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Showing 1-30 of 268 results for "A7210" within Papers
Jiu Jiang et al.
Vaccine, 32(23), 2696-2702 (2014-04-01)
Influenza is one of the most common infectious diseases endangering the health of humans, especially young children and the elderly. Although vaccination is the most effective means of protection against influenza, frequent mutations in viral surface antigens, low protective efficacy
Lin Dang et al.
Molecular medicine reports, 11(6), 4183-4189 (2015-02-05)
Atopic dermatitis (AD) is a chronic inflammatory skin disease with a genetic background. The C5a‑receptor (C5aR) pathway has been reported to be involved in AD; however, the precise pathogenesis remains to be elucidated. In the present study, the contribution of
Mohammad Kamruzzaman et al.
Luminescence : the journal of biological and chemical luminescence, 30(7), 1077-1082 (2015-02-17)
A new and sensitive spectrofluorimetric method has been proposed to determine trace amount of adenosine disodium triphosphate (ATP). The method is based on the fluorimetric interaction between gatifloxacin (GFLX)-aluminium (III) (Al(3+) ) complex and ATP and studied using UV-visible and
Ying-Hua Shieh et al.
International immunopharmacology, 24(2), 383-391 (2015-01-13)
Zerumbone is a sesquiterpene compound isolated from the rhizome of wild ginger, Zingiber zerumbet Smith. The rhizomes of the plant are used as a spice and traditional medicine. Zerumbone was shown to possess anticarcinogenic, anti-inflammatory, and antioxidant properties. However, the
Jinwook Choi et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(7), E718-E727 (2015-02-04)
Germinal center (GC) reaction is crucial in adaptive immune responses. The formation of GC is coordinated by the expression of specific genes including Blimp-1 and Bcl-6. Although gene expression is critically influenced by the status of chromatin structure, little is
Abdelmounaim Nouri et al.
Vaccine, 33(43), 5756-5763 (2015-10-01)
Envenomation is a public health problem in many regions of the world. The only available treatment is the serotherapy that has limited efficiency due to the delay of its administration. The goal of this study is to provide a new
Nariman A Balenga et al.
Nature communications, 6, 6763-6763 (2015-04-14)
Asthma, a common disorder that affects >250 million people worldwide, is defined by exaggerated bronchoconstriction to inflammatory mediators including acetylcholine (ACh), bradykinin and histamine-also termed airway hyper-responsiveness. Nearly 10% of people with asthma have severe, treatment-resistant disease, which is frequently
Kirsten Neubert et al.
Journal of immunology (Baltimore, Md. : 1950), 192(12), 5830-5838 (2014-05-16)
Dendritic cells (DCs) are central modulators of immune responses and, therefore, interesting target cells for the induction of antitumor immune responses. Ag delivery to select DC subpopulations via targeting Abs to DC inhibitory receptor 2 (DCIR2, clone 33D1) or to
J M Birmingham et al.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 44(9), 1188-1199 (2014-07-22)
Although morbidity and mortality rates from asthma are highest in patients > 65 years of age, the effect of older age on airway inflammation in asthma is not well established. To investigate age-related differences in the promotion of allergic inflammation
Jing-Nan Liu et al.
Experimental & molecular medicine, 46, e113-e113 (2014-09-13)
Although some studies have explained the immunomodulatory effects of statins, the exact mechanisms and the therapeutic significance of these molecules remain to be elucidated. This study not only evaluated the therapeutic potential and inhibitory mechanism of simvastatin in an ovalbumin
Md Abu Sayeed et al.
PLoS neglected tropical diseases, 9(7), e0003881-e0003881 (2015-07-15)
Vibrio cholerae is the cause of cholera, a severe watery diarrhea. Protection against cholera is serogroup specific. Serogroup specificity is defined by the O-specific polysaccharide (OSP) component of lipopolysaccharide (LPS). Here we describe a conjugate vaccine for cholera prepared via
Tami Annable et al.
Autoimmunity, 48(1), 29-39 (2014-12-09)
Subunit vaccines are typically poorly immunogenic when administered alone, and require adjuvants for robust responses. Triggering TLRs to boost antigen-specific adaptive immunity is an attractive approach to increase the potency and quality of vaccines. However, recent reports suggest that alterations
Daniela Tosoni et al.
The Journal of cell biology, 211(4), 845-862 (2015-11-26)
The cell fate determinant Numb orchestrates tissue morphogenesis and patterning in developmental systems. In the human mammary gland, Numb is a tumor suppressor and regulates p53 levels. However, whether this function is linked to its role in fate determination remains
T Scott Devera et al.
Toxins, 7(7), 2371-2384 (2015-06-30)
Protective immunity against anthrax is inferred from measurement of vaccine antigen-specific neutralizing antibody titers in serum samples. In animal models, in vivo challenges with toxin and/or spores can also be performed. However, neither of these approaches considers toxin-induced damage to
Christopher M Evans et al.
Nature communications, 6, 6281-6281 (2015-02-18)
In asthma, airflow obstruction is thought to result primarily from inflammation-triggered airway smooth muscle (ASM) contraction. However, anti-inflammatory and smooth muscle-relaxing treatments are often temporary or ineffective. Overproduction of the mucin MUC5AC is an additional disease feature that, while strongly
Khalil Karimi et al.
Journal of hepatology, 62(5), 1085-1091 (2014-12-23)
During pregnancy, acetaminophen is one of the very few medications recommended by physicians to treat fever or pain. Recent insights from epidemiological studies suggest an association between prenatal acetaminophen medication and an increased risk for development of asthma in children
Milton M Arimi et al.
Environmental technology, 36(19), 2410-2418 (2015-03-24)
Melanoidins are dark-coloured recalcitrant pollutants found in many industrial wastewaters including coffee-manufacturing effluent, molasses distillery wastewater (MDWW) and other wastewater with molasses as the raw material. The wastewaters are mostly treated with anaerobic digestion after some dilution to minimize the
Kanako Maki et al.
PloS one, 10(4), e0122986-e0122986 (2015-04-16)
Asthma is a chronic inflammatory disorder of the airways, involving oxidative stress. Upon oxidative stress, glutathione covalently binds to protein thiols to protect them against irreversible oxidation. This posttranslational modification, known as protein S-glutathionylation, can be reversed by glutaredoxin 1
Yun Hu et al.
Human vaccines & immunotherapeutics, 10(1), 64-72 (2013-10-05)
A number of vaccines conjugating nicotine haptens with carrier proteins have been developed to combat nicotine caused tobacco dependence. Some vaccines, such as NicVAX, NicQb, advanced into clinical trials, but none of them were successful. Most of those vaccines have
Bérangère Massot et al.
Journal of immunology (Baltimore, Md. : 1950), 192(12), 5635-5642 (2014-05-09)
Naive CD4 lymphocytes undergo a polarization process in the periphery to become induced Th17 (iTh17) cells. Using retinoic acid-related orphan receptor γt (RORγt)-gfp mice, we found that RORγt and the transcription factor promyelocytic leukemia zinc finger (PLZF) are valuable new
Saya Moriyama et al.
The Journal of experimental medicine, 211(7), 1297-1305 (2014-06-11)
Follicular helper T (Tfh) cells access the B cell follicle to promote antibody responses and are particularly important for germinal center (GC) reactions. However, the molecular mechanisms of how Tfh cells are physically associated with GCs are incompletely understood. We
Gareth R Williams et al.
The Journal of experimental medicine, 211(6), 1019-1025 (2014-05-07)
There is currently no paradigm in immunology that enables an accurate prediction of how the immune system will respond to any given agent. Here we show that the immunological responses induced by members of a broad class of inorganic crystalline
Masamichi Itoga et al.
PloS one, 10(3), e0123210-e0123210 (2015-04-01)
Estrogen influences the disease severity and sexual dimorphism in asthma, which is caused by complex mechanisms. Besides classical nuclear estrogen receptors (ERαβ), G-protein-coupled estrogen receptor (GPER) was recently established as an estrogen receptor on the cell membrane. Although GPER is
Motoyasu Onishi et al.
Vaccine, 32(25), 3004-3009 (2014-04-12)
Synthetic hemozoin (sHZ, also known as β-hematin) from monomeric heme is a particle adjuvant which activates antigen-presenting cells (APCs), such as dendritic cells and macrophages, and enhances humoral immune responses to several antigens, including ovalbumin, human serum albumin, and serine
Jui-Hsin Huang et al.
Journal of biomedical science, 22, 65-65 (2015-08-08)
Opportunistically nosocomial infections in hospitalized patients are often related to Clostridium difficile infections (CDI) due to disruption of the intestinal micro-flora by antibiotic therapies during hospitalization. Clostridial exotoxins A and B (TcdA and TcdB) specifically bind to unknown glycoprotein(s) in
Christopher D Lucas et al.
American journal of respiratory and critical care medicine, 191(6), 626-636 (2015-01-30)
Eosinophils are key effector cells in allergic diseases, including allergic rhinitis, eczema, and asthma. Their tissue presence is regulated by both recruitment and increased longevity at inflamed sites. To investigate the ability of the flavone wogonin to induce eosinophil apoptosis
Ina Callebaut et al.
American journal of rhinology & allergy, 28(4), 290-296 (2014-09-10)
The naso-ocular interaction in allergic rhinoconjunctivitis is well recognized from epidemiological, clinical, and experimental observations. The precise mechanisms remain incompletely understood. A new mouse model of allergic rhinoconjunctivitis was used to investigate the contribution of mast cells and trigeminal ganglia
Tímea Mosolygó et al.
Vaccine, 32(40), 5228-5233 (2014-08-01)
Urogenital tract infection with Chlamydia trachomatis is a leading cause of sexually transmitted infections. There is currently no commercially available vaccine against C. trachomatis. The highly conserved plasmid of chlamydiae has been considered to be a virulence factor and the
Tomoharu Yokooji et al.
International archives of allergy and immunology, 167(3), 193-202 (2015-09-04)
Aspirin (ASP)-facilitated absorption of ingested allergens is considered an exacerbating factor in the development of food allergy. Sodium cromoglycate (SCG) is used for the treatment of atopic dermatitis with food allergy, but the efficacy of SCG in ASP-exacerbated food-allergy reactions
Chung Park et al.
eLife, 4 (2015-08-11)
The HIV-1 envelope protein gp120 is both the target of neutralizing antibodies and a major focus of vaccine efforts; however how it is delivered to B cells to elicit an antibody response is unknown. Here, we show that following local
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