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Showing 1-30 of 42 results for "C160" within Papers
Eleanor I Ager et al.
BMC cancer, 11, 274-274 (2011-06-28)
Targeting of the renin angiotensin system (RAS) reduces tumour growth in experimental models of cancer. We aimed to establish if combined targeting of the 'classical' and 'alternative' arms of the RAS could result in synergistic inhibition of colorectal cancer (CRC)
Takashi Nishinaka et al.
Diabetes & vascular disease research, 17(1), 1479164119896975-1479164119896975 (2020-02-01)
Advanced glycation end-products, especially toxic advanced glycation end-products derived from glyceraldehyde (advanced glycation end-product-2) and glycolaldehyde (advanced glycation end-product-3), are biologically reactive compounds associated with diabetic complications. We previously demonstrated that toxic advanced glycation end-products were internalised into macrophage-like RAW264.7
Rifat Sabuhi et al.
American journal of physiology. Renal physiology, 299(4), F815-F820 (2010-07-30)
A positive association between renin-angiotensin system, especially AT1 receptor, and oxidative stress in the pathogenesis of hypertension and cardiovascular/renal diseases has been suggested. However, the role of oxidative stress, especially superoxide radicals in renal sodium handling in response to AT1
L Laflamme et al.
The Journal of biological chemistry, 271(37), 22729-22735 (1996-09-13)
In the present study, 3-day treatment of nondifferentiated NG108-15 cells with 100 nM angiotensin II (Ang II) induces morphological differentiation of neuronal cells characterized by the outgrowth of neurites. These morphological changes are correlated with an increase in the level
F M Heemskerk et al.
Brain research, 677(1), 29-38 (1995-04-17)
Most radiolabeled ligands for angiotensin II (Ang II) receptors do not discriminate between the AT1 and AT2 receptor subtypes, which must be distinguished by displacement with selective AT1 or AT2 ligands. We compared [125I]CGP 42112 with the non-selective agonist [125I]Sar1
Claudia A McCarthy et al.
Current hypertension reports, 15(1), 25-30 (2012-12-12)
It is quite well established that activation of the AT(2) receptor (AT(2)R) provides a counter-regulatory role to AT(1)R overactivity, particularly during pathological conditions. Indeed, a potential therapeutic role for the AT(2)R is currently being promulgated with the introduction of novel
Liping Zhu et al.
American journal of physiology. Heart and circulatory physiology, 302(12), H2553-H2559 (2012-04-24)
ANG II type 2 receptors (AT(2)R) elicit cardioprotective effects in part by stimulating the release of kinins; however, the mechanism(s) responsible have not been fully explored. We demonstrated previously that overexpression of AT(2)R increased expression of prolylcarboxypeptidase (PRCP; a plasma
Jian Yang et al.
Journal of hypertension, 30(6), 1176-1184 (2012-04-17)
The renin-angiotensin (Ang) system controls blood pressure, in part, by regulating renal tubular sodium transport. In the kidney, activation of the angiotensin II type 1 (AT(1)) receptor increases renal sodium reabsorption, whereas the angiotensin II type 2 (AT(2)) receptor produces
Claudia A McCarthy et al.
Stroke, 40(4), 1482-1489 (2009-02-28)
The angiotensin II type 2 receptor (AT(2)R) is implicated to be neuroprotective in stroke, although this premise has not been directly tested. Therefore, we have examined the neuroprotective effect of AT(2)R stimulation after intracerebroventricular administration of AT(2)R agonist CGP42112 in
Renfang Song et al.
American journal of physiology. Renal physiology, 298(3), F807-F817 (2009-12-25)
ANG II AT2 receptor (AT2R)-deficient mice exhibit abnormal ureteric bud (UB) budding, increased incidence of double ureters, and vesicoureteral reflux. However, the role of the AT2R during UB morphogenesis and the mechanisms by which aberrant AT2R signaling disrupts renal collecting
Shahnawaz Ali Bhat et al.
Molecular neurobiology, 56(4), 3005-3023 (2018-08-05)
Microglia-induced reactive oxygen species (ROS) production and inflammation play an imperative role in neurodegenerative diseases like Alzheimer's disease (AD) and Parkinson's disease (PD). It has been established that angiotensin II type-2 receptor (AT2R) activation is neuroprotective in central nervous system
Tomoko Kanome et al.
Hypertension research : official journal of the Japanese Society of Hypertension, 31(9), 1801-1810 (2008-10-31)
Angiotensin II (Ang II) is known to accelerate the progression of macrophage-driven atherosclerotic lesions. Acyl-CoA:cholesterol acyltransferase-1 (ACAT1) converts intracellular free cholesterol into cholesterol ester (CE) for storage in lipid droplets, and promotes foam cell formation in atherosclerotic lesions. The present
Shan Gao et al.
Peptides, 47, 36-44 (2013-06-25)
Angiotensin II (Ang II) type 1 receptor (AT1R) mediates the major cardiovascular effects of Ang II. However, the effects mediated via AT2R are still controversial. The aim of the present study is to define the effect of AT2R agonist CGP42112A
A Pelegrini-da-Silva et al.
Neuroscience, 164(3), 1263-1273 (2009-09-15)
Endogenous angiotensin (Ang) II and/or an Ang II-derived peptide, acting on Ang type 1 (AT(1)) and Ang type 2 (AT(2)) receptors, can carry out part of the nociceptive control modulated by periaqueductal gray matter (PAG). However, neither the identity of
F Côté et al.
The Journal of biological chemistry, 274(44), 31686-31692 (1999-10-26)
Microexplant cultures from three-day-old rats were used to investigate whether angiotensin II (Ang II), through its AT(1) and AT(2) receptors, could be involved in the morphological differentiation of cerebellar cells. Specific activation of the AT(2) receptor during 4-day treatment induced
Angiotensin II type 2 receptor agonists as therapies for ischemic stroke.
Anne M Dorrance
Hypertension (Dallas, Tex. : 1979), 60(6), 1391-1392 (2012-10-24)
Naghmeh Varghayee et al.
Journal of the renin-angiotensin-aldosterone system : JRAAS, 16(1), 79-91 (2013-04-06)
Cardiac hypertrophy in myocytes is in part regulated by changes in expression of a novel Ang II type 2 receptor (AT2-receptor) interacting protein identified as ATIP. The role of the AT2-receptor in cardiac hypertrophy is controversial, with some reports indicating
Francesca Sbrana et al.
American journal of physiology. Cell physiology, 295(1), C160-C172 (2008-05-16)
Membrane-cytoskeleton interaction regulates transmembrane currents through stretch-activated channels (SACs); however, the mechanisms involved have not been tested in living cells. We combined atomic force microscopy, confocal immunofluorescence, and patch-clamp analysis to show that stress fibers (SFs) in C2C12 myoblasts behave
Claudia A McCarthy et al.
Hypertension (Dallas, Tex. : 1979), 60(6), 1531-1537 (2012-10-24)
We have demonstrated previously that pretreatment with an angiotensin II type 2 receptor (AT(2)R) agonist is neuroprotective against a subsequent stroke independent of any changes in blood pressure. Therefore, in the current study, we have examined the potential neuroprotective effect
E Chamoux et al.
The Journal of clinical endocrinology and metabolism, 84(12), 4722-4730 (1999-12-22)
The aim of this study was to establish a link between the highly expressed angiotensin II (Ang II) type 2 receptor (AT2) in human fetal adrenal cells and the proposed apoptotic activity in the center of the gland. There was
Kumiko Taguchi et al.
Pharmacological research, 66(1), 41-50 (2012-04-03)
Angiotensin II type 2 receptor (AT(2)R) stimulation may cause vasodilation. It could thereby contribute to the antihypertensive effects of angiotensin II type 1 receptor (AT(1)R) antagonists since AT(1)R blockade reportedly increases endogenous levels of Ang II, and this may then
Lie Gao et al.
Hypertension (Dallas, Tex. : 1979), 52(4), 708-714 (2008-09-05)
Upregulation of angiotensin II type 1 receptors (AT(1)R) in the rostral ventrolateral medulla (RVLM) contributes to the sympathoexcitation in the chronic heart failure (CHF). However, the role of angiotensin II type 2 receptor (AT(2)R) is not clear. In this study
Peter M Abadir et al.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 31(6), 471-474 (2011-02-04)
Angiotensin subtype-1 receptor (AT(1)R) influences inflammatory processes through enhancing signal transducer and activator of transcription proteins 3 (STAT3) signal transduction, resulting in increased tumor necrosis factor-α (TNF-α) production. Although angiotensin subtype-2 receptor (AT(2)R), in general, antagonizes AT(1)R-stimulated activity, it is
Rafael Rivas-Santisteban et al.
Journal of neuroinflammation, 17(1), 243-243 (2020-08-19)
The renin-angiotensin system (RAS) is altered in Parkinson's disease (PD), a disease due to substantia nigra neurodegeneration and whose dopamine-replacement therapy, using the precursor levodopa, leads to dyskinesias as the main side effect. Angiotensin AT1 and AT2 receptors, mainly known
Rifat Sabuhi et al.
American journal of physiology. Renal physiology, 300(3), F700-F706 (2011-01-07)
Inflammation and oxidative stress are believed to contribute to hypertension in obesity/diabetes. Recently, we reported a role for the AT(2) receptor in blood pressure control in obese Zucker rats. However, the role of AT(2) receptors in inflammation and oxidative stress
D M Pechlivanova et al.
Peptides, 39, 152-156 (2012-12-04)
Phasic pain demonstrates significant diurnal variation in rats. Angiotensin II modulates pain transmission and the diurnal variation in nociception in several rodent pain models. The participation of AT2 receptors in the diurnal regulation of nociception is not yet elucidated. In
K Takekoshi et al.
Biochemical and biophysical research communications, 272(2), 544-550 (2000-06-02)
Angiotensin II subtype 2 receptor (AT(2)-R) is abundantly expressed in adrenal medullary chromaffin cells. However, the physiological roles of AT(2)-R in chromaffin cells remain to be clarified. Therefore, we investigated the effects of CGP42112 (AT(2)-R agonist) on catecholamine biosynthesis in
Nancy J Hong et al.
Hypertension (Dallas, Tex. : 1979), 60(3), 765-769 (2012-07-11)
NO reduces NaCl absorption by thick ascending limbs (TALs) by inhibiting the Na/K/2Cl cotransporter (NKCC2). We have shown that NO-induced inhibition of Na transport is reduced in Dahl salt-sensitive rat (SS) TALs. Angiotensin II increases NO production in TALs via
Carmen Diaz-Ruiz et al.
The journals of gerontology. Series A, Biological sciences and medical sciences, 75(3), 416-424 (2018-11-10)
Sirtuin 3 (SIRT3) and angiotensin play a major role in aging-related disorders. Both modulate oxidative stress and neurodegeneration. We investigated the interaction between SIRT3 and angiotensin II (AngII) in the dopaminergic system. Both in vivo and in vitro, treatment with
Angiotensin II type 2 receptor-mediated inhibition of norepinephrine release in isolated rat hearts.
Tetsumasa Sasaoka et al.
Journal of cardiovascular pharmacology, 52(2), 176-183 (2008-08-02)
We investigated whether endogenous and exogenous angiotensin II (Ang II) regulates norepinephrine (NE) release from cardiac sympathetic nerves via both Ang II type 2 receptors (AT2Rs) and Ang II type 1 receptors (AT1Rs). Using isolated rat hearts, sympathetic nerves were
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