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Showing 1-30 of 810 results for "A8199" within Papers
Bradley R Kraemer et al.
Neuroscience, 453, 222-236 (2020-12-01)
The p75 neurotrophin receptor (p75NTR) is a multifunctional protein that regulates cellular responses to pathological conditions in specific regions of the nervous system. Activation of p75NTR in certain neuronal populations induces proteolytic processing of the receptor, thereby generating p75NTR fragments
Argo Aug et al.
PloS one, 10(11), e0142053-e0142053 (2015-11-05)
E-cigarettes are widely believed to be safer than conventional cigarettes and have been even suggested as aids for smoking cessation. However, while reasonable with some regards, this judgment is not yet supported by adequate biomedical research data. Since bronchial epithelial
Ya-Hsuan Ho et al.
Biochimica et biophysica acta, 1851(2), 172-183 (2014-12-03)
Erythrocytes and megakaryocytes (MK) are derived from a common progenitor that undergoes lineage specification. Lysophosphatidic acid (LPA), a lipid growth factor was previously shown to be a regulator for erythropoietic process through activating LPA receptor 3 (LPA3). However, whether LPA
Owen G James et al.
Developmental cell, 56(9), 1346-1358 (2021-05-05)
Myelination is essential for central nervous system (CNS) formation, health, and function. Emerging evidence of oligodendrocyte heterogeneity in health and disease and divergent CNS gene expression profiles between mice and humans supports the development of experimentally tractable human myelination systems.
Seon Hee Kim et al.
Oncology reports, 34(1), 288-294 (2015-05-23)
MHY-449 is a novel dihydrobenzofuro[4,5-b][1,8]naphthyridin-6-one derivative designed and synthesized as a potential anticancer agent. The present study aimed to examine the anticancer activity and underlying mechanism of MHY-449. The cell viability assay performed in AGS human gastric carcinoma cells demonstrated
Ting Liu et al.
Oncotarget, 6(10), 7992-8006 (2015-03-24)
All-trans retinoic acid (ATRA) is a differentiating agent for the treatment of acute promyelocytic leukemia (APL). However, the therapeutic efficacy of ATRA has limitations. Tetrandrine is a traditional Chinese medicinal herb extract with antitumor effects. In this study, we investigated
Christopher R Lupfer et al.
PLoS pathogens, 10(9), e1004410-e1004410 (2014-09-26)
Enteropathogenic and enterohemorrhagic bacterial infections in humans are a severe cause of morbidity and mortality. Although NOD-like receptors (NLRs) NOD2 and NLRP3 have important roles in the generation of protective immune responses to enteric pathogens, whether there is crosstalk among
Marcos M S Paula et al.
Journal of biomedical materials research. Part A, 103(10), 3323-3330 (2015-04-29)
We report the effect of gold nanoparticles (AuNP) in an acute inflammation model induced by carrageenan (CG) and compared this effect with those induced by the antioxidant N-acetylcysteine (NAC) alone and by the synergistic effect of NAC and AuNP together.
Viktória Szabolcsi et al.
Glia, 63(4), 567-594 (2014-11-26)
The calcium-binding protein parvalbumin (PV) hallmarks subpopulations of interneurons in the murine brain. We serendipitously observed the de novo expression of PV in ependymal cells of the lateral ventricle wall following in vivo lesioning and brain slicing for the preparation
Zhang Yiran et al.
Oxidative medicine and cellular longevity, 2013, 516051-516051 (2013-04-12)
In this study, BRL 3A cells were treated with different Cd concentrations (0, 10, 20, and 40 μmol/L) for 12 h and preincubated with or without N-acetyl-L-cysteine (NAC) (2 mmol/L) for 30 min, and cells were treated with Cd (0
Sławomir Kasperczyk et al.
Clinical toxicology (Philadelphia, Pa.), 51(6), 480-486 (2013-06-05)
The aim of the study was to investigate whether treatment with N-acetylcysteine (NAC) is able to restore erythrocyte glutathione (GSH) content in workers exposed to lead. Additionally, we measured the leukocyte and erythrocyte activities of GSH-related enzymes, such as glutathione
Lu Zhao et al.
PloS one, 10(7), e0133289-e0133289 (2015-07-18)
Alzheimer's disease (AD) and osteoporosis are two closely related multifactorial progressively degenerative diseases that predominantly affect aged people. These two diseases share many common risk factors, including old age, being female, smoking, excessive drinking, low estrogen, and vitamin D3 levels.
Lynette C Foo
Cold Spring Harbor protocols, 2013(5), 421-432 (2013-05-03)
We describe the use of immunopanning to purify rodent astrocytes. Immunopanning of astrocytes permits the prospective isolation of astrocytes from the rodent brain. Prospective isolation refers to the direct selection of cells without multiple steps that extend over a few
Isabella Farhy-Tselnicker et al.
eLife, 10 (2021-09-09)
Astrocytes regulate the formation and function of neuronal synapses via multiple signals; however, what controls regional and temporal expression of these signals during development is unknown. We determined the expression profile of astrocyte synapse-regulating genes in the developing mouse visual
Jiao Cao et al.
International immunopharmacology, 26(1), 212-220 (2015-04-07)
Hepatocellular carcinoma (HCC) is one of the most common types of liver cancers with high recurrence rate and mortality rate. Recent studies have indicated that tetramethylpyrazine (TMP), a purified chemical extracted from Ligusticum wallichii Franchat (ChuanXiong), possessed antitumor effects on
Hyo Hyun Yang et al.
Journal of natural medicines, 68(3), 473-480 (2014-02-13)
Cellular senescence contributes to tissue and organismal aging, tumor suppression and progress, tissue repair and regeneration, and age-related diseases. Thus, aging intervention might be a promising target for treatment and prevention of diverse age-related diseases. In the present study, we
Mei-Yi Wu et al.
International urology and nephrology, 45(5), 1309-1318 (2013-01-04)
N-Acetylcysteine (NAC) is reported to have potential for preventing of contrast-induced nephropathy (CIN) in patients undergoing coronary angiography. However, the effectiveness of NAC in preventing CIN in patients undergoing contrast-enhanced computed tomography (CT) is still controversial. We conducted a meta-analysis
Guk Heui Jo et al.
International journal of oncology, 45(4), 1497-1506 (2014-07-06)
Sulforaphane, a naturally occurring isothiocyanate found in cruciferous vegetables, has received a great deal of attention because of its ability to inhibit cell proliferation and induce apoptosis in cancer cells. In this study, we investigated the anticancer activity of sulforaphane
Chu-I Lee et al.
Journal of cellular biochemistry, 116(9), 2074-2085 (2015-04-29)
Neuroblastoma is one of the most aggressive cancers and has a complex form of differentiation. We hypothesized that advanced cellular differentiation may alter the susceptibility of neuroblastoma to photodynamic treatment (PDT) and confer selective survival advantage. We demonstrated that hematoporphyrin
Brianne R O'Leary et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 21(7), 1741-1751 (2015-01-31)
Pancreatic ductal adenocarcinoma (PDA) cells are known to produce excessive amounts of reactive oxygen species (ROS), particularly superoxide, which may contribute to the aggressive and refractory nature of this disease. Extracellular superoxide dismutase (EcSOD) is an antioxidant enzyme that catalyzes
Adi Zheng et al.
Current cancer drug targets, 14(2), 156-166 (2013-11-28)
Curcumin, a polyphenol isolated from the plant Curcuma longa, displays chemotherapeutic and chemopreventive effects in diverse cancers, including colorectal cancer. A mono-carbonyl analogue B63 was synthesized through several chemical modifications of the basic structure of curcumin to increase its biological
Ufuk Ozer et al.
Molecular pharmacology, 88(6), 970-981 (2015-10-08)
Thymidylate synthase (TYMS; EC 2.1.1.15) catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) by N(5),N(10)-methyhlenetetrahydrofolate, forming dTMP for the maintenance of DNA replication and repair. Inhibitors of TYMS have been widely used in the treatment of neoplastic disease. A number of
Caroline Bylda et al.
Drug testing and analysis, 7(6), 457-466 (2014-09-19)
This paper describes a sample preparation method that complements a previously published liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay for acetaminophen and eight structurally-related compounds in human serum (C. Bylda, R. Thiele, U. Kobold, D.A. Volmer. Drug Test. Anal. 2014, 6
Qian Sun et al.
American journal of physiology. Gastrointestinal and liver physiology, 308(9), G757-G766 (2015-03-15)
Hepatic zinc deficiency has been well documented in alcoholic patients, but the mechanisms by which zinc deficiency mediates cell death have not been well defined. The objectives of this study were to determine whether alcohol perturbs subcellular zinc homeostasis and
Martha G Blackford et al.
Clinical therapeutics, 33(9), 1322-1330 (2011-09-06)
N-acetylcysteine (NAC) is the most effective therapy for acetaminophen (APAP) toxicity and is currently available for oral and intravenous (IV) administration. Although both routes are effective, use of the IV formulation has been increasing since becoming available in the United
Jianmiao Wang et al.
Respiratory research, 16, 37-37 (2015-04-08)
It is incompletely understood how cigarette smoke (CS) exposure affects lung mucosal immune responses during viral respiratory infections. B cell activating factor belonging to the tumor necrosis factor family (BAFF) plays an important role in the induction of secretory immunoglobulin
Li Zuo et al.
American journal of physiology. Cell physiology, 309(11), C759-C766 (2015-10-02)
Po2 cycling, often referred to as intermittent hypoxia, involves exposing tissues to brief cycles of low oxygen environments immediately followed by hyperoxic conditions. After experiencing long-term hypoxia, muscle can be damaged during the subsequent reintroduction of oxygen, which leads to
Qiuhua Zhang et al.
Molecular vision, 21, 604-611 (2015-05-28)
In models of diabetic retinopathy, insulin-like growth factor binding protein-3 (IGFBP-3) is protective to the retina, especially retinal microvascular endothelial cells (RECs), but the underlying mechanisms are unclear. For this study, we hypothesized that IGFBP-3 may reduce vascular endothelial growth
Jiaxing Song et al.
Journal of photochemistry and photobiology. B, Biology, 134, 27-36 (2014-05-06)
Cyclooxygenase 2 (COX-2) is an inducible enzyme that contributes to the generation of chronic inflammation and the development of cancer, and promotes neoplastic transformation, in response to chemical carcinogens and environmental stresses. In this study, we demonstrated that a sublethal
Hanqing Chen et al.
Small (Weinheim an der Bergstrasse, Germany), 11(34), 4366-4378 (2015-06-23)
Single walled carbon nanotubes (SWCNTs) have been shown to be highly effective against a wide range of bacteria. Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) infection is a well-known mediator to prolong hospitalization and initiate chronic inflammation, yet
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