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Showing 1-30 of 42 results for "C160" within Papers
Tomoko Kanome et al.
Hypertension research : official journal of the Japanese Society of Hypertension, 31(9), 1801-1810 (2008-10-31)
Angiotensin II (Ang II) is known to accelerate the progression of macrophage-driven atherosclerotic lesions. Acyl-CoA:cholesterol acyltransferase-1 (ACAT1) converts intracellular free cholesterol into cholesterol ester (CE) for storage in lipid droplets, and promotes foam cell formation in atherosclerotic lesions. The present
Shan Gao et al.
Peptides, 47, 36-44 (2013-06-25)
Angiotensin II (Ang II) type 1 receptor (AT1R) mediates the major cardiovascular effects of Ang II. However, the effects mediated via AT2R are still controversial. The aim of the present study is to define the effect of AT2R agonist CGP42112A
F Côté et al.
The Journal of biological chemistry, 274(44), 31686-31692 (1999-10-26)
Microexplant cultures from three-day-old rats were used to investigate whether angiotensin II (Ang II), through its AT(1) and AT(2) receptors, could be involved in the morphological differentiation of cerebellar cells. Specific activation of the AT(2) receptor during 4-day treatment induced
A Pelegrini-da-Silva et al.
Neuroscience, 164(3), 1263-1273 (2009-09-15)
Endogenous angiotensin (Ang) II and/or an Ang II-derived peptide, acting on Ang type 1 (AT(1)) and Ang type 2 (AT(2)) receptors, can carry out part of the nociceptive control modulated by periaqueductal gray matter (PAG). However, neither the identity of
Angiotensin II type 2 receptor agonists as therapies for ischemic stroke.
Anne M Dorrance
Hypertension (Dallas, Tex. : 1979), 60(6), 1391-1392 (2012-10-24)
Claudia A McCarthy et al.
Current hypertension reports, 15(1), 25-30 (2012-12-12)
It is quite well established that activation of the AT(2) receptor (AT(2)R) provides a counter-regulatory role to AT(1)R overactivity, particularly during pathological conditions. Indeed, a potential therapeutic role for the AT(2)R is currently being promulgated with the introduction of novel
L Laflamme et al.
The Journal of biological chemistry, 271(37), 22729-22735 (1996-09-13)
In the present study, 3-day treatment of nondifferentiated NG108-15 cells with 100 nM angiotensin II (Ang II) induces morphological differentiation of neuronal cells characterized by the outgrowth of neurites. These morphological changes are correlated with an increase in the level
Renfang Song et al.
American journal of physiology. Renal physiology, 298(3), F807-F817 (2009-12-25)
ANG II AT2 receptor (AT2R)-deficient mice exhibit abnormal ureteric bud (UB) budding, increased incidence of double ureters, and vesicoureteral reflux. However, the role of the AT2R during UB morphogenesis and the mechanisms by which aberrant AT2R signaling disrupts renal collecting
F M Heemskerk et al.
Brain research, 677(1), 29-38 (1995-04-17)
Most radiolabeled ligands for angiotensin II (Ang II) receptors do not discriminate between the AT1 and AT2 receptor subtypes, which must be distinguished by displacement with selective AT1 or AT2 ligands. We compared [125I]CGP 42112 with the non-selective agonist [125I]Sar1
Claudia A McCarthy et al.
Stroke, 40(4), 1482-1489 (2009-02-28)
The angiotensin II type 2 receptor (AT(2)R) is implicated to be neuroprotective in stroke, although this premise has not been directly tested. Therefore, we have examined the neuroprotective effect of AT(2)R stimulation after intracerebroventricular administration of AT(2)R agonist CGP42112 in
Takashi Nishinaka et al.
Diabetes & vascular disease research, 17(1), 1479164119896975-1479164119896975 (2020-02-01)
Advanced glycation end-products, especially toxic advanced glycation end-products derived from glyceraldehyde (advanced glycation end-product-2) and glycolaldehyde (advanced glycation end-product-3), are biologically reactive compounds associated with diabetic complications. We previously demonstrated that toxic advanced glycation end-products were internalised into macrophage-like RAW264.7
Eleanor I Ager et al.
BMC cancer, 11, 274-274 (2011-06-28)
Targeting of the renin angiotensin system (RAS) reduces tumour growth in experimental models of cancer. We aimed to establish if combined targeting of the 'classical' and 'alternative' arms of the RAS could result in synergistic inhibition of colorectal cancer (CRC)
Shahnawaz Ali Bhat et al.
Molecular neurobiology, 56(4), 3005-3023 (2018-08-05)
Microglia-induced reactive oxygen species (ROS) production and inflammation play an imperative role in neurodegenerative diseases like Alzheimer's disease (AD) and Parkinson's disease (PD). It has been established that angiotensin II type-2 receptor (AT2R) activation is neuroprotective in central nervous system
Liping Zhu et al.
American journal of physiology. Heart and circulatory physiology, 302(12), H2553-H2559 (2012-04-24)
ANG II type 2 receptors (AT(2)R) elicit cardioprotective effects in part by stimulating the release of kinins; however, the mechanism(s) responsible have not been fully explored. We demonstrated previously that overexpression of AT(2)R increased expression of prolylcarboxypeptidase (PRCP; a plasma
Francesca Sbrana et al.
American journal of physiology. Cell physiology, 295(1), C160-C172 (2008-05-16)
Membrane-cytoskeleton interaction regulates transmembrane currents through stretch-activated channels (SACs); however, the mechanisms involved have not been tested in living cells. We combined atomic force microscopy, confocal immunofluorescence, and patch-clamp analysis to show that stress fibers (SFs) in C2C12 myoblasts behave
Naghmeh Varghayee et al.
Journal of the renin-angiotensin-aldosterone system : JRAAS, 16(1), 79-91 (2013-04-06)
Cardiac hypertrophy in myocytes is in part regulated by changes in expression of a novel Ang II type 2 receptor (AT2-receptor) interacting protein identified as ATIP. The role of the AT2-receptor in cardiac hypertrophy is controversial, with some reports indicating
Claudia A McCarthy et al.
Hypertension (Dallas, Tex. : 1979), 60(6), 1531-1537 (2012-10-24)
We have demonstrated previously that pretreatment with an angiotensin II type 2 receptor (AT(2)R) agonist is neuroprotective against a subsequent stroke independent of any changes in blood pressure. Therefore, in the current study, we have examined the potential neuroprotective effect
Jian Yang et al.
Journal of hypertension, 30(6), 1176-1184 (2012-04-17)
The renin-angiotensin (Ang) system controls blood pressure, in part, by regulating renal tubular sodium transport. In the kidney, activation of the angiotensin II type 1 (AT(1)) receptor increases renal sodium reabsorption, whereas the angiotensin II type 2 (AT(2)) receptor produces
Rifat Sabuhi et al.
American journal of physiology. Renal physiology, 299(4), F815-F820 (2010-07-30)
A positive association between renin-angiotensin system, especially AT1 receptor, and oxidative stress in the pathogenesis of hypertension and cardiovascular/renal diseases has been suggested. However, the role of oxidative stress, especially superoxide radicals in renal sodium handling in response to AT1
C Sumners et al.
Proceedings of the National Academy of Sciences of the United States of America, 88(17), 7567-7571 (1991-09-01)
Both neurons and astrocytes contain specific receptors for angiotensin II (AII). We used selective ligands for the AT1 and AT2 types of AII receptors to investigate the expression of functional receptor subtypes in astrocyte cultures and neuron cultures from 1-day-old
Ana I Rodriguez-Perez et al.
Brain, behavior, and immunity, 87, 256-271 (2019-12-22)
Overactivity of the angiotensin-type-1 receptor (AT1)/NADPH-oxidase axis enhances aging processes, neuroinflammation and neurodegeneration. The role of AT2 receptors in the above-mentioned AT1-related effects in the aged brain, particularly substantia nigra, was investigated in this study. In the nigra, we observed
Nancy J Hong et al.
Hypertension (Dallas, Tex. : 1979), 60(3), 765-769 (2012-07-11)
NO reduces NaCl absorption by thick ascending limbs (TALs) by inhibiting the Na/K/2Cl cotransporter (NKCC2). We have shown that NO-induced inhibition of Na transport is reduced in Dahl salt-sensitive rat (SS) TALs. Angiotensin II increases NO production in TALs via
K Takekoshi et al.
Biochemical and biophysical research communications, 272(2), 544-550 (2000-06-02)
Angiotensin II subtype 2 receptor (AT(2)-R) is abundantly expressed in adrenal medullary chromaffin cells. However, the physiological roles of AT(2)-R in chromaffin cells remain to be clarified. Therefore, we investigated the effects of CGP42112 (AT(2)-R agonist) on catecholamine biosynthesis in
Angiotensin AT2 receptor-mediated neuroprotection and nitric oxide-bioavailability in stroke.
Kazushi Tsuda
Stroke, 40(7), e493-e493 (2009-06-06)
Flavia Axelband et al.
Regulatory peptides, 177(1-3), 27-34 (2012-05-09)
We recently demonstrated that Angiotensin-(3-4) [Ang-(3-4)], an Ang II-derived dipeptide, overcomes inhibition of plasma membrane Ca(2+)-ATPase promoted by nanomolar concentrations of Ang II in basolateral membranes of renal proximal tubule cells, with involvement of a so far unknown AT(2)R-dependent and
Angiotensin II type 2 receptor-mediated inhibition of norepinephrine release in isolated rat hearts.
Tetsumasa Sasaoka et al.
Journal of cardiovascular pharmacology, 52(2), 176-183 (2008-08-02)
We investigated whether endogenous and exogenous angiotensin II (Ang II) regulates norepinephrine (NE) release from cardiac sympathetic nerves via both Ang II type 2 receptors (AT2Rs) and Ang II type 1 receptors (AT1Rs). Using isolated rat hearts, sympathetic nerves were
Carmen Diaz-Ruiz et al.
The journals of gerontology. Series A, Biological sciences and medical sciences, 75(3), 416-424 (2018-11-10)
Sirtuin 3 (SIRT3) and angiotensin play a major role in aging-related disorders. Both modulate oxidative stress and neurodegeneration. We investigated the interaction between SIRT3 and angiotensin II (AngII) in the dopaminergic system. Both in vivo and in vitro, treatment with
R M A van de Wal et al.
Journal of cardiovascular pharmacology, 50(4), 372-379 (2007-12-01)
Several animal studies suggested that the angiotensin II type 2 (AT2) receptor subtype mediates vasodilation, yet the results in human arteries are less well described and more inconsistent. Therefore, we evaluated the role of the AT2 receptor stimulation on the
D M Pechlivanova et al.
Peptides, 39, 152-156 (2012-12-04)
Phasic pain demonstrates significant diurnal variation in rats. Angiotensin II modulates pain transmission and the diurnal variation in nociception in several rodent pain models. The participation of AT2 receptors in the diurnal regulation of nociception is not yet elucidated. In
Gábor Raffai et al.
American journal of physiology. Heart and circulatory physiology, 301(4), H1341-H1352 (2011-08-02)
This study determined the effect of ANG-(1-7) on salt-induced suppression of endothelium-dependent vasodilatation in the mesenteric arteries of male Sprague-Dawley rats. Chronic intravenous infusion of ANG-(1-7), oral administration of the nonpeptide mas receptor agonist AVE-0991, and acute preincubation of the
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