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Showing 1-30 of 623 results for "C1359" within Papers
Yujiao Fu et al.
Molecular pharmacology, 88(1), 161-170 (2015-02-27)
The timely resolution of inflammation prevents continued tissue damage after an initial insult. In the brain, the death of activated microglia by apoptosis has been proposed as one mechanism to resolve brain inflammation. How microglial death is regulated after activation
E Muraro et al.
Journal of translational medicine, 13, 204-204 (2015-06-28)
Locally advanced HER2-overexpressing breast cancer (BC) patients achieve a high rate of pathological complete responses (pCR) after neoadjuvant chemotherapy (NC). The apparently unaltered immune proficiency of these patients together with the immune-modulating activities of NC drugs suggest a potential contribution
Yuanyuan Cheng et al.
Oxidative medicine and cellular longevity, 2015, 434052-434052 (2015-08-13)
Leukotriene B4 12-hydroxydehydrogenase (LTB4DH) catalyzes the oxidation of proinflammatory LTB4 into less bioactive 12-oxo-LTB4. We recently discovered that LTB4DH was induced by two different natural products in combination. We previously isolated gallic acid from Radix Paeoniae through a bioactivity-guided fractionation
Jin Han et al.
ACS nano, 9(3), 2805-2819 (2015-02-18)
Electrophysiological phenotype development and paracrine action of mesenchymal stem cells (MSCs) are the critical factors that determine the therapeutic efficacy of MSCs for myocardial infarction (MI). In such respect, coculture of MSCs with cardiac cells has windowed a platform for
Q Zhao et al.
Cell death & disease, 5, e1438-e1438 (2014-10-03)
Anoikis, a special apoptotic process occurring in response to loss of cell adhesion to the extracellular matrix, is a fundamental surveillance process for maintaining tissue homeostasis. Resistance to anoikis characterises cancer cells and is a pre-requisite for metastasis. This study
K A Taylor et al.
Journal of thrombosis and haemostasis : JTH, 12(6), 987-998 (2014-03-25)
Pannexin-1 (Panx1) forms an anion-selective channel with a permeability up to ~1 kDa and represents a non-lytic, non-vesicular ATP release pathway in erythrocytes, leukocytes and neurons. Related connexin gap junction proteins have been reported in platelets; however, the expression and
Lingqian Chang et al.
Lab on a chip, 15(15), 3147-3153 (2015-06-25)
Current transfection technologies lead to significant inter-clonal variations. Previously we introduced a unique electrotransfection technology, Nanochannel-Electroporation (NEP), which can precisely and benignly transfect small cell populations (~100-200 cells) with single-cell resolution. Here we report on the development of a novel
Gang Yuan et al.
International journal of molecular sciences, 15(10), 18776-18788 (2014-10-21)
In accordance with the World Cancer Report, cancer has become the leading cause of mortality worldwide, and various therapeutic strategies have been developed at the same time. In the present study, biocompatible magnetic nanoparticles were designed and synthesized as high-performance
Karina Wegleiter et al.
Experimental neurology, 261, 501-509 (2014-08-12)
Premature birth represents a clinical situation of risk for brain injury. The diversity of pathophysiological processes complicates efforts to find effective therapeutic strategies. Excitotoxicity is one important factor in the pathogenesis of preterm brain injury. The observation that sigma-1 receptor
Sixing Li et al.
Analytical chemistry, 86(19), 9853-9859 (2014-09-19)
Precise reconstruction of heterotypic cell-cell interactions in vitro requires the coculture of different cell types in a highly controlled manner. In this article, we report a standing surface acoustic wave (SSAW)-based cell coculture platform. In our approach, different types of
Louise M Collins et al.
Molecular neurobiology, 51(3), 1432-1442 (2014-07-30)
Small molecule histone deacetylase inhibitors (HDIs) hold much promise as pharmacological modifiers of the epigenetic status of the central nervous system (CNS), given their ability to cross the blood-brain barrier. This is particularly relevant given the lack of disease-modifying therapies
Jie Lan et al.
Journal of immunology (Baltimore, Md. : 1950), 193(7), 3577-3589 (2014-08-26)
Latently HIV-1-infected cells are recognized as the last barrier toward viral eradication and cure. To purge these cells, we combined a provirus stimulant with a blocker of human CD59, a key member of the regulators of complement activation, to trigger
Joni H Ylostalo et al.
Cytotherapy, 16(11), 1486-1500 (2014-09-19)
Human mesenchymal stromal cells (MSCs) are being used in clinical trials, but the best protocol to prepare the cells for administration to patients remains unclear. We previously demonstrated that MSCs could be pre-activated to express therapeutic factors by culturing the
T Y Nguyen et al.
Journal of biomedical materials research. Part A, 103(9), 2974-2986 (2015-02-19)
Magnesium (Mg) alloy is an attractive class of metallic biomaterial for cardiovascular applications due to its biodegradability and mechanical properties. In this study, we investigated the degradation in blood, thrombogenicity, and cytocompatibility of Magnesium-Zinc-Strontium (Mg-Zn-Sr) alloys, specifically four Mg-4 wt
Damien Rioult et al.
Aquatic toxicology (Amsterdam, Netherlands), 153, 98-109 (2013-12-19)
In marine and estuarine species, immunotoxic and/or immunomodulatory mechanisms are the crossroad of interactions between xenobiotics, microorganisms and physicochemical variations of the environment. In mussels, immunity relies exclusively on innate responses carried out by cells collectively called hemocytes and found
E Litwa et al.
The Journal of steroid biochemistry and molecular biology, 144 Pt B, 334-347 (2014-08-06)
4-para-Nonylphenol (NP) is a non-ionic surfactant that has widespread and uncontrolled distribution in the environment. Little is known, however, about its actions on neuronal cells during critical developmental periods. This study aimed to investigate the mechanisms underlying the apoptotic and
Jiraporn Ousingsawat et al.
Nature communications, 6, 6245-6245 (2015-02-06)
Purinergic P2X7 receptors (P2X7R) are fundamental to innate immune response. In macrophages, transient stimulation of P2X7R activates several transport mechanisms and induces the scrambling of phospholipids with subsequent membrane blebbing and apoptosis. These processes support phagocytosis and subsequent killing of
Toshio Hisatomi et al.
Retina (Philadelphia, Pa.), 35(2), 310-318 (2014-08-12)
Brilliant Blue G is used as a surgical adjuvant for retinal surgery. Although BBG double or multiple staining was reported, the effectiveness and safety of repeated staining is still elusive. To further examine the effectiveness and safety, we examined BBG
S Sarkar et al.
Lab on a chip, 15(23), 4441-4450 (2015-10-13)
Acquired drug resistance is a key factor in the failure of chemotherapy. Due to intratumoral heterogeneity, cancer cells depict variations in intracellular drug uptake and efflux at the single cell level, which may not be detectable in bulk assays. In
Niels M B Smeets et al.
Acta biomaterialia, 10(10), 4143-4155 (2014-06-10)
The potential of poly(oligoethylene glycol methacrylate) (POEGMA) hydrogels with varying thermosensitivities as soft materials for biomedical applications is demonstrated. Hydrogels are prepared from hydrazide and aldehyde functionalized POEGMA precursors, yielding POEGMA hydrogels with a volume phase transition temperature (VPTT) below
Regina Miftakhova et al.
Cell cycle (Georgetown, Tex.), 14(12), 1948-1960 (2015-03-19)
It remains poorly understood how the haematopoietic stem/progenitor cells (HSPC) are attracted to their niches and the functional consequences of such interaction. In the present study, we show that the cell cycle regulator cyclin A1 in association with vascular endothelial
Makoto Aihara et al.
Molecular vision, 20, 606-615 (2014-05-16)
To investigate the effect of hyperbaric pressure on purified retinal ganglion cells (RGCs) and the additive effect of hyperbaric pressure on glutamate-induced RGC death. An RGC primary culture from 8-day-old Wistar rats was prepared and cultured in a hyperbaric chamber.
Mohamad M Adada et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(11), 4654-4669 (2015-07-26)
The bioactive sphingolipid sphingosine-1-phosphate (S1P) mediates cellular proliferation, mitogenesis, inflammation, and angiogenesis. These biologies are mediated through S1P binding to specific GPCRs [sphingosine-1-phosphate receptor (S1PR)1-5] and some other less well-characterized intracellular targets. Ezrin-radixin-moesin (ERM) proteins, a family of adaptor molecules
Bin-bin Yu et al.
Biological & pharmaceutical bulletin, 37(8), 1315-1322 (2014-05-30)
Oxaliplatin is widely used in the treatment of variety of cancers, including cancer of the testis and colorectum. Gap junctions (GJs) can amplify the cytotoxicity of antinoeoplastic drugs through the bystander effect in different cancer cells. In this study, we
Maria Daniela Vlad et al.
Materials science & engineering. C, Materials for biological applications, 110, 110658-110658 (2020-03-25)
Titanium alloy scaffolds with novel interconnected and non-periodic porous bone-like micro architecture were 3D-printed and filled with hydroxyapatite bioactive matrix. These novel metallic-ceramic hybrid scaffolds were tested in vitro by direct-contact osteoblast cell cultures for cell adhesion, proliferation, morphology and
Shekher Mohan et al.
Neurotoxicology, 46, 53-59 (2014-12-03)
Heme (Fe(2+) protoporphyrin IX) and hemin (Fe(3+)), the prosthetic group of hemoprotein, are cytotoxic due to their ability to contribute to the production of reactive oxygen species, increased intracellular calcium levels, and stimulate glutamate-mediated excitotoxicity. Previous work by our group
Alexandra Orchard et al.
Bioorganic & medicinal chemistry, 20(14), 4290-4302 (2012-06-26)
Twelve thiorhodamine derivatives have been examined for their ability to stimulate the ATPase activity of purified human P-glycoprotein (P-gp)-His(10), to promote uptake of calcein AM and vinblastine into multidrug-resistant, P-gp-overexpressing MDCKII-MDR1 cells, and for their rates of transport in monolayers
Tatsuya Ohsumi et al.
PloS one, 10(1), e0116647-e0116647 (2015-01-31)
Chemical disinfection of oral biofilms often leaves biofilm structures intact. This study aimed to examine whether the residual structure promotes secondary bacterial adhesion. Streptococcus mutans biofilms generated on resin-composite disks in a rotating disc reactor were disinfected completely with 70%
Long Li et al.
Biomaterials, 37, 218-229 (2014-12-03)
There is an urgent need to develop biomimetic bone tissue engineering scaffolds for the repair of critical-sized calvarial defect. In this study, we developed a new nanoparticle-embedded electrospun nanofiber scaffold for the controlled dual delivery of BMP-2 and dexamethasone (DEX).
Giosuè Annibalini et al.
Journal of endocrinological investigation, 37(9), 861-869 (2014-06-21)
Gender-related differences in sex hormones might have a key role in the development of atherosclerosis though direct vascular effects of sex hormones are not yet well understood. Thus, the main purpose of this study was to compare the effects of
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