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Showing 1-30 of 273 results for "b2629" within Papers

Investigating multiple candidate genes and nutrients in the folate metabolism pathway to detect genetic and nutritional risk factors for lung cancer.

Michael D Swartz et al.

PloS one, 8(1), e53475-e53475 (2013-02-02)

Folate metabolism, with its importance to DNA repair, provides a promising region for genetic investigation of lung cancer risk. This project investigates genes (MTHFR, MTR, MTRR, CBS, SHMT1, TYMS), folate metabolism related nutrients (B vitamins, methionine, choline, and betaine) and

Enhanced hepatic cholesterol accumulation induced by maternal betaine exposure is associated with hypermethylation of CYP7A1 gene promoter.

Nannan Zhao et al.

Endocrine, 64(3), 544-551 (2019-03-30)

Betaine contains three methyl groups and plays a critical role in regulating glucose and lipid metabolism via epigenetic modifications. However, it is unclear whether prenatal betaine intake could affect cholesterol metabolism of progeny through DNA methylation. Hence, pregnant rats were

Mutation in mitochondrial ribosomal protein S7 (MRPS7) causes congenital sensorineural deafness, progressive hepatic and renal failure and lactic acidemia.

Minal J Menezes et al.

Human molecular genetics, 24(8), 2297-2307 (2015-01-04)

Functional defects of the mitochondrial translation machinery, as a result of mutations in nuclear-encoded genes, have been associated with combined oxidative phosphorylation (OXPHOS) deficiencies. We report siblings with congenital sensorineural deafness and lactic acidemia in association with combined respiratory chain

Recognition of betaine as an inhibitor of lipopolysaccharide-induced nitric oxide production in activated microglial cells.

Banafsheh Amiraslani et al.

Iranian biomedical journal, 16(2), 84-89 (2012-07-18)

Neuroinflammation, as a major outcome of microglia activation, is an important factor for progression of neurodegenerative disorders including Alzheimer's disease and Parkinson's disease. Microglial cells, as the first-line defense in the central nervous system, act as a source of neurotoxic

Survival and psychomotor development with early betaine treatment in patients with severe methylenetetrahydrofolate reductase deficiency.

Eugene F Diekman et al.

JAMA neurology, 71(2), 188-194 (2013-12-11)

The impact of betaine treatment on outcome in patients with severe methylenetetrahydrofolate reductase (MTHFR) deficiency is presently unclear. To investigate the effect of betaine treatment on development and survival in patients with severe MTHFR deficiency. MEDLINE, EMBASE, and Cochrane databases

An improved Diagnostic PCR Assay for identification of Cryptic Heterozygosity for CGG Triplet Repeat Alleles in the Fragile X Gene (FMR1).

Mahmoud S Khaniani et al.

Molecular cytogenetics, 1, 5-5 (2008-05-13)

Fragile X syndrome (OMIM #300624) is the most common, recognised, heritable cause of mental retardation. Widespread testing is warranted by the relatively high frequency of the disorder, the benefits of early detection and the identification of related carriers whose offspring

Full-length single-cell RNA-seq applied to a viral human cancer: applications to HPV expression and splicing analysis in HeLa S3 cells.

Liang Wu et al.

GigaScience, 4, 51-51 (2015-11-10)

Viral infection causes multiple forms of human cancer, and HPV infection is the primary factor in cervical carcinomas. Recent single-cell RNA-seq studies highlight the tumor heterogeneity present in most cancers, but virally induced tumors have not been studied. HeLa is

Whole-exome analysis of foetal autopsy tissue reveals a frameshift mutation in OBSL1, consistent with a diagnosis of 3-M Syndrome.

Christian R Marshall et al.

BMC genomics, 16 Suppl 1, S12-S12 (2015-04-30)

We report a consanguineous couple that has experienced three consecutive pregnancy losses following the foetal ultrasound finding of short limbs. Post-termination examination revealed no skeletal dysplasia, but some subtle proximal limb shortening in two foetuses, and a spectrum of mildly

Examining gene-environment interactions in comorbid depressive and disruptive behavior disorders using a Bayesian approach.

Molly Adrian et al.

Journal of psychiatric research, 68, 125-133 (2015-08-01)

The objective of this study was to apply a Bayesian statistical analytic approach that minimizes multiple testing problems to explore the combined effects of chronic low familial support and variants in 12 candidate genes on risk for a common and

Salinity impacts photosynthetic pigmentation and cellular morphology changes by distinct mechanisms in Fremyella diplosiphon.

Shailendra P Singh et al.

Biochemical and biophysical research communications, 433(1), 84-89 (2013-03-05)

Fremyella diplosiphon is a freshwater cyanobacterium that exhibits complementary chromatic adaptation (CCA), which allows the organism to alter its pigmentation and cellular morphology to maximally harvest available green light (GL) and red light (RL) at different depth levels in its

Osmoprotectants suppress the production and activity of matrix metalloproteinases induced by hyperosmolarity in primary human corneal epithelial cells.

Ruzhi Deng et al.

Molecular vision, 20, 1243-1252 (2014-10-30)

Hyperosmolarity has been recognized as a proinflammatory stress in the pathogenesis of dry eye disease. This study investigated the suppressive effect of osmoprotectants (L-carnitine, erythritol, and betaine) on the production and activity of matrix metalloproteinases (MMPs) in primary human corneal

Influence of type of microorganism, food ingredients and food properties on high-pressure carbon dioxide inactivation of microorganisms.

L Garcia-Gonzalez et al.

International journal of food microbiology, 129(3), 253-263 (2009-01-23)

High pressure carbon dioxide (HPCD) treatment is currently considered as an attractive non-thermal process for preserving food. Industrial application of this technique requires, among others, systematic (quantitative) data on the inactivation of food relevant pathogenic and spoilage microorganisms, and in-depth

Glycine betaine catabolism contributes to Pseudomonas syringae tolerance to hyperosmotic stress by relieving betaine-mediated suppression of compatible solute synthesis.

Shanshan Li et al.

Journal of bacteriology, 195(10), 2415-2423 (2013-03-26)

Many bacteria can accumulate glycine betaine for osmoprotection and catabolize it as a growth substrate, but how they regulate these opposing roles is poorly understood. In Pseudomonas syringae B728a, expression of the betaine catabolism genes was reduced by an osmotic

DNA methylation potential: dietary intake and blood concentrations of one-carbon metabolites and cofactors in rural African women.

Paula Dominguez-Salas et al.

The American journal of clinical nutrition, 97(6), 1217-1227 (2013-04-12)

Animal models show that periconceptional supplementation with folic acid, vitamin B-12, choline, and betaine can induce differences in offspring phenotype mediated by epigenetic changes in DNA. In humans, altered DNA methylation patterns have been observed in offspring whose mothers were

Choline and betaine in health and disease.

Per Magne Ueland

Journal of inherited metabolic disease, 34(1), 3-15 (2010-05-07)

Choline is an essential nutrient, but is also formed by de novo synthesis. Choline and its derivatives serve as components of structural lipoproteins, blood and membrane lipids, and as a precursor of the neurotransmitter acetylcholine. Pre-and postnatal choline availability is

High prevalence of erythromycin-resistant Bordetella pertussis in Xi'an, China.

Z Wang et al.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 20(11), O825-O830 (2014-05-13)

Resistance of Bordetella pertussis, the causative agent of pertussis, to erythromycin is rare. Recently, several Chinese isolates were found to be erythromycin resistant. This study aimed to investigate the occurrence of pertussis in children suffering persistent cough and the prevalence

Solvent modulation strategy for superior antibody monomer/aggregate separation in cation exchange chromatography.

Simon Kluters et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1006, 37-46 (2015-11-02)

Cation exchange chromatography (CEX) is an integral part of many downstream processes for monoclonal antibodies (mAbs). However, in some cases CEX methods with standard mobile phase conditions do not lead to a sufficient removal of soluble antibody aggregates. The addition

Membrane protein stability depends on the concentration of compatible solutes--a single molecule force spectroscopic study.

Arpita Roychoudhury et al.

Biological chemistry, 394(11), 1465-1474 (2013-09-12)

Compatible solutes are small, uncharged, zwitter ionic, osmotically active molecules produced and accumulated by microorganisms inside their cell to counteract different kinds of environmental stress. They enhance protein stability without interfering with the metabolic pathways even at molar concentrations. In

Elevated levels of plasma lipofuscins in patients with chronic renal failure.

Z L Hegedus et al.

Archives internationales de physiologie et de biochimie, 96(5), 211-221 (1988-12-01)

The fluorescence excitation and emission spectra observed in plasma from patients with chronic renal failure were reproduced by the generation of soluble lipofuscins in normal plasma samples by incubation with mixtures of L-dopa, dopamine, L-norepinephrine, L-epinephrine, 3-hydroxy-DL-kynurenine and 3-hydroxy-anthranilic acid

Deciphering the role of multiple betaine-carnitine-choline transporters in the Halophile Vibrio parahaemolyticus.

Serge Y Ongagna-Yhombi et al.

Applied and environmental microbiology, 81(1), 351-363 (2014-10-26)

Vibrio parahaemolyticus is a halophile that is the predominant cause of bacterial seafood-related gastroenteritis worldwide. To survive in the marine environment, V. parahaemolyticus must have adaptive strategies to cope with salinity changes. Six putative compatible solute (CS) transport systems were

Plasma histamine in patients with chronic renal failure and nephrotic syndrome.

D S Gill et al.

Journal of clinical pathology, 44(3), 243-245 (1991-03-01)

Plasma histamine concentrations were measured using a commercially available monoclonal antibody radioimmunoassay in 38 patients with nephrotic syndrome, end stage renal failure, those receiving haemodialysis, and those receiving continuous ambulatory peritoneal dialysis to determine whether histamine may mediate damage to

Dimethylglycine accumulates in uremia and predicts elevated plasma homocysteine concentrations.

D O McGregor et al.

Kidney international, 59(6), 2267-2272 (2001-05-31)

Hyperhomocysteinemia is a risk factor for atherosclerosis that is common in chronic renal failure (CRF), but its cause is unknown. Homocysteine metabolism is linked to betaine-homocysteine methyl transferase (BHMT), a zinc metalloenzyme that converts glycine betaine (GB) to N,N dimethylglycine

Trehalose/2-sulfotrehalose biosynthesis and glycine-betaine uptake are widely spread mechanisms for osmoadaptation in the Halobacteriales.

Noha H Youssef et al.

The ISME journal, 8(3), 636-649 (2013-09-21)

We investigated the mechanisms of osmoadaptation in the order Halobacteriales, with special emphasis on Haladaptatus paucihalophilus, known for its ability to survive in low salinities. H. paucihalophilus genome contained genes for trehalose synthesis (trehalose-6-phosphate synthase/trehalose-6-phosphatase (OtsAB pathway) and trehalose glycosyl-transferring

Maternal nicotinamide supplementation causes global DNA hypomethylation, uracil hypo-incorporation and gene expression changes in fetal rats.

Yan-Jie Tian et al.

The British journal of nutrition, 111(9), 1594-1601 (2014-02-11)

Recent evidence shows that excess nicotinamide can cause epigenetic changes in developing rats. The aim of the present study was to investigate the effects of maternal nicotinamide supplementation on the fetus. Female rats were randomised into four groups fed a

Distribution of terfenadine and its metabolites in locusts studied by desorption electrospray ionization mass spectrometry imaging.

Line Rørbæk Olsen et al.

Analytical and bioanalytical chemistry, 407(8), 2149-2158 (2014-11-19)

Desorption electrospray ionization (DESI) mass spectrometry (MS) imaging was used to image locusts dosed with the antihistamine drug terfenadine. The study was conducted in order to elucidate a relatively high elimination rate of terfenadine from the locust hemolymph. In this

Silver-zwitterion organic-inorganic nanocomposite with antimicrobial and antiadhesive capabilities.

Rong Hu et al.

Langmuir : the ACS journal of surfaces and colloids, 29(11), 3773-3779 (2013-02-22)

In this work, we demonstrate a convenient, efficient, and environmentally benign strategy to achieving antimicrobial and antiadhesive purposes using a silver-zwitterion nanocomposite. The synthesis of the nanocomposite relies on loading zwitterionic polymer brushes with Ag(+) precursor ions, followed by their

Relocation of a rust resistance gene R 2 and its marker-assisted gene pyramiding in confection sunflower (Helianthus annuus L.).

L L Qi et al.

TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 128(3), 477-488 (2015-01-13)

The rust resistance gene R 2 was reassigned to linkage group 14 of the sunflower genome. DNA markers linked to R 2 were identified and used for marker-assisted gene pyramiding in a confection type genetic background. Due to the frequent

Release of betaine and dexpanthenol from vitamin E modified silicone-hydrogel contact lenses.

Kuan-Hui Hsu et al.

Current eye research, 40(3), 267-273 (2014-05-17)

To develop a contact lens system that will control the release of an osmoprotectant and a moisturizing agent with the aim to reduce symptoms of ocular dryness. Profiles of the release of osmoprotectant betaine and moisturizing agent dexpanthenol from senofilcon

Effect of maternal or post-weaning methyl donor supplementation on growth performance, carcass traits, and meat quality of pig offspring.

Yang Zhao et al.

Journal of the science of food and agriculture, 99(5), 2096-2107 (2018-10-10)

Limited studies have examined links between maternal methyl donor (MET) supplementation and the growth-development characteristics of offspring, and possible underlying mechanisms for such links. This study investigated the effect of maternal or post-weaning MET-supplementation on growth performance, carcass characteristics, and

Structural evidence for functional lipid interactions in the betaine transporter BetP.

Caroline Koshy et al.

The EMBO journal, 32(23), 3096-3105 (2013-10-22)

Bilayer lipids contribute to the stability of membrane transporters and are crucially involved in their proper functioning. However, the molecular knowledge of how surrounding lipids affect membrane transport is surprisingly limited and despite its general importance is rarely considered in

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