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Showing 1-30 of 1807 results for "A8097" within Papers
Yung-Ting Hsiao et al.
Environmental toxicology (2018-05-03)
Gefitinib has been used for cancer patients and curcumin (CUR), demethoxycurcumin (DMC), or bisdemethoxycurcumin (BDMC) also shown to induce cancer cell apoptosis. However, no report shows the combination of gefitinib with, CUR, DMC, or BDMC induce cell apoptosis and autophagy
Jingyun Zhang et al.
Scientific reports, 8(1), 13127-13127 (2018-09-05)
While biofilms are known to cause problems in many areas of human health and the industry, biofilms are important in a number of engineering applications including wastewater management, bioremediation, and bioproduction of valuable chemicals. However, excessive biofilm growth remains a
Iris Mattos Santos-Pirath et al.
Experimental hematology, 86, 67-77 (2020-05-19)
There exists an urgent need for the development of new drugs for the treatment of lymphoid neoplasms. The aim of this study was to evaluate the cytotoxic effect of the marine plastoquinone 9'-hydroxysargaquinone (9'-HSQ), focusing on investigation of the mechanism
Naresh Dumala et al.
Journal of applied toxicology : JAT, 39(7), 955-965 (2019-02-15)
The current study was intended to elucidate the cytotoxicity, genotoxicity ability of nickel oxide (NiO) nanoparticles (NPs) and assessment of preliminary mechanism of the toxicity. Characterization studies showed that NiO-NPs have a particle size of 17.94 (±3.48) nm. The particle
Balaram Das et al.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 22(6), 893-918 (2017-06-24)
Currently toxicological research in Silver nanoparticle is a leading issue in medical science. The surface chemistry and physical dimensions of silver nanoparticles (Ag-NPs) play an important role in toxicity. The aim of this present study was to evaluate the in
Xiao-Long Yuan et al.
Frontiers in pharmacology, 11, 570450-570450 (2020-11-13)
Fungal secondary metabolites serve as a rich resource for exploring lead compounds with medicinal importance. Diorcinol N (DN), a fungal secondary metabolite isolated from an endophytic fungus, Arthrinium arundinis, exhibits robust anticancer activity. However, the anticancer mechanism of DN remains
Suman Jyoti Deka et al.
Journal of bioinformatics and computational biology, 16(3), 1850002-1850002 (2018-03-24)
Chemical libraries constitute a reservoir of pharmacophoric molecules to identify potent anti-cancer agents. Virtual screening of heterocyclic compound library in conjugation with the agonist-competition assay, toxicity-carcinogenicity analysis, and string-based structural searches enabled us to identify several drugs as potential anti-cancer
David Emerson et al.
Applied and environmental microbiology, 81(23), 8066-8075 (2015-09-20)
The role that neutrophilic iron-oxidizing bacteria play in the Arctic tundra is unknown. This study surveyed chemosynthetic iron-oxidizing communities at the North Slope of Alaska near Toolik Field Station (TFS) at Toolik Lake (lat 68.63, long -149.60). Microbial iron mats
Jung-Sun Lee et al.
Oncotarget, 6(6), 4051-4065 (2015-03-03)
c-Met, a cognate receptor tyrosine kinase of hepatocyte growth factor, is overexpressed and/or mutated in number of tumors. Therefore, abrogation of c-Met signaling may serve as potential therapeutic targets. In this study, we generated Ads expressing single shRNA specific to
Yaqiu Sang et al.
Food & function, 7(9), 3703-3715 (2016-08-05)
Zearalenone (ZEA), a non-steroidal estrogenic mycotoxin, is widely present in cereals and agricultural products. The literature reports suggest that oxidative damage seems to be a key determinant of ZEA-induced toxicity, and the protective effect of resveratrol (RSV), an antioxidant phenolic
Yiqun Jiang et al.
Journal of colloid and interface science, 534, 574-585 (2018-09-29)
Nitrogen (N)-doped graphene aerogels (GAs) have recently emerged as a promising class of photocatalytic materials for a multitude of environmental applications. Their photocatalytic activity depends strongly on the type of N bonding configurations created in the host lattice, which in
Karuppiah Vijayakumar et al.
Microbial pathogenesis, 149, 104286-104286 (2020-06-06)
The present study evaluated the quebrachitol (QBC) antibiofilm and antivirulence potential against methicillin-resistant Staphylococcus aureus (MRSA). QBC inhibited MRSA biofilm formation at concentration dependent manner without affecting the bacterial growth. Then, QBC biofilm efficacy was confirmed with light and confocal
Dipanwita Das Mukherjee et al.
Biochimica et biophysica acta. Molecular cell research, 1867(10), 118762-118762 (2020-06-06)
Microtubules, the key components of the eukaryotic cytoskeleton and mitotic spindle, are one of the most sought-after targets for cancer chemotherapy, especially due to their indispensible role in mitosis. Cervical cancer is a prevalent malignancy among women of developing countries
You-Zhi Xu et al.
Oncology reports, 35(4), 2081-2088 (2016-02-06)
Cancer cells activate autophagy in response to anticancer therapies. Autophagy induction is a promising therapeutic approach to treat cancer. In a previous study, YL4073 inhibited the growth of liver cancer and induced liver cancer cell apoptosis. Here, we demonstrated the
Mahzad Akbarpour et al.
The Journal of clinical investigation, 130(8), 4456-4469 (2020-07-22)
Despite the widespread use of antibiotics, bacterial pneumonias in donors strongly predispose to the fatal syndrome of primary graft dysfunction (PGD) following lung transplantation. We report that bacterial endotoxin persists in human donor lungs after pathogen is cleared with antibiotics
Cristiane C Denardin et al.
Cell biology and toxicology, 33(2), 197-206 (2016-10-17)
Activated hepatic stellate cells (HSC) are the major source of collagen I in liver fibrosis. Eugenia uniflora L. is a tree species that is widely distributed in South America. E. uniflora L. fruit-popularly known as pitanga-has been shown to exert
Orkut Güçlü et al.
Cardiovascular toxicology, 20(2), 139-154 (2019-07-07)
Systemic chemotherapy-mediated cell toxicity is a major risk factor for cardiovascular disease and atherosclerosis. Life-threatening acute events of the FOLFIRI (irinotecan, folinic acid and 5-fluorouracil) regimen are mainly due to DNA damage induced by antimetabolite and topoisomerase inhibition effects. However
Yu Wu et al.
Scientific reports, 7(1), 15567-15567 (2017-11-16)
Intracellular pathogenic microorganisms and toxins exploit host cell mechanisms to enter, exert their deleterious effects as well as hijack host nutrition for their development. A potential approach to treat multiple pathogen infections and that should not induce drug resistance is
Ji-Hye Yim et al.
International journal of radiation biology, 93(11), 1197-1206 (2017-07-07)
Low-dose radiation has various biological effects such as adaptive responses, low-dose hypersensitivity, as well as beneficial effects. However, little is known about the particular proteins involved in these effects. Here, we sought to identify low-dose radiation-responsive phosphoproteins in normal fibroblast
Giovanni Caprioli et al.
Food & function, 9(7), 3665-3672 (2018-06-23)
This study aimed to investigate the ethanolic extract of T. lanceolatus, a species native to north-western Algeria, traditionally used as herbal tea, seasoning and a preservative for meat and poultry. HPLC analysis showed the presence of fourteen bioactive compounds, among
Xiaohong Yang et al.
Frontiers in bioengineering and biotechnology, 8, 468-468 (2020-06-18)
Effective clinical treatments of cartilage lesions in affected joints require large numbers of viable chondrogenic cells generated through in vivo stimulation or ex vivo expansion of chondrocytes isolated from small biopsy specimens. Conventional passaging of chondrocytes in culture provides sufficient
Xianhong Ou et al.
Oncology reports, 33(3), 1264-1274 (2014-12-23)
Nitidine chloride (NC), a novel benzo[c]phenanthridine alkaloid, induces the growth inhibition of cancer cells. Previously it was demonstrated that SMMC-7721 human hepatocellular carcinoma (HCC) cells are highly susceptible to the antiproliferative effects of NC. However, the specific mechanisms remained unclear.
Majid Balaei-Kahnamoei et al.
BMC chemistry, 15(1), 4-4 (2021-01-21)
Salvia macrosiphon Boiss. is an aromatic perennial herb belonging to the family Lamiaceae. Phytochemical studies and biological activities of this plant have been rarely documented in the literature. The current study aimed to investigate antibacterial and cytotoxic activity of different
Chunyang Du et al.
The international journal of biochemistry & cell biology, 90, 17-28 (2017-07-25)
Autophagy is an important homoeostatic mechanism for the lysosomal degradation of protein aggregates and damaged cytoplasmic components. Recent studies suggest that autophagy which is induced by TGF-β1 suppresses kidney fibrosis in renal tubular epithelial cells (RTECs) of obstructed kidneys. Sphingosine
Shanmugaraj Gowrishankar et al.
Research in microbiology, 165(4), 278-289 (2014-04-05)
Since Streptococcus mutans is the principal etiologic agent causing dental caries, by encompassing an array of unique virulence traits, emerging treatment strategies that specifically target the virulence of this pathogen may be promising as alternative approaches compared to conventional antibiotic
Marianna Horváth et al.
Scientific reports, 10(1), 5891-5891 (2020-04-05)
The increasing incidence of carbapenemase-producing K. pneumoniae strains (CP-Kps) in the last decade has become a serious global healthcare problem. Therapeutic options for the treatment of emerging hospital clones have drastically narrowed and therefore novel approaches must be considered. Here
No Soo Kim et al.
Journal of ethnopharmacology, 241, 112025-112025 (2019-06-13)
A rhizome of Phragmites communis Trinius has been used in traditional medicine to remove a heat, relieve vomiting and fever, nourish body fluids, and treat diseases like cancers. However, the safety of Phragmitis rhizoma has not yet been fully assessed.
Rituparna Roy et al.
Phytotherapy research : PTR, 33(4), 1084-1094 (2019-03-06)
In this study, the antitumor activity of two furanoflavanoid derivatives, Pongapin and Karanjin, was evaluated in comparison with Plumbagin, a plant-derived polyphenol with proven antitumor activity. The compounds differentially inhibit the growth of different cancer cell lines (most effective on
Adam C Soloff et al.
Frontiers in immunology, 11, 2027-2027 (2020-10-06)
Pleural effusions, when benign, are attributed to cardiac events and suffusion of fluid within the pleural space. When malignant, lymphatic obstruction by tumor and failure to absorb constitutively produced fluid is the predominant formulation. The prevailing view has been challenged
Sophia G Espanola et al.
Nature cell biology, 22(12), 1411-1422 (2020-11-25)
Haematopoietic stem and progenitor cells (HSPCs) have been the focus of developmental and regenerative studies, yet our understanding of the signalling events regulating their specification remains incomplete. We demonstrate that supt16h, a component of the Facilitates chromatin transcription (FACT) complex
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