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Showing 31-60 of 2604 results for "C1231" within Papers
Ekaterina S Menchinskaya et al.
Natural product communications, 8(10), 1377-1380 (2013-12-21)
In non-cytotoxic concentrations, frondoside A (1) from the sea cucumber Cucumaria okhotensis and cucumarioside A2-2 (2) from C. japonica, as well as their complexes with cholesterol block the activity of membrane transport P-glycoprotein in cells of the ascite form of
Eriks Smagris et al.
Hepatology (Baltimore, Md.), 61(1), 108-118 (2014-06-12)
A sequence polymorphism (rs738409, I148M) in patatin-like phospholipid domain containing protein 3 (PNPLA3) is strongly associated with nonalcoholic fatty liver disease (NAFLD), but the mechanistic basis for this association remains enigmatic. Neither ablation nor overexpression of wild-type PNPLA3 affects liver
Marilia C O Sprandel et al.
Cardiovascular diabetology, 14, 107-107 (2015-08-14)
We previously showed that unesterified-cholesterol transfer to high-density lipoprotein (HDL), a crucial step in cholesterol esterification and role in reverse cholesterol transport, was diminished in non-diabetic patients with coronary artery disease (CAD). The aim was to investigate whether, in patients
Swathi Seshadri et al.
Acta ophthalmologica, 93(4), e266-e274 (2014-12-10)
To investigate the relationship between retinal microvascular reactivity, circulatory markers for CVD risk and systemic antioxidative defence capacity in healthy middle-aged individuals with low to moderate risk of CVD. Retinal vascular reactivity to flickering light was assessed in 102 healthy
Dominique Hansen et al.
Experimental physiology, 100(7), 818-828 (2015-05-13)
What is the central question of this study? It remains uncertain whether significant fat-free mass wasting occurs early after coronary artery bypass graft surgery, and the aetiology of this wasting in these particular conditions is unexplored. What is the main
Hidetaka Hamasaki et al.
Journal of diabetes research, 2015, 526201-526201 (2015-06-13)
To investigate the association between daily physical activity and metabolic risk factors in Japanese adults with prediabetes or untreated early type 2 diabetes (T2D). Daily physical activity level was measured using a triaxial accelerometer. We assessed correlations between physical activity
Brendan M Everett et al.
The American journal of cardiology, 116(4), 532-537 (2015-06-18)
Natriuretic peptides are positively associated with incident cardiovascular disease (CVD), but data in women, particularly with regard to improvements in risk prediction, are sparse. We measured the N-terminal prohormone form of B-type natriuretic peptide (NT-proBNP) in 480 cases of incident
Thomas Berg et al.
Liver international : official journal of the International Association for the Study of the Liver, 35(2), 448-454 (2014-10-17)
Predictors of response to treatment with peginterferon plus ribavirin are well established. In these post-hoc analyses of the REALIZE study, we sought to identify predictors of response for telaprevir-based triple therapy. Patients from the REALIZE study with baseline data for
Zhuoran Wang et al.
Scientific reports, 5, 12012-12012 (2015-07-15)
Cyclic adenosine monophosphate (cAMP) plays an important role in many biological processes as a second messenger, and cAMP treatment has been reported to extend the lifespan of wild-type Drosophila melanogaster. Our study showed that exogenous cAMP improved ageing-related phenotypes by
Christiana A Georgiou et al.
Food chemistry, 145, 918-926 (2013-10-17)
In recent years, cholesterol oxidation products (COPs) have drawn scientific interest, particularly due to their implications on human health. A big number of these compounds have been demonstrated to be cytotoxic, mutagenic, and carcinogenic. The main source of COPs is
Prue Cormie et al.
BJU international, 115(2), 256-266 (2014-01-29)
To determine if supervised exercise minimises treatment toxicity in patients with prostate cancer initiating androgen-deprivation therapy (ADT). This is the first study to date that has investigated the potential role of exercise in preventing ADT toxicity rather than recovering from
Tomokazu Sumida et al.
Nature communications, 6, 6241-6241 (2015-02-27)
Hypertension induces structural remodelling of arteries, which leads to arteriosclerosis and end-organ damage. Hyperplasia of vascular smooth muscle cells (VSMCs) and infiltration of immune cells are the hallmark of hypertensive arterial remodelling. However, the precise molecular mechanisms of arterial remodelling
Itandehui Castro-Quezada et al.
European journal of nutrition, 54(4), 523-534 (2014-07-10)
To examine the association between dietary glycaemic index (GI) and dietary glycaemic load (GL) with cardiovascular disease (CVD) risk factors in a rural elderly population. A cross-sectional study was conducted in 343 subjects (60-74 years) residing in a Spanish rural
ITCH modulates SIRT6 and SREBP2 to influence lipid metabolism and atherosclerosis in ApoE null mice.
R Stöhr et al.
Scientific reports, 5, 9023-9023 (2015-03-18)
Atherosclerosis is a chronic inflammatory disease characterized by the infiltration of pro-inflammatory macrophages into a lipid-laden plaque. ITCH is an E3 ubiquitin ligase that has been shown to polarize macrophages to an anti-inflammatory phenotype. We therefore investigated the effect of
Sophie Stukas et al.
Journal of lipid research, 55(8), 1721-1729 (2014-06-22)
A key step in plasma HDL maturation from discoidal to spherical particles is the esterification of cholesterol to cholesteryl ester, which is catalyzed by LCAT. HDL-like lipoproteins in cerebrospinal fluid (CSF) are also spherical, whereas nascent lipoprotein particles secreted from
Yong-Zhe Zhu et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 35(4), 1347-1359 (2015-02-28)
Although it has been widely accepted that Enterovirus 71 (EV71) enters permissive cells via receptor-mediated endocytosis, the details of entry mechanism for EV71 still need more exploration. This study aimed to investigate the role of lipid rafts in the early
Hepatitis C virus replication compartment formation: mechanism and drug target.
Vineela Chukkapalli et al.
Gastroenterology, 146(5), 1164-1167 (2014-03-29)
Omar F Khan et al.
Nano letters, 15(5), 3008-3016 (2015-03-20)
Targeted RNA delivery to lung endothelial cells has the potential to treat conditions that involve inflammation, such as chronic asthma and obstructive pulmonary disease. To this end, chemically modified dendrimer nanomaterials were synthesized and optimized for targeted small interfering RNA
Chenyang Shi et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 69, 191-200 (2015-02-11)
Vascular endothelial growth factor (VEGF) is an important target for cancer therapy. In the present study, we conjugated the novel fully-human anti-VEGF165 monoclonal antibody, mAb165, with a PEGylated liposome (lip) to produce a monoclonal antibody-conjugated PEGylated liposome (mAb-lip). Physical characterization
Pramod J Kasabe et al.
Protein expression and purification, 116, 30-41 (2015-08-16)
The novel bacterium, Rhodococcus sp. PKPD-CL was isolated and identified from the 'Chilika Lake' located at Odisha state of India, which is a largest brackish water habitat in Asia. Rhodococcus sp. PKPD-CL produces extracellular halo tolerant, detergent and organic solvent
Meta-analysis of fructose and cholesterol: a concern regarding missing data.
Laura Chiavaroli et al.
The Journal of nutrition, 144(4), 538-539 (2014-03-22)
Alessandro Mantovani et al.
PloS one, 10(8), e0135329-e0135329 (2015-08-08)
Accumulating evidence suggests that nonalcoholic fatty liver disease (NAFLD) is associated with left ventricular diastolic dysfunction (LVDD) in nondiabetic individuals. To date, there are very limited data on this topic in patients with type 2 diabetes and it remains uncertain
Kazumasa Yamagishi et al.
Atherosclerosis, 237(2), 400-403 (2014-12-03)
To examine whether coenzyme Q10, a potent antioxidant, is associated with risk of dementia, which has not yet been elucidated. We performed a case-control study nested in a community-based cohort of approximately 6000 Japanese aged 40-69 years at baseline (1984-1994).
H Wang et al.
Journal of neuroendocrinology, 27(7), 600-608 (2015-04-10)
The prevalence of obesity among child-bearing women has increased significantly. The adverse consequences of maternal obesity on the descendants have been well accepted, although few studies have examined the underlying mechanisms. We investigated whether neonatal overfeeding in female mice alters
Juan Huan et al.
Biosensors & bioelectronics, 73, 221-227 (2015-06-19)
An amplified solid-state electrochemiluminescence (ECL) biosensor for detection of cholesterol in near-infrared (NIR) range was constructed based on CdTe quantum dots (QDs) decorated multiwalled carbon nanotubes@reduced graphene nanoribbons (CdTe-MWCNTs@rGONRs), which were prepared by electrostatic interactions. The CdTe QDs decorated on
Gultekin Genctoy et al.
Artificial organs, 39(9), 748-755 (2015-05-06)
Cardiac valvular calcification (CVC) in end-stage renal disease is shown to be a component of malnutrition, inflammation, atherosclerosis, calcification (MIAC) syndrome. Thoracic periaortic fat tissue (T-PAFT) is shown to be increased in patients with end-stage renal disease (ESRD), and has
Valentina Boddi et al.
The journal of sexual medicine, 11(2), 431-438 (2014-01-28)
Sexual dysfunctions (SDs) are dictated by predisposing, precipitating, maintaining, and contextual factors, the latter of which can help sexual problems to emerge. Even if the lack of sexual privacy is one of the most common contextual issues, it has not
Motoki Sano
Nihon rinsho. Japanese journal of clinical medicine, 71(9), 1661-1666 (2013-11-12)
Ezetimibe is a unique inhibitor of intestinal cholesterol absorption. Ezetimibe selectively inhibits intestinal cholesterol absorption by blocking Niemann-Pick C1-like 1 (NPCIL1). Ezetimibe accelerates VLDL and TG degradation. Therefore, ezetimibe ameliorates postprandial hyperlipidemia. Ezetimibe inhibited the progression of nonalcoholic fatty liver
Anna Marchenkova et al.
Molecular pain, 11, 71-71 (2015-11-19)
ATP-gated P2X3 receptors are important transducers of nociceptive stimuli and are almost exclusively expressed by sensory ganglion neurons. In mouse trigeminal ganglion (TG), P2X3 receptor function is unexpectedly enhanced by pharmacological block of natriuretic peptide receptor-A (NPR-A), outlining a potential
Marek Kucera et al.
Angiology, 65(9), 794-799 (2013-10-29)
Treatment with statins to achieve target low-density lipoprotein cholesterol (LDL-C) levels is still associated with residual risk. Lipoprotein subfraction evaluation can provide additional information regarding atherogenicity in these individuals. Patients (n = 40) with hypercholesterolemia (29 females, mean age 63
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