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Showing 1-30 of 49 results for "B1911" within Papers
Paul D Scott et al.
Vaccine, 29(38), 6584-6591 (2011-07-19)
We have shown earlier that a single dose of cloned defective interfering (DI) influenza A virus strongly protects mice from disease following a lethal challenge with different subtypes of influenza A virus. These animals suffered no clinical disease but experienced
Sita Awasthi et al.
The Journal of clinical investigation, 131(23) (2021-10-08)
Nucleoside-modified mRNA vaccines have gained global attention because of COVID-19. We evaluated a similar vaccine approach for preventing a chronic, latent genital infection rather than an acute respiratory infection. We used animal models to compare an HSV-2 trivalent nucleoside-modified mRNA
Laurie A Robak et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(18), 5768-5783 (2009-05-08)
Myelin-associated glycoprotein (MAG) is a sialic acid-binding Ig-family lectin that functions in neuronal growth inhibition and stabilization of axon-glia interactions. The ectodomain of MAG is comprised of five Ig-like domains and uses neuronal cell-type-specific mechanisms to signal growth inhibition. We
Sung-Jin Kim et al.
Bone, 138, 115497-115497 (2020-07-01)
Adult bone homeostasis requires a fine-tuned balance between the activity of osteoblasts and osteoclasts. This osteoblast-osteoclast coupling is therapeutically important because it limits the efficacy of most anabolic or anti-resorptive treatments for osteoporosis. Sirtuin6 (SIRT6), a histone deacetylase, was implicated
Valerie Bríd O'Leary et al.
Scientific reports, 7(1), 1790-1790 (2017-05-13)
PARTICLE (Gene PARTICL- 'Promoter of MAT2A-Antisense RadiaTion Induced Circulating LncRNA) expression is transiently elevated following low dose irradiation typically encountered in the workplace and from natural sources. This long non-coding RNA recruits epigenetic silencers for cis-acting repression of its neighbouring
Paul Gutwein et al.
The American journal of pathology, 174(6), 2061-2072 (2009-05-14)
Podocytes are a crucial cell type in the kidney and play an important role in the pathology of glomerular kidney diseases like membranous nephropathy (MN). The identification of new factors involved in the progression of glomerular kidney diseases is of
Andrzej T Foik et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 38(50), 10709-10724 (2018-11-07)
To combat retinal degeneration, healthy fetal retinal sheets have been successfully transplanted into both rodent models and humans, with synaptic connectivity between transplant and degenerated host retina having been confirmed. In rodent studies, transplants have been shown to restore responses
Manjunatha M Venkataswamy et al.
Journal of immunology (Baltimore, Md. : 1950), 183(3), 1644-1656 (2009-07-22)
The attenuated strain of Mycobacterium bovis known as bacille Calmette-Guérin (BCG) has been widely used as a vaccine for prevention of disease by Mycobacterium tuberculosis, but with relatively little evidence of success. Recent studies suggest that the failure of BCG
Hau-Wen Li et al.
Scientific reports, 9(1), 20163-20163 (2019-12-29)
The accessory nidamental gland (ANG) is a female reproductive organ found in most squid and cuttlefish that contains a consortium of bacteria. These symbiotic bacteria are transmitted from the marine environment and selected by the host through an unknown mechanism.
Tomasz Gogiel et al.
Acta biochimica Polonica, 64(3), 507-512 (2017-08-09)
The extracellular matrix components show specific distribution patterns within various structures of the umbilical cord, among which Wharton's jelly is especially collagen-rich tissue. Cathepsin L is a potent cysteine protease engaged in degradation of extracellular matrix proteins, including collagens. We
Ying Zhang et al.
Journal of cellular and molecular medicine, 24(1), 521-529 (2019-10-29)
Mesenchymal stem cells (MSCs) are previously found to have potential capacity to differentiate into osteocytes when exposed to specific stimuli. However, the detailed molecular mechanism during this progress remains largely unknown. In the current study, we characterized the lncRNA NKILA
Hannes Datler et al.
Molecular immunology, 111, 32-42 (2019-04-09)
The peripheral activation of autoreactive T cells and subsequent central nervous system (CNS) immune cell infiltration are key events relevant for experimental autoimmune encephalomyelitis (EAE), a commonly employed multiple sclerosis (MS) model, influenced by TH1 and TH17 mediated immunity. The
Erin Egelkrout et al.
Plant cell, tissue and organ culture, 1-8 (2020-05-13)
Porcine Epidemic Diarrhea Virus (PEDV) causes severe diarrhea and mortality in piglets. Robust immunity may break the transmission cycle. Expression of antigens in maize grains is a promising method for producing low-cost vaccines. As a first step, we expressed maize
The evaluation of angiogenesis and matrix metalloproteinase-2 secretion in bone marrow of multiple myeloma patients before and after the treatment
Bolkun L, et al.
Advances in Medical Sciences, 58(1), 118-125 (2013)
Jian Wu et al.
The Journal of biological chemistry, 296, 100496-100496 (2021-03-06)
Bone morphogenetic proteins (BMPs) secreted by a variety of cell types are known to play essential roles in cell differentiation and matrix formation in the bone, cartilage, muscle, blood vessel, and neuronal tissue. BMPs activate intracellular effectors via C-terminal phosphorylation
Epigenetic regulation of Runx2 transcription and osteoblast differentiation by nicotinamide phosphoribosyltransferase
Ling M, et al.
Cell & Bioscience, 7(1), 27-27 (2017)
Wioletta Ratajczak-Wrona et al.
Archivum immunologiae et therapiae experimentalis, 68(6), 32-32 (2020-10-31)
A proliferation-inducing ligand (APRIL) is a member of the tumor necrosis factor superfamily that was first identified as a factor favoring tumorigenesis. APRIL is important fitness and survival factors for B cells and plasma cells in the periphery. Considering this
Jingyuan Li et al.
Developmental biology, 441(1), 191-203 (2018-07-08)
Cleft palate is one of the most common craniofacial congenital defects in humans. It is associated with multiple genetic and environmental risk factors, including mutations in the genes encoding signaling molecules in the sonic hedgehog (Shh) pathway, which are risk
Salma E Jiménez-Badillo et al.
Scientific reports, 7(1), 13351-13351 (2017-10-19)
The Catsper1 gene, whose expression is restricted to male germ cells, has great importance in reproductive biology because of its function in sperm motility and fertilization. We previously reported that the promoter of this gene has transcriptional activity in either
Therese Wohlschlager et al.
Methods in molecular biology (Clifton, N.J.), 2132, 669-682 (2020-04-20)
Tectonins are conserved defense proteins of innate immune systems featuring a β-propeller fold. Tectonin 2 from Laccaria bicolor, Lb-Tec2, is the first fungal representative of the tectonin superfamily that has been described. In-depth characterization revealed a specificity for O-methylated glycans
Andrzej Swistowski et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(50), 15703-15712 (2009-12-18)
Multiple recent reports implicate amyloid precursor protein (APP) signaling in the pathogenesis of Alzheimer's disease, but the APP-dependent signaling network involved has not been defined. Here, we report a novel consensus sequence for interaction with the PDZ-1 and PDZ-2 domains
Jungho Jang et al.
Scientific reports, 8(1), 7211-7211 (2018-05-10)
The conversion of carbon dioxide to formate is a fundamental step for building C1 chemical platforms. Methylobacterium extorquens AM1 was reported to show remarkable activity converting carbon dioxide into formate. Formate dehydrogenase 1 from M. extorquens AM1 (MeFDH1) was verified
Yi Sun et al.
Veterinary research, 42, 62-62 (2011-05-17)
Babesia divergens is a tick-transmitted apicomplexan parasite for which asexual multiplication in its vertebrate hosts is restricted to erythrocytes. Current knowledge of invasion of these target cells is limited. An efficient in vitro invasion assay was set up to gain
Sung-Jin Kim et al.
Experimental & molecular medicine, 52(5), 793-803 (2020-05-10)
Neuronal regulation of energy and bone metabolism is important for body homeostasis. Many studies have emphasized the importance of synaptic adhesion molecules in the formation of synapses, but their roles in physiology still await further characterization. Here, we found that
Guanting Qiu et al.
Experimental eye research, 80(4), 515-525 (2005-03-23)
Previous studies evaluating neural stem cells transplanted into the mature retina have demonstrated limited levels of graft-host integration and photoreceptor differentiation. The purpose of this investigation is to enhance photoreceptor cell differentiation and integration of retinal progenitor cells (RPC) following
Christopher J Farrell et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 14(23), 7711-7716 (2008-12-03)
Oncolytic herpes simplex virus 1 (oHSV) vectors treat tumors in preclinical models and have been used safely in phase I clinical trials for patients with cancer. Infection of tumors with oHSV also induces specific antitumor immunity. We investigated whether this
Min Ling et al.
Cell & bioscience, 7, 27-27 (2017-05-27)
Bone degenerative disorders like osteoporosis may be initiated by age-related shifts in anabolic and catabolic responses that control bone homeostasis. Although there are studies suggesting that metabolic changes occur with stem cell differentiation, the molecular mechanisms governing energy metabolism and
Gerry Nganou et al.
Frontiers in molecular neuroscience, 11, 234-234 (2018-07-26)
The building of the brain is a multistep process that requires the coordinate expression of thousands of genes and an intense nucleocytoplasmic transport of RNA and proteins. This transport is mediated by karyopherins that comprise importins and exportins. Here, we
Junwei Li et al.
Human vaccines & immunotherapeutics, 10(5), 1211-1220 (2014-03-19)
Frequent mutation of influenza viruses keep vaccinated and non-vaccinated populations vulnerable to new infections, causing serious burdens to public health and the economy. Vaccination with universal influenza vaccines would be the best way to effectively protect people from infection caused
Malgorzata Adamczyk et al.
PloS one, 12(9), e0185516-e0185516 (2017-09-30)
Saccharomyces cerevisiae responds to glucose availability in the environment, inducing the expression of the low-affinity transporters and high-affinity transporters in a concentration dependent manner. This cellular decision making is controlled through finely tuned communication between multiple glucose sensing pathways including
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