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Showing 1-30 of 1847 results for "A7506" within Papers
Arshad Mehmood Abbasi et al.
International journal of molecular sciences, 16(6), 13507-13527 (2015-06-16)
Mango (Mangifera indica L.), also called "the king of fruits", is one of the most popular fruits in tropical regions. Pulp and peel samples of mango cultivars were analyzed to estimate total phenolic, total flavonoid and total anthocyanin contents. Phenolic
Asuka Yuda et al.
Journal of cellular physiology, 230(1), 150-159 (2014-06-07)
Appropriate mechanical loading during occlusion and mastication play an important role in maintaining the homeostasis of periodontal ligament (PDL) tissue. Connective tissue growth factor (CTGF/CCN2), a matricellular protein, is known to upregulate extracellular matrix production, including collagen in PDL tissue.
Valéria Dornelles Gindri Sinhorin et al.
Ecotoxicology and environmental safety, 106, 181-187 (2014-05-21)
The aim of this study was to investigate the effects of acute glyphosate (active ingredient) exposure on the oxidative stress biomarkers and antioxidant defenses of a hybrid surubim (Pseudoplatystoma sp). The fish were exposed to different herbicide concentrations for 96
Talent Chipiti et al.
Acta poloniae pharmaceutica, 72(1), 119-127 (2015-04-09)
The study was intended to explore the antioxidant potential and phytochemical content of the ethanol and aqueous extracts of the leaf and root samples of Cissus cornifolia (Baker) Splanch (Vitaceae) across a series of four in vitro models. The results
João F Requicha et al.
Tissue engineering. Part A, 20(17-18), 2483-2492 (2014-03-01)
Human and canine periodontium are often affected by an inflammatory pathology called periodontitis, which is associated with severe damages across tissues, namely, in the periodontal ligament, cementum, and alveolar bone. However, the therapies used in the routine dental practice, often
Heng Cai et al.
Journal of neuropathology and experimental neurology, 74(1), 25-37 (2014-12-04)
The blood-tumor barrier (BTB) restricts the delivery of chemotherapeutic drug molecules to tumor tissues. We found that the endothelial cell (EC) receptor molecule Roundabout 4 (Robo4) is endogenously expressed in human brain microvascular ECs and that it is upregulated in
Andrew J Schwab et al.
PloS one, 9(7), e103112-e103112 (2014-07-24)
Spinal muscular atrophy (SMA) is an autosomal recessive disorder leading to paralysis and early death due to reduced SMN protein. It is unclear why there is such a profound motor neuron loss, but recent evidence from fly and mouse studies
Haitao Yu et al.
Toxicology and applied pharmacology, 280(3), 502-510 (2014-09-10)
Ahr activation is known to be associated with synovitis and exacerbated rheumatoid arthritis (RA), but its contributions to bone loss have not been completely elucidated. Osteoblast proliferation and differentiation are abnormal at the erosion site in RA. Here, we reported
Luis O Morales et al.
Plant, cell & environment, 38(5), 878-891 (2014-04-03)
Wavelengths in the ultraviolet (UV) region of the solar spectrum, UV-B (280-315 nm) and UV-A (315-400 nm), are key environmental signals modifying several aspects of plant physiology. Despite significant advances in the understanding of plant responses to UV-B and the identification of
Qingjie Wang et al.
American journal of physiology. Heart and circulatory physiology, 309(11), H1894-H1903 (2015-10-11)
Epoxyeicosatrienoic acids (EETs) have beneficial effects on cardiovascular disease. Soluble epoxide hydrolase (sEH) metabolizes EETs to less active diols, thus diminishing their biological activity. sEH inhibitors can suppress the progression of atherosclerotic lesions in animal models. However, the regulation of
Juliane Pasold et al.
International journal of nanomedicine, 10, 1131-1143 (2015-02-25)
In the present study, silica nanoparticles (sNP) coupled with insulin-like growth factor 1 (IGF-1) were loaded on a collagen-based scaffold intended for cartilage repair, and the influence on the viability, proliferation, and differentiation potential of human primary articular chondrocytes was
U Tanaka et al.
Oral diseases, 21(8), 977-986 (2015-09-04)
We previously demonstrated that a dominant-negative Sprouty2 (Spry2) mutation promotes osteoblast proliferation and differentiation after basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF) stimulation, whereas it diminishes proliferation of gingival epithelial cells, thereby inducing favourable conditions for periodontal
Guan Yang et al.
Stem cells (Dayton, Ohio), 32(11), 2939-2948 (2014-06-27)
In mouse, continuous growth of the postnatal incisor is coordinated by two populations of multipotent progenitor cells, the dental papilla mesenchymal cells and dental epithelial stem cells, residing at the proximal end of the incisor, yet the molecular mechanism underlying
Marc Bürzle et al.
Molecular aspects of medicine, 34(2-3), 436-454 (2013-03-20)
Transporters for vitamin C and its oxidized form dehydroascorbic acid (DHA) are crucial to maintain physiological concentrations of this important vitamin that is used in a variety of biochemical processes. The human SLC23 family consists of the Na(+)-dependent vitamin C
Jonathan E Kohler et al.
The Journal of surgical research, 153(1), 121-127 (2009-01-03)
Caspase-3, a pro-apoptotic enzyme, represents a class of proteins in which the active site contains reduced thiol (S-H) groups and is modulated by heavy metal cations, such as Zn(2+). We explored the effects of the thiol oxidant monochloramine (NH(2)Cl) on
Flávia Andressa Pidone Ribeiro et al.
Archives of oral biology, 59(8), 815-821 (2014-05-28)
The aim of this study was to evaluate the chemopreventive activity of an apple extract following medium-term oral carcinogenesis assay induced by 4-nitroquinoline-1-oxide (4NQO). A total of 30 male Wistar rats were distributed into five groups as follows (n=6 per
L Ia Timen et al.
Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology, (5)(5), 89-92 (2014-02-08)
Glucose and ascorbate used for endoscopic hemostasis metabolic preventive to prevent recurrent ulcer bleeding. Unacceptable joint use in endohemostasis ascorbate and hydrogen peroxide.
Koji Y Arai et al.
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 20(4), 399-408 (2014-02-11)
Repeated mechanical stresses applied to the same region of the skin are thought to induce morphological changes known as wrinkle. However, the underlying mechanisms are not fully understood. To study the mechanisms, we examined effects of repeated mechanical stress on
Wilfrida Nyanduko Nyairo et al.
Environmental monitoring and assessment, 187(11), 691-691 (2015-10-18)
Mau Forest in the upper reaches of the Mara River basin has recently undergone increased forest destruction followed by human settlement and agricultural activities. These anthropogenic activities may be contributing nutrients and heavy metals, ultimately polluting the river water and
Yingshuai Liu et al.
Journal of colloid and interface science, 439, 7-11 (2014-12-03)
Polyamine-capped gold nanorods (AuNRs) were developed as nanoprobes for localized surface Plasmon resonance (LSPR)-based simple, selective, and sensitive detection of Cu(2+) ions. Poly(sodium-4-styrenesulfonate) (PSS) and polyethylenimine (PEI) was successively adsorbed on the positively charged AuNRs via electrostatic adsorption, resulting in
Nicole Seegers et al.
Journal of biomolecular screening, 19(9), 1266-1274 (2014-05-30)
Indoleamine 2,3-dioxygenase (IDO1) and tryptophan 2,3-dioxygenase (TDO) are two structurally different enzymes that have a different tissue distribution and physiological roles, but both catalyze the conversion of tryptophan to N-formylkynurenine (NFK). IDO1 has been clinically validated as a small-molecule drug
Ivana Milic et al.
Journal of mass spectrometry : JMS, 50(3), 603-612 (2015-03-25)
Highly reactive lipid peroxidation-derived carbonyls (oxoLPP) modify protein nucleophiles via Michael addition or Schiff base formation. Once formed, Michael adducts can be further stabilized via cyclic hemiacetals with or without loss of water. Depending on the mechanism of their formation
Yuxia Zhou et al.
Journal of chromatographic science, 53(5), 830-835 (2014-12-07)
Dispersive liquid-liquid microextraction based on the solidification of a floating organic droplet combined with high-performance liquid chromatography with ultraviolet detection (HPLC-UV) was developed for the determination of clevidipine and its primary metabolite in Sprague-Dawley rat plasma samples. During the extraction
Lini Zhao et al.
Journal of cellular physiology, 230(3), 716-731 (2014-09-10)
The purposes of this study were to investigate the potential roles of miR-34c in regulating blood-tumor barrier (BTB) functions and its possible molecular mechanisms. The over-expression of miR-34c significantly impaired the integrity and increased the permeability of BTB, which were
Zhimei Zhong et al.
European journal of medicinal chemistry, 43(10), 2171-2177 (2007-12-08)
Chitosan (CS) with two different molecular weights was modified by reacting with 4-hydroxyl-5-chloride-1,3-benzene-disulfo-chloride or 2-hydroxyl-5-chloride-1,3-benzene-disulfo-chloride to give new 2-(4(or 2)-hydroxyl-5-chloride-1,3-benzene-di-sulfanimide)-chitosan (2-HCBSAHCS, 2-HCBSALCS, 4-HCBSAHCS, 4-HCBSALCS). The structure of the derivatives was characterized by FT-IR and 13C NMR spectroscopy. The antioxidant activities
Nataša Obermajer et al.
Journal of immunology (Baltimore, Md. : 1950), 193(10), 4988-4999 (2014-10-12)
The ultimate goal in transplantation medicine is the promotion of operational tolerance. Although Th cells of the Th17 type have been predominantly associated with rejection of allogeneic solid organ grafts, regulatory T (T(reg)) cells appear to foster operational tolerance. Induced
Zohreh Mazloom et al.
Pakistan journal of biological sciences : PJBS, 16(22), 1597-1600 (2014-02-12)
Diabetes mellitus as one of the most prevalent endocrine disease is associated with high oxidative stress. Anxiety, stress and depression are common neuropsychiatric features in diabetic patients. Hyperglycemia leads to increased oxidative stress which in turn diminishes antioxidant defense system.
William H Parker et al.
Biochemical and biophysical research communications, 458(2), 262-267 (2015-02-04)
Intracellular vitamin C, or ascorbic acid, has been shown to prevent the apoptosis of cultured vascular pericytes under simulated diabetic conditions. We sought to determine the mechanism by which ascorbate is transported into pericytes prior to exerting this protective effect.
Melissa Sullivan et al.
Fish physiology and biochemistry, 40(5), 1399-1405 (2014-04-01)
Carotenoids may act as antioxidants under many circumstances. We examined the importance of carotenoids as antioxidants in the gonads of male convict cichlids (Amatitlania nigrofasciata), a species in which males lack the carotenoid-based breeding coloration that characterizes females. Male fish
Koneni V Sashidhara et al.
Bioorganic & medicinal chemistry letters, 21(22), 6709-6713 (2011-10-11)
The synthesis of a series of benzocoumarin keto-enamine schiff bases is reported. The novel compounds were evaluated for their antihyperlipidemic activity in the hyperlipidemic hamster model. The compound 11 at a dose of 10 mg/kg body weight significantly lowered the
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