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Showing 1-30 of 268 results for "A7210" within Papers
Yan Li et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 64(10), 767-774 (2015-09-01)
Asthma is thought to result from the generation of T helper type 2 (Th2) responses, leading to bronchial inflammation. Interleukin (IL)-35 is a recently described member of IL-12 cytokine family that plays a critical role in influencing Th cell differentiation
Sean O Ryan et al.
Journal of immunology (Baltimore, Md. : 1950), 192(12), 5561-5570 (2014-05-06)
Common variable immunodeficiency (CVID), the most frequent symptomatic primary immune deficiency in humans, is a heterogeneous group of immunologic disorders estimated to affect 1:10,000-1:50,000. Although a clear disease etiology remains elusive, a common characteristic of CVID is deficient IgG Ab
J Zhang et al.
Mucosal immunology, 7(5), 1139-1150 (2014-01-30)
Inflammatory bowel disease (IBD) is characterized for dysregulated intestinal inflammation. Conflicting reports have shown that activation of inflammasome could promote or decrease intestinal inflammation in an acute colitis model, whereas the involvement of inflammasome activation in chronic colitis is poorly
Michelle Farazi et al.
Journal of leukocyte biology, 96(2), 245-254 (2014-04-10)
Decline in CD4 T cell immune responses is associated with aging. Although a number of immunological defects have been identified in elderly mice (>18 months old), a key early-onset immune defect at middle age could be a driver or contributor
Annette Ives et al.
Nature communications, 6, 6555-6555 (2015-03-25)
Activation of the NLRP3 inflammasome by microbial ligands or tissue damage requires intracellular generation of reactive oxygen species (ROS). We present evidence that macrophage secretion of IL1β upon stimulation with ATP, crystals or LPS is mediated by a rapid increase
Pou Kuan Leong et al.
BioFactors (Oxford, England), 41(5), 314-323 (2015-08-27)
Reactive oxygen species (ROS)-mediated activation of inflammasome is involved in the development of a wide spectrum of diseases. We aimed to investigate whether (-)schisandrin B [(-)Sch B], a phytochemical that can induce cellular antioxidant response, can suppress the inflammasome activation.
J L Ather et al.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 45(7), 1245-1258 (2015-01-24)
Inhalational antigen tolerance typically protects against the development of allergic airway disease but may be overcome to induce allergic sensitization preceding the development of asthma. We examined in vivo whether pre-existing inhalational antigen tolerance could be overcome by activation of
Yeqin Wang et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 23(2), 297-309 (2014-12-17)
Here, we report a simple and low-cost oral oligodeoxynucleotide (ODN) delivery system targeted to the gut Peyer's patches (PPs). This system requires only Dulbecco's modified eagle's medium, calcium chloride, ODNs, and basic laboratory equipment. ODN nanocapsules (ODNcaps) were directly delivered
Tasuku Akiyama et al.
Pain, 156(7), 1240-1246 (2015-04-02)
We investigated roles for spinal neurons expressing the neurokinin-1 receptor (NK1R) and/or gastrin-releasing peptide receptor (GRPR) in a mouse model of ovalbumin (OVA)-induced chronic atopic dermatitis. Mice receiving repeated topical application of OVA exhibited atopic-like skin lesions and behavioral signs
Yanely Tirado et al.
Human vaccines & immunotherapeutics, 11(3), 657-661 (2015-02-12)
Tuberculosis (TB) is one of the most important causes of mortality and morbidity due to infectious diseases. BCG, the vaccine in use, is not fully protective against TB. In a previous study, we have shown that proteoliposomes (outer membrane extracts)
Sarang Tartey et al.
Journal of immunology (Baltimore, Md. : 1950), 195(2), 519-527 (2015-06-05)
Akirin2, an evolutionarily conserved nuclear protein, is an important factor regulating inflammatory gene transcription in mammalian innate immune cells by bridging the NF-κB and SWI/SNF complexes. Although Akirin is critical for Drosophila immune responses, which totally rely on innate immunity
Min Chen et al.
Journal of immunology (Baltimore, Md. : 1950), 194(6), 2607-2615 (2015-02-13)
Autophagy is required for the long-term maintenance of Ag-specific memory B cells. However, whether autophagy is also important for the initial formation of memory B cells remains unclear. In this study, we show that newly generated memory B cells do
Yun Hu et al.
Human vaccines & immunotherapeutics, 10(1), 64-72 (2013-10-05)
A number of vaccines conjugating nicotine haptens with carrier proteins have been developed to combat nicotine caused tobacco dependence. Some vaccines, such as NicVAX, NicQb, advanced into clinical trials, but none of them were successful. Most of those vaccines have
Chaolan Shi et al.
International immunopharmacology, 24(2), 211-218 (2014-12-17)
The sulfated polysaccharide from Porphyra was hypothesized to exhibit immunoregulatory, anti-tumor and anti-inflammatory activity, but its anti-allergic activity is not fully understood. Therefore, the aim of this study was to isolate sulfated polysaccharide from Porphyra haitanensis (PHPS) and investigate its
Michel J Massaad et al.
Molecular and cellular biology, 34(23), 4343-4354 (2014-09-24)
The Wiskott-Aldrich syndrome protein (WASp) is important for actin polymerization in T cells and for their migration. WASp-interacting protein (WIP) binds to and stabilizes WASp and also interacts with actin. Cytoskeletal and functional defects are more severe in WIP(-/-) T
Sebastian Scheer et al.
PloS one, 9(11), e112469-e112469 (2014-11-15)
The human intestinal parasite Schistosoma mansoni causes a chronic disease, schistosomiasis or bilharzia. According to the current literature, the parasite induces vigorous immune responses that are controlled by Th2 helper cells at the expense of Th1 helper cells. The latter
Ryuji Matsumura et al.
The Journal of biological chemistry, 290(24), 15313-15326 (2015-05-07)
Sialyl Lewis X (sLe(x)) antigen functions as a common carbohydrate determinant recognized by all three members of the selectin family. However, its expression and function in mice remain undefined due to the poor reactivity of conventional anti-sLe(x) monoclonal antibodies (mAbs)
Weiwei Huang et al.
Vaccine, 33(36), 4479-4485 (2015-07-25)
Acinetobacter baumannii (A. baumannii) is an important conditioned pathogen that causes nosocomial and community-associated infections. In this study, we sought to investigate whether outer membrane protein W (OmpW) is a potential target for eliciting protective immunity against A. baumannii infections.
Linxiang Lan et al.
The EMBO journal, 34(11), 1493-1508 (2015-03-05)
In this study, we have used techniques from cell biology, biochemistry, and genetics to investigate the role of the tyrosine phosphatase Shp2 in tumor cells of MMTV-PyMT mouse mammary glands. Genetic ablation or pharmacological inhibition of Shp2 induces senescence, as
L Karra et al.
Mucosal immunology, 8(4), 852-862 (2014-12-04)
Chronic mucosal inflammation is the hallmark of important and common airway diseases, such as allergic rhinitis (AR) and asthma. Lipoxin A4 (LXA4) is an endogenous pro-resolving mediator for mucosal inflammation that decreases allergic and asthmatic responses. Lipoxin B4 (LXB4) is
Huijeong Ahn et al.
Cytokine, 71(2), 223-231 (2014-12-03)
Methylsulfonylmethane (MSM) is an organosulfur compound and the health benefits associated with MSM include inflammation. Although MSM has been shown to have various physiological effects, no study has yet focused on inflammasome activation. The inflammasome is a multiprotein complex that
Firdose Begum Shaik et al.
Biochemical and biophysical research communications, 463(4), 600-605 (2015-06-13)
Asthma is a complex highly prevalent airway disease that is a major public health problem for which current treatment options are inadequate. Recently, farnesoid X receptor (FXR) has been shown to exert anti-inflammatory actions in various disease conditions, but there
Marina Boukhvalova et al.
Journal of virology, 89(19), 9825-9840 (2015-07-17)
Subunit vaccines based on the herpes simplex virus 2 (HSV-2) glycoprotein D (gD-2) have been the major focus of HSV-2 vaccine development for the past 2 decades. Based on the promising data generated in the guinea pig model, a formulation
Sridhar Jaligama et al.
Environmental science & technology, 49(14), 8769-8776 (2015-06-27)
The ″in situ burning" of trapped crude oil on the surface of Gulf waters during the 2010 Deepwater Horizon (DWH) oil spill released numerous pollutants, including combustion-generated particulate matter (PM). Limited information is available on the respiratory impact of inhaled
Xijun Ou et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(31), 11431-11436 (2014-07-24)
The adaptor Downstream-of-Kinase (DOK) 3 functions as a negative regulator and attenuates B-cell receptor-mediated calcium signaling. Although DOK3 is dispensable for early B-cell development, its role in plasma cell (PC) differentiation is unknown. Here, we show that Dok3(-/-) mice have
Yi-Fan Hong et al.
Journal of microbiology and biotechnology, 24(12), 1629-1635 (2014-08-13)
It is known that lactic acid bacteria (LAB) have many beneficial health effects, including antioxidative activity and immune regulation. In this study, the immune regulatory effects of Lactobacillus sakei and Lactobacillus plantarum, which are found in different types of kimchi
Hartinio N Nahampun et al.
Plant cell reports, 34(6), 969-980 (2015-02-14)
Oral administration of maize-expressed H3N2 nucleoprotein induced antibody responses in mice showing the immunogenicity of plant-derived antigen and its potential to be utilized as a universal flu vaccine. Influenza A viruses cause influenza epidemics that are devastating to humans and
Hamid Reza Nouri et al.
Immunologic research, 62(3), 280-291 (2015-05-11)
Liposome-protamine-DNA nanoparticles (LPD) are safe, effective, and non-toxic adjuvants that induce Th1-like immune responses. We hypothesized that encapsulation of allergens into liposomes could be an appropriate option for immunotherapy. The present study evaluated the immunotherapeutic potential of a recombinant hybrid
Thomas E Sussan et al.
American journal of physiology. Lung cellular and molecular physiology, 309(1), L27-L36 (2015-05-10)
Asthma development and pathogenesis are influenced by the interactions of airway epithelial cells and innate and adaptive immune cells in response to allergens. Oxidative stress is an important mediator of asthmatic phenotypes in these cell types. Nuclear erythroid 2-related factor
Enhancing Effect of Trachelogenin from Trachelospermi caulis Extract on Intestinal Barrier Function.
Hee Soon Shin et al.
Biological & pharmaceutical bulletin, 38(11), 1707-1713 (2015-08-14)
Trachelospermi caulis is used widely as an herbal medicine in oriental countries to attenuate fever and pain. We wished to reveal the novel function of this herb and its active component on barrier function in intestinal epithelial cells. Monolayers of
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