of Asthma, 51(10), 997-1003 (2014-10-02)
Mast cell infiltration into airway smooth muscle (ASM) bundle is an important feature of asthma. Extracellular adenosine triphosphate (eATP) contributes to the initiation of airway inflammation. eATP induces mast cells migration by acting through purinergic receptors. CD39 is an ectonucleotidase
Charlotte R Grant et al.
Hepatology (Baltimore, Md.), 59(3), 1007-1015 (2013-06-22)
Autoimmune hepatitis (AIH) is an important cause of severe liver disease and is associated with both quantitative and qualitative regulatory T-cell (Treg) impairments. Tregs express CD39, an ectonucleotidase responsible for extracellular nucleotide hydrolysis, culminating in the production of immunosuppressive adenosine.
Koichi Gonda et al.
Methods in molecular biology (Clifton, N.J.), 348, 247-258 (2006-09-22)
Xenopus egg extract is an ideal material to identify nuclear remodeling activities important for nuclear cloning. Since the protocol for egg extract preparation was established more than 20 yr ago, egg extract has been widely used as a source for
Flavia Mazzarda et al.
Lab on a chip, 20(16), 3011-3023 (2020-07-24)
Prior work supports the hypothesis that ATP release through connexin hemichannels drives spontaneous Ca2+ signaling in non-sensory cells of the greater epithelial ridge (GER) in the developing cochlea; however, direct proof is lacking. To address this issue, we plated cochlear
Caitlin M MacCarthy et al.
International journal of oncology, 43(4), 1244-1252 (2013-08-08)
Expression of the ENTPD5/mt-PCPH onco-protein and overexpression of the normal ENTPD5/PCPH protein contribute to the malignant transformation of diverse mammalian cell types, and PCPH is mutated and/or deregulated in various human tumor types. Expression of PCPH or mt-PCPH caused similar
Xing Liu et al.
Plant physiology, 160(4), 1985-1995 (2012-10-17)
Recent evidence indicates that extracellular nucleotides regulate plant growth. Exogenous ATP has been shown to block auxin transport and gravitropic growth in primary roots of Arabidopsis (Arabidopsis thaliana). Cells limit the concentration of extracellular ATP in part through the activity
David Lu et al.
The Journal of biological chemistry, 288(26), 19040-19049 (2013-05-17)
The establishment of set points for cellular activities is essential in regulating homeostasis. Here, we demonstrate key determinants of the fibrogenic set point of cardiac fibroblasts (CFs) by focusing on the pro-fibrotic activity of ATP, which is released by CFs.
A Thiolat et al.
Arthritis & rheumatology (Hoboken, N.J.), 66(2), 273-283 (2014-02-08)
The rationale for blocking interleukin-6 (IL-6) in rheumatoid arthritis (RA) lies chiefly in the proinflammatory effect of this cytokine. Few studies have evaluated the consequences of anti-IL-6 receptor (IL-6R) antibody treatment on Treg cells. This study was undertaken to elucidate
François Martin et al.
Trends in molecular medicine, 18(12), 742-749 (2012-10-23)
The immune system has important roles in limiting the spread of cancer and shaping the tumor microenvironment. Although the contributions of T helper 17 (Th17) cells (a subtype of CD4(+) T lymphocytes) to autoimmunity and allergy response are well known
Signe E Cremer et al.
PloS one, 14(11), e0224891-e0224891 (2019-11-14)
Domestic dogs share the same environment as humans, and they represent a valuable animal model to study naturally-occurring human disease. Platelet proteomics holds promise for the discovery of biomarkers that capture the contribution of platelets to the pathophysiology of many
Werner E G Müller et al.
Acta biomaterialia, 118, 233-247 (2020-10-20)
Amorphous Ca-phosphate (ACP) particles stabilized by inorganic polyphosphate (polyP) were prepared by co-precipitation of calcium and phosphate in the presence of polyP (15% [w/w]). These hybrid nanoparticles showed no signs of crystallinity according to X-ray diffraction analysis, in contrast to
Martina Nowak-Machen et al.
American journal of respiratory cell and molecular biology, 48(5), 601-609 (2013-01-26)
Critically ill patients are routinely exposed to high concentrations of supplemental oxygen for prolonged periods of time, which can be life-saving in the short term, but such exposure also causes severe lung injury and increases mortality. To address this therapeutic
Veena Roberts et al.
Transplantation, 101(7), e194-e204 (2017-02-16)
Renal ischemia-reperfusion injury (IRI) leads to acute kidney injury and renal fibrosis. CD39 is a key purinergic enzyme in the hydrolysis of adenosine triphosphate (ATP) and increased CD39 enzymatic activity protects from acute IRI but its effect on renal fibrosis
Joanne S J Chia et al.
Journal of biomedicine & biotechnology, 2012, 320495-320495 (2012-11-03)
Diabetes mellitus encompasses two distinct disease processes: autoimmune Type 1 (T1D) and nonimmune Type 2 (T2D) diabetes. Despite the disparate aetiologies, the disease phenotype of hyperglycemia and the associated complications are similar. In this paper, we discuss the role of
Fátima Husein Abdalla et al.
Molecular and cellular biochemistry, 381(1-2), 1-8 (2013-06-26)
This study investigated the effect of quercetin on nucleoside triphosphate diphosphohydrolase (NTP-Dase), 50-nucleotidase, adenosine deaminase (ADA), and acetylcholinesterase (AChE) activities in synaptosomes from cerebral cortex of adult rats exposed to cadmium (Cd). Rats were exposed to Cd (2.5 mg/Kg) and
Thomas J Bushart et al.
American journal of botany, 100(1), 161-174 (2012-10-11)
Gravity regulates the magnitude and direction of a trans-cell calcium current in germinating spores of Ceratopteris richardii. Blocking this current with nifedipine blocks the spore's downward polarity alignment, a polarization that is fixed by gravity ∼10 h after light induces
Kyle Begovich et al.
Molecular cell, 79(6), 991-1007 (2020-08-12)
Stress granules (SGs) are condensates of mRNPs that form in response to stress. SGs arise by multivalent protein-protein, protein-RNA, and RNA-RNA interactions. However, the role of RNA-RNA interactions in SG assembly remains understudied. Here, we describe a yeast SG reconstitution
Contribution of CD39 to the immunosuppressive microenvironment of acute myeloid leukaemia at diagnosis.
Nicolas Dulphy et al.
British journal of haematology, 165(5), 722-725 (2014-03-29)
Reece A Sophocleous et al.
British journal of pharmacology, 177(12), 2812-2829 (2020-02-06)
P2X4 receptors are emerging therapeutic targets for treating chronic pain and cardiovascular disease. Dogs are well-recognised natural models of human disease, but information regarding P2X4 receptors in dogs is lacking. To aid the development and validation of P2X4 receptor ligands
[Partial purification and properties of potato apyrase].
C LIEBECQ et al.
Bulletin de la Societe de chimie biologique, 45, 573-594 (1963-01-01)
Robert A Amos et al.
Nature plants, 8(11), 1289-1303 (2022-11-11)
Rhamnogalacturonan I (RG-I) is a major plant cell wall pectic polysaccharide defined by its repeating disaccharide backbone structure of [4)-α-D-GalA-(1,2)-α-L-Rha-(1,]. A family of RG-I:Rhamnosyltransferases (RRT) has previously been identified, but synthesis of the RG-I backbone has not been demonstrated in
Maogen Chen et al.
Arthritis and rheumatism, 65(5), 1181-1193 (2013-02-13)
Current approaches offer no cures for rheumatoid arthritis (RA). Accumulating evidence has revealed that manipulation of bone marrow-derived mesenchymal stem cells (BM-MSCs) may have the potential to control or even prevent RA, but BM-MSC-based therapy faces many challenges, such as
Søren T Jepsen et al.
Sensors (Basel, Switzerland), 19(3) (2019-01-31)
Back scatter interferometry (BSI) is a sensitive method for detecting changes in the bulk refractive index of a solution in a microfluidic system. Here we demonstrate that BSI can be used to directly detect enzymatic reactions and, for the first
Zenichiro Saze et al.
Blood, 122(1), 9-18 (2013-05-17)
Antibody-independent role of B cells in modulating T-cell responses is incompletely understood. Freshly isolated or cultured B cells isolated from the peripheral blood of 30 normal donors were evaluated for CD39 and CD73 coexpression, the ability to produce adenosine 5'-monophosphate
Pedro Latorre-Muro et al.
Cell metabolism, 33(3), 598-614 (2021-02-17)
The architecture of cristae provides a spatial mitochondrial organization that contains functional respiratory complexes. Several protein components including OPA1 and MICOS complex subunits organize cristae structure, but upstream regulatory mechanisms are largely unknown. Here, in vivo and in vitro reconstitution experiments show
Kyung-Eun Gil et al.
The Plant cell, 29(11), 2882-2894 (2017-10-25)
Cellular proteins undergo denaturation and oxidative damage under heat stress, forming insoluble aggregates that are toxic to cells. Plants possess versatile mechanisms to deal with insoluble protein aggregates. Denatured proteins are either renatured to their native conformations or removed from
Matthias Zebisch et al.
Acta crystallographica. Section F, Structural biology and crystallization communications, 69(Pt 3), 257-262 (2013-03-23)
Nucleoside triphosphate diphosphohydrolases (NTPDases) are a large class of nucleotidases that hydrolyze the (γ/β)- and (β/α)-anhydride bonds of nucleoside triphosphates and diphosphates, respectively. NTPDases are found throughout the eukaryotic domain. In addition, a very small number of members can be
Heather B Cohen et al.
Blood, 122(11), 1935-1945 (2013-08-03)
Sepsis is a highly fatal disease caused by an initial hyperinflammatory response followed by a state of profound immunosuppression. Although it is well appreciated that the initial production of proinflammatory cytokines by macrophages accompanies the onset of sepsis, it remains
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