C1359

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Showing 1-30 of 623 results for "C1359" within Papers

EP2 Receptor Signaling Regulates Microglia Death.

Yujiao Fu et al.

Molecular pharmacology, 88(1), 161-170 (2015-02-27)

The timely resolution of inflammation prevents continued tissue damage after an initial insult. In the brain, the death of activated microglia by apoptosis has been proposed as one mechanism to resolve brain inflammation. How microglial death is regulated after activation

MUC1 extracellular domain confers resistance of epithelial cancer cells to anoikis.

Q Zhao et al.

Cell death & disease, 5, e1438-e1438 (2014-10-03)

Anoikis, a special apoptotic process occurring in response to loss of cell adhesion to the extracellular matrix, is a fundamental surveillance process for maintaining tissue homeostasis. Resistance to anoikis characterises cancer cells and is a pre-requisite for metastasis. This study

Intracellular sphingosine kinase 2-derived sphingosine-1-phosphate mediates epidermal growth factor-induced ezrin-radixin-moesin phosphorylation and cancer cell invasion.

Mohamad M Adada et al.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(11), 4654-4669 (2015-07-26)

The bioactive sphingolipid sphingosine-1-phosphate (S1P) mediates cellular proliferation, mitogenesis, inflammation, and angiogenesis. These biologies are mediated through S1P binding to specific GPCRs [sphingosine-1-phosphate receptor (S1PR)1-5] and some other less well-characterized intracellular targets. Ezrin-radixin-moesin (ERM) proteins, a family of adaptor molecules

Total flavonoids of litsea coreana enhance the cytotoxicity of oxaliplatin by increasing gap junction intercellular communication.

Bin-bin Yu et al.

Biological & pharmaceutical bulletin, 37(8), 1315-1322 (2014-05-30)

Oxaliplatin is widely used in the treatment of variety of cancers, including cancer of the testis and colorectum. Gap junctions (GJs) can amplify the cytotoxicity of antinoeoplastic drugs through the bystander effect in different cancer cells. In this study, we

Unique characteristics of human mesenchymal stromal/progenitor cells pre-activated in 3-dimensional cultures under different conditions.

Joni H Ylostalo et al.

Cytotherapy, 16(11), 1486-1500 (2014-09-19)

Human mesenchymal stromal cells (MSCs) are being used in clinical trials, but the best protocol to prepare the cells for administration to patients remains unclear. We previously demonstrated that MSCs could be pre-activated to express therapeutic factors by culturing the

In vitro interactions of blood, platelet, and fibroblast with biodegradable magnesium-zinc-strontium alloys.

T Y Nguyen et al.

Journal of biomedical materials research. Part A, 103(9), 2974-2986 (2015-02-19)

Magnesium (Mg) alloy is an attractive class of metallic biomaterial for cardiovascular applications due to its biodegradability and mechanical properties. In this study, we investigated the degradation in blood, thrombogenicity, and cytocompatibility of Magnesium-Zinc-Strontium (Mg-Zn-Sr) alloys, specifically four Mg-4 wt

Phenotypic drug profiling in droplet microfluidics for better targeting of drug-resistant tumors.

S Sarkar et al.

Lab on a chip, 15(23), 4441-4450 (2015-10-13)

Acquired drug resistance is a key factor in the failure of chemotherapy. Due to intratumoral heterogeneity, cancer cells depict variations in intracellular drug uptake and efflux at the single cell level, which may not be detectable in bulk assays. In

Hyperbaric pressure and increased susceptibility to glutamate toxicity in retinal ganglion cells in vitro.

Makoto Aihara et al.

Molecular vision, 20, 606-615 (2014-05-16)

To investigate the effect of hyperbaric pressure on purified retinal ganglion cells (RGCs) and the additive effect of hyperbaric pressure on glutamate-induced RGC death. An RGC primary culture from 8-day-old Wistar rats was prepared and cultured in a hyperbaric chamber.

Novel titanium-apatite hybrid scaffolds with spongy bone-like micro architecture intended for spinal application: In vitro and in vivo study.

Maria Daniela Vlad et al.

Materials science & engineering. C, Materials for biological applications, 110, 110658-110658 (2020-03-25)

Titanium alloy scaffolds with novel interconnected and non-periodic porous bone-like micro architecture were 3D-printed and filled with hydroxyapatite bioactive matrix. These novel metallic-ceramic hybrid scaffolds were tested in vitro by direct-contact osteoblast cell cultures for cell adhesion, proliferation, morphology and

Iron oxide nanoparticle-mediated development of cellular gap junction crosstalk to improve mesenchymal stem cells' therapeutic efficacy for myocardial infarction.

Jin Han et al.

ACS nano, 9(3), 2805-2819 (2015-02-18)

Electrophysiological phenotype development and paracrine action of mesenchymal stem cells (MSCs) are the critical factors that determine the therapeutic efficacy of MSCs for myocardial infarction (MI). In such respect, coculture of MSCs with cardiac cells has windowed a platform for

Plant Natural Products Calycosin and Gallic Acid Synergistically Attenuate Neutrophil Infiltration and Subsequent Injury in Isoproterenol-Induced Myocardial Infarction: A Possible Role for Leukotriene B4 12-Hydroxydehydrogenase?

Yuanyuan Cheng et al.

Oxidative medicine and cellular longevity, 2015, 434052-434052 (2015-08-13)

Leukotriene B4 12-hydroxydehydrogenase (LTB4DH) catalyzes the oxidation of proinflammatory LTB4 into less bioactive 12-oxo-LTB4. We recently discovered that LTB4DH was induced by two different natural products in combination. We previously isolated gallic acid from Radix Paeoniae through a bioactivity-guided fractionation

Provirus activation plus CD59 blockage triggers antibody-dependent complement-mediated lysis of latently HIV-1-infected cells.

Jie Lan et al.

Journal of immunology (Baltimore, Md. : 1950), 193(7), 3577-3589 (2014-08-26)

Latently HIV-1-infected cells are recognized as the last barrier toward viral eradication and cure. To purge these cells, we combined a provirus stimulant with a blocker of human CD59, a key member of the regulators of complement activation, to trigger

Class-IIa Histone Deacetylase Inhibition Promotes the Growth of Neural Processes and Protects Them Against Neurotoxic Insult.

Louise M Collins et al.

Molecular neurobiology, 51(3), 1432-1442 (2014-07-30)

Small molecule histone deacetylase inhibitors (HDIs) hold much promise as pharmacological modifiers of the epigenetic status of the central nervous system (CNS), given their ability to cross the blood-brain barrier. This is particularly relevant given the lack of disease-modifying therapies

Cyclin A1 regulates the interactions between mouse haematopoietic stem and progenitor cells and their niches.

Regina Miftakhova et al.

Cell cycle (Georgetown, Tex.), 14(12), 1948-1960 (2015-03-19)

It remains poorly understood how the haematopoietic stem/progenitor cells (HSPC) are attracted to their niches and the functional consequences of such interaction. In the present study, we show that the cell cycle regulator cyclin A1 in association with vascular endothelial

Brilliant Blue G double staining enhances successful internal limiting membrane peeling with minimal adverse effect by low cellular permeability into live cells.

Toshio Hisatomi et al.

Retina (Philadelphia, Pa.), 35(2), 310-318 (2014-08-12)

Brilliant Blue G is used as a surgical adjuvant for retinal surgery. Although BBG double or multiple staining was reported, the effectiveness and safety of repeated staining is still elusive. To further examine the effectiveness and safety, we examined BBG

Injectable poly(oligoethylene glycol methacrylate)-based hydrogels with tunable phase transition behaviours: physicochemical and biological responses.

Niels M B Smeets et al.

Acta biomaterialia, 10(10), 4143-4155 (2014-06-10)

The potential of poly(oligoethylene glycol methacrylate) (POEGMA) hydrogels with varying thermosensitivities as soft materials for biomedical applications is demonstrated. Hydrogels are prepared from hydrazide and aldehyde functionalized POEGMA precursors, yielding POEGMA hydrogels with a volume phase transition temperature (VPTT) below

Anoctamin 6 mediates effects essential for innate immunity downstream of P2X7 receptors in macrophages.

Jiraporn Ousingsawat et al.

Nature communications, 6, 6245-6245 (2015-02-06)

Purinergic P2X7 receptors (P2X7R) are fundamental to innate immune response. In macrophages, transient stimulation of P2X7R activates several transport mechanisms and induces the scrambling of phospholipids with subsequent membrane blebbing and apoptosis. These processes support phagocytosis and subsequent killing of

A small molecule with anticancer and antimetastatic activities induces rapid mitochondrial-associated necrosis in breast cancer.

Anja Bastian et al.

The Journal of pharmacology and experimental therapeutics, 353(2), 392-404 (2015-02-28)

Therapy for treatment-resistant breast cancer provides limited options and the response rates are low. Therefore, the development of therapies with alternative chemotherapeutic strategies is necessary. AG311 (5-[(4-methylphenyl)thio]-9H-pyrimido[4,5-b]indole-2,4-diamine), a small molecule, is being investigated in preclinical and mechanistic studies for treatment

Effect of silica and gold nanoparticles on macrophage proliferation, activation markers, cytokine production, and phagocytosis in vitro.

Simona Bancos et al.

International journal of nanomedicine, 10, 183-206 (2015-01-08)

The accumulation of durable nanoparticles (NPs) in macrophages following systemic administration is well described. The ultimate biological impact of this accumulation on macrophage function, however, is not fully understood. In this study, nontoxic doses of two durable NPs, SiO2 and

Effects of sex hormones on inflammatory response in male and female vascular endothelial cells.

Giosuè Annibalini et al.

Journal of endocrinological investigation, 37(9), 861-869 (2014-06-21)

Gender-related differences in sex hormones might have a key role in the development of atherosclerosis though direct vascular effects of sex hormones are not yet well understood. Thus, the main purpose of this study was to compare the effects of

Residual structure of Streptococcus mutans biofilm following complete disinfection favors secondary bacterial adhesion and biofilm re-development.

Tatsuya Ohsumi et al.

PloS one, 10(1), e0116647-e0116647 (2015-01-31)

Chemical disinfection of oral biofilms often leaves biofilm structures intact. This study aimed to examine whether the residual structure promotes secondary bacterial adhesion. Streptococcus mutans biofilms generated on resin-composite disks in a rotating disc reactor were disinfected completely with 70%

Controlled dual delivery of BMP-2 and dexamethasone by nanoparticle-embedded electrospun nanofibers for the efficient repair of critical-sized rat calvarial defect.

Long Li et al.

Biomaterials, 37, 218-229 (2014-12-03)

There is an urgent need to develop biomimetic bone tissue engineering scaffolds for the repair of critical-sized calvarial defect. In this study, we developed a new nanoparticle-embedded electrospun nanofiber scaffold for the controlled dual delivery of BMP-2 and dexamethasone (DEX).

The effect of oscillatory mechanical stimulation on osteoblast attachment and proliferation.

Ashkan Aryaei et al.

Materials science & engineering. C, Materials for biological applications, 52, 129-134 (2015-05-09)

The aim of this paper is to investigate the effect of the magnitude and duration of oscillatory mechanical stimulation on osteoblast attachment and proliferation as well as the time gap between seeding and applying the stimulation. Cells were exposed to

Gram-scale synthesis of coordination polymer nanodots with renal clearance properties for cancer theranostic applications.

Fuyao Liu et al.

Nature communications, 6, 8003-8003 (2015-08-08)

An ultrasmall hydrodynamic diameter is a critical factor for the renal clearance of nanoparticles from the body within a reasonable timescale. However, the integration of diagnostic and therapeutic components into a single ultrasmall nanoparticle remains challenging. In this study, pH-activated

Effects of cell-cell contact and oxygen tension on chondrogenic differentiation of stem cells.

Bin Cao et al.

Biomaterials, 64, 21-32 (2015-06-27)

While cell condensation has been thought to enhance chondrogenesis, no direct evidence so far confirms that cell-cell contact itself increases chondrogenic differentiation of stem cells, since the change of cell-cell contact is usually coupled with those of other cell geometry

Regulation of multidrug resistance proteins by genistein in a hepatocarcinoma cell line: impact on sorafenib cytotoxicity.

Juan Pablo Rigalli et al.

PloS one, 10(3), e0119502-e0119502 (2015-03-18)

Hepatocellular carcinoma (HCC) is the fifth most frequent cancer worldwide. Sorafenib is the only drug available that improves the overall survival of HCC patients. P-glycoprotein (P-gp), Multidrug resistance-associated proteins 2 and 3 (MRP2 and 3) and Breast cancer resistance protein

Reduction of the inflammatory responses against alginate-poly-L-lysine microcapsules by anti-biofouling surfaces of PEG-b-PLL diblock copolymers.

Milica Spasojevic et al.

PloS one, 9(10), e109837-e109837 (2014-10-28)

Large-scale application of alginate-poly-L-lysine (alginate-PLL) capsules used for microencapsulation of living cells is hampered by varying degrees of success, caused by tissue responses against the capsules in the host. A major cause is proinflammatory PLL which is applied at the

Prion protein interaction with soil humic substances: environmental implications.

Gabriele Giachin et al.

PloS one, 9(6), e100016-e100016 (2014-06-18)

Transmissible spongiform encephalopathies (TSE) are fatal neurodegenerative disorders caused by prions. Animal TSE include scrapie in sheep and goats, and chronic wasting disease (CWD) in cervids. Effective management of scrapie in many parts of the world, and of CWD in

NH4(+) triggers the release of astrocytic lactate via mitochondrial pyruvate shunting.

Rodrigo Lerchundi et al.

Proceedings of the National Academy of Sciences of the United States of America, 112(35), 11090-11095 (2015-08-20)

Neural activity is accompanied by a transient mismatch between local glucose and oxygen metabolism, a phenomenon of physiological and pathophysiological importance termed aerobic glycolysis. Previous studies have proposed glutamate and K(+) as the neuronal signals that trigger aerobic glycolysis in

Differential regulation of macrophage phenotype by mature and pro-nerve growth factor.

Kimberly S Williams et al.

Journal of neuroimmunology, 285, 76-93 (2015-07-23)

To characterize the role of neurotrophin receptors on macrophages, we investigated the ability of nerve growth factor (NGF) and its precursor, proNGF, to regulate human macrophage phenotype. The p75 neurotrophin receptor (p75(NTR)) and TrkA were concentrated within overlapping domains on

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