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Showing 1-30 of 208 results for "C2674" within Papers
Inês Mahú et al.
Cell metabolism, 31(6), 1120-1135 (2020-05-14)
Anti-obesity drugs in the amphetamine (AMPH) class act in the brain to reduce appetite and increase locomotion. They are also characterized by adverse cardiovascular effects with origin that, despite absence of any in vivo evidence, is attributed to a direct sympathomimetic action
Esmé T I van der Gracht et al.
iScience, 24(1), 101954-101954 (2021-01-19)
Factors that govern the complex formation of memory T cells are not completely understood. A better understanding of the development of memory T cell heterogeneity is however required to enhance vaccination and immunotherapy approaches. Here we examined the impact of pathogen- and
Sandrine Verpoorten et al.
Acta physiologica (Oxford, England), 228(3), e13395-e13395 (2019-10-11)
The prevalence of obesity is a major risk factor for cardiovascular and metabolic diseases including impaired skeletal muscle regeneration. Since skeletal muscle regenerative capacity is regulated by satellite cells, we aimed to investigate whether a high-fat diet impairs satellite cell
Yehia F El Garem et al.
Journal of andrology, 23(6), 825-829 (2002-10-26)
Inhibin B is bidirectionally secreted by Sertoli cells, basal secretion into the circulation exerts negative feedback on follicle-stimulating hormone secretion, and serum inhibin B is considered a marker of spermatogenesis. The precise role of apical secretion is unknown. The objective
Juliet R Girard et al.
eLife, 10 (2021-10-30)
Mechanistic studies of Drosophila lymph gland hematopoiesis are limited by the availability of cell-type-specific markers. Using a combination of bulk RNA-Seq of FACS-sorted cells, single-cell RNA-Seq, and genetic dissection, we identify new blood cell subpopulations along a developmental trajectory with
A Gaspar et al.
Journal of medicine and life, 4(2), 172-177 (2011-07-22)
The aim of this study was to obtain four collagen based porous scaffolds and to assess their in vitro biocompatibility and biodegradability in order to use them for skin tissue engineering. We have prepared four variants of collagen-based biodegradable sponges
The CHARGE syndrome-associated protein FAM172A controls AGO2 nuclear import.
Sallis, et al.
Life science alliance, 6 (2023)
Philipp-Sebastian Koch et al.
Frontiers in physiology, 12, 722394-722394 (2021-10-19)
Endothelial wingless-related integration site (Wnt)-/β-catenin signaling is a key regulator of the tightly sealed blood-brain barrier. In the hepatic vascular niche angiokine-mediated Wnt signaling was recently identified as an important regulator of hepatocyte function, including the determination of final adult
David Scully et al.
Acta physiologica (Oxford, England), 225(3), e13207-e13207 (2018-10-20)
The use of platelets as biomaterials has gained intense research interest. However, the mechanisms regarding platelet-mediated skeletal myogenesis remain to be established. The aim of this study was to determine the role of platelet releasate in skeletal myogenesis and muscle
Lisa M Augustine et al.
Drug metabolism and disposition: the biological fate of chemicals, 33(1), 182-189 (2004-10-21)
A major function of xenobiotic and endobiotic transporters is to move a wide range of organic substances across cell membranes. Sertoli cells play an important role in protecting developing germ cells by forming a physiological barrier, limiting exposure to potentially
Anna Adam-Artigues et al.
Science advances, 8(20), eabk2746-eabk2746 (2022-05-21)
Anti-HER2 therapies have markedly improved prognosis of HER2-positive breast cancer. However, different mechanisms play a role in treatment resistance. Here, we identified AXL overexpression as an essential mechanism of trastuzumab resistance. AXL orchestrates epithelial-to-mesenchymal transition and heterodimerizes with HER2, leading
Naomi Ohbayashi et al.
Applied and environmental microbiology, 78(16), 5839-5844 (2012-06-12)
The clostridial collagenases G and H are multidomain proteins. For collagen digestion, the domain arrangement is likely to play an important role in collagen binding and hydrolysis. In this study, the full-length collagenase H protein from Clostridium histolyticum was expressed
Human group 2 innate lymphoid cells do not express the IL-5 receptor.
Adam K A Wright et al.
The Journal of allergy and clinical immunology, 140(5), 1430-1433 (2017-05-16)
Rumela Chakrabarti et al.
Methods in molecular biology (Clifton, N.J.), 1267, 367-380 (2015-02-01)
Metastatic spread of cancer cells is the main cause of death of breast cancer patients. A better understanding of the molecular mechanism of cancer metastasis is essential for the development of novel and effective therapies. The biological complexity of the
M Feldman et al.
Journal of applied microbiology, 113(2), 438-447 (2012-05-09)
Periodontitis is an inflammatory disease of polymicrobial origin that affects the tooth-supporting tissues. With the spread of antibiotic resistance among pathogenic bacteria, alternative strategies are required to better control infectious diseases such as periodontitis. The aim of our study was
Irina Yu Zhuravleva et al.
Materials science & engineering. C, Materials for biological applications, 118, 111473-111473 (2020-12-02)
Bioprosthetic heart valves made from bovine pericardium (BP) and porcine pericardium (PP) preserved with glutaraldehyde (GA) are commonly used in valve surgeries but prone to calcification in many patients. In this study, we compared BP and PP preserved with GA
Yulia Shwartz et al.
Cell, 182(3), 578-593 (2020-07-18)
Piloerection (goosebumps) requires concerted actions of the hair follicle, the arrector pili muscle (APM), and the sympathetic nerve, providing a model to study interactions across epithelium, mesenchyme, and nerves. Here, we show that APMs and sympathetic nerves form a dual-component
Derek J Milner et al.
Cell and tissue research, 372(3), 507-522 (2018-01-11)
Advances in stem cell biology and materials science have provided a basis for developing tissue engineering methods to repair muscle injury. Among stem cell populations with potential to aid muscle repair, adipose-derived mesenchymal stem cells (ASC) hold great promise. To
Athanasios Papadas et al.
Cell reports, 40(7), 111201-111201 (2022-08-18)
Stimulatory type 1 conventional dendritic cells (cDC1s) engage in productive interactions with CD8+ effectors along tumor-stroma boundaries. The paradoxical accumulation of "poised" cDC1s within stromal sheets is unlikely to simply reflect passive exclusion from tumor cores. Drawing parallels with embryonic
Elaeophora schneideri Wehr and Dickmans, 1935 in white-tailed deer from the Edwards Plateau of Texas.
D D Waid et al.
Journal of wildlife diseases, 20(4), 342-345 (1984-10-01)
Lenka Gahurova et al.
Epigenetics & chromatin, 10, 25-25 (2017-05-17)
Gametogenesis in mammals entails profound re-patterning of the epigenome. In the female germline, DNA methylation is acquired late in oogenesis from an essentially unmethylated baseline and is established largely as a consequence of transcription events. Molecular and functional studies have
Thomas J Edkins et al.
Clinical and vaccine immunology : CVI, 19(4), 562-569 (2012-02-24)
Collagenase Clostridium histolyticum (CCH) contains a fixed ratio of class I (AUX-I) and class II (AUX-II) collagenases and is used as treatment for Dupuytren's contracture. These two Zn-dependent enzymes, produced by the Gram-positive bacterium Clostridium histolyticum, are related functionally to
Miriam Landfors et al.
Cell discovery, 3, 17013-17013 (2017-05-23)
Sertoli cells have dual roles during the cells' lifetime. In the juvenile mammal, Sertoli cells proliferate and create the structure of the testis, and during puberty they cease to proliferate and take on the adult role of supporting germ cells
David Smith et al.
Frontiers in cellular and infection microbiology, 11, 733811-733811 (2021-09-28)
Gastrointestinal (GI) infections in sheep have significant implications for animal health, welfare and productivity, as well as being a source of zoonotic pathogens. Interactions between pathogens and epithelial cells at the mucosal surface play a key role in determining the
Anna Sophia Jauch et al.
Cancer cell international, 22(1), 398-398 (2022-12-11)
Hyaluronan receptor LYVE-1 is expressed by liver sinusoidal endothelial cells (LSEC), lymphatic endothelial cells and specialized macrophages. Besides binding to hyaluronan, LYVE-1 can mediate adhesion of leukocytes and cancer cells to endothelial cells. Here, we assessed the impact of LYVE-1
Sze Wan Hung et al.
Frontiers in pharmacology, 12, 714790-714790 (2021-11-02)
Endometriosis is defined as endometrial tissues found outside the uterine cavity. ProEGCG is a prodrug of Epigallocatechin gallate (EGCG), a potent polyphenol found in green tea. It inhibits the development of endometriotic lesions of mouse model in vivo, with higher
Karl-F Bergeron et al.
Disease models & mechanisms, 9(11), 1283-1293 (2016-09-03)
Waardenburg syndrome is a neurocristopathy characterized by a combination of skin and hair depigmentation, and inner ear defects. In the type 4 form, these defects show comorbidity with Hirschsprung disease, a disorder marked by an absence of neural ganglia in
Karolina Piekarska et al.
Nature communications, 13(1), 856-856 (2022-02-16)
Cell-based immunotherapies can provide safe and effective treatments for various disorders including autoimmunity, cancer, and excessive proinflammatory events in sepsis or viral infections. However, to achieve this goal there is a need for deeper understanding of mechanisms of the intercellular
Asieh Khalilpour et al.
Chemistry & biodiversity, 16(5), e1800563-e1800563 (2019-02-12)
A series of novel thiazolo[3,2-a]pyrimidines were synthesized and characterized by FT-IR, 1 H, 13 C-NMR and mass techniques. Their antioxidant activities were investigated by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay and the results showed that all the synthesized compounds exhibit good
Snahlata Singh et al.
Nature cell biology, 22(5), 591-602 (2020-04-15)
Triple-negative breast cancer (TNBC) is characterized by a high degree of immune infiltrate in the tumour microenvironment, which may influence the fate of TNBC cells. We reveal that loss of the tumour suppressive transcription factor Elf5 in TNBC cells activates
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