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Showing 1-30 of 568 results for "A9415" within Papers
Polyxeni Alexiou et al.
Archiv der Pharmazie, 347(11), 798-805 (2014-08-28)
SPD-304 was discovered as a promising tumor necrosis factor alpha (TNF) antagonist that promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. However, SPD-304 contains a potentially toxic 3-alkylindole moiety, which can be bioactivated
Hidde M Kroon et al.
Journal of surgical oncology, 109(4), 348-351 (2014-02-14)
Isolated limb infusion (ILI) was developed as a simplified and minimally invasive alternative to isolated limb perfusion (ILP) to treat unresectable limb melanoma. A number of centers around the world have reported their results using this procedure. In this study
The flavagline FL3 interferes with the association of Annexin A2 with the eIF4F initiation complex and transiently stimulates the translation of annexin A2 mRNA.
Grindheim, et al.
Frontiers in Cell and Developmental Biology, 11, 1094941-1094941 (2023)
Ross O Meyers et al.
Bioorganic & medicinal chemistry letters, 19(16), 4752-4755 (2009-07-21)
Synthesis of seven semi-synthetic analogs of NDGA is described. An approach to NDGA derivatization is described in which the ortho-phenolic groups are tethered together by one atom, forming a 5-membered heterocyclic ring. The analogs were evaluated for cytotoxicity in four
Min Huang et al.
BMC complementary and alternative medicine, 15, 146-146 (2015-05-13)
Geranium wilfordii is one of the major species used as Herba Geranii (lao-guan-cao) in China, it is commonly used solely or in polyherbal formulations for treatment of joint pain resulted from rheumatoid arthritis (RA) and gout. This herb is used
Byungil Kim et al.
Molecular cell, 78(4), 624-640 (2020-05-08)
The primary interactions between incoming viral RNA genomes and host proteins are crucial to infection and immunity. Until now, the ability to study these events was lacking. We developed viral cross-linking and solid-phase purification (VIR-CLASP) to characterize the earliest interactions
Olga A Efimova et al.
Reproduction (Cambridge, England), 149(3), 223-233 (2014-12-17)
We report the sequential changes in 5-hydroxymethylcytosine (5hmC) patterns in the genome of human preimplantation embryos during DNA methylation reprogramming. We have studied chromosome hydroxymethylation and methylation patterns in triploid zygotes and blastomeres of cleavage-stage embryos. Using indirect immunofluorescence, we
KIAA1429-mediated m6A modification of CHST11 promotes progression of diffuse large B-cell lymphoma by regulating Hippo-YAP pathway.
Chen, et al.
Cellular and Molecular Biology Letters, 28, 32-32 (2023)
Stefano Fumagalli et al.
Genes & development, 26(10), 1028-1040 (2012-05-17)
Impairment of ribosome biogenesis leads to p53 induction and cell cycle arrest, a checkpoint involved in human disease. Induction of p53 is attributed to the binding and inhibition of human double minute 2 (Hdm2) by a subset of ribosomal proteins
Igor Arregi et al.
PloS one, 10(6), e0130610-e0130610 (2015-06-20)
Nucleophosmin (NPM) is a nucleocytoplasmic shuttling protein, normally enriched in nucleoli, that performs several activities related to cell growth. NPM mutations are characteristic of a subtype of acute myeloid leukemia (AML), where mutant NPM seems to play an oncogenic role.
Lioudmila V Sharova et al.
DNA research : an international journal for rapid publication of reports on genes and genomes, 16(1), 45-58 (2008-11-13)
Degradation of mRNA is one of the key processes that control the steady-state level of gene expression. However, the rate of mRNA decay for the majority of genes is not known. We successfully obtained the rate of mRNA decay for
Jonathan Steinman et al.
Journal of surgical oncology, 109(5), 405-409 (2013-12-10)
Isolated limb infusion (ILI) is a percutaneous method of delivering regional chemotherapy to patients with recurrent tumors of the extremity. This study determines predictors of response, survival, and limb salvage. Single institution data from a prospective clinical trial and subsequent
Karoline St-Martin Crites et al.
Journal of inflammation (London, England), 12, 62-62 (2015-11-10)
Hyperinflammation is a hallmark feature of cystic fibrosis (CF) airways. However, inflammation has also been documented systemically and, more recently, in extrapulmonary CF-affected tissues such as the pancreas and intestine. The pathogenesis of CF-related inflammation and more specifically the role
Kate M MacDonald et al.
Nature communications, 14(1), 556-556 (2023-02-03)
Micronuclei (MN) are cytosolic bodies that sequester acentric fragments or mis-segregated chromosomes from the primary nucleus. Spontaneous rupture of the MN envelope allows recognition by the viral receptor cyclic GMP-AMP synthase (cGAS), initiating interferon signaling downstream of DNA damage. Here
Emanuela Matteucci et al.
Experimental cell research, 319(12), 1865-1874 (2013-05-11)
Here, we report a complex regulation of endothelin-1 (ET-1) axis driven by epigenetic reactions in 1833-bone metastatic cells, emphasizing the importance in skeletal metastasis from breast carcinoma. Inhibitors of histone deacetylases, trichostatin A (TSA), and of DNA methylases, 5'-Azacytidine (Aza)
Antao Chang et al.
The Journal of infectious diseases, 212(9), 1509-1520 (2015-10-16)
Treatment of mice with lipopolysaccharide (LPS) and the liver-specific transcriptional inhibitor D-(+)-galactosamine (GalN) induces fatal hepatitis, which is mediated by tumor necrosis factor α (TNF-α) and characterized by massive hepatic apoptosis. Previous studies suggest that GalN increases the sensitivity to
Dongwan Kim et al.
Cell, 181(4), 914-921 (2020-04-25)
SARS-CoV-2 is a betacoronavirus responsible for the COVID-19 pandemic. Although the SARS-CoV-2 genome was reported recently, its transcriptomic architecture is unknown. Utilizing two complementary sequencing techniques, we present a high-resolution map of the SARS-CoV-2 transcriptome and epitranscriptome. DNA nanoball sequencing shows that
Fei Liu et al.
Journal of cell communication and signaling, 16(1), 103-113 (2021-07-02)
Nasopharyngeal carcinoma (NPC) is the most common malignant tumor of the head and neck region and is characterized by an increased risk of developing chemoresistance after treatment. The present study demonstrated that estrogen-related receptor α (ERRα) was upregulated in cisplatin-
Shilpi Verma et al.
PLoS pathogens, 10(8), e1004268-e1004268 (2014-08-15)
TNF-related apoptosis inducing ligand (TRAIL) death receptors (DR) regulate apoptosis and inflammation, but their role in antiviral defense is poorly understood. Cytomegaloviruses (CMV) encode many immune-modulatory genes that shape host immunity, and they utilize multiple strategies to target the TNF-family
Sanki Asakawa et al.
PloS one, 10(3), e0119428-e0119428 (2015-03-06)
Nickel (Ni) ions easily elute from many alloys and elicit inflammation and allergies. Previous studies have shown that infections due to the implantation of medical devices cause inflammation and enhance the elution of Ni ions (Ni²⁺). However, cross-talk between infection-
RNA-mediated demixing transition of low-density condensates.
Kim, et al.
Nature Communications, 14, 2425-2425 (2023)
Hiram Luna-Munguia et al.
The Journal of pharmacology and experimental therapeutics, 352(2), 368-378 (2014-12-17)
As a member of the multidrug-resistance associated protein (MRP) family, MRP2 affects the brain entry of different endogenous and exogenous compounds. Considering the role of this transporter at the blood-brain barrier, the regulation is of particular interest. However, there is
Janaki N Sudhakar et al.
Biology of the cell, 106(10), 359-376 (2014-07-25)
During the initiation of cell death, mitochondrial protein, apoptosis-inducing factor (AIF), is transported to the nucleus. The mechanism of AIF nuclear translocation, however, is not clear. After protein synthesis, the AIF is originally targetted to the mitochondria, and the nuclear
Agnese Cristini et al.
Nature communications, 13(1), 2961-2961 (2022-05-27)
RNase H2 is a specialized enzyme that degrades RNA in RNA/DNA hybrids and deficiency of this enzyme causes a severe neuroinflammatory disease, Aicardi Goutières syndrome (AGS). However, the molecular mechanism underlying AGS is still unclear. Here, we show that RNase
B Walker et al.
Journal of thrombosis and haemostasis : JTH, 13(7), 1325-1334 (2015-05-07)
Platelet secretion is critical to development of acute thrombotic occlusion. Platelet dense granules contain a variety of important hemostatically active substances. Nevertheless, biogenesis of platelet granules is poorly understood. Serum- and glucocorticoid-inducible kinase 1 (SGK1) has been shown to be
Supriya Sen et al.
Cell systems, 10(2), 169-182 (2020-01-24)
Pathogen-derived lipopolysaccharide (LPS) and cytokine tumor necrosis factor (TNF) activate NFκB with distinct duration dynamics, but how immune response genes decode NFκB duration to produce stimulus-specific expression remains unclear. Here, detailed transcriptomic profiling of combinatorial and temporal control mutants identified
Thomas Schwarzl et al.
Journal of molecular biology, 427(21), 3368-3374 (2015-09-13)
Identifying changes in the transcriptional regulation of target genes from high-throughput studies is important for unravelling molecular mechanisms controlled by a given perturbation. When measuring global transcript levels only, the effect of the perturbation [e.g., transcription factor (TF) overexpression or
Yingmin Wu et al.
Molecular cancer, 18(1), 87-87 (2019-04-14)
Long noncoding RNAs (lncRNAs) have emerged as critical players in cancer progression, but their functions in colorectal cancer (CRC) metastasis have not been systematically clarified. lncRNA expression profiles in matched normal and CRC tissue were checked using microarray analysis. The
Laura Pisapia et al.
International journal of oncology, 47(2), 481-489 (2015-06-18)
Many solid tumours including melanoma, glioblastoma, and breast carcinomas express MHC class II molecules (MHC II). The surface expression of these molecules confers to non-hematopoietic tumour cells the role of non-professional antigen presenting cells and the ability to potentially stimulate
Jie Du et al.
Developmental cell, 55(6), 737-753 (2020-11-22)
Bacterial infection triggers a cytokine storm that needs to be resolved to maintain the host's wellbeing. Here, we report that ablation of m6A methyltransferase subunit METTL14 in myeloid cells exacerbates macrophage responses to acute bacterial infection in mice, leading to
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