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Showing 1-30 of 367 results for "C0780" within Papers
Olivier Braissant
Journal of inherited metabolic disease, 35(4), 655-664 (2012-01-19)
While it was thought that most of cerebral creatine is of peripheral origin, AGAT and GAMT are well expressed in CNS where brain cells synthesize creatine. While the creatine transporter SLC6A8 is expressed by microcapillary endothelial cells (MCEC) at blood-brain
Eleonora Araújo Dos Reis et al.
Metabolic brain disease, 28(3), 509-517 (2013-02-23)
Phenylketonuria (PKU) is the most frequent aminoacidopathy that damage the central nervous system and is characterized by neural injury, mental retardation and accumulation of phenylalanine and its metabolites in plasma and tissues. So far, the only effective protection against brain
Yona Kim et al.
International journal of molecular medicine, 34(6), 1688-1698 (2014-10-02)
The present study was conducted to investigate whether the high antioxidant activity induced by selenium (Sel) treatment and selenoprotein M (SelM) overexpression affected the protein profile of the brain cortex. To accomplish this, the changes in global protein expression were
J S Johnson et al.
Journal of animal science, 93(1), 71-81 (2015-01-09)
Environmentally induced heat stress (HS) negatively influences production variables in agriculturally important species. However, the extent to which HS experienced in utero affects nutrient partitioning during the rapid lean tissue accretion phase of postnatal growth is unknown. Study objectives were
Jaroslaw Zalewski et al.
Thrombosis and haemostasis, 113(6), 1258-1269 (2015-03-06)
Determinants of intracoronary thrombus (ICT) composition in patients with ST-elevation myocardial infarction (STEMI) are largely unknown. We sought to investigate whether plasma fibrin phenotype and platelet reactivity affect ICT ultrastructure. We assessed the content of fibrin, platelets and erythrocytes including
Baharak Farhanji et al.
European journal of pharmacology, 765, 171-178 (2015-08-25)
Several studies have assumed that myoepithelial cells (MECs) loss may contribute to epithelial tumor induction and/or progression. We adopted an in vitro assay and a syngeneic mice breast cancer model with histological and molecular characteristics resembling human lesions to evaluate
Barbara Hargrave et al.
PloS one, 9(12), e115235-e115235 (2014-12-30)
Myocardial ischemia can damage heart muscle and reduce the heart's pumping efficiency. This study used an ischemic swine heart model to investigate the potential for gene electro transfer of a plasmid encoding vascular endothelial growth factor for improving perfusion and
Evan L Pannkuk et al.
Radiation research, 184(2), 121-133 (2015-08-01)
Due to concerns surrounding potential large-scale radiological events, there is a need to determine robust radiation signatures for the rapid identification of exposed individuals, which can then be used to guide the development of compact field deployable instruments to assess
Juxiang Cao et al.
Science signaling, 8(392), ra87-ra87 (2015-09-04)
The anaphase-promoting complex or cyclosome with the subunit Cdh1 (APC/C(Cdh1)) is an E3 ubiquitin ligase involved in the control of the cell cycle. Here, we identified sporadic mutations occurring in the genes encoding APC components, including Cdh1, in human melanoma
N Tamasawa et al.
Lipids, 28(9), 833-836 (1993-09-01)
An analytical method for the determination of cholesterol sulfate (CS) in plasma using gas-liquid chromatography was developed. We measured plasma CS concentrations in patients with liver cirrhosis and hypercholesterolemia as examples of disorders that involve aberrations in cholesterol metabolism. Patients
Feng Hua Ma et al.
AJR. American journal of roentgenology, 204(6), W724-W730 (2015-05-23)
The purpose of this article is to investigate the proton MR spectroscopy ((1)H-MRS) features of solid adnexal tumors and to evaluate the efficacy of (1)H-MRS for differentiating benign from malignant solid adnexal tumors. Sixty-nine patients with surgically and histologically proven
Rithiele Gonçalves et al.
International journal of environmental research and public health, 11(11), 11438-11449 (2014-11-08)
Crotamine is one of the main constituents of the venom of the South American rattlesnake Crotalus durissus terrificus. Here we sought to investigate the inflammatory and toxicological effects induced by the intrahippocampal administration of crotamine isolated from Crotalus whole venom.
Mattia Quattrocelli et al.
The Journal of clinical investigation, 125(12), 4463-4482 (2015-11-17)
Conditions such as muscular dystrophies (MDs) that affect both cardiac and skeletal muscles would benefit from therapeutic strategies that enable regeneration of both of these striated muscle types. Protocols have been developed to promote induced pluripotent stem cells (iPSCs) to
Hayley Dickinson et al.
The Cochrane database of systematic reviews, 12(12), CD010846-CD010846 (2014-12-20)
Creatine is an amino acid derivative and, when phosphorylated (phosphocreatine), is involved in replenishing adenosine triphosphate (ATP) via the creatine kinase reaction. Cells obtain creatine from a diet rich in fish, meat, or dairy and by endogenous synthesis from the
Abdurrezzak Börekçi et al.
Angiology, 66(4), 339-345 (2014-05-17)
Reactive oxygen species have been implicated in the pathogenesis of contrast-induced nephropathy (CIN). We investigated the relationship between CIN with paraoxonase 1 (PON-1) activity and oxidative stress markers (total antioxidant status [TAS], total oxidant status [TOS], and oxidative stress index
Emilie R Muelly et al.
The Journal of clinical investigation, 123(4), 1809-1820 (2013-03-13)
Maple syrup urine disease (MSUD) is an inherited disorder of branched chain amino acid metabolism presenting with neonatal encephalopathy, episodic metabolic decompensation, and chronic amino acid imbalances. Dietary management enables survival and reduces risk of acute crises. Liver transplantation has
Katherine Halievski et al.
Experimental neurology, 269, 224-232 (2015-05-02)
Transgenic expression of neurotrophic factors in skeletal muscle has been found to protect mice from neuromuscular disease, including spinal bulbar muscular atrophy (SBMA), triggering renewed interest in neurotrophic factors as therapeutic agents for treating neuromuscular disease. Because SBMA is an
Sophie L Woehrer et al.
The EMBO journal, 34(4), 559-577 (2015-01-16)
The loading of small interfering RNAs (siRNAs) and microRNAs into Argonaute proteins is enhanced by Hsp90 and ATP in diverse eukaryotes. However, whether this loading also occurs independently of Hsp90 and ATP remains unclear. We show that the Tetrahymena Hsp90
Mohamed M Abdel-Daim et al.
Canadian journal of physiology and pharmacology, 93(1), 45-51 (2014-11-28)
Tilmicosin (TIL) is a long-acting macrolide antibiotic approved for the treatment of cattle with Bovine Respiratory Disease. However, overdose of TIL has been reported to induce cardiotoxicity. The purpose of our experiment was to evaluate the protective effects of Commiphora
Masaharu Ishihara et al.
Circulation journal : official journal of the Japanese Circulation Society, 79(6), 1255-1262 (2015-04-29)
New criteria for diagnosis of acute myocardial infarction (AMI) were proposed in 2000 as a universal definition, in which cardiac troponin (cTn) was the preferred biomarker. A large number of patients formerly classified by creatine kinase (CK) as unstable angina
Wang Qingsong et al.
Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc, 40(3), 223-229 (2013-06-26)
The mechanism underlying delayed neuropsychological sequelae (DNS) after acute carbon monoxide (CO) poisoning is unclear. There are no effective treatments for DNS. As part of a new generation of antioxidants, edaravone has been reported to improve clinical outcomes in patients
Zheng Xiang et al.
Molecular bioSystems, 11(4), 1067-1078 (2015-01-30)
The cooperative material basis of the multi-component and multi-target mechanism of action of Traditional Chinese Medicine (TCM) is difficult to elucidate because of the current lack of appropriate techniques and strategies. In this paper, we focus on rhubarb treatment of
Samit Malhotra et al.
Continuum (Minneapolis, Minn.), 19(1 Sleep Disorders), 67-85 (2013-02-13)
This review discusses the various causes of primary hypersomnias with emphasis on clinical recognition, diagnosis, and treatment options. Narcolepsy is probably the most fascinating syndrome causing excessive daytime sleepiness. With increasing understanding of the hypocretin/orexin pathways and the neurotransmitters that
Davide Capodanno et al.
International journal of cardiology, 199, 319-325 (2015-08-05)
The CHA2DS2-VASc and HAS-BLED are well-validated stroke risk prediction scores for atrial fibrillation (AF), but their role in risk stratification of major adverse cardiac events (MACEs) and major bleeding for non-AF patients undergoing percutaneous coronary intervention (PCI) is unknown. Consecutive
Ana M Rodrigues et al.
Acta reumatologica portuguesa, 40(2), 110-124 (2015-07-30)
Rheumatic and musculoskeletal diseases (RMD) are prevalent and leading causes of disability and consumption of healthcare and social resources. EpiReumaPt is a national population-based survey developed by the Portuguese Society of Rheumatology that aimed to estimate the prevalence of RMDs
Arunachalam Subramanian et al.
NMR in biomedicine, 18(4), 213-225 (2005-01-01)
This article describes proton MR spectroscopic analysis of cerebrospinal fluid of 167 children suffering from meningitis and 24 control cases. Quantification of 12 well-separated and commonly observed cerebrospinal fluid metabolites viz., beta-hydroxybutyrate, lactate, alanine, acetate, acetone, acetoacetate, pyruvate, glutamine, citrate
Lot Van de Moortel et al.
Journal of critical care, 29(5), 786-790 (2014-04-08)
To investigate the prognostic significance of low serum creatine kinase (CK) activity in intensive care unit patients. The study population consisted of 1899 patients, divided in a "normal" (CK > 20 U/L) and "low" CK group (CK ≤ 20 U/L).
Naina Shah et al.
Liver international : official journal of the International Association for the Study of the Liver, 33(3), 398-409 (2013-02-14)
Patients with cirrhosis frequently develop renal dysfunction, a proportion of who do not fulfill criteria for hepatorenal syndrome (HRS). We hypothesized that the kidneys in these patients would exhibit histological and biomarker evidence of kidney injury. We looked specifically for
Joshua Park et al.
PloS one, 10(4), e0124914-e0124914 (2015-04-10)
The objective of this study was to investigate the efficacy of using quantitative magnetic resonance imaging (MRI) as a non-invasive tool for the monitoring of gene therapy for muscular dystrophy. The clinical investigations for this family of diseases often involve
Yuanyuan Liu et al.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 20(4), 548-553 (2013-02-15)
Cognitive reserve (CR) modulates the relationship between clinical and pathological phenotypes by restricting the negative effect of cerebral lesions on cognition, according to the CR hypothesis. In this study, we evaluated 18 healthy subjects and 21 patients with mild cognitive
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