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Showing 1-29 of 29 results for "B82251" within Papers
G D Castro et al.
Teratogenesis, carcinogenesis, and mutagenesis, 13(5), 235-245 (1993-01-01)
We and others previously reported that CCl4 reactive metabolites are able to covalently bind to liver DNA either in vivo or in vitro. However, no demonstration of the structure of resulting adducts is available in literature. That information would be
C Jochmann et al.
Pharmacology & toxicology, 75(1), 7-16 (1994-07-01)
The role of glutathione (GSH) and protein thiols in the pathobiochemical process of CBrCl3 cytotoxicity was investigated in isolated hepatocytes. Administration of 0.5, 1.0 and 1.5 mmol/l CBrCl3 affected cellular viability as assessed by trypan blue exclusion, release of lactate
M Sano et al.
Journal of toxicology and environmental health, 43(3), 339-350 (1994-11-01)
Recently potentiation of oxidative damage in rat red blood cells (rRBC) incubated with t-butylhydroperoxide (BHP) in combination with bromotrichloromethane (BrCCI3) was demonstrated. The mechanism by which this combination (BrCCI3/BHP) potentiates the oxidative damage to rRBC was investigated in this study.
O Danni et al.
Research communications in chemical pathology and pharmacology, 76(3), 355-366 (1992-06-01)
The liver toxicity of several halogen compound mixtures have been tested. The compounds were selected on the basis of their metabolic pathways: carbon tetrachloride (CT) and trichlorobromomethane (TCBM) undergo a dehalogenation via P450-dependent enzyme system, 1,2-dichloroethane (DCE) and 1,2-dibromoethane (DBE)
S L Fanelli et al.
Chemico-biological interactions, 98(3), 223-236 (1995-12-22)
The reaction between cholesterol (Ch) and trichloromethyl or trichloromethyl peroxyl radicals was studied. The latter were generated from CCl4 either by benzoyl peroxide (BP) catalysis or via thermal activation or by liver microsomal NADPH-dependent biotransformation of CBrCl3. The structure of
Inhibition of vitamin B12-dependent methionine biosynthesis by chloroform and carbon tetrachloride.
T A Alston
Biochemical pharmacology, 42(12), R25-R28 (1991-11-27)
Emilio M Ungerfeld et al.
Microorganisms, 7(5) (2019-05-01)
There is an interest in controlling rumen methanogenesis as an opportunity to both decrease the emissions of greenhouse gases and improve the energy efficiency of rumen fermentation. However, the effects of inhibiting rumen methanogenesis on fermentation are incompletely understood even
Journal of the Chemical Society. Chemical Communications, 747-747 (1994)
M Manno et al.
Toxicology, 100(1-3), 175-183 (1995-06-26)
Human haemoglobin (Hb), methaemalbumin (MHA) or rat liver microsomal cytochrome P-450 (P-450) were incubated anaerobically at microM concentrations with 1 mM carbon tetrachloride (CCl4), trichlorobromomethane (CCl3Br), chloroform (CHCl3) or methylene chloride (CH2Cl2) in presence of 1 mM sodium dithionite as
C Goldring et al.
Lipids, 28(2), 141-145 (1993-02-01)
4-Hydroxy-trans-2-nonenal (HNE) is a highly reactive product of lipid peroxidation originating from the break-down of phospholipid-bound polyunsaturated fatty acids of cellular membranes. Despite its biological relevance, this aldehyde is only occasionally determined due to the complexity of previously described procedures.
G D Castro et al.
Free radical research, 23(5), 431-442 (1995-11-01)
Free radicals generated by benzoyl peroxide-mediated catalytic decomposition of bromotrichloromethane (eg. trichloromethyl) were allowed to react under nitrogen or under air with uracil. Under nitrogen two reaction products were formed, one was identified as 5-chlorouracil and the other as a
C K Moon et al.
Drug and chemical toxicology, 15(1), 81-91 (1992-01-01)
Brazilin, the main constituent of Caesalpinia sappan, is an antioxidative substance that has catechol moiety in its chemical structure. Considering the antioxidant-activity of brazilin, it was expected to have protective effects on the toxicities of radical generating chemicals. The incubation
Géraldine Peiro et al.
BioFactors (Oxford, England), 24(1-4), 89-96 (2006-01-13)
The objective of our study was to compare the information obtained through the use of three different urinary biomarkers of lipoperoxidation during the time course of a bromotrichloromethane (BrCCl3) induced oxidative stress in rats. These biomarkers were malondialdehyde (MDA) measured
Tetrahedron, 50, 31-31 (1994)
E A Glende et al.
Toxicology and applied pharmacology, 113(1), 159-162 (1992-03-11)
It was found that the four toxigenic agents, CCl4, CHCl3, CBrCl3, and 1,1-dichloroethylene (vinylidene chloride) all share the property of activating phospholipase A2 (PLA2) of isolated hepatocytes in suspension, as determined over a 60- or 120-min time period. In all
R Carini et al.
Biochemical pharmacology, 43(10), 2111-2115 (1992-05-28)
IdB 1016 is a new silybin-phospholipid complex which is more bioavailable than the flavonoid silybin itself and displays free radical scavenging and antioxidant properties in liver microsomes. We report here that the addition of increasing concentrations of IdB 1016 to
Y Osawa et al.
The Journal of biological chemistry, 268(4), 2953-2959 (1993-02-05)
The stoichiometric reductive debromination of BrCCl3 to a trichloromethyl radical by myoglobin caused the prosthetic heme to become covalently cross-linked to the protein moiety and transformed myoglobin from an oxygen storage protein to an oxidase. This was shown in experiments
Y Osawa et al.
The Journal of biological chemistry, 269(22), 15481-15487 (1994-06-03)
It was previously shown that the reductive debromination of BrCCl3 to trichloromethyl radical by human hemoglobin leads to formation of dissociable altered heme products, two of which are identical to those formed from myoglobin and one which is novel. In
Macromolecules, 27, 5863-5863 (1994)
Françoise Guéraud et al.
Free radical biology & medicine, 40(1), 54-62 (2005-12-13)
Free radical reactions are involved in the pathogenesis of numerous diseases, so there is a real need to develop biomarkers that reflect these reactions in vivo. 4-Hydroxy-2-nonenal (HNE) is a major product of the lipid peroxidation process that is a
A Wilks et al.
Biochemistry, 37(9), 2889-2896 (1998-04-16)
The reduction of CBrCl3 by the heme-heme oxygenase complex forms dissociable and covalently bound heme products. No such products are formed with mesoheme in which the heme vinyl substituents are replaced by ethyl groups. The dissociable heme products are chromatographically
K Müller et al.
Biochemistry and molecular biology international, 31(3), 405-412 (1993-11-01)
The changes in nucleotide content during CBrCl3 treatment were investigated. In the first 5-10 minutes a significant ATP decrease was detected. The GTP loss leading to 57% of the initial level after 10 min surpasses the ATP loss which leads
G D Castro et al.
Free radical biology & medicine, 17(5), 419-428 (1994-11-01)
The interaction between free radicals derived from the catalytic decomposition of bromotrichloromethane and 5-methylcytosine (5MC) under different conditions were studied. The structures of the reaction products formed was established by the GC/MS analysis of their trimethylsilyl derivatives. Under anaerobic conditions
J T Kindt et al.
The Journal of biological chemistry, 267(13), 8739-8743 (1992-05-05)
Recent studies have shown that a protein-bound heme adduct formed from the reaction of BrCCl3 with myoglobin was due to bonding of the proximal histidine residue through the ring I vinyl of a heme-CCl2 moiety. The present study reveals that
Y F Wang et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 38(5), 451-458 (2000-04-14)
Tissue slices are a useful biological system for lipid peroxidation studies but their use for DNA damage studies is not well characterized. Hence, the present study investigates DNA damage in rat liver slices, in comparison with isolated rat liver nuclei
H Chen et al.
Free radical biology & medicine, 14(5), 509-517 (1993-05-01)
Oxidative damage to heme proteins in rat liver tissue slices was studied. Tissue slices were incubated in Krebs-Ringer phosphate (KRP) buffer at 37 degrees C with and without the presence of prooxidants. The absorbance spectra (500-640 nm) of heme proteins
S Azri-Meehan et al.
Fundamental and applied toxicology : official journal of the Society of Toxicology, 22(2), 172-177 (1994-02-01)
The interactive toxicity of two nontoxic concentrations of chloroform (CHCl3) and bromotrichloromethane (BrCCl3) was examined in precision-cut rat liver slices. Liver slices were prepared from male Sprague-Dawley rats (220-250 g) pretreated with phenobarbital for 4 days. Toxicants were administered 1
M D Cameron et al.
Archives of biochemistry and biophysics, 367(1), 115-121 (1999-06-22)
Phanerochaete chrysosporium, grown on cellulose, produced a cellobiose-dependent dehydrogenase which reduced both ferric iron and molecular oxygen, resulting in the generation of the hydroxyl radical. The hydroxyl radical was detected in reaction mixtures with and without the addition of exogenous
Matthias Pirlich et al.
Free radical biology & medicine, 33(2), 283-291 (2002-07-11)
Chronic ethanol consumption is associated with increased protein oxidation and decreased proteolysis in the liver. We tested the hypothesis that even single-dose treatment with ethanol or bromotrichloromethane causes increased protein oxidation and a distinct proteolytic response in cultured hepatocytes. HepG2
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