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Showing 1-30 of 47 results for "C77007" within Papers
Heba Alaa Hosiny Abd Elhameed et al.
Macromolecular bioscience, 20(7), e2000040-e2000040 (2020-05-26)
Over the past decade, search for novel materials for nucleic acid delivery has prompted a special interest in polymeric nanoparticles (NPs). In this study, the biological applicability of a water-soluble cationic lipopolymer (WSLP) obtained by the modification of high molecular
Atul A Lohade et al.
AAPS PharmSciTech, 17(6), 1298-1311 (2015-12-23)
Targeted drug delivery systems for cancer improves anti-tumor efficacy and reduces systemic toxicity by restricting availability of cytotoxic drugs within tumors. Targeting moieties, such as natural ligands (folic acid, transferrin, and biotin) which are overexpressed on tumors, have been used
Natalya S Petrova et al.
Nucleic acids research, 40(5), 2330-2344 (2011-11-15)
The conjugation of siRNA to molecules, which can be internalized into the cell via natural transport mechanisms, can result in the enhancement of siRNA cellular uptake. Herein, the carrier-free cellular uptake of nuclease-resistant anti-MDR1 siRNA equipped with lipophilic residues (cholesterol
Ivan V Chernikov et al.
Nucleic acid therapeutics, 29(1), 33-43 (2018-12-19)
The objective of this study was to analyze the effects of fluorophores on the intracellular accumulation and biological activity of small interfering RNA (siRNA) and its cholesterol conjugates. In this study, we used stem-loop real-time PCR and calibration curves to
Jasmin Monpara et al.
Drug delivery and translational research, 9(1), 106-122 (2018-08-23)
The aims of the research work were to synthesize ethyl(cholesteryl carbamoyl)-L-arginate (ECCA), an arginine-conjugated cholesterol derivative, and to evaluate its application as a gene delivery vector. The interactions of ECCA with DNA duplex were studied using molecular dynamics (MD) simulations.
André O'Reilly Beringhs et al.
AAPS PharmSciTech, 22(3), 90-90 (2021-03-06)
Contrast-enhanced X-ray computed tomography plays an important role in cancer imaging and disease progression monitoring. Imaging using radiopaque nanoparticle platforms can provide insights on the likelihood of nanoparticle accumulation and can enable image-guided therapies. Perfluorooctyl bromide (PFOB)-loaded nanocapsules designed for
Shugo Yamashita et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 157, 85-96 (2020-10-12)
Bone-drug targeting therapies using nanoparticles based on targeting ligands remain challenging due to their uptake clearance at non-target sites such as the liver, kidney, and spleen. Furthermore, the distribution sites of nanoparticles in bones have not been fully investigated, thus
Huangliang Zheng et al.
International journal of pharmaceutics, 558, 187-200 (2019-01-18)
To overstep the dilemma of chemical drug degradation within powerful lysosomes of tumor associated macrophages (TAMs), a sialic acid-polyethylenimine-cholesterol (SA-PEI-CH) modified liposomal doxorubicin (DOX-SPCL) was designed with both TAMs targeting and smart lysosomal trafficking. The modified liposome DOX-SPCL performed particle
Shan Guan et al.
Nature nanotechnology, 14(3), 287-297 (2019-01-30)
Developing safe and efficient non-viral delivery systems remains a major challenge for in vivo applications of gene therapy, especially in cystic fibrosis. Unlike conventional cationic polymers or lipids, the emerging poloxamine-based copolymers display promising in vivo gene delivery capabilities. However
Sridevi Gorle et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 59, 83-93 (2014-04-29)
Gene transfer using non-viral vectors is a promising approach for the safe delivery of nucleic acid therapeutics. In this study, we investigate a lipid-based system for targeted gene delivery to malignant cells overexpressing the folate receptor (FR). Cationic liposomes were
Preeti Kumari et al.
Drug delivery, 24(1), 209-223 (2017-02-06)
Polymeric micelles have been widely explored preclinically as suitable delivery systems for poorly soluble chemotherapeutic drugs in cancer therapy. The present study reported the development of cholesterol (Ch)-conjugated poly(D,L-Lactide) (PLA)-based polymeric micelles (mPEG-PLA-Ch) for effective encapsulation and delivery of curcumin
Hao Li et al.
Investigative ophthalmology & visual science, 58(12), 5142-5150 (2017-10-08)
Intravitreal injection of antiangiogenic agents is becoming a standard treatment for neovascular retinal diseases. Sustained release of therapeutics by injecting colloidal carriers is a promising approach to reduce the injection frequency, which reduces treatment burdens and the risk of complications
Davide Schiroli et al.
Molecular therapy. Nucleic acids, 17, 891-906 (2019-09-03)
Autosomal dominantly inherited genetic disorders such as corneal dystrophies are amenable to allele-specific gene silencing with small interfering RNA (siRNA). siRNA delivered to the cornea by injection, although effective, is not suitable for a frequent long-term treatment regimen, whereas topical
Rita Ghosh et al.
Langmuir : the ACS journal of surfaces and colloids, 36(21), 5829-5838 (2020-05-12)
PEGylated vesicles are known to serve as blood-persistent drug-delivery systems (DDSs) with potential applications in intravenous drug administration. pH-responsive PEGylated vesicles are also among the most promising stimuli-responsive carriers for drug delivery and controlled release for cancer chemotherapy. Herein, we
Remant Kc et al.
Stem cells and development, 28(11), 734-744 (2018-12-27)
Nonviral gene therapy with specific short interfering RNAs (siRNAs) against BCR-Abl can be an alternative and/or supportive therapy of chronic myeloid leukemia (CML) with tyrosine kinase inhibitors (TKIs), given the often observed resistance to TKIs in clinical setting. In this
Vivek Badwaik et al.
Macromolecular bioscience, 16(1), 63-73 (2015-08-11)
A family of cationic Pluronic-based polyrotaxanes (PR(+)), threaded with 2-hydroxypropyl-β-cyclodextrin (HPCD), was synthesized for pDNA delivery into multiple cell lines. All PR(+) formed highly stable, positively charged pDNA complexes that were < 250 nm in diameter. The cellular uptake and
Zhaleh Pourmoazzen et al.
Colloids and surfaces. B, Biointerfaces, 186, 110685-110685 (2019-12-10)
Two fractions of kraft lignin of low and high molecular weight were reacted with cholesteryl chloroformate (Chol.Cl) to produce a modified lignin that demonstrated very high hydrophobicity. Surprisingly, both fractions displayed discernible melting points as opposed to the starting lignin.
Chanyoung Song et al.
International journal of nanomedicine, 12, 7501-7517 (2017-10-27)
In this study, we suggest a designer vaccine adjuvant that can mimic the drainage of pathogens into lymph nodes and activate innate immune response in lymph nodes. By the amination of multivalent carboxyl groups in poly-(γ-glutamic acid) (γ-PGA) nanomicelles, the
Pankaj Omprakash Pathak et al.
Carbohydrate research, 408, 33-43 (2015-04-05)
Asialoglycoprotein receptors (ASGPR) are hepatocyte bound receptors, which exhibit receptor mediated endocytosis (RME) for galactose specific moieties. Arabinogalactan (AG), a liver specific high galactose containing branched polysaccharide was hydrophobized using cholesterol (CHOL) as a lipid anchor via a two step
Elham Pishavar et al.
Biotechnology progress, 36(3), e2952-e2952 (2019-12-18)
IL-12 is a pleiotropic cytokine, which shows an ideal applicant for tumor immunotherapy, because of its features of creating an interconnection between innate (NK cells) and adaptive (cytotoxic T lymphocyte) immunity. IL-12 gene therapy is a useful technique to deliver
Qingjing Tian et al.
Drug delivery and translational research, 7(5), 642-653 (2017-07-12)
Tocopheryl polyethylene glycol 1000 succinate (TPGS) is considered a promising surfactant, but its high critical micelle concentration (CMC) limits its application. Cholesterol is hydrophobic, can act as a tumor-targeting ligand, and has strong binding ability with taxoids. Based on this
Anna D Peters et al.
Organic & biomolecular chemistry, 16(35), 6479-6490 (2018-08-30)
A bis(cyclam)-capped cholesterol lipid designed to bind C-X-C chemokine receptor type 4 (CXCR4) was synthesised in good overall yield from 4-methoxyphenol through a seven step synthetic route, which also provided a bis(cyclam) intermediate bearing an octaethyleneglycol-primary amine that can be
Yamir Islam et al.
Journal of pharmaceutical sciences, 109(10), 3134-3144 (2020-07-06)
Latent and active levels of cerebral matrix metalloproteinase 9 (MMP-9) are elevated in neurological diseases and brain injuries, contributing to neurological damage and poor clinical outcomes. This study aimed developing peptide-based nanoparticles with ability to cross the blood-brain-barrier (BBB) and
Xiangxuan Huang et al.
International journal of nanomedicine, 12, 2215-2226 (2017-03-31)
A novel amphiphilic pH-sensitive triblock polymer brush (poly(β-amino esters)-
Wanyi Tai et al.
Science advances, 6(25), eabb0310-eabb0310 (2020-07-01)
Protein-based imaging agents and therapeutics are superior in structural and functional diversity compared to small molecules and are much easier to design or screen. Antibodies or antibody fragments can be easily raised against virtually any target. Despite these fundamental advantages
Ganesh Shimoga et al.
Materials (Basel, Switzerland), 13(7) (2020-03-29)
Two xerogels made of 4-pyridyl cholesterol (PC) and silver-nanocomposites (SNCs) thereof have been studied for their efficient reduction of 4-nitrophenol (4-NP) to 4-aminophenol (4-AP) in the presence of aqueous sodium borohydride. Since in-situ silver doping will be effective in ethanol
Yawo A Mondjinou et al.
Bioconjugate chemistry, 29(11), 3550-3560 (2018-11-08)
A family of five water-soluble Gd3+:1,4,7,10-tetraazacyclododecane-1,4,7-tetraacetic acid-modified polyrotaxane (PR) magnetic resonance contrast agents bearing mixtures of 2-hydroxypropyl-β-cyclodextrin and 4-sulfobutylether-β-cyclodextrin macrocycles threaded onto Pluronic cores were developed as long circulating magnetic resonance contrast agents. Short diethylene glycol diamine spacers were utilized
Sun-Young Kim et al.
Biomaterials, 130, 56-66 (2017-04-02)
In this study, synthetic vaccine nanoparticles (SVNPs) that efficiently targeted lymph nodes, where immune responses against foreign antigens are primed, were developed to enhance antitumor immunity. The size (20-70 nm) and surface character (amination) of poly(γ-glutamic acid)-based SVNPs were selected for
Priya Shrivastava et al.
Journal of microencapsulation, 38(2), 108-123 (2020-12-04)
The present study was conducted to formulate and investigate liposomes for the dual drug delivery based on anti-tubercular drug(s) combination i.e. Isoniazid (INH) and Rifampicin (RIF). Mannosylated and non mannosylated liposomes were prepared by lipid thin film hydration method, using
Xinhua Cao et al.
Chemistry, an Asian journal, 11(22), 3196-3204 (2016-10-28)
A series of bicholesteryl-based gelators with different central linker atoms C, N, and O (abbreviated to GC, GN, and GO, respectively) have been designed and synthesized. The self-assembly processes of these gelators were investigated by using gelation tests, field-emission scanning
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