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Showing 1-30 of 2346 results for "c5670" within Papers
Kiranj K Chaudagar et al.
Clinical and experimental hypertension (New York, N.Y. : 1993), 36(8), 557-566 (2014-02-05)
Telmisartan possesses endothelial protective effects due to angiotensin II type 1 receptor antagonist, peroxisome proliferator-activated receptor γ (PPARγ) agonist and antioxidant action. Therefore, our objective was to study effect of telmisartan on angiogenic responsiveness of coronary endothelial cells (cECs) of
Clément Menuet et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(45), 15110-15122 (2014-11-08)
Brainstem catecholaminergic neurons play key roles in the autonomic, neuroendocrine, and behavioral responses to glucoprivation, yet the functions of the individual groups are not fully understood. Adrenergic C3 neurons project widely throughout the brain, including densely to sympathetic preganglionic neurons
Fei Ma et al.
Meat science, 95(1), 22-26 (2013-05-07)
The effects of high pressure processing (HPP) on the water-binding capacity and texture profile (TPA) of salt-soluble meat protein (SSMP) containing 0.2% CaCl2 and 0.6% κ-carrageenan (SSMP-CK) gels were investigated. The results showed that 300-400 MPa improved water-binding capacity and
Jae Ho Jo et al.
Biomedical materials (Bristol, England), 10(4), 045007-045007 (2015-07-15)
This study was undertaken to evaluate the effects of different rhBMP-2 release profiles in defect areas around dental implants on osseointegration and bone regeneration. Four beagle dogs (13-15 kg) were used. The defect was 3 mm deep and there was a 1 mm
Gimano D Amatngalim et al.
Journal of immunology (Baltimore, Md. : 1950), 194(7), 3340-3350 (2015-02-26)
Basal cells play a critical role in the response of the airway epithelium to injury and are recently recognized to also contribute to epithelial immunity. Antimicrobial proteins and peptides are essential effector molecules in this airway epithelial innate immunity. However
Corey P Parlet et al.
Journal of leukocyte biology, 97(4), 769-778 (2015-01-22)
Alcoholics are at increased risk of Staphylococcus aureus skin infection and serious sequelae, such as bacteremia and death. Despite the association between alcoholism and severe S. aureus skin infection, the impact of EtOH on anti-S. aureus cutaneous immunity has not
Stefan Spulber et al.
PloS one, 9(4), e94227-e94227 (2014-04-18)
Perfluorooctane sulfonate (PFOS) is a widely spread environmental contaminant. It accumulates in the brain and has potential neurotoxic effects. The exposure to PFOS has been associated with higher impulsivity and increased ADHD prevalence. We investigated the effects of developmental exposure
Daniela Sieghart et al.
Journal of cellular and molecular medicine, 19(1), 187-197 (2014-10-15)
Balneotherapy employing sulphurous thermal water is still applied to patients suffering from diseases of musculoskeletal system like osteoarthritis (OA) but evidence for its clinical effectiveness is scarce. Since the gasotransmitter hydrogen sulphide (H2 S) seems to affect cells involved in
Stanley Wong et al.
PloS one, 10(8), e0135965-e0135965 (2015-09-01)
Protein splicing is mediated by inteins that auto-catalytically join two separated protein fragments with a peptide bond. Here we engineered a genetically encoded synthetic photoactivatable intein (named LOVInC), by using the light-sensitive LOV2 domain from Avena sativa as a switch
Hirotada Hirama et al.
Langmuir : the ACS journal of surfaces and colloids, 29(2), 519-524 (2012-12-14)
We report a simple method for forming monodispersed, uniformly shaped gel microbeads with precisely controlled sizes. The basis of our method is the placement of monodispersed sodium alginate droplets, formed by a microfluidic device, on an agarose slab gel containing
Eagleson M.
Concise Encyclopedia Chemistry, 887-887 (1994)
Long M G Bui et al.
Infection and immunity, 83(2), 470-481 (2014-11-12)
An undetermined feature of Staphylococcus aureus pathogenesis is its persistence and then relapse of disease. This has been explained by its switch to alternative lifestyles, mainly as biofilm or small-colony variants (SCVs). Studying the native characteristics of SCVs has been
Li Li et al.
PloS one, 10(7), e0132827-e0132827 (2015-07-18)
Archaeological silk provides abundant information for studying ancient technologies and cultures. However, due to the spontaneous degradation and the damages from burial conditions, most ancient silk fibers which suffered the damages for thousands of years were turned into invisible molecular
Tim Indersmitten et al.
Journal of neurophysiology, 113(7), 2953-2966 (2015-02-13)
The Q175 knockin mouse model of Huntington's disease (HD) carries a CAG trinucleotide expansion of the human mutant huntingtin allele in its native mouse genomic context and recapitulates the genotype more closely than transgenic models. In this study we examined
Marie E Oskarsson et al.
The Journal of biological chemistry, 290(24), 15121-15132 (2015-04-30)
Deposition of β cell toxic islet amyloid is a cardinal finding in type 2 diabetes. In addition to the main amyloid component islet amyloid polypeptide (IAPP), heparan sulfate proteoglycan is constantly present in the amyloid deposit. Heparan sulfate (HS) side
Satoshi Watanabe et al.
PloS one, 10(9), e0136846-e0136846 (2015-09-12)
Nitric oxide (NO) modulates the dynamics of central olfactory networks and has been implicated in olfactory processing including learning. Land mollusks have a specialized olfactory lobe in the brain called the procerebral (PC) lobe. The PC lobe produces ongoing local
Zheng Wu et al.
Neuropharmacology, 97, 95-103 (2015-05-24)
Pharmacological tools that interact with the mechanisms that regulate vesicular filling and release of the neurotransmitter L-glutamate would be of enormous value. In this study, we provide physiological evidence that the glutamate analog, 3-aminoglutarate (3-AG), acts as a false transmitter
Ying Liu et al.
Biochimica et biophysica acta, 1848(1 Pt A), 67-75 (2014-10-07)
Molecular interactions between engineered nanomaterials (ENM) and biomembranes are not well understood. This study investigated the effects of particle size and surface functional group on polystyrene nanoparticles' (PNPs) potency for biomembrane disruption. Electrochemical impedance spectroscopy was used to measure changes
Christopher A Rice et al.
Antimicrobial agents and chemotherapy, 59(4), 2037-2044 (2015-01-22)
Naegleria fowleri is a pathogenic free-living amoeba (FLA) that causes an acute fatal disease known as primary amoebic meningoencephalitis (PAM). The major problem for infections with any pathogenic FLA is a lack of effective therapeutics, since PAM has a case
Venkata Saran Solleti et al.
The Journal of antimicrobial chemotherapy, 70(3), 784-796 (2014-11-25)
This work was carried out to construct a novel liposomal azithromycin formulation and examine its antimicrobial effects against Pseudomonas aeruginosa. The liposomal azithromycin formulation was prepared by the dehydration-rehydration vesicle method and its characterizations were tested. The MIC and the
B Haghshenas et al.
Journal of applied microbiology, 118(4), 1048-1057 (2015-01-27)
Investigation on the use of herbal-based biopolymers for probiotic-Lactobacillus plantarum 15HN-encapsulation is presented. The objectives are to enhance its oral delivery, colonic release and survival rate of these probiotic cultures in gastrointestinal environment. Nine types of herbal-based polymers blend with
Yan Xiao et al.
Archives of virology, 160(3), 649-662 (2014-12-17)
Since the highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) variant emerged in 2006, it has caused death in more than 20 million pigs in China and other Southeast Asian countries, making it the most destructive swine pathogen currently
J M Moreno-Baquero et al.
Food chemistry, 138(1), 1-8 (2012-12-26)
This work studies the effect of packing cracked seasoned olives with NaCl, KCl, and CaCl(2) mixture brines on their mineral nutrients and sensory attributes, using RSM methodology. The Na, K, Ca, and residual natural Mn contents in flesh as well
Jinyuan Chen et al.
Bulletin of environmental contamination and toxicology, 95(2), 145-149 (2015-06-21)
The recent increase in nanomaterial usage has led to concerns surrounding its health risks and environmental impact. The food chain is an important pathway for high-trophic-level organisms absorbing and enriching nanomaterials. Our study therefore simulated nanometer titanium dioxide (nano-TiO2) transfer
Priscila R De Batista et al.
PloS one, 9(8), e104020-e104020 (2014-08-06)
Hypertension is considered as a low-grade inflammatory disease, with adaptive immunity being an important mediator of this pathology. TLR4 may have a role in the development of several cardiovascular diseases; however, little is known about its participation in hypertension. We
Douglas S Rehder et al.
mAbs, 11(1), 145-152 (2018-10-27)
While characterizing a therapeutic IgG4 monoclonal antibody (mAb), we observed a variant with a mass 1177 Da larger than the predominant mAb form that could not be ascribed to previously described modifications. Through successive rounds of experimentation, we localized the mass addition
Matthias Buntru et al.
Biotechnology and bioengineering, 112(5), 867-878 (2014-11-26)
Cell-free protein synthesis is a powerful method for the high-throughput production of recombinant proteins, especially proteins that are difficult to express in living cells. Here we describe a coupled cell-free transcription-translation system based on tobacco BY-2 cell lysates (BYLs). Using
Céline Loriol et al.
Nature communications, 5, 5113-5113 (2014-10-15)
Sumoylation plays important roles in the modulation of protein function, neurotransmission and plasticity, but the mechanisms regulating this post-translational system in neurons remain largely unknown. Here we demonstrate that the synaptic diffusion of Ubc9, the sole conjugating enzyme of the
Peter S Hasenhuetl et al.
Molecular pharmacology, 88(1), 12-18 (2015-04-16)
The membrane transporters for the monoamines serotonin (SERT) and dopamine (DAT) are prominent targets of various psychoactive substances, including competitive inhibitors, such as tricyclic antidepressants, methylphenidate, and cocaine. Upon rapid application of a substrate, SERT and DAT display an inwardly
M-F Wu et al.
Free radical research, 48(7), 794-805 (2014-04-01)
One major pathological hallmark of Alzheimer's disease (AD) is accumulation of senile plaques in patients' brains, mainly composed of amyloid beta-peptide (Aβ). Nicotinamide adenine dinucleotide (NAD) has emerged as a common mediator regulating energy metabolism, mitochondrial function, aging, and cell
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