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Showing 1-30 of 140 results for "C5080" within Papers
Marianne T Vestermark et al.
Acta orthopaedica, 82(5), 614-621 (2011-09-08)
Allografts are often used during revision hip replacement surgery for stabilization of the implant. Resorption of the allograft may exceed new bone formation, and instability of the prosthesis can develop. We investigated whether strontium could regulate the imbalance of fast
Stéphanie Michineau et al.
Arteriosclerosis, thrombosis, and vascular biology, 34(8), 1747-1755 (2014-05-31)
Inflammation plays a critical role in the development of abdominal aortic aneurysms (AAAs). Because stromal cell-derived factor 1 (SDF-1) is known for its ability to attract inflammatory cells, we investigated whether SDF-1/chemokine (C-X-C motif) receptor 4 (CXCR4) axis is expressed
Cordula Stillhart et al.
Pharmaceutical research, 31(12), 3426-3444 (2014-06-26)
In vitro lipolysis is widely utilized for predicting in vivo performance of oral lipid-based formulations (LBFs). However, evaluation of LBFs in the absence of an absorption sink may have limited in vivo relevance. This study aimed at employing biopharmaceutical modeling
Linda Hong et al.
Langmuir : the ACS journal of surfaces and colloids, 31(24), 6933-6941 (2015-06-02)
Liquid crystalline nanoparticles have shown great potential for application in fields of drug delivery and agriculture. However, optimized approaches to generating these dispersions have long been sought after. This study focused on understanding the mechanism of formation of cubosomes during
Melina Schellhorn et al.
Oncotarget, 6(36), 39342-39356 (2015-10-30)
The antitumorigenic mechanism of the selective cyclooxygenase-2 (COX-2) inhibitor celecoxib is still a matter of debate. Using lung cancer cell lines (A549, H460) and metastatic cells derived from a lung cancer patient, the present study investigates the impact of celecoxib
Tomohiko Matsuzawa et al.
FEMS yeast research, 13(3), 259-266 (2013-01-15)
Fission yeast flocculates nonsexually by induction of the flocculin encoded by gsf2(+) which is controlled by the positive regulator Mbx2. Here, we report a novel gene designated gsf1(+) found to be a negative regulator of nonsexual flocculation. We identified gsf1(+)
Shenae L Cafe et al.
Bio-protocol, 10(14), e3689-e3689 (2021-03-05)
The acrosome reaction is a highly regulated exocytotic event that primes spermatozoa for successful fertilization. Upon induction, acrosomal exocytosis proceeds via a wave of vesiculation that radiates across the sperm head, destabilizing the acrosomal vesicle and resulting in the release
J Spinner et al.
Journal of mass spectrometry : JMS, 49(12), 1306-1313 (2014-12-06)
Drugs deposited in human teeth are well preserved; the spectrum of toxicological investigations may therefore be supplemented by an analysis method for drugs in teeth. A liquid chromatography-electrospray ionization tandem mass spectrometry assay for the detection and quantification of basic
Leiron Ferrarese et al.
Cell reports, 24(13), 3455-3465 (2018-09-27)
Excitatory synaptic input reaches the soma of a cortical excitatory pyramidal neuron via anatomically segregated apical and basal dendrites. In vivo, dendritic inputs are integrated during depolarized network activity, but how network activity affects apical and basal inputs is not understood. Using
Nadezhda S Sabeva et al.
Bio-protocol, 7(17) (2017-11-03)
We developed a protocol for photoconversion of endocytic marker FM1-43 followed by electron microscopy analysis of synaptic boutons at the Drosophila neuromuscular junction. This protocol allows detection of stained synaptic vesicle even when release rates are very low, such as
Taylor D Skokan et al.
Current biology : CB, 30(19), 3713-3723 (2020-08-17)
Hydra vulgaris exhibits a remarkable capacity to reassemble its body plan from a disordered aggregate of cells. Reassembly begins by sorting two epithelial cell types, endoderm and ectoderm, into inner and outer layers, respectively. The cellular features and behaviors that
G Cebrián et al.
International journal of food microbiology, 188, 67-74 (2014-08-05)
The NaCl MNICs (maximum non-inhibitory concentrations) and MICs (minimum inhibitory concentrations) for growth of various strains of six bacterial species were determined and then compared with those obtained for seven other solutes. The influence of prior growth conditions on the
Sudarshan Kurwadkar et al.
Journal of contaminant hydrology, 170, 86-94 (2014-12-03)
Dinotefuran (DNT), imidacloprid (IMD), and thiamethoxam (THM) are commonly used neonicotinoid insecticides in a variety of agriculture operations. Although these insecticides help growers control pest infestation, the residual environmental occurrence of insecticides may cause unintended adverse ecological consequences to non-target
Yutang Wang et al.
Atherosclerosis, 226(1), 29-39 (2012-10-10)
Abdominal aortic aneurysm (AAA) affects ∼5% men aged over 65 years and is an important cause of death in this population. Research into AAA pathogenesis has been fuelled by the need to identify new diagnostic biomarkers and therapeutic targets for
Maria Rita Karlocai et al.
eLife, 10 (2021-04-28)
The molecular mechanisms underlying the diversity of cortical glutamatergic synapses are still incompletely understood. Here, we tested the hypothesis that presynaptic active zones (AZs) are constructed from molecularly uniform, independent release sites (RSs), the number of which scales linearly with
Patcharin Tep-Areenan et al.
Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 95 Suppl 12, S63-S68 (2013-03-22)
To investigate the effects of gamma-mangostin on vascular tone and its mechanisms in the isolated rat aorta. Aortic rings from male Wistar rats were precontracted with methoxamine. Changes in tension were measured using an isometric force transducer and recorded on
Hui Chen et al.
Methods in enzymology, 638, 139-165 (2020-05-18)
A major event in early embryo development is the awakening of the embryonic genome, a process of large-scale transcriptional induction termed zygotic genome activation (ZGA). To understand how ZGA is controlled temporally and spatially, tools are required to image and
Rolf P Kreutz et al.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 24(3), 321-326 (2013-02-23)
Inflammation is implicated in the progression of coronary artery disease and the molecular processes of inflammation and thrombosis are closely intertwined. Elevated levels of C-reactive protein (CRP) have been associated with an elevated risk of adverse ischaemic events after coronary
Lixiao Ni et al.
Chemosphere, 91(5), 608-615 (2013-01-29)
The objectives of this work were to prepare and characterize an anti-algal sustained-release granule, then study its mode of action on Microcystis aeruginosa. The anti-algal sustained-release granule was prepared with artemisinin using alginate-chitosan microcapsule technology and characterized by a high
Noemi Holderith et al.
Cell reports, 32(4), 107968-107968 (2020-07-30)
Elucidating the molecular mechanisms underlying the functional diversity of synapses requires a high-resolution, sensitive, diffusion-free, quantitative localization method that allows the determination of many proteins in functionally characterized individual synapses. Array tomography permits the quantitative analysis of single synapses but
Losee L Ling et al.
Nature, 517(7535), 455-459 (2015-01-07)
Antibiotic resistance is spreading faster than the introduction of new compounds into clinical practice, causing a public health crisis. Most antibiotics were produced by screening soil microorganisms, but this limited resource of cultivable bacteria was overmined by the 1960s. Synthetic
[Ammonium chloride and the calcium chloride loading test for the diagnosis of renal tubular acidosis].
S Takahashi et al.
Nihon rinsho. Japanese journal of clinical medicine, 43(9), 1836-1842 (1985-09-01)
Changyang Linghu et al.
Cell, 183(6), 1682-1698 (2020-11-25)
In order to analyze how a signal transduction network converts cellular inputs into cellular outputs, ideally one would measure the dynamics of many signals within the network simultaneously. We found that, by fusing a fluorescent reporter to a pair of
Olivier Biner et al.
PloS one, 10(12), e0143963-e0143963 (2015-12-03)
Hyaluronidases are important venom components acting as spreading factor of toxic compounds. In several studies this spreading effect was tested on vertebrate tissue. However, data about the spreading activity on invertebrates, the main prey organisms of spiders, are lacking. Here
F Vela-Soria et al.
Talanta, 129, 209-218 (2014-08-17)
The population is continuously exposed to endocrine disrupting chemicals (EDCs). This has influenced an increase in diseases and syndromes that are more frequent nowadays. Therefore, it is necessary to develop new analytical procedures to evaluate the exposure with the ultimate
Melina J Scholze et al.
Development (Cambridge, England), 145(11) (2018-05-05)
Asymmetric division is crucial for embryonic development and stem cell lineages. In the one-cell Caenorhabditis elegans embryo, a contractile cortical actomyosin network contributes to asymmetric division by segregating partitioning-defective (PAR) proteins to discrete cortical domains. In the current study, we
Chao-Han Lai et al.
Annals of surgery, 258(6), 1103-1110 (2013-01-09)
To investigate whether recombinant thrombomodulin containing all the extracellular domains (rTMD123) has therapeutic potential against aneurysm development. The pathogenesis of abdominal aortic aneurysm (AAA) is characterized by chronic inflammation and proteolytic degradation of extracellular matrix. Thrombomodulin, a transmembrane glycoprotein, exerts
Robert B Hamanaka et al.
Science signaling, 6(261), ra8-ra8 (2013-02-07)
Proper regulation of keratinocyte differentiation within the epidermis and follicular epithelium is essential for maintenance of epidermal barrier function and hair growth. The signaling intermediates that regulate the morphological and genetic changes associated with epidermal and follicular differentiation remain poorly
Olof Gustafsson et al.
Global challenges (Hoboken, NJ), 2(7), 1800031-1800031 (2018-07-11)
Access to drinking water is one of the greatest global challenges today. In this study, the virus removal properties of mille-feuille nanocellulose-based filter papers of varying thicknesses from simulated waste water (SWW) matrix are evaluated for drinking water purification applications.
Xiangyang Li et al.
Carbohydrate polymers, 92(2), 1133-1142 (2013-02-13)
Fourteen commercial LM-pectin samples were investigated in this study. The degree of esterification (DE) varied from 9.6% to 42.0% and the degree of amidation (DA) from 0% to 25%. Chemical and structural characteristics were examined using atomic absorption (AA), dilute
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