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Showing 1-30 of 50 results for "A9731" within Papers
Junaid Afzal et al.
Cell reports, 40(4), 111146-111146 (2022-07-30)
The vast potential of human induced pluripotent stem-cell-derived cardiomyocytes (hiPSC-CMs) in preclinical models of cardiac pathologies, precision medicine, and drug screening remains to be fully realized because hiPSC-CMs are immature without adult-like characteristics. Here, we present a method to accelerate
Shuxia Fan et al.
Bio-protocol, 8(18), e3018-e3018 (2018-09-20)
Blood platelets are critical for hemostasis and thrombosis, but also play diverse roles during immune responses. We have recently reported that platelets migrate at sites of infection in vitro and in vivo. Importantly, platelets use their ability to migrate to
FRESH 3D bioprinting a contractile heart tube using human stem cell-derived cardiomyocytes.
Bliley, et al.
Biofabrication, 14 (2022)
Preeti Ashok et al.
Frontiers in bioengineering and biotechnology, 8, 571425-571425 (2020-11-17)
Functional heart cells and tissues sourced from human pluripotent stem cells (hPSCs) have great potential for substantially advancing treatments of cardiovascular maladies. Realization of this potential will require the development of cost-effective and tunable bioprocesses for manufacturing hPSC-based cell therapeutics.
Jeffrey Aalders et al.
MethodsX, 7, 101065-101065 (2020-10-03)
Three-dimensional (3D) cell culturing has several advantages over 2D cultures. 3D cell cultures more accurately mimic the in vivo environment, which is vital to obtain reliable results in disease modelling and toxicity testing. With the introduction of the Yamanaka factors
Qiulian Zhou et al.
MedComm, 4(3), e299-e299 (2023-06-16)
Circulating circular RNAs (circRNAs) are emerging as novel biomarkers for cardiovascular diseases (CVDs). Machine learning can provide optimal predictions on the diagnosis of diseases. Here we performed a proof-of-concept study to determine if combining circRNAs with an artificial intelligence approach
Jacqueline M Bliley et al.
Science translational medicine, 13(603) (2021-07-23)
The role that mechanical forces play in shaping the structure and function of the heart is critical to understanding heart formation and the etiology of disease but is challenging to study in patients. Engineered heart tissues (EHTs) incorporating human induced
Robert E Chapin et al.
Birth defects research. Part B, Developmental and reproductive toxicology, 107(6), 225-242 (2016-12-27)
The last two decades have seen an increasing search for in vitro models that can replace the use of animals for safety testing. We adapted the methods from a recent nonquantitative report of spermatogenesis occurring in ex vivo mouse testis
J M González-Domínguez et al.
Colloids and surfaces. B, Biointerfaces, 212, 112363-112363 (2022-02-06)
Given their large surface area and versatile chemical reactivity, single-walled carbon nanotubes (SWCNTs) are regarded as the basis of new pharmacological complexes. In this study, SWCNTs are chemically functionalized with fluorescein, folic acid, and capecitabine, a drug that is commonly
Fabian Philipp Kreutzer et al.
Basic research in cardiology, 117(1), 9-9 (2022-03-03)
Cardiac fibroblasts constitute the major cell type of the murine and human heart. Once activated, they contribute to an excessive deposition of extracellular matrix (ECM) leading to cardiac fibrosis and subsequently organ dysfunction. With the exception of the pulmonary drugs
Mario Sanches et al.
mAbs, 12(1), 1802188-1802188 (2020-08-21)
As biologics have become a mainstay in the development of novel therapies, protein engineering tools to expand on their structural advantages, namely specificity, affinity, and valency are of interest. Antibodies have dominated this field as the preferred scaffold for biologics
Zhonggang Hou et al.
Current protocols, 2(2), e361-e361 (2022-02-08)
CRISPR-Cas systems provide researchers with eukaryotic genome editing tools and therapeutic platforms that make it possible to target disease mutations in somatic organs. Most of these tools employ Type II (e.g., Cas9) or Type V (e.g., Cas12a) CRISPR enzymes to
Junting Zhang et al.
Analytical and bioanalytical chemistry, 409(18), 4459-4465 (2017-05-21)
Fourier transform infrared (FTIR) spectroscopy is one of the widely used vibrational spectroscopic methods in protein structural analysis. The protein solution sample loaded in demountable CaF
Thomas J Esparza et al.
Scientific reports, 10(1), 22370-22370 (2020-12-24)
There are currently few approved effective treatments for SARS-CoV-2, the virus responsible for the COVID-19 pandemic. Nanobodies are 12-15 kDa single-domain antibody fragments that can be delivered by inhalation and are amenable to relatively inexpensive large scale production compared to other
Bo Zhang et al.
Amino acids, 49(11), 1831-1841 (2017-08-24)
Compared with traditional anti-tumor drugs, antimicrobial peptides as novel anti-tumor agents have prominent advantages of higher specificity and circumvention of multi-drug resistance. BP100 is a multifunctional membrane-active peptide with high antimicrobial activity. Taking BP100 as a lead peptide, we designed
Millie Heo et al.
Communications biology, 3(1), 614-614 (2020-10-28)
Antibodies with antibacterial activity need to bind to the bacterial surface with affinity, specificity, and sufficient density to induce efficient elimination. To characterize the anti-bacterial antibody repertoire, we developed an in-droplet bioassay with single-antibody resolution. The assay not only allowed
Monika M Gladka et al.
Nature communications, 12(1), 84-84 (2021-01-06)
The disruption in blood supply due to myocardial infarction is a critical determinant for infarct size and subsequent deterioration in function. The identification of factors that enhance cardiac repair by the restoration of the vascular network is, therefore, of great
Tobias Jakobi et al.
Frontiers in cardiovascular medicine, 9, 844441-844441 (2022-06-11)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) has emerged as a major cause of morbidity and mortality worldwide, placing unprecedented pressure on healthcare. Cardiomyopathy is described in patients with severe COVID-19 and increasing evidence suggests that cardiovascular involvement
Mauricio Sendeski et al.
Radiology, 251(3), 697-704 (2009-04-16)
To determine whether a type of contrast medium (CM), iodixanol, modifies outer medullary descending vasa recta (DVR) vasoreactivity and nitric oxide (NO) production in isolated microperfused DVR. Animal handling conformed to the Animal Care Committee Guidelines of all participating institutions.
Grace Huang et al.
Theranostics, 12(9), 4415-4430 (2022-06-09)
Background and Purpose: Myocardial infarction (MI) in diabetic patients results in higher mortality and morbidity. We and others have previously shown that bone marrow-endothelial progenitor cells (EPCs) promote cardiac neovascularization and attenuate ischemic injury. Lately, small extracellular vesicles (EVs) have
Fabrice Jaffré et al.
Circulation, 140(3), 207-224 (2019-06-06)
More than 90% of individuals with Noonan syndrome (NS) with mutations clustered in the CR2 domain of RAF1 present with severe and often lethal hypertrophic cardiomyopathy (HCM). The signaling pathways by which NS RAF1 mutations promote HCM remain elusive, and
Faxiang Xu et al.
STAR protocols, 2(3), 100740-100740 (2021-09-02)
Metabolic homeostasis is critical for cell pluripotency and differentiation in human embryonic stem cells (hESCs). It has been reported that metabolic changes specifically regulate cellular signaling during hESC differentiation. This protocol describes procedures for both cell culture and detection of
Xueli Zhang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1110-1111, 87-93 (2019-02-21)
The aim of the present study was to purify the natural chlorogenic acid (CGA) monomer from Heijingang potatoes and investigate its interaction with recombinant human serum albumin (rHSA). The potato extract (PE) was purified using macroporous resins and solvent, and
Poster Presentations Young Scientist Awards (Poster).
The journal of physiological sciences : JPS, 65(Suppl 2), SA111-SA208 (2015-07-01)
Lucía Sanjurjo et al.
Antioxidants (Basel, Switzerland), 12(5) (2023-05-27)
Atherosclerosis, a process in which macrophages play a key role, is accelerated in diabetes. Elevated concentrations of serum-oxidized low-density lipoproteins (oxLDL) represent a common feature of both conditions. The main goal of this study was to determine the contribution of
Alireza Rafieerad et al.
Advanced functional materials, 31(30), 2100015-2100015 (2022-03-11)
The application of nontoxic 2D transition-metal carbides (MXenes) has recently gained ground in bioelectronics. In group-4 transition metals, tantalum possesses enhanced biological and physical properties compared to other MXene counterparts. However, the application of tantalum carbide for bioelectrodes has not
Hui Fang et al.
American journal of physiology. Cell physiology, 313(6), C632-C643 (2017-09-15)
Proteinuria is a characteristic of chronic kidney disease and also a causative factor that promotes the disease progression, in part, via activation of the intrarenal renin-angiotensin system (RAS). (Pro)renin receptor (PRR), a newly discovered component of the RAS, binds renin
Bridget L Menasche et al.
Science advances, 6(48) (2020-11-29)
Major histocompatibility complex (MHC)-unrestricted cytotoxic lymphocytes (CLs) such as natural killer (NK) cells can detect and destroy tumor and virus-infected cells resistant to T cell-mediated killing. Here, we performed genome-wide genetic screens to identify tumor-intrinsic genes regulating killing by MHC-unrestricted
Robert J Turner et al.
SLAS discovery : advancing life sciences R & D, 25(6), 591-604 (2020-05-20)
Kidney fibrosis presents a hallmark of chronic kidney disease. With ever-increasing patient numbers and limited treatment options available, novel strategies for therapeutic intervention in kidney disease are warranted. Fibrosis commonly results from a wound healing response to repeated or chronic
D Moreno et al.
Theriogenology, 84(7), 1053-1060 (2015-08-19)
The aim of this study was to develop an in vitro embryo culture medium without either fetal calf serum or BSA, using various growth factors and cytokines (GFs-CYKs; IGF-I, IGF-II, bFGF, LIF, GM-CSF, TGF-β1, and PDGF-BB), and other molecules with
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