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Showing 1-30 of 49 results for "B1911" within Papers
Erin Egelkrout et al.
Plant cell, tissue and organ culture, 1-8 (2020-05-13)
Porcine Epidemic Diarrhea Virus (PEDV) causes severe diarrhea and mortality in piglets. Robust immunity may break the transmission cycle. Expression of antigens in maize grains is a promising method for producing low-cost vaccines. As a first step, we expressed maize
Tomasz Gogiel et al.
Acta biochimica Polonica, 64(3), 507-512 (2017-08-09)
The extracellular matrix components show specific distribution patterns within various structures of the umbilical cord, among which Wharton's jelly is especially collagen-rich tissue. Cathepsin L is a potent cysteine protease engaged in degradation of extracellular matrix proteins, including collagens. We
Hau-Wen Li et al.
Scientific reports, 9(1), 20163-20163 (2019-12-29)
The accessory nidamental gland (ANG) is a female reproductive organ found in most squid and cuttlefish that contains a consortium of bacteria. These symbiotic bacteria are transmitted from the marine environment and selected by the host through an unknown mechanism.
Ying Zhang et al.
Journal of cellular and molecular medicine, 24(1), 521-529 (2019-10-29)
Mesenchymal stem cells (MSCs) are previously found to have potential capacity to differentiate into osteocytes when exposed to specific stimuli. However, the detailed molecular mechanism during this progress remains largely unknown. In the current study, we characterized the lncRNA NKILA
Sita Awasthi et al.
The Journal of clinical investigation, 131(23) (2021-10-08)
Nucleoside-modified mRNA vaccines have gained global attention because of COVID-19. We evaluated a similar vaccine approach for preventing a chronic, latent genital infection rather than an acute respiratory infection. We used animal models to compare an HSV-2 trivalent nucleoside-modified mRNA
Laurie A Robak et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(18), 5768-5783 (2009-05-08)
Myelin-associated glycoprotein (MAG) is a sialic acid-binding Ig-family lectin that functions in neuronal growth inhibition and stabilization of axon-glia interactions. The ectodomain of MAG is comprised of five Ig-like domains and uses neuronal cell-type-specific mechanisms to signal growth inhibition. We
Paul D Scott et al.
Vaccine, 29(38), 6584-6591 (2011-07-19)
We have shown earlier that a single dose of cloned defective interfering (DI) influenza A virus strongly protects mice from disease following a lethal challenge with different subtypes of influenza A virus. These animals suffered no clinical disease but experienced
Sung-Jin Kim et al.
Bone, 138, 115497-115497 (2020-07-01)
Adult bone homeostasis requires a fine-tuned balance between the activity of osteoblasts and osteoclasts. This osteoblast-osteoclast coupling is therapeutically important because it limits the efficacy of most anabolic or anti-resorptive treatments for osteoporosis. Sirtuin6 (SIRT6), a histone deacetylase, was implicated
Hannes Datler et al.
Molecular immunology, 111, 32-42 (2019-04-09)
The peripheral activation of autoreactive T cells and subsequent central nervous system (CNS) immune cell infiltration are key events relevant for experimental autoimmune encephalomyelitis (EAE), a commonly employed multiple sclerosis (MS) model, influenced by TH1 and TH17 mediated immunity. The
Valerie Bríd O'Leary et al.
Scientific reports, 7(1), 1790-1790 (2017-05-13)
PARTICLE (Gene PARTICL- 'Promoter of MAT2A-Antisense RadiaTion Induced Circulating LncRNA) expression is transiently elevated following low dose irradiation typically encountered in the workplace and from natural sources. This long non-coding RNA recruits epigenetic silencers for cis-acting repression of its neighbouring
Manjunatha M Venkataswamy et al.
Journal of immunology (Baltimore, Md. : 1950), 183(3), 1644-1656 (2009-07-22)
The attenuated strain of Mycobacterium bovis known as bacille Calmette-Guérin (BCG) has been widely used as a vaccine for prevention of disease by Mycobacterium tuberculosis, but with relatively little evidence of success. Recent studies suggest that the failure of BCG
Paul Gutwein et al.
The American journal of pathology, 174(6), 2061-2072 (2009-05-14)
Podocytes are a crucial cell type in the kidney and play an important role in the pathology of glomerular kidney diseases like membranous nephropathy (MN). The identification of new factors involved in the progression of glomerular kidney diseases is of
Andrzej T Foik et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 38(50), 10709-10724 (2018-11-07)
To combat retinal degeneration, healthy fetal retinal sheets have been successfully transplanted into both rodent models and humans, with synaptic connectivity between transplant and degenerated host retina having been confirmed. In rodent studies, transplants have been shown to restore responses
Magdalene J Seiler et al.
Investigative ophthalmology & visual science, 58(1), 614-630 (2017-01-28)
To characterize a recently developed model, the retinal degenerate immunodeficient S334ter line-3 rat (SD-Foxn1 Tg(S334ter)3Lav) (RD nude rat), and to test whether transplanted rat fetal retinal sheets can elicit lost responses to light. National Institutes of Health nude rats (SD-Foxn1
Shangfu Li et al.
Cell death & disease, 11(9), 762-762 (2020-09-18)
PKC-δ is an important molecule for B-cell proliferation and tolerance. B cells have long been recognized to play a part in osteoimmunology and pathological bone loss. However, the role of B cells with PKC-δ deficiency in bone homeostasis and the
Jacek Kudelski et al.
Journal of clinical medicine, 10(16) (2021-08-28)
Human urinary bladder cancer is a huge worldwide oncological problem causing many deaths every year. The degradation of extracellular matrix (ECM) induced by molecules such as matrix metalloproteinases (MMPs) is one of the main factors influencing the process of metastasis
Dorottya Laczkó et al.
Immunity, 53(4), 724-732 (2020-08-14)
SARS-CoV-2 infection has emerged as a serious global pandemic. Because of the high transmissibility of the virus and the high rate of morbidity and mortality associated with COVID-19, developing effective and safe vaccines is a top research priority. Here, we
S Chander Rao et al.
Archives of virology, 158(1), 133-143 (2012-09-27)
Genetic engineering of peanut (Arachis hypogaea L.) using the gene encoding for the nucleocapsid protein (N gene) of peanut bud necrosis virus (PBNV; genus Tospovirus, family Bunyaviridae) was used to impart resistance to bud necrosis disease in peanut (PBND), a
A Warford et al.
British journal of biomedical science, 77(3), 135-141 (2020-04-01)
MicroRNAs (miRNAs) regulate the translation of mRNA during gene expression and investigations have highlighted their importance in pathophysiology. qRT-PCR is currently the gold standard method for detecting changes in miRNA expression. However, when used on heterogeneous samples, it cannot identify
Junwei Li et al.
Human vaccines & immunotherapeutics, 10(5), 1211-1220 (2014-03-19)
Frequent mutation of influenza viruses keep vaccinated and non-vaccinated populations vulnerable to new infections, causing serious burdens to public health and the economy. Vaccination with universal influenza vaccines would be the best way to effectively protect people from infection caused
Malgorzata Adamczyk et al.
PloS one, 12(9), e0185516-e0185516 (2017-09-30)
Saccharomyces cerevisiae responds to glucose availability in the environment, inducing the expression of the low-affinity transporters and high-affinity transporters in a concentration dependent manner. This cellular decision making is controlled through finely tuned communication between multiple glucose sensing pathways including
Joel R Wilmore et al.
Cell host & microbe, 23(3), 302-311 (2018-02-27)
Serum immunoglobulin A (IgA) antibodies are readily detected in mice and people, but the mechanisms underlying the induction of serum IgA and its role in host protection remain uncertain. We report that select commensal bacteria induce several facets of systemic
Frank Rauch et al.
Bone, 107, 131-142 (2017-11-28)
Osteogenesis imperfecta (OI) type V is caused by an autosomal dominant mutation in the IFITM5 gene, also known as BRIL. The c.-14C>T mutation in the 5'UTR of BRIL creates a novel translational start site adding 5 residues (MALEP) in frame
Nana H Overgaard et al.
Vaccine, 35(42), 5629-5636 (2017-09-10)
The relationship between the antigen dose and the quality of an immune response generated upon immunization is poorly understood. However, findings show that the immune system is indeed influenced by the antigen dose; hence underlining the importance of correctly determining
Bikendra Maharjan et al.
Carbohydrate polymers, 251, 117023-117023 (2020-11-05)
Natural hydrogel scaffolds usually exhibit insufficient mechanical strength which remains a major challenge in bone tissue engineering. In this study, the limitation was addressed by incorporating regenerated cellulose (rCL) nanofibers into chitosan (CS) hydrogel. The rCL nanofibers were regenerated from
Bipin K Pandey et al.
Plant physiology, 174(4), 2316-2332 (2017-06-24)
Phosphorus (P) deficiency limits plant growth and yield. Since plants can absorb only the inorganic form of P (Pi), a large portion of soil P (organic and inorganic P complexes) remains unused. Here, we identified and characterized a PHR2-regulated, novel
Commensal microbes induce serum IgA responses that protect against polymicrobial sepsis
Wilmore JR, et al.
Cell host & microbe, 23(3), 302-311 (2018)
Somying Patntirapong et al.
Acta histochemica, 123(1), 151659-151659 (2020-12-08)
The main objective of this study was to analyze the changes in osteoblast behaviors by two different methods, a simple digital image analysis method and conventional assays. Osteoblast progenitor cells and osteoblasts were treated with alendronate (ALN; a nitrogen-containing bisphosphonate).
Min Ling et al.
Cell & bioscience, 7, 27-27 (2017-05-27)
Bone degenerative disorders like osteoporosis may be initiated by age-related shifts in anabolic and catabolic responses that control bone homeostasis. Although there are studies suggesting that metabolic changes occur with stem cell differentiation, the molecular mechanisms governing energy metabolism and
Christopher J Farrell et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 14(23), 7711-7716 (2008-12-03)
Oncolytic herpes simplex virus 1 (oHSV) vectors treat tumors in preclinical models and have been used safely in phase I clinical trials for patients with cancer. Infection of tumors with oHSV also induces specific antitumor immunity. We investigated whether this
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