B0631

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Showing 1-10 of 10 results for "B0631" within Papers

Detection of DNA strand breaks in apoptotic cells by flow- and image-cytometry.

Zbigniew Darzynkiewicz et al.

Methods in molecular biology (Clifton, N.J.), 682, 91-101 (2010-11-09)

Extensive DNA fragmentation that generates a multitude of DNA double-strand breaks (DSBs) is a hallmark of apoptosis. A widely used approach to identify apoptotic cells relies on labeling DSBs in situ with fluorochromes. Flow or image cytometry is then used

Germline NPM1 mutations lead to altered rRNA 2'-O-methylation and cause dyskeratosis congenita.

Daphna Nachmani et al.

Nature genetics, 51(10), 1518-1529 (2019-10-02)

RNA modifications are emerging as key determinants of gene expression. However, compelling genetic demonstrations of their relevance to human disease are lacking. Here, we link ribosomal RNA 2'-O-methylation (2'-O-Me) to the etiology of dyskeratosis congenita. We identify nucleophosmin (NPM1) as

The mutagenic properties of BrdUTP in a random mutagenesis process.

Xiangdong Ma et al.

Molecular biology reports, 35(4), 663-667 (2007-09-18)

To explore the mutagenic properties of the nucleotide analogue bromodeoxyuridine triphosphate (BrdUTP), the wild type alpha-amylase (xamy) gene from Xanthomonas campestris pv. campestris 8004 was used as a mutational target. It was mutated using PCR techniques to partially replace deoxythymidine

Ribosomal profiling during prion disease uncovers progressive translational derangement in glia but not in neurons.

Claudia Scheckel et al.

eLife, 9 (2020-09-23)

Prion diseases are caused by PrPSc, a self-replicating pathologically misfolded protein that exerts toxicity predominantly in the brain. The administration of PrPSc causes a robust, reproducible and specific disease manifestation. Here, we have applied a combination of translating ribosome affinity

Visualization of heavy ion tracks by labeling 3'-OH termini of induced DNA strand breaks

Konishi T, et al.

Journal of Radiation Research, 52(4), 433-440 (2011)

Effect of 5-fluoro-2?-deoxyuridine (FdUrd) on 5-bromo-2?-deoxyuridine (BrdUrd) incorporation into DNA, measured with a monoclonal BrdUrd antibody and by the BrdUrd/hoechst quenching effect

Ellwart J and Dormer P

Cytometry, 6(6), 513-520 (1985)

Insights into the mechanisms of sister chromatid exchange formation.

A Wojcik et al.

Cytogenetic and genome research, 104(1-4), 304-309 (2004-05-27)

The DNA lesions responsible for the formation of sister chromatid exchanges (SCEs) have been the object of research for a long time. SCEs can be visualized by growing cells for either two rounds of replication in the presence of 5-bromo-2'-deoxyuridine

Visualizing the dynamics of chromosome structure formation coupled with DNA replication.

Eisuke Gotoh

Chromosoma, 116(5), 453-462 (2007-05-16)

A basic question of cell biology is how DNA folds to chromosome. Numbers of examples have suggested the involvement of DNA replication in chromosome structure formation. To visualize and identify the dynamics of chromosome structure formation and to elucidate the

The impact of bcl-2 expression and bax deficiency on prostate homeostasis in vivo

Bruckheimer EM, et al.

Oncogene, 19(20), 2404-2404 (2000)

Avian models in teratology and developmental toxicology

Developmental Toxicology, 85-103 (2012)

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