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Showing 1-30 of 591 results for "A7502" within Papers
Jingyang Wang et al.
International immunopharmacology, 23(1), 60-65 (2014-08-19)
Isoproterenol, a synthetic non-selective β-adrenergic agonist, is often used during the immediate postoperative period after open heart surgery for its chronotropic and vasodilatory effects. It has been demonstrated that isoproterenol pretreatment followed by immediate LPS administration leads to reduced tumor
Hiroharu Oki et al.
Monoclonal antibodies in immunodiagnosis and immunotherapy, 34(3), 174-180 (2015-06-20)
Podoplanin (PDPN/Aggrus/T1α), a platelet aggregation-inducing type I transmembrane sialoglycoprotein, is involved in tumor invasion and metastasis. Furthermore, podoplanin expression was reported to be involved in poor prognosis of several cancers. Although many anti-podoplanin monoclonal antibodies (MAbs), such as NZ-1 and
Elumalai Satheeshkumar et al.
Analytica chimica acta, 879, 111-117 (2015-05-24)
A new method based on photochemical formation of silver nanoparticles (AgNPs) was developed for detection of tyrosine (Tyr). To selectively detect Tyr and to simplify the detection procedure, the photoactivity of Tyr was utilized to trigger the photochemical reduction in
Filippa Fleetwood et al.
Scientific reports, 4, 7518-7518 (2014-12-18)
Angiogenesis plays an important role in cancer and ophthalmic disorders such as age-related macular degeneration and diabetic retinopathy. The vascular endothelial growth factor (VEGF) family and corresponding receptors are regulators of angiogenesis and have been much investigated as therapeutic targets.
Shouli Wang et al.
Oncology reports, 33(2), 819-825 (2014-12-09)
During the last decade, microRNAs (miRNAs) have been identified as potential biomarkers and therapeutic targets for multiple malignancies; yet, few studies exist on intrahepatic cholangiocarcinoma (ICC). In the present study, a miRNA microarray was applied to determine the significant miRNAs
A muscle-liver-fat signalling axis is essential for central control of adaptive adipose remodelling.
Noriaki Shimizu et al.
Nature communications, 6, 6693-6693 (2015-04-02)
Skeletal muscle has a pleiotropic role in organismal energy metabolism, for example, by storing protein as an energy source, or by excreting endocrine hormones. Muscle proteolysis is tightly controlled by the hypothalamus-pituitary-adrenal signalling axis via a glucocorticoid-driven transcriptional programme. Here
Jian-jun Chen et al.
PloS one, 9(12), e115221-e115221 (2014-12-23)
Sex-based differences are prominent in affective disorders, but there are no biomarkers available to support sex-specific, laboratory-based diagnostics for male and female bipolar disorder (BD) patients. Here, a NMR-based metabonomic approach was used to preliminarily identify sex-specific urinary metabolite biomarkers
Ching-Ju Shen et al.
Taiwanese journal of obstetrics & gynecology, 54(3), 217-220 (2015-07-15)
To investigate the effect of breastfeeding on the change of visfatin levels in postpartum women. Twenty-nine postpartum women were enrolled into the study. All measurements were completed at the 2(nd) and 16(th) week postpartum. Women who had been continuously breastfeeding
Zuo Tong How et al.
Journal of chromatography. A, 1370, 135-146 (2014-12-03)
This paper reports a new analytical method for the analysis of 18 amino acids in natural waters using solid-phase extraction (SPE) followed by liquid chromatography-electrospray tandem mass spectrometry (LC-MS/MS) operated in multiple reaction monitoring mode. Two different preconcentration methods, solid-phase
Quangui Sun et al.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 67(10), 491-498 (2015-07-23)
Hepatocellular carcinoma (HCC) is the fifth most common cancer in men and the seventh in women worldwide. Chronic heavy alcohol consumption is a major risk factor for the development of HCC. However, the mechanism underlying the direct association between alcohol
Fang Wu et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 35(12), 1966-1976 (2015-07-02)
The active zone (AZ) is a thickening of the presynaptic membrane where exocytosis takes place. Chemical synapses contain neurotransmitter-loaded synaptic vesicles (SVs) that at rest are tethered away from the synaptic release site, but after the presynaptic inflow of Ca(+2)
XiaoWei Qian et al.
Anesthesiology, 121(2), 336-351 (2014-05-02)
Recent studies suggest that the transient receptor potential melastatin 2 (TRPM2) channel plays an important role in inflammation and immune response. However, the role and mechanism of TRPM2 in polymicrobial sepsis remain unclear. The authors explored the effects of genetic
Babs E Verstrepen et al.
PloS one, 9(11), e112568-e112568 (2014-11-14)
The mosquito-borne West Nile virus (WNV) causes human and animal disease with outbreaks in several parts of the world including North America, the Mediterranean countries, Central and East Europe, the Middle East, and Africa. Particularly in elderly people and individuals
Amy A Boaro et al.
FEMS microbiology ecology, 90(3), 802-815 (2014-10-08)
Integrated 'omics have been used on pure cultures and co-cultures, yet they have not been applied to complex microbial communities to examine questions of perturbation response. In this study, we used integrated 'omics to measure the perturbation response of a
Jussi Heinonsalo et al.
PloS one, 10(7), e0131561-e0131561 (2015-07-02)
Ectomycorrhizal (ECM) symbiosis has been proposed to link plant photosynthesis and soil organic matter (SOM) decomposition through the production of fungal enzymes which promote SOM degradation and nitrogen (N) uptake. However, laboratory and field evidence for the existence of these
Lorenz Thurner et al.
Journal of autoimmunity, 61, 17-28 (2015-05-26)
Recently we identified in a wide spectrum of autoimmune diseases frequently occurring proinflammatory autoantibodies directed against progranulin, a direct inhibitor of TNFR1 & 2 and of DR3. In the present study we investigated the mechanisms for the breakdown of self-tolerance
Blanca Murillo et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(32), 11266-11280 (2015-08-14)
Human mutations in ZIC2 have been identified in patients with holoprosencephaly and schizophrenia. Similarly, Zic2 mutant mice exhibit holoprosencephaly in homozygosis and behavioral and morphological schizophrenic phenotypes associated with forebrain defects in heterozygosis. Despite the devastating effects of mutations in
Linna Du et al.
Combinatorial chemistry & high throughput screening, 18(8), 809-818 (2015-08-04)
Paecilomyces tenuipes, one of the commonly used Chinese medicinal fungus, has received much attention over the world, which possesses various active compounds and biological activities. However, little toxicological information is available. Therefore, the present study evaluated the potential toxicity of
Long Li et al.
Journal of pharmacological sciences, 127(3), 244-250 (2015-04-04)
Oleoylethanolamine (OEA), an endogenous high-affinity agonist of peroxisome proliferator-activated receptor alpha (PPAR-α), has revealed the pharmacological properties in the treatment of obesity, atherosclerosis and other diseases through the modulation of lipid metabolism. To assess whether OEA can also regulate non-alcoholic
Eunjeong Kim et al.
Scientific reports, 5, 8272-8272 (2015-02-06)
Capicua (CIC) has been implicated in pathogenesis of spinocerebellar ataxia type 1 and cancer in mammals; however, the in vivo physiological functions of CIC remain largely unknown. Here we show that Cic hypomorphic (Cic-L(-/-)) mice have impaired bile acid (BA)
Melissa Paoloni et al.
PloS one, 10(6), e0129954-e0129954 (2015-06-20)
Interleukin (IL)-12 is a pro-inflammatory cytokine that mediates T-helper type 1 responses and cytotoxic T-cell activation, contributing to its utility as anti-cancer agent. Systemic administration of IL-12 often results in unacceptable toxicity; therefore, strategies to direct delivery of IL-12 to
Susmita Singh et al.
Current microbiology, 63(1), 94-99 (2011-05-19)
The ability of Aspergillus fumigatus L-amino acid oxidase (L-aao) to cause the resolution of racemic mixtures of DL-amino acids was investigated with DL-alanine, DL-phenylalanine, DL-tyrosine, and DL-aspartic acid. A chiral column, Crownpak CR+ was used for the analysis of the
Daizy Paliwal et al.
The Journal of general virology, 95(Pt 8), 1689-1700 (2014-05-06)
Hepatitis E virus (HEV), a major cause of acute viral hepatitis across the world, is a non-enveloped, plus-strand RNA virus. Its genome codes three proteins, pORF1 (multifunctional polyprotein), pORF2 (capsid protein) and pORF3 (multi-regulatory protein). pORF1 encodes methyltransferase, putative papain-like
Gad Cotter et al.
European journal of heart failure, 16(12), 1362-1371 (2014-11-06)
Worsening heart failure (WHF) in the first 7 days after an admission for acute HF (AHF) has been proposed as a therapeutic target in several recent AHF studies and was a co-primary endpoint of the VERITAS studies. Patients were randomized
Elaine Waldron-Roby et al.
PloS one, 10(10), e0141439-e0141439 (2015-10-28)
The apoptotic cascade is an orchestrated event, whose final stages are mediated by effector caspases. Regulatory binding proteins have been identified for caspases such as caspase-3, -7, -8, and -9. Many of these proteins belong to the inhibitor of apoptosis
Gang Qin et al.
Medicine, 93(28), e338-e338 (2014-12-20)
For patients with acute-on-chronic liver failure (ACLF), artificial liver support system (ALSS) may help prolong lifespan and function as a bridge to liver transplantation (LT), but data on its long-term benefit are lacking. We conducted this prospective, controlled study to
Malgorzata Klukowska et al.
American journal of dentistry, 28(5), 273-284 (2015-12-31)
To compare the clinical, microbiological and metabonomic profiles of subjects with high and low levels of chronic gingival bleeding during a controlled oral hygiene regimen intervention including sequential phases of rigorous therapeutic oral hygiene followed by experimental gingivitis (EG). Two
Chunyan Li et al.
BioMed research international, 2015, 345413-345413 (2015-07-15)
To investigate the effect of CXCL13 (C-X-C motif chemokine 13) on hepatocellular carcinoma and clarify the potential mechanisms. 32 patients with hepatocellular carcinoma and 12 healthy controls were recruited for analyzing the expression of CXCL13 by RT-PCR (reverse transcription-polymerase chain
Ewa Gruszewska et al.
Clinical laboratory, 61(11), 1769-1774 (2016-01-07)
The aim of this study was to evaluate the prevalence of alcoholic (ASH) and non-alcoholic steatohepatitis (NASH) in alcoholics by non-invasive biochemical markers: AshTest and NashTest. The tested group consisted of 142 alcoholic patients. All biochemical markers were assessed using
Athar A Badar et al.
European heart journal, 35(48), 3426-3433 (2014-10-01)
Angina pectoris is common in patients with heart failure and reduced ejection fraction (HF-REF) but its relationship with outcomes has not been well defined. This relationship was investigated further in a retrospective analysis of the Controlled Rosuvastatin Multinational Trial in
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