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Showing 1-30 of 2604 results for "c1231" within Papers
Rouyanne T Ras et al.
The American journal of clinical nutrition, 101(4), 733-741 (2015-03-27)
Plant sterols (PSs) lower LDL cholesterol, an established risk factor for coronary artery disease (CAD). No direct evidence is available supporting a reduced risk of CAD for foods with added PSs. Endothelial dysfunction is seen as an early indicator of
Sieglinde Zelzer et al.
International journal of molecular sciences, 16(5), 11689-11698 (2015-05-27)
Metabolic dysfunctions might play a crucial role in the pathophysiology of thyroid dysfunctions. This study aimed to investigate the impact of a controlled diet (normal versus high fat feeding) on hypothyroid and hyperthyroid Sprague Dawley rats. Female Sprague Dawley rats
HuiLing Lu et al.
PloS one, 9(10), e111002-e111002 (2014-10-24)
Vaspin (visceral-adipose-tissue-derived-serine-protease-inhibitor) is a recently identified adipokine with putative insulin-sensitizing properties. Plasma vaspin responses to surgery-induced weight loss are sparse and contradictory. We evaluated changes in vaspin levels and relationship to post-operative outcomes in men (n = 22) and women (n = 55) undergoing
Kei Fukami et al.
Journal of cardiovascular pharmacology, 65(3), 289-295 (2015-01-31)
Food or supplement-derived L-carnitine is changed to trimethylamine (TMA) by interstinal microbiota, which is further metabolized to trimethylamine-N-oxide (TMAO), being involved in the promotion of atherosclerosis in animal models. Meanwhile, carnitine deficiency has played a role in accelerated atherosclerosis in
Natália Bueno Leite et al.
Biophysical journal, 109(5), 936-947 (2015-09-04)
Polybia-MP1 (MP1) is a bioactive host-defense peptide with known anticancer properties. Its activity is attributed to excess serine (phosphatidylserine (PS)) on the outer leaflet of cancer cells. Recently, higher quantities of phosphatidylethanolamine (PE) were also found at these cells' surface.
Kerstin Rohde et al.
BMC genetics, 16, 31-31 (2015-04-19)
The human Aldoketoreductase 1B10 gene (AKR1B10) encodes one of the enzymes belonging to the family of aldoketoreductases and may be involved in detoxification of nutrients during digestion. Further, AKR1B10 mRNA (messenger ribonucleic acid) expression was diminished in brain regions potentially
Nihal Saad Elbialy et al.
Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 23(2), 182-187 (2015-05-15)
Ehrlich tumors were grown in female balb mice by subcutaneous injection of Ehrlich ascites carcinoma cells. Mice bearing Ehrlich tumor were injected with saline, DOX in solution or DOX encapsulated within liposomes prepared from DMPC/CHOL/DPPG/PEG-PE (100:100:60:4) in molar ratio. Cytotoxicity
Diane J Greene et al.
Journal of lipid research, 56(9), 1669-1678 (2015-07-24)
We previously reported that reducing the expression of cholesteryl ester transfer protein (CETP) disrupts cholesterol homeostasis in SW872 cells and causes an ∼50% reduction in TG. The causes of this reduced TG content, investigated here, could not be attributed to
Amrita Das et al.
PLoS neglected tropical diseases, 8(8), e3091-e3091 (2014-08-22)
With the paucity of new drugs and HIV co-infection, vaccination remains an unmet research priority to combat visceral leishmaniasis (VL) requiring strong cellular immunity. Protein vaccination often suffers from low immunogenicity and poor generation of memory T cells for long-lasting
Lei Guo et al.
Toxicology and applied pharmacology, 277(1), 21-29 (2014-03-15)
Human exposure to arsenic in drinking water is a widespread public health concern, and such exposure is known to be associated with many human diseases. The detailed molecular mechanisms about how arsenic species contribute to the adverse human health effects
Anna Maisa et al.
AIDS (London, England), 29(12), 1445-1457 (2015-08-06)
HIV-infected (HIV+) individuals have an increased risk of atherosclerosis and cardiovascular disease which is independent of antiretroviral therapy and traditional risk factors. Monocytes play a central role in the development of atherosclerosis, and HIV-related chronic inflammation and monocyte activation may
Md Nazir Hossen et al.
Journal of drug targeting, 22(7), 600-609 (2014-05-09)
We previously developed a ligand-targeted liposome, referred to as a prohibitin-targeted nanoparticle (PTNP), for specifically delivering encapsulated drugs into vascular endothelial cells in adipose tissue. In this study, we explored the critical factors for the successful development and application of
Robin P F Dullaart et al.
Clinical biochemistry, 47(12), 1028-1032 (2014-04-29)
Thyroid hormones play a key role in hepatic lipid metabolism. Although hypothyroidism is associated with increased prevalence of non-alcoholic fatty liver disease (NAFLD), the relationship of NAFLD with low normal thyroid function is unclear. We tested the association of serum
Aamer Sandoo et al.
Clinical and experimental rheumatology, 32(6), 914-921 (2014-08-26)
Patients with rheumatoid arthritis (RA) are at an increased risk for cardiovascular disease (CVD) resulting from impairments in vascular function and morphology. CVD risk prediction scores can identify patients at high risk of CVD, but little is known about whether
Marsha-Lyn McKoy et al.
Journal of medicinal food, 17(11), 1183-1188 (2014-07-25)
A sapogenin-rich preparation from Jamaican bitter yam (Dioscorea polygonoides) has been shown to reduce blood cholesterol concentrations in hypercholesterolemic rats and mice. Also, diosgenin supplementation has been reported to have antilipemic effects in several animal species. We investigated potential mechanisms
Mariana Rodríguez-Ramírez et al.
American journal of hypertension, 28(8), 1024-1030 (2015-01-27)
Prehypertension (preHTN) increases the risk of developing hypertension. The objectives of this study were to estimate the prevalence of preHTN in the Mexican adult population and evaluate the association between hypomagnesemia and preHTN. This study was a 2-phase, population-based study.
May A Beydoun et al.
PloS one, 9(8), e103490-e103490 (2014-08-20)
The associations between nutritional biomarkers and measures of sleep quantity and quality remain unclear. Cross-sectional data from the National Health and Nutrition Examination Surveys (NHANES) 2005-2006 were used. We selected 2,459 adults aged 20-85, with complete data on key variables.
Sauli Uotila et al.
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine, 33(11), 1941-1948 (2014-10-23)
Coronary microvascular dysfunction, observed as impaired coronary vasodilator capacity, is an early manifestation of coronary artery disease. Inflammation plays an important role in different stages of atherogenesis. To study the role of vessel wall inflammation in the development of coronary
Chiara Lazzeri et al.
Scandinavian cardiovascular journal : SCJ, 49(1), 14-19 (2015-02-07)
Mild renal impairment (estimated GFR 60-89 ml/min/1.73 m(2)) is a strong independent risk factor for mortality in ST-elevation myocardial infarction (STEMI), and is submitted to mechanical revascularization. Patients with renal impairment have decreased excretion of uric acid (UA) and they
Anna Waśkiewicz et al.
Kardiologia polska, 71(4), 359-365 (2013-06-22)
Studies showed that alcohol intake affects various biomarkers (lipids, blood pressure [BP], homocysteine, diabetes, haemostatic factors) associated with the risk of coronary heart disease. To determinate cardiovascular (CV) risk factor profile in a population Polish men stratified according to alcohol
W Gibson Wood et al.
Journal of neurochemistry, 129(4), 559-572 (2013-12-18)
High serum/plasma cholesterol levels have been suggested as a risk factor for Alzheimer's disease (AD). Some reports, mostly retrospective epidemiological studies, have observed a decreased prevalence of AD in patients taking the cholesterol lowering drugs, statins. The strongest evidence causally
Piotr Bandosz et al.
International journal of cardiology, 185, 313-319 (2015-04-02)
The present study is aimed to examine whether recent changes in population total cholesterol (TC) levels in Poland might be attributed to increased use statins. Two independent, nationally representative cross-sectional studies were conducted in adults aged 18-79 years in 2002
Anna Maria Fulghesu et al.
Fertility and sterility, 103(3), 808-814 (2015-02-01)
To assess whether birth weight influences the metabolic and hormonal profile of adolescents with polycystic ovary syndrome (PCOS). Retrospective study. University outpatient clinic. One hundred seventy consecutive adolescents 12 to 19 years of age with PCOS, 15 of whom were small
Serdar Saraç et al.
The Journal of international medical research, 43(3), 385-392 (2015-03-13)
To determine the relationships between serum leptin and levels of lipoprotein(a) [Lp(a)], apolipoprotein A-1 (ApoA-1) and apolipoprotein B (ApoB) in patients with cholelithiasis. Patients with ultrasound-confirmed cholelithiasis and controls frequency-matched for age, sex, body mass index, fasting blood glucose and
Rachana Shah et al.
American journal of kidney diseases : the official journal of the National Kidney Foundation, 66(2), 266-273 (2015-03-22)
Cardiometabolic disease is a major cause of morbidity and mortality in persons with chronic kidney disease (CKD). Fractalkine (CX3CL1) is a potential mediator of both atherosclerosis and metabolic disease. Studies of the relationship of CX3CL1 with risk of cardiovascular disease
Zerrin Sezgin-Bayindir et al.
AAPS PharmSciTech, 16(1), 108-117 (2014-09-11)
The aim of this study was to prepare candesartan cilexetil-loaded niosomes and mixed niosomes to enhance the aqueous solubility of the drug, thus improving its oral bioavailability. The formulations were prepared using various types and combinations of surfactants, copolymers, and
Maria Luisa Eliana Luisi et al.
Internal and emergency medicine, 10(6), 671-676 (2015-03-01)
Dietary habits are widely reported to play a primary role in the occurrence of coronary artery disease (CAD). Cardiac rehabilitation is a multidisciplinary intervention that includes nutritional education. Proper nutrition plays an important role in cardiovascular health outcomes and in
P I Burgess et al.
Diabetic medicine : a journal of the British Diabetic Association, 31(12), 1643-1650 (2014-05-16)
To report the prevalence of all grades of diabetic retinopathy and associations with demographic, clinical and biochemical variables in people with diabetes in Southern Malawi. We report baseline data from a 24-month prospective cohort study. Subjects were systematically sampled from
Ji Hee Kang et al.
AAPS PharmSciTech, 15(5), 1087-1092 (2014-05-23)
We previously reported that a liposome encapsulating polyethylenimine/oligonucleotides is suitable for in vivo delivery of nucleic acid therapeutics. However, toxicity of polyethylenimine is an obstacle in clinical application. To develop a liposome encapsulating polyplexes applicable to clinical use, we proposed
Alexis Broisat et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 55(10), 1678-1684 (2014-08-27)
(99m)Tc-cAbVCAM1-5, a single-domain antibody fragment directed against mouse or human vascular cell adhesion molecule 1 (VCAM-1), recently has been proposed as a new imaging agent for the detection of inflamed atherosclerotic lesions. Indeed, in a mouse model of atherosclerosis, (99m)Tc-cAbVCAM1-5
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