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Showing 1-30 of 72 results for "c6852" within Papers
A F Vanin et al.
Biofizika, 58(1), 126-136 (2013-05-09)
Current notions and new experimental data of the authors on physico-chemical features of dinitrosyl iron complexes with natural thiol-containing ligands (glutathione or cysteine), underlying the ability of the complexes to act as NO molecule and nitrosonium ion donors, are considered.
Christopher M Jenkins et al.
Biochemistry, 52(24), 4250-4263 (2013-05-25)
The multifaceted roles of calcium-independent phospholipase A2β (iPLA2β) in numerous cellular processes have been extensively examined through utilization of the iPLA2-selective inhibitor (E)-6-(bromomethylene)-3-(1-naphthalenyl)-2H-tetrahydropyran-2-one (BEL). Herein, we employed accurate mass/high resolution mass spectrometry to demonstrate that the active site serine (S465)
N A Strutyns'ka et al.
Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 59(1), 3-10 (2013-05-30)
In experiments in vivo and in vitro on the mitochondria isolated from the control and spontaneously hypertensive rats (SHR) hearts, we studied the effects of a donor of hydrogen sulfide (H2S), NaHS, and H2S biosynthesis substrate, L-cysteine, on the sensitivity
Anna B Meier et al.
Nature biotechnology, 41(12), 1787-1800 (2023-04-04)
The epicardium, the mesothelial envelope of the vertebrate heart, is the source of multiple cardiac cell lineages during embryonic development and provides signals that are essential to myocardial growth and repair. Here we generate self-organizing human pluripotent stem cell-derived epicardioids
Zrinka Karačić et al.
Biological chemistry, 393(12), 1523-1532 (2013-05-15)
Human dipeptidyl peptidase III (DPP III) is a member of the metallopeptidase family M49, involved in protein metabolism and oxidative stress response. DPPIII crystal structure shows the two lobe-like domains separated by a wide cleft. The human enzyme has a
Mingdeng Liu et al.
Water science and technology : a journal of the International Association on Water Pollution Research, 67(11), 2444-2450 (2013-06-12)
In the present work, cysteine-modified orange peel (COP) for the removal of Cu(II) from aqueous solutions has been developed and comparatively studied with diethylenetriamine-modified orange peel (DOP). Both COP and DOP were systematically evaluated via their capabilities for adsorbing Cu(II)
Jiahua Li et al.
American journal of physiology. Cell physiology, 305(2), C190-C196 (2013-05-17)
Claudins constitute a family of tight junction transmembrane proteins whose first extracellular loop (ECL1) determines the paracellular permeability and ion selectivity in epithelia. There are two cysteines in the ECL1 that are conserved among all claudins. We hypothesized that these
Pramod Kumar Yadav et al.
The Journal of biological chemistry, 288(27), 20002-20013 (2013-05-24)
Mercaptopyruvate sulfurtransferase (MST) is a source of endogenous H2S, a gaseous signaling molecule implicated in a wide range of physiological processes. The contribution of MST versus the other two H2S generators, cystathionine β-synthase and γ-cystathionase, has been difficult to evaluate
T L Stepuro et al.
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 99(1), 111-119 (2013-05-11)
The aim of the present study was to investigate the role of nitric oxide (NO) in the regulation of hemoglobin oxygen affinity (HOA) in the presence of different oxygen partial pressure. In this research the effect of NO donors on
Conditional immortalization of human atrial myocytes for the generation of in vitro models of atrial fibrillation.
Harlaar, et al.
Nature Biomedical Engineering, 6, 389-402 (2022)
D J Powell et al.
Poultry science, 92(8), 2163-2173 (2013-07-23)
Early posthatch satellite cell (SC) mitotic activity is a critical component of muscle development and growth. Satellite cells are stem cells that can be induced by nutrition to follow other cellular developmental pathways. The objective of the current study was
Wei Seong Toh et al.
Methods in molecular biology (Clifton, N.J.), 407, 333-349 (2008-05-06)
Human embryonic stem cells (hESCs) have the ability to self-replicate and differentiate into cells from all three embryonic germ layers, thereby holding great promise for tissue regeneration applications. However, controlling the differentiation of hESCs and obtaining homogenous differentiated cell populations
Nianqin Sun et al.
STAR protocols, 5(1), 102835-102835 (2024-01-15)
Creating in vitro culture platforms for monkey embryos is crucial for understanding the initial 4 weeks of early primate embryogenesis. Here, we present a protocol to culture cynomolgus monkey embryos in vitro for 25 days post-fertilization and to delineate the key developmental
Gustavo H C Varca et al.
Drug development and industrial pharmacy, 41(3), 430-435 (2014-01-15)
The performance of the standardized extrusion-spheronization technique, operational conditions, formulation parameters and storage of the final product over the bioactivity of papain containing pellets has been evaluated to obtain an insight into the potential of the technique for the manufacture
Nitric oxide quenches the fire in heart mitochondria.
Paul T Schumacker
Nature medicine, 19(6), 666-667 (2013-06-08)
Wei Seong Toh et al.
Methods in molecular biology (Clifton, N.J.) (2014-07-13)
Human embryonic stem cells (hESCs) have the ability to self-renew and differentiate into any cell lineage of the three germ layers, therefore holding great promise for regenerative applications in dentistry and medicine. We previously described a micromass culture system as
Durga P Neupane et al.
PLoS pathogens, 18(8), e1010731-e1010731 (2022-08-13)
Children are particularly susceptible to typhoid fever caused by the bacterial pathogen Salmonella Typhi. Typhoid fever is prevalent in developing countries where diets can be less well-balanced. Here, using a murine model, we investigated the role of the macronutrient composition
Colin T Stomberski et al.
Cell reports, 41(4), 111538-111538 (2022-10-27)
Accumulating evidence suggests that protein S-nitrosylation is enzymatically regulated and that specificity in S-nitrosylation derives from dedicated S-nitrosylases and denitrosylases that conjugate and remove S-nitrosothiols, respectively. Here, we report that mice deficient in the protein denitrosylase SCoR2 (S-nitroso-Coenzyme A Reductase
The CIAMIB: a Large and Metabolically Diverse Collection of Inflammation-Associated Bacteria from the Murine Gut.
Wong, et al.
mBio, 13, e0294921-e0294921 (2023)
Laurine Legroux et al.
Journal of neuroscience methods, 247, 23-31 (2015-03-31)
Flow cytometry is an efficient and powerful technique to characterize and quantify numerous cells. However, the strengths of this technique have not been widely harnessed in neurosciences due to the critical step of CNS tissue preparation into a single cell
Rana Barakat et al.
MicrobiologyOpen, 3(1), 1-14 (2013-12-07)
The blue-green phenazine, Pyocyanin (PYO), is a well-known virulence factor produced by Pseudomonas aeruginosa, notably during cystic fibrosis lung infections. It is toxic to both eukaryotic and bacterial cells and several mechanisms, including the induction of oxidative stress, have been
Richard S. Lord, J. Alexander Bralley
Laboratory Evaluations for Integrative and Functional Medicine (2008)
Fangfang Zhang et al.
Frontiers in cell and developmental biology, 10, 1038867-1038867 (2022-10-25)
Cardiomyocytes (CMs) derived from human induced pluripotent stem cells (hiPSCs) represent an excellent in vitro model in cardiovascular research. Changes in their action potential (AP) dynamics convey information that is essential for disease modeling, drug screening and toxicity evaluation. High-throughput
[Targeted effect profile - proven effectiveness].
MMW Fortschritte der Medizin, 155(5), 70-71 (2013-05-10)
Vandana Kumari et al.
Bio-protocol, 12(22) (2023-01-10)
Babesiosis is a tick-borne disease caused by pathogens belonging to the genus Babesia. In humans, the disease presents as a malaria-like illness and can be fatal in immunocompromised and elderly people. In the past few years, human babesiosis has been
Theresa Mau et al.
mSphere, 4(2) (2019-03-22)
Between October 2016 and June 2017, a C57BL/6J mouse colony that was undergoing a pre- and perinatal methyl donor supplementation diet intervention to study the impact of parental nutrition on offspring susceptibility to disease was found to suffer from an
Michael Hellwig et al.
Journal of agricultural and food chemistry, 63(30), 6723-6730 (2015-07-18)
Maillard reaction products (MRPs) are taken up in substantial amounts with the daily diet, but the majority are not transported across the intestinal epithelium. The aim of this study was to obtain first insights into the stability of dietary MRPs
Borna Ghosh et al.
The Journal of biological chemistry, 288(24), 17420-17431 (2013-05-04)
General anesthetics exert many of their CNS actions by binding to and modulating membrane-embedded pentameric ligand-gated ion channels (pLGICs). The structural mechanisms underlying how anesthetics modulate pLGIC function remain largely unknown. GLIC, a prokaryotic pLGIC homologue, is inhibited by general
Biochemistry: Oxidation controls the DUB step.
Michael J Clague
Nature, 497(7447), 49-50 (2013-05-03)
Austin G Rottinghaus et al.
Cell systems, 13(3), 204-214 (2021-11-13)
Microbial biosensors have diverse applications in metabolic engineering and medicine. Specific and accurate quantification of chemical concentrations allows for adaptive regulation of enzymatic pathways and temporally precise expression of diagnostic reporters. Although biosensors should differentiate structurally similar ligands with distinct
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