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Showing 1-30 of 1807 results for "A8097" within Papers
Saptarshi Roy et al.
Molecular and biochemical parasitology, 238, 111297-111297 (2020-07-04)
Like mammalian cells, helminth parasites are equipped with an array of enzymatic anti-oxidant system which has an adaptive strategy to cope up with several conditions of stress that arise from host immune response or drug treatment. Earlier, we had reported
Kwang-Youn Kim et al.
BMC complementary and alternative medicine, 19(1), 274-274 (2019-10-23)
Recent research has suggested that autophagy can provide a better mechanism for inducing cell death than current therapeutic strategies. This study investigated the effects of using an ethanol extract of Chrysanthemum zawadskii Herbich (ECZ) to induce apoptosis and autophagy associated
Suganya Kannan et al.
Journal of basic microbiology, 59(9), 936-949 (2019-07-28)
Vibrio harveyi is a marine luminous pathogen, which causes biofilm-mediated infections, pressures the search for an innovative alternate approach to strive against vibriosis in aquaculture. This study anticipated to explore the effect of glycolipid biosurfactant as an antipathogenic against V.
Hyejoung Cho et al.
Evidence-based complementary and alternative medicine : eCAM, 2018, 6917590-6917590 (2018-07-22)
Photodynamic therapy (PDT) is generally safer and less invasive than conventional strategies for head and neck cancer treatment. However, currently available photosensitizers have low selectivity for tumor cells, and the burden and side effects are so great that research is
Marzena Szwed et al.
The international journal of biochemistry & cell biology, 70, 57-67 (2015-11-02)
Conjugates of anthracyclines are a new possibility for anticancer agent delivery, which seems to be a very promising alternative to the currently used cancer treatment strategies. In our study, we investigated the ability of a doxorubicin-transferrin (DOX-TRF) conjugate to induce
Xiaoqian Zou et al.
Gene, 760, 145017-145017 (2020-08-07)
Cytoplasmic vacuolization usually occurs in cells treated with different agents and substances. We found that LZ-106, an analog of enoxacin, is a potent lysosomotropic agent, contributing to the formation of cytoplasmic vacuoles in cells. Studies of LZ-106-induced vacuolization in H460
Filipe Pinto et al.
The Journal of pathology, 251(1), 87-99 (2020-03-11)
The oncogene brachyury (TBXT) is a T-box transcription factor that is overexpressed in multiple solid tumors and is associated with tumor aggressiveness and poor patient prognosis. Gliomas comprise the most common and aggressive group of brain tumors, and at the
Kamala Pant et al.
Mutation research. Genetic toxicology and environmental mutagenesis, 786-788, 87-97 (2015-07-28)
In the international validation study of the in vivo rat alkaline comet assay (comet assay), the Japanese Center for the Validation of Alternative Methods (JaCVAM) provided three coded chemicals to BioReliance, 1,3-dichloropropene, ethionamide and busulfan, to be tested in a
Yao Wang et al.
Journal of tissue engineering and regenerative medicine, 12(7), 1545-1555 (2018-04-25)
Because guided bone regeneration (GBR) process is pronouncedly affected by the micro-environment in the defect, the surface stiffness of collagen membranes as a constituent part of the micro-environment was investigated in this study. The objective of this study was to
Hillary L Shane et al.
Toxicological sciences : an official journal of the Society of Toxicology, 178(1), 127-137 (2020-07-11)
Health-care workers have an increased incidence of allergic disease compared with the general public and are exposed to a variety of high-level disinfectants. Although exposure to these agents has been associated with allergic disease, findings between epidemiology and animal studies
Domenico Savio et al.
WIREs. Water, 5(3), e1282-e1282 (2018-05-22)
Over the past 15 years, pioneering interdisciplinary research has been performed on the microbiology of hydrogeologically well-defined alpine karst springs located in the Northern Calcareous Alps (NCA) of Austria. This article gives an overview on these activities and links them to
Susanta Pahari et al.
Autophagy, 16(6), 1021-1043 (2019-08-30)
Host-directed therapies are gaining considerable impetus because of the emergence of drug-resistant strains of pathogens due to antibiotic therapy. Therefore, there is an urgent need to exploit alternative and novel strategies directed at host molecules to successfully restrict infections. The
Mohammad Sherjeel Javed Khan et al.
International journal of biological macromolecules, 132, 772-783 (2019-04-01)
In this research work, polyurethane sponge (PUS) is used as a readily removable substrate for the synthesis of different nanoparticles on the surface and its use in reducing toxic dyes. An aqueous solution of 0.5 wt% chitosan (CH) was coated
Xin Zhang et al.
American journal of cancer research, 10(2), 545-563 (2020-03-21)
Brain metastasis is a major cause of mortality in melanoma patients. The blood-brain barrier (BBB) prevents most anti-tumor compounds from entering the brain, which significantly limits their use in the treatment of brain metastasis. One strategy in the development of
Masanari Maeta et al.
Scientific reports, 10(1), 13213-13213 (2020-08-09)
DNA-directed RNA polymerase II (pol II) is composed of ten core and two dissociable subunits. The dissociable subcomplex is a heterodimer of Rpb4/Polr2d and Rpb7/Polr2g, which are encoded by RPB4/polr2d and RPB7/polr2g genes, respectively. Functional studies of Rpb4/Polr2d in yeast
Moritz Knoche et al.
Planta, 248(2), 293-306 (2018-05-01)
Microcracks in the cuticle of developing apples are aligned with ridges on the inner cuticle surface and are indicative of stress-strain concentrations above the anticlinal cell walls. Microcracks occur in cuticles of most fruits. Growth strains are considered causal. In
Sourav Pakrashi et al.
Neurochemical research, 45(8), 1962-1973 (2020-06-04)
The detrimental impact on the food chain due to the overuse of rotenone is partly responsible for alpha-synuclein (α-syn) mediated neurotoxicity. It is hypothesized that rotenone overdose leads to cytosolic proteopathy resulting in modulation of apoptosis and autophagic pathways. The
Nicole A Seebacher et al.
The Journal of biological chemistry, 291(8), 3796-3820 (2015-11-26)
Pgp is functional on the plasma membrane and lysosomal membrane. Lysosomal-Pgp can pump substrates into the organelle, thereby trapping certain chemotherapeutics (e.g. doxorubicin; DOX). This mechanism serves as a "safe house" to protect cells against cytotoxic drugs. Interestingly, in contrast
Li Liu et al.
Journal of molecular medicine (Berlin, Germany), 98(11), 1573-1589 (2020-09-09)
Autophagy is a conserved self-degradation system closely related to cancer progression. Small molecule inhibitors of autophagy have proven to be efficient tools in cancer therapy and are in high demand. Here we report the discovery of two compounds (LZ02/01) capable
Sílvia Lemos et al.
Anti-cancer drugs, 31(5), 507-517 (2020-01-15)
Different types of tumors often present an overexpression of cyclooxygenase-2. The aim of this study was to evaluate the effects of parecoxib (NSAID, cyclooxygenase-2 selective inhibitor) in the behavior of the human osteosarcoma MG-63 cell line, concerning several biological features.
Eun-Jin Yun et al.
Cell death & disease, 11(9), 771-771 (2020-09-19)
Temozolomide (TMZ) is widely used for treating glioblastoma multiforme (GBM), however, the treatment of such brain tumors remains a challenge due to the development of resistance. Increasing studies have found that TMZ treatment could induce autophagy that may link to
Mohd Owais Ansari et al.
Scientific reports, 9(1), 6912-6912 (2019-05-08)
Iron oxide nanoparticles (IONPs) are known to induce cytotoxicity in various cancer cell lines through the generation of reactive oxygen species (ROS). However, the studies on its potential to induce toxicity in normal cell lines and in vivo system are
Namita Saxena et al.
Materials science & engineering. C, Materials for biological applications, 111, 110792-110792 (2020-04-14)
Superparamagnetic iron oxide nanoparticles (SPIONs) were optimally synthesized employing two energy sources viz. thermal and microwave using low temperature co-precipitation process. Both methods yielded particles with optimum physicochemical properties for biomedical applications like smaller size (~6--7 nm), narrow size distribution (standard
Takao Matsubara et al.
Clinical orthopaedics and related research, 471(3), 792-802 (2012-09-26)
Wide-margin resections are an accepted method for treating soft tissue sarcoma. However, a wide-margin resection sometimes impairs function because of the lack of normal tissue. To preserve the normal tissue surrounding a tumor, we developed a less radical (ie, without
Wei Hu et al.
Autophagy, 15(4), 707-725 (2019-01-08)
Helicobacter pylori (H. pylori) is a common human pathogenic bacterium. Once infected, it is difficult for the host to clear this organism using the innate immune system. Increased antibiotic resistance further makes it challenging for effective eradication. However, the mechanisms
I-Lun Hsin et al.
British journal of cancer, 123(3), 449-458 (2020-05-26)
Adaptive drug resistance is an unfavourable prognostic factor in cancer therapy. Pemetrexed-resistant lung cancer cells possess high-metastatic ability via ERK-ZEB1 pathway-activated epithelial-mesenchymal transition. GMI is a fungal immunomodulatory protein that suppresses the survival of several cancer cells. Cell viability was
Xinbing Sui et al.
Molecular medicine reports, 11(2), 1214-1220 (2014-11-06)
The tumor suppressor p53 is widely known for its ability to induce cell cycle arrest or cell death, therefore preventing neoplastic progression. Previous studies have demonstrated novel roles for p53 in the regulation of autophagy and senescence. p53 can not
Meng-Yang Jia et al.
Colloids and surfaces. B, Biointerfaces, 164, 247-254 (2018-02-08)
Cathodic polarization antifouling deserves attention because of its environmentally friendly nature and good sustainability. It has been proven that cathodic voltages applied on metal substrates exhibit outstanding antifouling effects. However, most metals immersed in marine environment are protected by insulated
Violet Aileen Senapati et al.
Journal of applied toxicology : JAT, 35(10), 1179-1188 (2015-06-19)
Chromium oxide (Cr2 O3 ) nanoparticles (NPs) are being increasingly used as a catalyst for aromatic compound manufacture, abrading agents and as pigments (e.g., Viridian). Owing to increased applications, it is important to study the biological effects of Cr2 O3 NPs
Sophia Karastogianni et al.
Journal of inorganic biochemistry, 118, 48-58 (2012-11-06)
The mononuclear complex [Mn(thiophenyl-2-carboxylate)(2)(H(3)tea)] (1), where H(3)tea=triethanolamine has been synthesized, characterized, while the DNA binding properties and the antioxidant activity were studied. The crystal structure of 1 is also reported. The interaction between 1 and calf thymus double stranded (ds)
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