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Showing 1-30 of 617 results for "C5138" within Papers
Qian He et al.
Glia, 65(8), 1251-1263 (2017-05-26)
Activation of microglia resulting in exacerbated inflammation expression plays an important role in degeneration of dopaminergic (DA) neurons in the pathogenesis of Parkinson's disease (PD). However, how this enhanced inflammation is induced in microglia remains largely unclear. Here, in the
Fanny Guimont-Desrochers et al.
Journal of immunology (Baltimore, Md. : 1950), 182(9), 5193-5197 (2009-04-22)
The combined phenotypic expression of CD11c(low)B220(+)CD122(+)DX5(+) has been used to define a novel cell type termed IFN-producing killer dendritic cells (IKDC). IKDC readily produce IFN-gamma and demonstrate spontaneous cytotoxic activity toward tumors, suggesting that a modulation of IKDC number may
Martin Gelbard et al.
The Journal of urology, 187(6), 2268-2274 (2012-04-17)
Collagenase Clostridium histolyticum is an investigational nonsurgical treatment for Peyronie disease. In this phase 2b, double-blind, randomized, placebo controlled study we determined the safety and efficacy of collagenase C. histolyticum and assessed a patient reported outcome questionnaire. A total of
Yan Xu et al.
Nature communications, 13(1), 4555-4555 (2022-08-06)
Hepatic specification and functional maturation are tightly controlled throughout development. N6-methyladenosine (m6A) is the most abundant RNA modification of eukaryotic mRNAs and is involved in various physiological and pathological processes. However, the function of m6A in liver development remains elusive.
Paola Bianchimano et al.
Microbiome, 10(1), 174-174 (2022-10-18)
The gut microbiome plays an important role in autoimmunity including multiple sclerosis and its mouse model called experimental autoimmune encephalomyelitis (EAE). Prior studies have demonstrated that the multiple sclerosis gut microbiota can contribute to disease, hence making it a potential
Yanqin Liu et al.
Journal of cellular and molecular medicine, 25(16), 7690-7708 (2021-06-20)
The maternal-foetal interface is an immune-privileged site where the semi-allogeneic embryo is protected from attacks by the maternal immune system. Uterine macrophages are key players in establishing and maintaining pregnancy, and the dysregulation of the M1-M2 subpopulation balance causes abortion.
Cancan Du et al.
Journal of cellular and molecular medicine, 24(14), 7802-7813 (2020-05-26)
Tumour-derived exosomes have been shown to induce pre-metastatic niche formation, favoring metastatic colonization of tumour cells, but the underlying molecular mechanism is still not fully understood. In this study, we showed that exosomes derived from the LLC cells could indeed
F T D Kaplan
Drugs of today (Barcelona, Spain : 1998), 47(9), 653-667 (2011-10-06)
Collagenase clostridium histolyticum is a novel treatment for Dupuytren's contracture, approved by the U.S. Food and Drug Administration in February 2010. Prior to its availability, surgery was the only treatment for contracture related to this disorder. Dupuytren's disease is a
Jing Yu et al.
Spine, 40(15), 1149-1157 (2015-04-22)
Investigation of the elastic network in disc annulus and its function. To investigate the involvement of the elastic network in the structural interconnectivity of the annulus and to examine its possible mechanical role. The lamellae of the disc are now
Carmelo Luci et al.
Cellular and molecular gastroenterology and hepatology, 13(1), 173-191 (2021-08-20)
Spleen tyrosine kinase (SYK) signaling pathway regulates critical processes in innate immunity, but its role in parenchymal cells remains elusive in chronic liver diseases. We investigate the relative contribution of SYK and its substrate c-Abl Src homology 3 domain-binding protein-2
You Yu et al.
Nature communications, 13(1), 1151-1151 (2022-03-05)
Autism spectrum disorder (ASD), a group of neurodevelopmental disorders characterized by social communication deficits and stereotyped behaviors, may be associated with changes to the gut microbiota. However, how gut commensal bacteria modulate brain function in ASD remains unclear. Here, we
Yanling Gou et al.
Human reproduction (Oxford, England), 34(4), 646-658 (2019-03-07)
How is the activation of estrogen receptor β (ERβ) in endometriotic stromal cells (ESCs) involved in macrophage recruitment to promote the pathogenesis of endometriosis? ERβ modulates the production of C-C motif chemokine ligand 2 (CCL2) via nuclear factor kappa-light-chain-enhancer of
Ibrutinib Inhibits BTK Signaling in Tumor-Infiltrated B Cells and Amplifies Antitumor Immunity by PD-1 Checkpoint Blockade for Metastatic Prostate Cancer.
Deng, et al.
Cancers, 15 (2023)
Ge Qin et al.
Nature communications, 11(1), 1669-1669 (2020-04-05)
Programmed cell death protein-1 (PD-1)/programmed cell death ligand-1 (PD-L1) interaction plays a crucial role in tumor-associated immune escape. Here, we verify that triple-negative breast cancer (TNBC) has higher PD-L1 expression than other subtypes. We then discover that nucleophosmin (NPM1) binds
María Alejandra Parigiani et al.
Cancers, 12(8) (2020-07-28)
Background: Cathepsin L (Ctsl) is a cysteine protease mainly located within the endosomal/lysosomal cell compartment. High expression of Ctsl indicates poor prognosis in human breast cancer. However, the cell type-specific Ctsl functions responsible for this association remain elusive. Methods: Because
Di Mu et al.
International immunopharmacology, 82, 106342-106342 (2020-03-07)
The endotoxin tolerance (ET) of Kupffer cells (KCs) is an important protective mechanism for limiting endotoxin shock. As a key anti-inflammatory molecule, the roles and mechanism of Forkhead protein O3a (Foxo3a) in ET of KCs are not yet well understood.
Young-Sil Lee et al.
Nutrients, 12(1) (2020-01-16)
Atopic dermatitis (AD) is a chronic inflammatory skin disease in humans. In this study, we evaluated the effects of a mixture (NCM 1921) of omega-3 butter, omega-3 beef tallow oil, omega-3 lard oil, caprylic acid, lauric acid, choline, and Fe
Lei Wu et al.
Cancer immunology research, 8(5), 710-721 (2020-03-04)
Metabolic reprogramming is critical for the polarization and function of tumor-associated macrophages (TAM) and hepatocarcinogenesis, but how this reprogramming occurs is unknown. Here, we showed that receptor-interacting protein kinase 3 (RIPK3), a central factor in necroptosis, is downregulated in hepatocellular
Yuchen Xu et al.
Frontiers in bioengineering and biotechnology, 8, 590013-590013 (2020-12-18)
Background: Traditional rehabilitation with uniformed intensity would ignore individual tolerance and introduce the second injury to stroke survivors due to overloaded training. However, effective control of the training intensity of different stroke survivors is still lacking. The purpose of the
Dan-Ping Wei et al.
Journal of cellular and molecular medicine, 25(3), 1771-1782 (2021-01-14)
Cyp26a1 had important roles in mouse embryo implantation and was highly expressed in some of NK cells at the human maternal-foetal interface in early pregnancy. However, the regulatory effect of Cyp26a1 on NK cells remains poorly understood. Through qPCR and
Haixiang Qin et al.
The FEBS journal, 288(18), 5406-5429 (2021-03-12)
Transcription factor SOX9 was a biomarker for prostate cancer (Pca) with poor prognosis. Nevertheless, the regulatory mechanism underlying SOX9 upregulation still remains unclear. Several cytokines have been reported to be involved in the regulation of SOX9, suggesting that cancer-associated fibroblasts
Dongze Zhang et al.
Frontiers in cardiovascular medicine, 9, 871852-871852 (2022-05-14)
Withdrawal of cardiac vagal activity is associated with ventricular arrhythmia-related high mortality in patients with type 2 diabetes mellitus (T2DM). Our recent study found that reduced cell excitability of cardiac vagal postganglionic (CVP) neurons is involved in cardiac vagal dysfunction
Natalia Nunez et al.
Gut microbes, 14(1), 2058851-2058851 (2022-04-05)
Enterococcus faecalis is a bacterial species present at a subdominant level in the human gut microbiota. This commensal turns into an opportunistic pathogen under specific conditions involving dysbiosis and host immune deficiency. E. faecalis is one of the rare pathobionts
Fabio Marongiu et al.
Current protocols in stem cell biology, Chapter 1, Unit 1E-Unit 1E (2010-03-05)
Mesenchymal stem cells (MSCs) have the ability to differentiate into osteocytes, chondrocytes, and adipocytes and possess immunomodulatory properties. Amniotic membrane from human term placenta is a potential source of multipotent MSCs that could be useful for regenerative medicine. This unit
Kenta Moriwaki et al.
Mucosal immunology (2021-09-01)
Receptor interacting protein kinase 1 (RIPK1) is a cytosolic multidomain protein that controls cell life and death. While RIPK1 promotes cell death through its kinase activity, it also functions as a scaffold protein to promote cell survival by inhibiting FADD-caspase
Long Shen et al.
Cancer letters, 472, 40-49 (2019-12-21)
Macrophages serve as the first line of communication between tumors and the rest of the immune system, and understanding the interplay between macrophage and tumor cells is essential for developing novel macrophage-based strategy against tumor. Here, we show that deletion
Yoshiyuki Matsushita et al.
Communications biology, 3(1), 516-516 (2020-09-20)
The colonisation of freshwater environments by marine fishes has historically been considered a result of adaptation to low osmolality. However, most marine fishes cannot synthesise the physiologically indispensable fatty acid, docosahexaenoic acid (DHA), due to incomplete DHA biosynthetic pathways, which
Zong-Keng Kuo et al.
Scientific reports, 6, 32884-32884 (2016-09-13)
Bone tissue engineering provides many advantages for repairing skeletal defects. Although many different kinds of biomaterials have been used for bone tissue engineering, safety issues must be considered when using them in a clinical setting. In this study, we examined
Lu Li et al.
Redox biology, 30, 101412-101412 (2020-01-07)
Non-alcoholic fatty liver disease (NAFLD) is an emerging global disease with increasing prevalence. However, the mechanism of NAFLD development is not fully understood. To elucidate the cell-specific role of nuclear factor erythroid-derived 2-like 2 (NRF2) in the pathogenesis of NAFLD
Adele Mucci et al.
EMBO molecular medicine, 13(10), e13598-e13598 (2021-08-31)
The immunosuppressive microenvironment surrounding tumor cells represents a key cause of treatment failure. Therefore, immunotherapies aimed at reprogramming the immune system have largely spread in the past years. We employed gene transfer into hematopoietic stem and progenitor cells to selectively express
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