CN
Search Within
A7413
Applied Filters:
Keyword:'A7413'
Showing 1-28 of 28 results for "A7413" within Papers
Siamak Kazemi-Darabadi et al.
International journal of surgery (London, England), 12(8), 751-756 (2014-06-28)
Healing of skin wound is a multi-factorial and complex process. Treatment of diabetic wounds is still a major clinical challenge. Recently, stem cell transplantation to chronic wounds is favored. The objective of this study was to evaluate effects of pre-labeled
Anthoneth Ndidi Ezejiofor et al.
Journal of basic and clinical physiology and pharmacology, 26(6), 595-601 (2014-12-17)
Considering the antihyperglycemic and antioxidant activities of herbs, this study has evaluated the morphological changes, hypoglycemic effect, and comparative ameliorating effects of Costus afer Ker Gawl leaf and glibenclamide on pancreatic injury induced by alloxan. Thirty adult male albino rats
Zhichao Liu et al.
PLoS computational biology, 7(12), e1002310-e1002310 (2011-12-24)
Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI types (hepatotoxic side effects) seen in the clinic can be translated
Piyasi Mukhopadhyay et al.
International journal of biological macromolecules, 72, 640-648 (2014-09-23)
Chitosan-alginate (CS/ALG) nanoparticles were prepared by formation of an ionotropic pre-gelation of an alginate (ALG) core entrapping insulin, followed by chitosan (CS) polyelectrolyte complexation, for successful oral insulin administration. Mild preparation process without harsh chemicals is aimed at improving insulin
Krzysztof Krawczyk et al.
Science (New York, N.Y.), 368(6494), 993-1001 (2020-05-30)
Sophisticated devices for remote-controlled medical interventions require an electrogenetic interface that uses digital electronic input to directly program cellular behavior. We present a cofactor-free bioelectronic interface that directly links wireless-powered electrical stimulation of human cells to either synthetic promoter-driven transgene
Fatemeh Zare et al.
Lasers in medical science, 35(3), 547-556 (2019-07-25)
Pathophysiologic conditions associated with diabetes mellitus affect mesenchymal stem cells (MSCs), and this phenomenon may lead to some diabetic secondary complications. The present study was conducted to evaluate the impact of photobiomodulation (PBM) on rat diabetic MSC (DMSC) behavior in
Tong Liu et al.
Cardiovascular therapeutics, 32(4), 178-183 (2014-05-13)
The pleiotropic effects of glitazones may favorably affect atrial remodeling. We sought to investigate the effects of peroxisome proliferator-activated receptor-γ (PPAR-γ) activator rosiglitazone on atrial structural remodeling and atrial fibrillation (AF) promotion in alloxan-induced diabetic rabbits. Twenty alloxan-induced diabetic rabbits
Morus nigra leaf extract improves glycemic response and redox profile in the liver of diabetic rats.
Carolina Morais Araujo et al.
Food & function, 6(11), 3490-3499 (2015-08-22)
Diabetes mellitus (DM) is a chronic metabolic disorder characterized by hyperglycemia and alterations in the carbohydrate, lipid, and protein metabolism. DM is associated with increased oxidative stress and pancreatic beta cell damage, which impair the production of insulin and the
Isabella F D Pinto et al.
Journal of medicinal food, 18(7), 802-809 (2015-02-05)
Coconut water (CW) is a natural nutritious beverage, which contains several biologically active compounds that are traditionally used in the treatment of diarrhea and rehydration. Several works with CW have been related with antioxidant activity, which is very important in
Yongpeng Diao et al.
Chinese medical journal, 127(20), 3623-3629 (2014-10-16)
Therapeutic angiogenesis has been shown to promote blood vessel growth and improve tissue perfusion. Vascular endothelial growth factor (VEGF) plays an important role in angiogenesis. However, it has side effects that limit its therapeutic utility in vivo, especially at high
Nigel Greene et al.
Chemical research in toxicology, 23(7), 1215-1222 (2010-06-18)
Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential
Dongqin Yang et al.
EBioMedicine, 47, 114-127 (2019-09-10)
There are many reports of the anti-tumour effects of exogenous adenosine in gastrointestinal tumours. Gemcitabine, a first line agent for patients with poor performance status, and adenosine have structural similarities. For these reasons, it is worth exploring the therapeutic efficacy
Jubril Olayinka Akolade et al.
Journal of medicinal food, 17(10), 1122-1128 (2014-08-20)
This study was aimed at assessing the potential of essential oil from the leaf of Hoslundia opposita in the treatment of diabetes. Forty-eight rats (Rattus norvegicus) were randomized into two groups; nondiabetic and diabetic groups, each with four subgroups. Animals
Hongpo Wu et al.
Plant & cell physiology, 61(3), 505-518 (2019-11-19)
Recessively inherited mutant alleles of Mlo genes (mlo) confer broad-spectrum penetration resistance to powdery mildew pathogens in angiosperm plants. Although a few components are known to be required for mlo resistance, the detailed molecular mechanism underlying this type of immunity
Ailton Santos Sena Júnior et al.
BMC sports science, medicine & rehabilitation, 12, 45-45 (2020-08-11)
Type 1 diabetes mellitus (T1DM) is a metabolic disease characterized by hyperglycemia and excessive generation of reactive oxygen species caused by autoimmune destruction of beta-cells in the pancreas. Among the antioxidant compounds, Curcuma longa (CL) has potential antioxidant effects and
Luciano Ribeiro Filgueiras et al.
BMC pulmonary medicine, 14, 177-177 (2014-11-16)
We have previously shown that diabetic rats are more susceptible to sepsis, but that the Acute lung injury (ALI) secondary to sepsis is less intense than in non-diabetics. In the present study, we further investigated the ALI-secondary to sepsis in
Ofer Elhanani et al.
Cell reports, 31(5), 107591-107591 (2020-05-07)
The emerging appreciation of plasticity among pancreatic lineages has created interest in harnessing cellular reprogramming for β cell replacement therapy of diabetes. Current reprogramming methodologies are inefficient, largely because of a limited understanding of the underlying mechanisms. Using an in vitro
Peng Bai et al.
Nature medicine, 25(8), 1266-1273 (2019-07-10)
The ability to safely control transgene expression with simple synthetic gene switches is critical for effective gene- and cell-based therapies. In the present study, the signaling pathway controlled by human transient receptor potential (TRP) melastatin 8 (hTRPM8), a TRP channel
H O B Oloyede et al.
Journal of ethnopharmacology, 166, 313-322 (2015-03-10)
Dioscoreophyllum cumminsii (Stapf) Diels leaves are used in the management of diabetics in Nigeria. Thus, the antidiabetic activity of aqueous D. cumminsii leaf extract and its capability to halt oxidative stress and dyslipidemia in alloxan-induced diabetic rats was investigated. Antidiabetic
O B Oloyede et al.
Journal of ethnopharmacology, 157, 309-319 (2014-08-31)
Blighia sapida leaves are used in the management of diabetes in Nigeria. Thus the antidiabetic activity of methanolic Blighia sapida leaf extract and its capability to halt oxidative stress and dyslipidemia in alloxan-induced diabetic rats were investigated. In vitro antioxidant
Walid Hamdy El-Tantawy et al.
Archives of physiology and biochemistry, 121(3), 116-122 (2015-06-13)
Antidesma bunius L (Phyllanthaceae) is commonly known to local people in North-east Thailand as a medicinal plant. To investigate hypoglycaemic activities of methanolic extract of A. bunius in type 1 diabetes. A daily dose of A. bunius extract (250 mg/kg body
O A Adaramoye et al.
Andrologia, 46(8), 878-886 (2013-09-07)
The antihyperglycaemic effect of kolaviron (KV), a biflavonoid from Garcinia kola has been established in previous studies. In this study, we investigated the effect of KV (200 mg kg(-1) ) on the antioxidant, hormonal and spermatogenic indices of alloxan-diabetic male
Leandro P Moura et al.
Lipids in health and disease, 10, 77-77 (2011-05-17)
Diabetes mellitus is associated with metabolic dysfunctions, including alterations in circulating lipid levels and fat tissue accumulation, which causes, among other pathologies, non-alcoholic fatty liver disease (NAFLD). The objective of this study was to analyse the effects of physical exercise
Jingtan Zhu et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 7(8), 1903185-1903185 (2020-04-25)
Tissue optical clearing techniques have provided important tools for large-volume imaging. Aqueous-based clearing methods are known for good fluorescence preservation and scalable size maintenance, but are limited by long incubation time, insufficient clearing performance, or requirements for specialized devices. Additionally
Sean Ekins et al.
Drug metabolism and disposition: the biological fate of chemicals, 38(12), 2302-2308 (2010-09-17)
Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predictive in vivo, in vitro, and in silico models to identify compounds
Akira Kotani et al.
Journal of pharmaceutical and biomedical analysis, 97, 47-53 (2014-05-13)
The effects of hyperglycemia on the pharmacokinetics of valproic acid (VPA) were examined by time-concentration profiles of plasma VPA accompanied with blood glucose (BG) changing. In addition, time-concentration profiles of plasma free fatty acids (FFAs) were also obtained to examine
S Tahira et al.
The West Indian medical journal, 63(4), 294-299 (2014-11-28)
To investigate hypoglycaemic, hypolipidaemic and pancreatic beta cell regeneration activities of Momordica charantia L fruits(MC). Alloxan induced diabetic rabbits were treated with methanolic and ethanolic MC extract. Effects of plant extracts and the drug glibenclamide on serum glucose, lipid profile
Mohamed A Amin et al.
Archives of pharmacal research, 37(8), 1016-1031 (2013-12-03)
Diabetes is one of the leading causes of impaired wound healing. The objective of this study was to develop a bee venom-loaded wound dressing with an enhanced healing and anti-inflammatory effects to be examined in diabetic rats. Different preparations of
Page 1 of 1