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Showing 1-30 of 2291 results for "C8106" within Papers
Jiraporn Ousingsawat et al.
Nature communications, 6, 6245-6245 (2015-02-06)
Purinergic P2X7 receptors (P2X7R) are fundamental to innate immune response. In macrophages, transient stimulation of P2X7R activates several transport mechanisms and induces the scrambling of phospholipids with subsequent membrane blebbing and apoptosis. These processes support phagocytosis and subsequent killing of
Ronak Savla et al.
Pharmaceutical research, 31(12), 3487-3502 (2014-06-13)
Design and synthesis of a tumor responsive nanoparticle-based system for imaging and treatment of various cancers. Manganese oxide nanoparticles (Mn3O4 NPs) were synthesized and modified with LHRH targeting peptide or anti-melanoma antibodies (cancer targeting moieties) and a MMP2 cleavable peptide
Jae-Sung Kim et al.
Oncology reports, 33(4), 1775-1782 (2015-01-31)
In the present study, we examined the anticancer properties of berberine in KB oral cancer cells with a specific focus on its cellular mechanism. Berberine did not affect the cell viability of the primary human normal oral keratinocytes that were
Angela Schlipp et al.
Cardiovascular research, 104(2), 245-257 (2014-09-13)
We determined the contribution of the desmosomal cadherin desmoglein-2 to cell-cell cohesion in cardiomyocytes. In the intercalated disc, providing mechanical strength and electrical communication between adjacent cardiomyocytes, desmoglein-2 is closely associated with N-cadherin and gap junctions. We studied intercalated discs
Amy L Strong et al.
Stem cells international, 2015, 412467-412467 (2015-08-25)
Adipose-derived stromal/stem cells (ASCs) are adult stem cells that have the potential to differentiate into mesenchymal lineage cells. The abundance of ASCs in adipose tissue and easy accessibility with relatively little donor site morbidity make them attractive candidate cells for
Bryan D Monesson-Olson et al.
PloS one, 9(5), e96641-e96641 (2014-05-06)
Vertebrate hair cells are responsible for the high fidelity encoding of mechanical stimuli into trains of action potentials (spikes) in afferent neurons. Here, we generated a transgenic zebrafish line expressing Channelrhodopsin-2 (ChR2) under the control of the hair-cell specific myo6b
Evgenia Dobrinskikh et al.
American journal of physiology. Renal physiology, 306(9), F941-F951 (2014-02-28)
The renal glomerulus forms a selective filtration barrier that allows the passage of water, ions, and small solutes into the urinary space while restricting the passage of cells and macromolecules. The three layers of the glomerular filtration barrier include the
Francesca Incardona et al.
eLife, 4, e06938-e06938 (2015-06-19)
The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by replicating selected results from a substantial number of high-profile papers in the field of cancer biology published between 2010 and 2012. This Registered report
Kasper Klein et al.
Journal of microbiological methods, 109, 110-116 (2014-12-30)
Several rod-shaped pathogens including Escherichia coli, Salmonella spp. and Klebsiella pneumonia are capable of adopting highly filamentous cell shapes under certain circumstances. This phenomenon occurs as a result of continued cell elongation during growth without the usual septation into single
Man Qiao et al.
Luminescence : the journal of biological and chemical luminescence, 30(7), 1159-1166 (2015-03-05)
A simple and sensitive resonance Rayleigh scattering (RRS) spectra method was developed for the determination of calf thymus DNA (ctDNA). The enhanced RRS signals were based on the interactions between ctDNA and aminoglycoside antibiotics (AGs) including kanamycin (KANA), tobramycin (TOB)
Izabella Kovacs et al.
The New phytologist, 208(3), 860-872 (2015-06-23)
Nitric oxide (NO) is a ubiquitous signaling molecule involved in a wide range of physiological and pathophysiological processes in animals and plants. Although its significant influence on plant immunity is well known, information about the exact regulatory mechanisms and signaling
Christopher A Rice et al.
Antimicrobial agents and chemotherapy, 59(4), 2037-2044 (2015-01-22)
Naegleria fowleri is a pathogenic free-living amoeba (FLA) that causes an acute fatal disease known as primary amoebic meningoencephalitis (PAM). The major problem for infections with any pathogenic FLA is a lack of effective therapeutics, since PAM has a case
Mitsukazu Sakata et al.
Breeding science, 64(4), 309-320 (2015-04-29)
Hybrid incompatibility plays an important role in establishment of post-zygotic reproductive isolation. To unveil genetic basis of hybrid incompatibilities between diverged species of genus Oryza AA genome species, we conducted genetic dissection of hybrid sterility loci, S22(t), which had been
Antonella Fazio et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 37(2), 805-815 (2015-09-12)
The benzophenone garcinol from dried fruit rind of Garcinia indica counteracts malignancy, an effect at least in part due to stimulation of apoptosis. The proapototic effect of garcinol is attributed in part to inhibition of histone acetyltransferases and thus modification
J M Moreno-Baquero et al.
Food chemistry, 138(1), 1-8 (2012-12-26)
This work studies the effect of packing cracked seasoned olives with NaCl, KCl, and CaCl(2) mixture brines on their mineral nutrients and sensory attributes, using RSM methodology. The Na, K, Ca, and residual natural Mn contents in flesh as well
Zheng Wu et al.
Neuropharmacology, 97, 95-103 (2015-05-24)
Pharmacological tools that interact with the mechanisms that regulate vesicular filling and release of the neurotransmitter L-glutamate would be of enormous value. In this study, we provide physiological evidence that the glutamate analog, 3-aminoglutarate (3-AG), acts as a false transmitter
Helen J Whalley et al.
Nature communications, 6, 7437-7437 (2015-06-17)
Centrosome separation is critical for bipolar spindle formation and the accurate segregation of chromosomes during mammalian cell mitosis. Kinesin-5 (Eg5) is a microtubule motor essential for centrosome separation, and Tiam1 and its substrate Rac antagonize Eg5-dependent centrosome separation in early
Vladislav V Makarenko et al.
American journal of physiology. Cell physiology, 308(2), C146-C154 (2014-11-08)
Arterial blood O2 levels are detected by specialized sensory organs called carotid bodies. Voltage-gated Ca(2+) channels (VGCCs) are important for carotid body O2 sensing. Given that T-type VGCCs contribute to nociceptive sensation, we hypothesized that they participate in carotid body
Long M G Bui et al.
Infection and immunity, 83(2), 470-481 (2014-11-12)
An undetermined feature of Staphylococcus aureus pathogenesis is its persistence and then relapse of disease. This has been explained by its switch to alternative lifestyles, mainly as biofilm or small-colony variants (SCVs). Studying the native characteristics of SCVs has been
Mariko Yokota et al.
Experimental dermatology, 23 Suppl 1, 27-31 (2014-09-23)
Moisturization of the skin plays an important role in maintaining skin homeostasis. Although it is understood that skin dryness initiates the formation of fine wrinkles, there are few objective reports to support that understanding. The purpose of this study was
R K Kar et al.
Pakistan journal of biological sciences : PJBS, 16(24), 1991-1996 (2014-02-13)
Regulation of stomatal aperture is crucial in terrestrial plants for controlling water loss and gaseous exchange with environment. While much is known of signaling for stomatal opening induced by blue light and the role of hormones, little is known about
Ostreopsis cf. ovata dynamics in the NW Mediterranean Sea in relation to biotic and abiotic factors.
Olga Carnicer et al.
Environmental research, 143(Pt B), 89-99 (2015-09-15)
An expansion of the distribution of Ostreopsis cf. ovata, a dinoflagellate which produces palytoxin-like compounds, has been reported in recent years. Economical and social interests are affected by blooms, as they are responsible for respiratory and skin problems in humans
Jack Chai et al.
Biophysical journal, 109(2), 407-414 (2015-07-23)
Embryonic morphogenesis takes place via a series of dramatic collective cell movements. The mechanisms that coordinate these intricate structural transformations across an entire organism are not well understood. In this study, we used gentle mechanical deformation of developing zebrafish embryos
Adam Fekete et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(42), 14032-14045 (2014-10-17)
Mitral cells express low-voltage activated Cav3.3 channels on their distal apical tuft dendrites (McKay et al., 2006; Johnston and Delaney, 2010). They also discharge Na(+)-dependent dendritic action potentials and release glutamate from these dendrites. Around resting membrane potentials, between -65
Ismail M Fareez et al.
International journal of biological macromolecules, 72, 1419-1428 (2014-12-03)
The vulnerability of probiotics at low pH and high temperature has limited their optimal use as nutraceuticals. This study addressed these issues by adopting a physicochemical driven approach of incorporating Lactobacillus plantarum LAB12 into chitosan (Ch) coated alginate-xanthan gum (Alg-XG)
Jessica Aceto et al.
PloS one, 10(6), e0126928-e0126928 (2015-06-11)
Teleost fish such as zebrafish (Danio rerio) are increasingly used for physiological, genetic and developmental studies. Our understanding of the physiological consequences of altered gravity in an entire organism is still incomplete. We used altered gravity and drug treatment experiments
Dariela Almeda et al.
Biomaterials, 41, 37-44 (2014-12-20)
Liposomes may be engineered to target inflamed endothelium by mimicking ligand-receptor interactions between leukocytes and cytokine-activated endothelial cells (ECs). The upregulation and assembly of vascular cell adhesion molecule-1 (VCAM1) and E-selectin on the cell membrane upon exposure to cytokines have
Zohreh Majidnia et al.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 105, 105-113 (2015-08-16)
In this paper, both maghemite (γ-Fe2O3) and titanium oxide (TiO2) nanoparticles were synthesized and mixed in various ratios and embedded in PVA and alginate beads. Batch sorption experiments were applied for removal of barium ions from aqueous solution under sunlight
Ying Liu et al.
Biochimica et biophysica acta, 1848(1 Pt A), 67-75 (2014-10-07)
Molecular interactions between engineered nanomaterials (ENM) and biomembranes are not well understood. This study investigated the effects of particle size and surface functional group on polystyrene nanoparticles' (PNPs) potency for biomembrane disruption. Electrochemical impedance spectroscopy was used to measure changes
Raz Palty et al.
Cell research, 25(8), 963-980 (2015-07-04)
Calcium flux through store-operated calcium entry is a major regulator of intracellular calcium homeostasis and various calcium signaling pathways. Two key components of the store-operated calcium release-activated calcium channel are the Ca(2+)-sensing protein stromal interaction molecule 1 (STIM1) and the
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