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Showing 1-30 of 591 results for "A7502" within Papers
Motofumi Kumazoe et al.
Scientific reports, 5, 9474-9474 (2015-04-01)
Green tea extract (GTE) induces apoptosis of cancer cells without adversely affecting normal cells. Several clinical trials reported that GTE was well tolerated and had potential anti-cancer efficacy. Epigallocatechin-3-O-gallate (EGCG) is the primary compound responsible for the anti-cancer effect of
Sabry A El-Naggar et al.
Pharmaceutical biology, 53(2), 235-241 (2014-10-08)
Cyclophosphamide (CTX) is a common anticancer agent used for the treatment of several malignancies. However, upon treatment, it induces severe toxicity due to its oxidative stress capability. Propolis, a natural product collected by honey bees, has shown several biological activities
Heng-Jun Gao et al.
Journal of cancer research and clinical oncology, 141(7), 1151-1162 (2014-12-03)
Monocarboxylate transporter 4 (MCT4) is a critical component in the glycolytic metabolism of cancer cells, and is also important for malignant behavior. We investigated the expression profile of MCT4, its prognostic value in hepatocellular carcinoma (HCC) patients, its role in
Lenea Nørskov-Lauritsen et al.
FEBS letters, 589(5), 588-597 (2015-01-27)
Investigation of post-translational modifications of receptor proteins is important for our understanding of receptor pharmacology and disease physiology. However, our knowledge about post-translational modifications of class C G protein-coupled receptors and how these modifications regulate expression and function is very
Min-Yu Chung et al.
Journal of medicinal food, 18(11), 1198-1206 (2015-04-04)
A number of compounds isolated from mushrooms have exhibited disease-modifying effects. We sought to investigate the mechanisms responsible for the anti-inflammatory effects of an extract from the mushroom species Sarcodon asparatus (SAE). Male BALB/c mice (N=42; 6 weeks old) were
Hanliu Wang et al.
Biochemistry, 54(42), 6475-6481 (2015-09-30)
We report the use of hydrogen-deuterium amide exchange coupled to mass spectrometry (HDX-MS) to study the interfaces of and conformational changes accompanying CsgE oligomerization. This protein plays an important role in enteric bacteria biofilm formation. Biofilms provide protection for enteric
Hyun Jung Lee et al.
Intervirology, 58(1), 14-21 (2015-01-17)
Interferon (IFN)-based therapy for chronic hepatitis C (CHC) is cost-effective and is associated with reduced risk of disease progression. We aimed to assess the incidence of cirrhosis and hepatocellular carcinoma (HCC) and to identify risk factors associated with disease progression.
Xingfu Yin et al.
Journal of medicinal food, 18(9), 987-998 (2015-05-12)
In this study, we investigated the anti-diabetic effect of Aster sphathulifolius (AS) extract in C57BL/KsJ-db/db mice. The db/db mice were orally administered with AS 50% ethanol extract at concentrations of 50, 100, and 200 mg/kg/day (db/db-AS50, db/db-AS100, and db/db-AS200, respectively)
Jimmy Belotte et al.
PloS one, 10(8), e0135739-e0135739 (2015-08-25)
Ovarian cancer is the deadliest of all gynecologic cancers. Recent evidence demonstrates an association between enzymatic activity altering single nucleotide polymorphisms (SNP) with human cancer susceptibility. We sought to evaluate the association of SNPs in key oxidant and antioxidant enzymes
Kevin J Dueck et al.
Journal of virology, 89(10), 5382-5394 (2015-03-06)
Vaccinia E3 protein has the biochemical capacity of binding to double-stranded RNA (dsRNA). The best characterized biological functions of the E3 protein include its host range function, suppression of cytokine expression, and inhibition of interferon (IFN)-induced antiviral activity. Currently, the
M N Adams et al.
Oncogene, 34(11), 1375-1383 (2014-04-01)
Many cancers are dependent on inappropriate activation of epidermal growth factor receptor (EGFR), and drugs targeting this receptor can improve patient survival, although benefits are generally short-lived. We reveal a novel mechanism linking EGFR and the membrane-spanning, cancer-promoting protein CDCP1
A Mayordomo-Febrer et al.
Experimental eye research, 131, 84-92 (2014-12-06)
Glaucoma models are helpful to study disease characteristics and to design new therapeutic options. Metabolomic profiling approach have been used to elucidating the molecular characteristics of the aqueous humor. Juvenile male Wistar rats experimental (n = 15) and controls (n
Hee Jae Lee et al.
The Journal of nutritional biochemistry, 26(11), 1254-1260 (2015-08-19)
Metabolic homeostasis is maintained by the coordinated regulation of several physiological processes and organ crosstalk. Especially, the interaction between adipose tissue and liver is critical for the regulation of glucose and lipid metabolism. This study investigated the involvement of resveratrol
Melissa A Babcook et al.
Molecular cancer therapeutics, 13(10), 2288-2302 (2014-08-15)
Docetaxel chemotherapy remains a standard of care for metastatic castration-resistant prostate cancer (CRPC). Docetaxel modestly increases survival, yet results in frequent occurrence of side effects and resistant disease. An alternate chemotherapy with greater efficacy and minimal side effects is needed.
Tanuja Rajah et al.
PloS one, 10(4), e0123711-e0123711 (2015-04-29)
The cathepsin B inhibitor, benzyloxycarbonyl-phenylalanine-alanine-fluoromethyl ketone (z-FA-FMK) readily inhibits anti-CD3-induced human T cell proliferation, whereas the analogue benzyloxycarbonyl-phenylalanine-alanine-diazomethyl ketone (z-FA-DMK) had no effect. In contrast, benzyloxycarbonyl-phenylalanine-alanine-chloromethyl ketone (z-FA-CMK) was toxic. The inhibition of T cell proliferation mediated by z-FA-FMK requires
Sara Heebøll et al.
Pharmacological research, 95-96, 34-41 (2015-03-31)
Non-alcoholic fatty liver disease and non-alcoholic steatohepatitis (NASH) are increasing clinical problems for which effective treatments are required. The polyphenol resveratrol prevents the development of fatty liver disease in a number of experimental studies. We hypothesized that it could revert
Jing-Ping Wang et al.
Molecular and cellular biochemistry, 407(1-2), 123-133 (2015-05-28)
Topoisomerase II inhibitor ellipticine effectively suppressed the growth of human non-small-cell-lung-cancer (NSCLC) epithelial cells. Previously, we reported the drug activity was consummated through parallel nucleus migration of p53 and Akt in A549 cells. While inducing cell death, the drug activity
Xiaoming Xie et al.
Molecular cancer therapeutics, 13(7), 1813-1825 (2014-05-03)
Targeted gene therapy is a promising approach for treating prostate cancer after the discovery of prostate cancer-specific promoters such as prostate-specific antigen, rat probasin, and human glandular kallikrein. However, these promoters are androgen dependent, and after castration or androgen ablation
Ning Ding et al.
Circulation. Cardiovascular genetics, 7(5), 615-624 (2014-07-23)
Growing evidence indicates that the presence of toll-like receptor 4 (TLR4) on platelets is a key regulator of platelet number and function. Platelets exposed to TLR4 agonists may serve to activate other cells such as neutrophils and endothelial cells in
Ze-Jun Ma et al.
Journal of diabetes research, 2015, 390428-390428 (2015-09-09)
Tripterygium glycosides tablet (TGT) is a Chinese traditional medicine that has been shown to protect podocytes from injury and reduce the proteinuria. The aim of this study was to assess the effect of TGT on renal tubulointerstitial fibrosis and its
S Nadalin et al.
Pediatric transplantation, 19(4), 358-365 (2015-04-17)
Biliary complications remain a major challenge for long-term success after LT, as it is, as a rule, the most common technical - early and late - complication that occurs, and because these complications contribute to a significant number of late
Jing-Chun Han et al.
Pharmaceutical biology, 52(12), 1624-1628 (2014-10-08)
Glycyrrhizin (GL), the major ingredient isolated from licorice, exerts multiple pharmacological activities. To elucidate the protective mechanism of GL towards lithocholic acid (LCA)-induced liver toxicity using lipidomics. GL (200 mg/kg) dissolved in corn oil was treated intraperitoneally for 7 d. On the
Eszter E Najbauer et al.
The journal of physical chemistry. B, 119(33), 10496-10510 (2015-07-23)
The conformers of α-serine were investigated by matrix-isolation IR spectroscopy combined with NIR laser irradiation. This method, aided by 2D correlation analysis, enabled unambiguously grouping the spectral lines to individual conformers. On the basis of comparison of at least nine
Hee Jae Lee et al.
Journal of medicinal food, 18(11), 1207-1213 (2015-05-15)
Low-grade chronic inflammation (metaflammation) is a major contributing factor for the onset and development of metabolic diseases, such as type 2 diabetes, obesity, and cardiovascular disease. Nicotinamide riboside (NR), which is present in milk and beer, is a functional vitamin
Zhenwei Gong et al.
American journal of physiology. Endocrinology and metabolism, 309(3), E283-E292 (2015-06-11)
Humanin (HN) is an endogenous mitochondria-associated peptide that has been shown to protect against various Alzheimer's disease-associated insults, myocardial ischemia-reperfusion injury, and reactive oxygen species-induced cell death. We have shown previously that HN improves whole body glucose homeostasis by improving
Suvi Kalliokoski et al.
Journal of molecular medicine (Berlin, Germany), 93(1), 51-62 (2014-09-12)
Typical features of celiac disease are small-bowel villus atrophy, crypt hyperplasia, and inflammation which develop gradually concomitant with ingestion of gluten. In addition, patients have anti-transglutaminase 2 (TG2) autoantibodies in their serum and tissues. The aim of this study was
Tsuneyuki Oku et al.
The British journal of nutrition, 114(10), 1550-1559 (2015-10-17)
Resistant glucan (RG) and hydrogenated resistant glucan (HRG) are newly developed non-digestible carbohydrate materials that decrease lifestyle-related diseases. The bioavailability of RG and HRG was investigated by in vitro experiments using human and rat small intestinal enzymes and by in
Lei Zhu et al.
The Journal of biological chemistry, 290(22), 13791-13799 (2015-04-12)
Prior work showed that expression of acyl carrier proteins (ACPs) of a diverse set of bacteria replaced the function of Escherichia coli ACP in lipid biosynthesis. However, the AcpAs of Lactococcus lactis and Enterococcus faecalis were inactive. Both failed to
Jocelyn Turpin et al.
Journal of virology, 89(2), 931-951 (2014-10-31)
Human T-cell lymphotropic virus type 1 (HTLV-1) and HTLV-2 encode auxiliary proteins that play important roles in viral replication, viral latency, and immune escape. The presence of auxiliary protein-encoding open reading frames (ORFs) in HTLV-3, the latest HTLV to be
Sigal Sofer et al.
Molecular and cellular endocrinology, 414, 29-41 (2015-07-25)
New evidance highlights the importance of food timing. Recently, we showed that a low-calorie diet with carbohydrates eaten mostly at dinner changed diurnal hormone secretion and led to greater weight loss and improved metabolic status in obese people. Herein, we
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