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Showing 1-30 of 39 results for "C7802" within Papers
Zachary L Bergeron et al.
Toxins, 4(11), 1082-1119 (2012-12-04)
Scorpion toxins have been central to the investigation and understanding of the physiological role of potassium (K⁺) channels and their expansive function in membrane biophysics. As highly specific probes, toxins have revealed a great deal about channel structure and the
Jing Feng et al.
The Journal of biological chemistry, 288(18), 12544-12553 (2013-03-21)
Potassium channel functions are often deciphered by using selective and potent scorpion toxins. Among these toxins, only a limited subset is capable of selectively blocking small conductance Ca(2+)-activated K(+) (SK) channels. The structural bases of this selective SK channel recognition
Josiane Budni et al.
Pharmacology, biochemistry, and behavior, 101(1), 148-154 (2012-01-10)
Potassium (K(+)) channels have been implicated in depressive disorders and in the mechanism of action of antidepressants. Considering that several studies have indicated that folic acid plays an important role in the pathophysiology of depression, the present study investigated the
Asif K Mustafa et al.
Circulation research, 109(11), 1259-1268 (2011-10-08)
Nitric oxide, the classic endothelium-derived relaxing factor (EDRF), acts through cyclic GMP and calcium without notably affecting membrane potential. A major component of EDRF activity derives from hyperpolarization and is termed endothelium-derived hyperpolarizing factor (EDHF). Hydrogen sulfide (H(2)S) is a
The charybdotoxin family of K+ channel-blocking peptides.
C Miller
Neuron, 15(1), 5-10 (1995-07-01)
Kumiko Nakamura et al.
European journal of pharmacology, 694(1-3), 98-103 (2012-09-12)
We previously reported that two types of K(+) channels, the BK type Ca(2+)-activated K(+) channel coupled with phospholipase C (PLC) and the voltage-dependent K(+) channel (Kv channel), are, respectively, involved in the prostanoid TP receptor- and muscarinic M(2) receptor-mediated inhibition
Kai Wang et al.
The Journal of physiology, 589(Pt 24), 6093-6104 (2011-10-26)
Human embryonic stem cells (hESCs) are an important cellular model for studying ion channel function in the context of a human cardiac cell and will provide a wealth of information about both heritable arrhythmias and acquired electrophysiological disorders. However, detailed
Morgana Moretti et al.
European journal of pharmacology, 687(1-3), 21-27 (2012-05-12)
Considering that the administration of ascorbic acid elicits an antidepressant-effect in mice by a mechanism which involves an interaction with N-methyl-D-aspartate receptors and the l-arginine-nitric oxide-cGMP pathway and taking into account that the stimulation of this pathway is associated with
Andrew Mackenzie et al.
Life sciences, 92(23), 1131-1137 (2013-05-07)
Rheumatoid arthritis (RA) is associated with high cardiovascular mortality. Impaired endothelial cell (EC) function and elevated angiotensin II levels may be central to the link between vascular dysfunction and RA. Here we investigated the action of angiotensin type 1 receptor
Rong Chen et al.
Biophysical journal, 101(11), 2652-2660 (2012-01-21)
The conduction properties of the voltage-gated potassium channel Kv1.3 and its modes of interaction with several polypeptide venoms are examined using Brownian dynamics simulations and molecular dynamics calculations. Employing an open-state homology model of Kv1.3, we first determine current-voltage and
Suparerk Laohapitakworn et al.
American journal of physiology. Cell physiology, 301(1), C137-C149 (2011-03-11)
Besides being a Ca²-regulating hormone, parathyroid hormone (PTH) has also been shown to regulate epithelial transport of certain ions, such as Cl, HCO₃, and Na, particularly in the kidney. Although the intestinal epithelium also expressed PTH receptors, little was known
Jung Hee Jang et al.
Veterinary parasitology, 186(3-4), 281-288 (2011-12-14)
Fasciola hepatica causes biliary epithelial hyperplasia and obstructive jaundice in humans and animals. Using a planar lipid bilayer technique, we further characterized the single channel property of large conductance K(+)-permeable channels that were previously identified from F. hepatica. The single
Ville Pulkkinen et al.
American journal of physiology. Lung cellular and molecular physiology, 303(11), L956-L966 (2012-09-11)
Activation of taste receptors (TAS2Rs) by bitter taste agonists has been reported to cause bronchodilation. The aim of this study was to extend the information on the effects of bitter taste agonists on responses induced by different contractile mediators in
Colin J Stoneking et al.
American journal of physiology. Cell physiology, 304(9), C858-C872 (2013-02-15)
We have isolated a K(+)-selective, Ca(2+)-dependent whole cell current and single-channel correlate in the human erythroleukemia (HEL) cell line. The whole cell current was inhibited by the intermediate-conductance KCa3.1 inhibitors clotrimazole, TRAM-34, and charybdotoxin, unaffected by the small-conductance KCa2 family
Paola Failli et al.
Cardiovascular drugs and therapy, 26(4), 285-292 (2012-07-07)
Both carbon monoxide (CO) and nitric oxide (NO) are two gaseous molecules performing relevant functions in mammals. In order to better understand their actions in the cardiovascular system, we have investigated the effects of CORM-3, (tricarbonylchloro(glycinato)ruthenium(II), a water soluble CO-releasing
Xiaoliang Chen et al.
Journal of cardiovascular pharmacology, 59(5), 413-425 (2012-01-06)
The nature of the potassium channels involved in determining endothelium-derived hyperpolarizing factor-mediated relaxation was investigated in first-order small mesenteric arteries from male endothelial nitric oxide synthase (eNOS-/-)-knockout and control (+/+) mice. Acetylcholine-induced endothelium-dependent relaxation of small mesenteric arteries of eNOS-/-
Daniel González-Hedström et al.
Nutrients, 12(2) (2020-02-26)
Childhood obesity is associated with metabolic and cardiovascular comorbidities. The development of these alterations may have its origin in early life stages such as the lactation period through metabolic programming. Insulin resistance is a common complication in obese patients and
Takuya Kawanai
Environmental toxicology and pharmacology, 32(3), 417-422 (2011-10-19)
The effects of triclosan, an environmental pollutant from household items and health care products, on membrane potential and intracellular Ca(2+) concentrations of rat thymocytes were examined by a flow cytometry with fluorescent probes, di-BA-C(4) and fluo-3-AM, because triclosan is often
Erik J Behringer et al.
Arteriosclerosis, thrombosis, and vascular biology, 33(8), 1892-1901 (2013-06-01)
Intercellular conduction of electrical signals underlies spreading vasodilation of resistance arteries. Small- and intermediate-conductance Ca(2+)-activated K(+) channels of endothelial cells serve a dual function by initiating hyperpolarization and modulating electrical conduction. We tested the hypothesis that regulation of electrical signaling
Structural determinants of scorpion toxin affinity: the charybdotoxin (alpha-KTX) family of K(+)-channel blocking peptides.
T C Tenenholz et al.
Reviews of physiology, biochemistry and pharmacology, 140, 135-185 (2000-06-17)
Zhengmao Hua et al.
Methods in molecular biology (Clifton, N.J.), 995, 19-30 (2013-03-16)
Ion channels function as multi-protein complexes made up of ion-conducting α-subunits and regulatory β-subunits. To detect, identify, and quantitate the regulatory β-subunits in functioning K(+) channel complexes, we have chemically derivatized peptide-toxins that specifically react with strategically placed cysteine residues
M L Garcia et al.
The American journal of physiology, 269(1 Pt 1), C1-10 (1995-07-01)
Over the last few years, a considerable amount of information has been obtained regarding K+ channels. Different areas of research have contributed to knowledge in this field. Charybdotoxin (ChTX), a 37-amino acid peptide isolated from venom of the scorpion Leiurus
José George F Albuquerque et al.
BMC complementary and alternative medicine, 17(1), 376-376 (2017-07-30)
In northeastern Brazil, grape pomace has become a potential alternative byproduct because of the recover phenolic compounds from the vinification process. Comparative analyses were performed between lyophilized extract of grape skins from pomace, described as fermented (FGS), and fresh, unfermented
J M Doughty et al.
The American journal of physiology, 276(3 Pt 2), H1107-H1112 (1999-03-10)
In rat mesenteric artery, endothelium-derived hyperpolarizing factor (EDHF) is blocked by a combination of apamin and charybdotoxin (ChTX). The site of action of these toxins has not been established. We compared the effects of ChTX and apamin applied selectively to
Azadeh Nikouee et al.
The journal of physical chemistry. B, 116(17), 5132-5140 (2012-04-12)
The effect of the pore-blocking peptides charybdotoxin and margatoxin, both scorpion toxins, on currents through human voltage-gated hK(v)1.3 wild-type and hK(v)1.3_H399N mutant potassium channels was characterized by the whole-cell patch clamp technique. In the mutant channels, both toxins hardly blocked
Yonghua Chen et al.
Respiratory physiology & neurobiology, 180(2-3), 323-330 (2012-01-11)
This study investigates the firing properties of the inspiratory-activated and inspiratory-inhibited airway vagal preganglionic neurons located in the external formation of the nucleus ambiguus. The results showed that inspiratory-activated and inspiratory-inhibited neurons are distributed with different density and site preference
Dan Gordon et al.
The journal of physical chemistry. B, 116(6), 1933-1941 (2012-01-20)
Using a novel rigid body Brownian dynamics algorithm, we investigate how a spherically asymmetrical polyamine molecule, a branched analogue of spermine, interacts with the external vestibule of the voltage-gated potassium channel, Kv1.2. Simulations reveal that the blocker, with a charge
M Hanner et al.
The Journal of biological chemistry, 273(26), 16289-16296 (1998-06-20)
Coexpression of alpha and beta subunits of the high conductance Ca2+-activated K+ (maxi-K) channel leads to a 50-fold increase in the affinity for 125I-charybdotoxin (125I-ChTX) as compared with when the alpha subunit is expressed alone (Hanner, M., Schmalhofer, W. A.
Marta Baranowska-Kuczko et al.
Pharmacological research, 66(3), 251-259 (2012-05-26)
Endocannabinoids exhibit vasodilatory properties and reduce blood pressure in vivo. However, the influence and mechanism of action of the prominent endocannabinoid, anandamide (AEA), in pulmonary arteries are not known. The present study determined the vascular response to AEA in isolated
Transepithelial impedance analysis of chloride secretion.
Ashvani K Singh et al.
Methods in molecular medicine, 70, 129-142 (2002-03-29)
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