C3646

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Multiple effects of chitosan on plant systems: solid science or hype.

Lee A Hadwiger

Plant science : an international journal of experimental plant biology, 208, 42-49 (2013-05-21)

Chitosan, a naturally occurring polymer, became available in the 1980s in industrial quantities enabling it to be tested as an agricultural chemical. A usual procedure for developing agricultural chemicals starts by testing a number of different chemically synthesized molecules on

Pustulan Activates Chicken Bone Marrow-Derived Dendritic Cells In Vitro and Promotes Ex Vivo CD4+ T Cell Recall Response to Infectious Bronchitis Virus.

Frederik T Larsen et al.

Vaccines, 8(2) (2020-05-21)

Infectious bronchitis virus (IBV) is a highly contagious avian coronavirus. IBV causes substantial worldwide economic losses in the poultry industry. Vaccination with live-attenuated viral vaccines, therefore, are of critical importance. Live-attenuated viral vaccines, however, exhibit the potential for reversion to

Nanoparticles with surface antibody against CD98 and carrying CD98 small interfering RNA reduce colitis in mice.

Bo Xiao et al.

Gastroenterology, 146(5), 1289-1300 (2014-02-08)

Nanoparticles have been explored as carriers of small interfering RNAs (siRNAs) and might be developed to treat patients with inflammatory bowel disease (IBD). Overexpression of CD98 on the surface of colonic epithelial cells and macrophages promotes the development and progression

In vitro cell culture evaluation and in vivo efficacy of amphiphilic chitosan for oral insulin delivery.

R Shelma et al.

Journal of biomedical nanotechnology, 9(2), 167-176 (2013-05-01)

The overall goal of this paper was to enhance the bioavailability of orally delivered insulin. A mucoadhesive amphiphilic chitosan derivative, lauroyl sulphated chitosan (LSCS) was used as the oral carrier for insulin. Trans epithelial electrical resistance experiment was performed on

Preparation and characterization of EDTAD-modified magnetic-Fe3O4 chitosan composite: application of comparative adsorption of dye wastewater with magnetic chitosan.

Hongyu Yang et al.

Water science and technology : a journal of the International Association on Water Pollution Research, 68(1), 209-216 (2013-07-05)

Ethylenediaminetetraacetic dianhydride (EDTAD)-modified magnetic-Fe3O4 chitosan (EMC), prepared using the cross-link agent glutaraldehyde and chemicals Fe3O4, chitosan, and EDTAD, was used to compare the adsorption of methylene blue (MB) with magnetic chitosan (MC). The composite structure was confirmed by multiple characterization

Synthesis and characterization of diopside particles and their suitability along with chitosan matrix for bone tissue engineering in vitro and in vivo.

J Pradeep Kumar et al.

Journal of biomedical nanotechnology, 10(6), 970-981 (2014-04-23)

The scaffolds for bone tissue engineering should be porous to harbor the growth of new tissue ingrowths, biodegradable with no toxic end products, and biocompatible with no cytotoxicity. In this study we report that Diopside (CaMgSi2O6) (Dp) particles can be

Bioengineering a highly vascularized matrix for the ectopic transplantation of islets.

Cara E Ellis et al.

Islets, 5(5), 216-225 (2013-11-23)

Islet transplantation is a promising treatment for Type 1 diabetes; however limitations of the intra-portal site and poor revascularization of islets must be overcome. We hypothesize that engineering a highly vascularized collagen-based construct will allow islet graft survival and function

Mechanical characterization of biocompatible microspheres and microcapsules by direct compression.

Ling Zhao et al.

Artificial cells, blood substitutes, and immobilization biotechnology, 32(1), 25-40 (2004-03-19)

The mechanical properties of biocompatible microparticles including alginate microspheres and alginate-chitosan microcapsules with different wall thickness were determined using a micromanipulation technique. Single microparticles with diameters of 20-60 microm were compressed to a given deformation and held, and compressed to

The use of chitosan-based scaffolds to enhance regeneration in the nervous system.

Sara Gnavi et al.

International review of neurobiology, 109, 1-62 (2013-10-08)

Various biomaterials have been proposed to build up scaffolds for promoting neural repair. Among them, chitosan, a derivative of chitin, has been raising more and more interest among basic and clinical scientists. A number of studies with neuronal and glial

Synthesis and preliminary cellular evaluation of phosphonium chitosan derivatives as novel non-viral vector.

Changyun Qian et al.

Carbohydrate polymers, 97(2), 676-683 (2013-08-06)

In this study, N-phosphonium chitosans (NPCSs) with two degrees of substitution were synthesized in a homogeneous system as nonviral gene vectors. Grafted polymer/DNA complexes at various charge ratios were formulated and characterized. Particle sizes of NPCS/DNA complexes were between 110

Advances in chitosan-based drug delivery vehicles.

Liming Hu et al.

Nanoscale, 5(8), 3103-3111 (2013-03-22)

Within the past few years, chitosan-based drug delivery vehicles have become some of the most attractive to be studied. In contrast to all other polysaccharides, chitosan has demonstrated its unique characteristics for drug delivery platforms, including its active primary amino

In vitro ALP and osteocalcin gene expression analysis and in vivo biocompatibility of N-methylene phosphonic chitosan nanofibers for bone regeneration.

Pallab Datta et al.

Journal of biomedical nanotechnology, 9(5), 870-879 (2013-06-28)

Most polymeric nanofibers used for bone tissue engineering lack adequate functional groups for bioactivity. This study explores the potential of nanofibers of phosphate functionalized derivative of chitosan-N-methylene phosphonic chitosan (NMPC) for bone tissue engineering. Nanofibers were fabricated by electrospinning of

Optimization of self-nanoemulsifying systems for the enhancement of in vivo hypoglycemic efficacy of glimepiride transdermal patches.

Osama A A Ahmed et al.

Expert opinion on drug delivery, 11(7), 1005-1013 (2014-04-08)

To optimize and use of glimepiride (GMD)-loaded self-nanoemulsifying delivery systems (SNEDs) for the preparation of transdermal patches. Mixture design was utilized to optimize GMD-loaded SNEDs in acidic and aqueous pH media. Optimized GMD-loaded SNEDs were used in the preparation of

Chitosan-hyaluronan: promotion of mucociliary differentiation of respiratory epithelial cells and development of olfactory receptor neurons.

Tsung-Wei Huang et al.

Artificial cells, nanomedicine, and biotechnology, 47(1), 564-570 (2019-03-13)

Developing a biomaterial that promotes regeneration of both respiratory epithelium (RE) and olfactory neuroepithelium (ON) improves the surgical outcome of endoscopic sinus surgery. Although chitosan (CS) inhibits mucociliary differentiation of RE, it has been reported to regenerate ON. In addition

Involvement of mTOR-autophagy in the selection of primitive mesenchymal stem cells in chitosan film 3-dimensional culture.

Hsiao-Ying Chiu et al.

Scientific reports, 7(1), 10113-10113 (2017-09-02)

Mesenchymal stem cells (MSCs) in conventional monolayer culture are heterogeneous and contain a significant portion of senescent cells. MSCs cultured on chitosan film form 3-dimenional spheres, increase in stemness and differentiation capability; however, the underlying mechanisms remain elusive. We first

Development of innovative oil-core self-organized nanovesicles prepared with chitosan and lecithin using a 2(3) full-factorial design.

Sandra Elisa Haas et al.

Pharmaceutical development and technology, 19(7), 769-778 (2013-09-04)

The aim of this study was to develop innovative nanosystems with isopropyl myristate as the oil core of self-assembly nanovesicles constituted of chitosan and lecithin using a 2(3) factorial design. The factors analyzed were chitosan (X1, levels 4 and 8

Structural insights into the substrate-binding mechanism for a novel chitosanase.

Qianqian Lyu et al.

The Biochemical journal, 461(2), 335-345 (2014-04-29)

Chitosanase is able to specifically cleave β-1,4-glycosidic bond linkages in chitosan to produce a chito-oligomer product, which has found a variety of applications in many areas, including functional food and cancer therapy. Although several structures for chitosanase have been determined

Synthesis of chitosan 3,6-diphenylcarbamate-2-urea derivatives and their applications as chiral stationary phases for high-performance liquid chromatography.

Lili Zhang et al.

Journal of chromatography. A, 1365, 86-93 (2014-09-30)

Fourteen chitosan 3,6-diphenylcarbamate-2-urea derivatives were synthesized using well-deacetylated chitosan and the corresponding phenyl isocyanates. After coating them on silica gel, their chiral recognition abilities were evaluated as the chiral stationary phases (CSPs) for high-performance liquid chromatography. These coated-type CSPs exhibited

Characteristics of melanocyte spheroids formed through different biomaterial-induced processes.

Wen-Chu Hsiao et al.

Journal of the Formosan Medical Association = Taiwan yi zhi, 118(1 Pt 1), 152-161 (2018-03-04)

Cell behaviors in three-dimensional spheroids are known to be different from those in monolayer cultures; however, very few studies have compared the characteristics of cell spheroids formed through different biomaterial-induced processes. This study investigated the mechanism of melanocyte spheroid formation

Inhibition of Rac1 activity by controlled release of NSC23766 from chitosan microspheres effectively ameliorates osteoarthritis development in vivo.

Shouan Zhu et al.

Annals of the rheumatic diseases, 74(1), 285-293 (2013-11-22)

Osteoarthritis (OA) is a degenerative joint disease characterised by cartilage degradation and chondrocyte hypertrophy. A recent study showed that Rac1 promoted expression of MMP13 and chondrocyte hypertrophy within the growth plate. These findings warrant further investigations on the roles of

Layer-by-layer immobilized catalase on electrospun nanofibrous mats protects against oxidative stress induced by hydrogen peroxide.

Rong Huang et al.

Journal of biomedical nanotechnology, 10(7), 1346-1358 (2014-05-09)

Catalase, a kind of redox enzyme and generally recognized as an efficient agent for protecting cells against hydrogen peroxide (H2O2)-induced cytotoxicity. The immobilization of catalase was accomplished by depositing the positively charged chitosan and the negatively charged catalase on electrospun

Chitosan-containing bread made using marine shellfishery byproducts: functional, bioactive, and quality assessment of the end product.

Tomas Lafarga et al.

Journal of agricultural and food chemistry, 61(37), 8790-8796 (2013-08-22)

Chitosan is nature's second most abundant polymer after cellulose and forms the structural support in crustacean shell material and Basidomycete mushroom stalks. Chitosan is a known antimicrobial agent but, to date, was not examined as an antimicrobial agent in bread

Preparation and properties of chitosan/calcium phosphate composites for bone repair.

Shinn-Jyh Ding

Dental materials journal, 25(4), 706-712 (2007-03-07)

Chitosan/calcium phosphate (CaP) composites composed of bioactive calcium phosphate and flexible chitosan were made by a simple mixing-and-heating method. Phase composition, morphology, and mechanical properties--including in-air and in vitro fatigue behavior - were evaluated. Experimental results showed that the chitosan

Antioxidant and antimicrobial activity of Maillard reaction products from xylan with chitosan/chitooligomer/glucosamine hydrochloride/taurine model systems.

Shuping Wu et al.

Food chemistry, 148, 196-203 (2013-11-23)

The structure, UV absorbance, browning intensity, fluorescence changes, antioxidant activity and antimicrobial assessment of Maillard reaction products (MRPs) derived from xylan with chitosan, chitooligomer, glucosamine hydrochloride and taurine model systems were evaluated. The results revealed that all MRPs had similar

Effect of incorporation of nanoscale bioactive glass and hydroxyapatite in PCL/chitosan nanofibers for bone and periodontal tissue engineering.

K T Shalumon et al.

Journal of biomedical nanotechnology, 9(3), 430-440 (2013-04-30)

A biomimetic scaffold which can very closely mimic the extracellular matrix of the bone was fabricated by incorporating nano-bioceramic particles such as nano bioglass (nBG) and nano hydroxyapatite (nHAp) within electrospun nanofibrous scaffold. A comparative study between nHAp incorporated poly(caprolactone)

Immobilization of nitrite oxidizing bacteria using biopolymeric chitosan media.

Pranee Lertsutthiwong et al.

Journal of environmental sciences (China), 25(2), 262-267 (2013-04-20)

The effects of chitosan characteristics including the degree of deacetylation, molecular weight, particle size, pH pretreatment and immobilization time on the immobilization of nitrite-oxidizing bacteria (NOB) on biopolymeric chitosan were investigated. Nitrite removal efficiency of immobilized NOB depended on the

Proteomic profiling of Stemona alkaloids production response to chitosan elicitor.

S Dheeranupattana et al.

Pakistan journal of biological sciences : PJBS, 16(18), 950-954 (2014-02-08)

The study purposed to investigate the protein expression of Stemona alkaloids biosynthesis response to chitosan elicitor by 2D gel electrophoresis. The total proteins extraction of Stemona roots were performed for comparison with the control and chitosan treatments. It was found

Recent progress in chitosan bio-based soft nanomaterials.

Abdelkrim El Kadib et al.

Journal of nanoscience and nanotechnology, 14(1), 308-331 (2014-04-16)

Polysaccharides are a new class of pervasive biopolymers that display many advantages including wide availability, sustainability, inherent inclusion of chemical functionality, biocompatibility and biodegradability. Current efforts are focused on the catalytic transformation of these macromolecules into fuels and platform chemicals.

Early fungi from the Proterozoic era in Arctic Canada.

Corentin C Loron et al.

Nature, 570(7760), 232-235 (2019-05-24)

Fungi are crucial components of modern ecosystems. They may have had an important role in the colonization of land by eukaryotes, and in the appearance and success of land plants and metazoans1-3. Nevertheless, fossils that can unambiguously be identified as

Engineering interfacial properties by anionic surfactant-chitosan complexes to improve stability of oil-in-water emulsions.

Kyriaki G Zinoviadou et al.

Food & function, 3(3), 312-319 (2012-02-03)

Oil-in-water emulsions (10% w/w n-tetradecane) were prepared at pH = 5.7 by using, as surface active agents, electrostatically formed complexes of sodium stearoyl lactylate (SSL) at a concentration of 0.4% (w/w) and chitosan (CH) in a concentration range between 0

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