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Showing 1-30 of 140 results for "C5080" within Papers
Christopher R So et al.
ACS nano, 9(6), 5782-5791 (2015-05-15)
The recognition of atomically distinct surface features by adsorbed biomolecules is central to the formation of surface-templated peptide or protein nanostructures. On mineral surfaces such as calcite, biomolecular recognition of, and self-assembly on, distinct atomic kinks and steps could additionally
Peilan Zhou et al.
European journal of pharmacology, 703(1-3), 83-90 (2013-02-19)
Opioid dependence is a serious worldwide health problem. Buprenorphine was used as an alternative to methadone for the treatment of opioid dependence, especially for pregnant women. Thienorphine was a partial opioid agonist with long-lasting antinociceptive effect and high oral bioavailability
Marie-Laurence Lemay et al.
Bio-protocol, 8(1), e2674-e2674 (2018-01-05)
This protocol describes a straightforward method to generate specific mutations in the genome of strictly lytic phages. Briefly, a targeting CRISPR-Cas9 system and a repair template suited for homologous recombination are provided inside a bacterial host, here the Gram-positive model
Abdelmoneim Eshra et al.
eLife, 10 (2021-10-07)
The Ca2+-dependence of the priming, fusion, and replenishment of synaptic vesicles are fundamental parameters controlling neurotransmitter release and synaptic plasticity. Despite intense efforts, these important steps in the synaptic vesicles' cycle remain poorly understood due to the technical challenge in
Francesca Vallese et al.
Nature communications, 11(1), 6069-6069 (2020-11-29)
Membrane contact sites between virtually any known organelle have been documented and, in the last decades, their study received momentum due to their importance for fundamental activities of the cell and for the subtle comprehension of many human diseases. The
Congwei Wang et al.
Bio-protocol, 8(19), e3029-e3029 (2018-10-23)
Ribonucleoprotein particles (mRNPs) are complexes consisting of mRNAs and RNA-binding proteins (RBPs) which control mRNA transcription localization, turnover, and translation. Some mRNAs within the mRNPs have been shown to undergo degradation or storage. Those transcripts can lack general mRNA elements
Roya Ravarian et al.
Journal of biomedical materials research. Part A, 103(9), 2898-2908 (2015-02-19)
A nonuniform degradation of physical mixture of organic-inorganic biomaterials increases their risk of failure. In this study a chemical bonding between chitosan and bioglass was used as an alternative product to address this issue. To prepare a homogenous composite, chitosan
Zoltán Ivics et al.
Nature protocols, 9(4), 810-827 (2014-03-15)
The pig has emerged as an important large animal model in biomedical and pharmaceutical research. We describe a protocol for high-efficiency germline transgenesis and sustained transgene expression in pigs by using the Sleeping Beauty (SB) transposon system. The protocol is
Harshavardhan V Pawar et al.
Journal of pharmaceutical sciences, 103(6), 1720-1733 (2014-04-05)
Wafers combining weight ratios of Polyox with carrageenan (75/25) or sodium alginate (50/50) containing streptomycin and diclofenac were prepared to improve chronic wound healing. Gels were freeze-dried using a lyophilisation cycle incorporating an annealing step. Wafers were characterised for morphology
Susanne K Hansen et al.
Stem cell research, 17(2), 306-317 (2016-10-26)
The neurodegenerative disease spinocerebellar ataxia type 3 (SCA3) is caused by a CAG-repeat expansion in the ATXN3 gene. In this study, induced pluripotent stem cell (iPSC) lines were established from two SCA3 patients. Dermal fibroblasts were reprogrammed using an integration-free
Gabriella Costabile et al.
Molecular pharmaceutics, 12(8), 2604-2617 (2015-05-15)
Inhaled antivirulence drugs are currently considered a promising therapeutic option to treat Pseudomonas aeruginosa lung infections in cystic fibrosis (CF). We have recently shown that the anthelmintic drug niclosamide (NCL) has strong quorum sensing (QS) inhibiting activity against P. aeruginosa
Richard D Collage et al.
Critical care medicine, 41(11), e352-e360 (2013-07-28)
Calcium plays an essential role in nearly all cellular processes. As such, cellular and systemic calcium concentrations are tightly regulated. During sepsis, derangements in such tight regulation frequently occur, and treating hypocalcemia with parenteral calcium administration remains the current practice
Matthias Rieckher et al.
Bio-protocol, 7(2) (2017-02-28)
Eukaryotic cells contain various types of cytoplasmic, non-membrane bound ribonucleoprotein (RNP) granules that consist of non-translating mRNAs and a versatile set of associated proteins. One prominent type of RNP granules are Processing bodies (P bodies), which majorly harbors translationally inactive
Ima Avalos Vizcarra et al.
Biointerphases, 8(1), 22-22 (2014-04-08)
Bacterial adhesion and biofilm growth can cause severe biomaterial-related infections and failure of medical implants. To assess the antifouling properties of engineered coatings, advanced approaches are needed for in situ monitoring of bacterial viability and growth kinetics as the bacteria
Minho Noh et al.
Cell systems, 5(4), 418-426 (2017-10-02)
Escherichia coli gene expression knockdown using synthetic small RNA (sRNA) can be fine-tuned by altering sRNA sequences to modulate target mRNA-binding ability, but this requires thorough checking for off-target effects. Here, we present an sRNA gene expression knockdown system fine-tuned
Rekha Raghunathan et al.
MethodsX, 6, 2329-2347 (2019-10-30)
We describe a protocol for glycomic and proteomic profiling that uses serial enzyme digestions from the surface of fresh frozen or fixed tissue slides. The abundances of the extracted glycans and peptides are determined using liquid chromatography-mass spectrometry. In a
Bogdan Parakhonskiy et al.
Journal of nanobiotechnology, 13, 53-53 (2015-09-05)
Recent reports highlighting the role of particle geometry have suggested that anisotropy can affect the rate and the pathway of particle uptake by cells. Therefore, we investigate the internalization by cells of porous calcium carbonate particles with different shapes and
Marina Makrecka et al.
Molecular and cellular biochemistry, 395(1-2), 1-10 (2014-06-01)
In the heart, a nutritional state (fed or fasted) is characterized by a unique energy metabolism pattern determined by the availability of substrates. Increased availability of acylcarnitines has been associated with decreased glucose utilization; however, the effects of long-chain acylcarnitines
Ashwati Raghunath
BMJ case reports, 2013, doi:10-doi:10 (2013-01-04)
The patient is a 52-year-old man with schizophrenia who developed severe, unremitting gingival pain after his ziprasidone dosage was increased from 80 to 120 mg. His physical examination and laboratory findings were unremarkable. He did not have any extra-pyramidal side
Pragya Goel et al.
Bio-protocol, 9(1) (2019-02-15)
Presynaptic boutons at nerve terminals are densely packed with synaptic vesicles, specialized organelles for rapid and regulated neurotransmitter secretion. Upon depolarization of the nerve terminal, synaptic vesicles fuse at specializations called active zones that are localized at discrete compartments in
Lucas F B Nogueira et al.
Materials science & engineering. C, Materials for biological applications, 58, 1-6 (2015-10-20)
The high biocompatibility and resorbability of polymeric membranes have encouraged their use to manufacture medical devices. Here, we report on the preparation of membranes consisting of carrageenan, a naturally occurring sulfated polysaccharide that forms helical structures in the presence of
Kevin M Brown et al.
Bio-protocol, 8(4) (2018-04-13)
Toxoplasma gondii is a member of the deadly phylum of protozoan parasites called Apicomplexa. As a model apicomplexan, there is a great wealth of information regarding T. gondii's 8,000+ protein coding genes including sequence variation, expression, and relative contribution to
O G Afanasieva et al.
Bulletin of experimental biology and medicine, 154(2), 224-227 (2013-01-19)
We studied the effect of a composition of major and trace elements including calcium chloride, sodium chloride, iron (II) sulfate, zinc sulfate, chromium (III) chloride, and potassium bromide on orientation and exploratory behavior and conditioned response of animals in the
Swagata Ghatak et al.
eLife, 8 (2019-11-30)
Human Alzheimer's disease (AD) brains and transgenic AD mouse models manifest hyperexcitability. This aberrant electrical activity is caused by synaptic dysfunction that represents the major pathophysiological correlate of cognitive decline. However, the underlying mechanism for this excessive excitability remains incompletely
Enrique Jambrina et al.
Journal of biomolecular screening, 21(5), 468-479 (2016-02-04)
N-methyl-D-aspartate receptors (NMDARs) are ionotropic glutamate receptors that play an important role in synaptic plasticity and learning and memory formation. Malfunctioning of NMDARs, in particular the reduction in NMDAR activity, is thought to be implicated in major neurological disorders. NMDAR
I-Cheng Chen et al.
Environmental science & technology, 49(6), 3575-3583 (2015-02-20)
The contamination of the environment with traditional therapeutics due to metabolic excretion, improper disposal, and industrial waste has been well-recognized. However, knowledge of the environmental distribution and fate of emerging classes of nanomedicine is scarce. This work investigates the effect
Hann Ling Wong et al.
Plant methods, 14, 56-56 (2018-07-14)
Small GTPases act as molecular switches that regulate various plant responses such as disease resistance, pollen tube growth, root hair development, cell wall patterning and hormone responses. Thus, to monitor their activation status within plant cells is believed to be
Lisa M Hebda et al.
Journal of forensic sciences, 60(5), 1322-1330 (2015-08-11)
DNA identification of human remains is often necessary when decedents are skeletonized; however, poor DNA recovery and polymerase chain reaction (PCR) inhibition are frequently encountered, a situation exacerbated by burial. In this research, the utility of integrating soil DNA isolation
Christin Herrmann et al.
Bio-protocol, 7(6) (2017-08-29)
Nucleosomes are the core units of cellular chromatin and are comprised of 147 base pairs (bp) of DNA wrapped around an octamer of histone proteins. Proteins such as chromatin remodelers, transcription factors, and DNA repair proteins interact dynamically with chromatin
Po-Jung Jimmy Huang et al.
Analytical chemistry, 87(13), 6890-6895 (2015-06-11)
Mercury is a highly toxic heavy metal, and detection of Hg(2+) by biosensors has attracted extensive research interest in the past decade. In particular, a number of DNA-based sensing strategies have been developed. Well-known examples include thymine-Hg(2+) interactions and Hg(2+)-activated
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