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Showing 1-30 of 82 results for "cd105 antibody" within Papers
Sixiang Shi et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 56(6), 927-932 (2015-04-18)
The critical challenge in abdominal aortic aneurysm (AAA) research is the accurate diagnosis and assessment of AAA progression. Angiogenesis is a pathologic hallmark of AAA, and CD105 is highly expressed on newly formed vessels. Our goal was to use (64)Cu-labeled
C Li et al.
British journal of cancer, 88(9), 1424-1431 (2003-06-05)
CD105 and its ligand transforming growth factor beta (TGFbeta) are modulators of angiogenesis, which drives tumour growth and metastasis. Tumour microvessel density (MVD) has proven to be an important determinant of prognosis. In this study, we have examined the prognostic
Fatima H Karzai et al.
BJU international, 116(4), 546-555 (2014-11-20)
TRC105 is a chimeric immunoglobulin G1 monoclonal antibody that binds endoglin (CD105). This phase I open-label study evaluated the safety, pharmacokinetics and pharmacodynamics of TRC105 in patients with metastatic castration-resistant prostate cancer (mCRPC). Patients with mCRPC received escalating doses of
F P Barry et al.
Biochemical and biophysical research communications, 265(1), 134-139 (1999-11-05)
Mesenchymal stem cells are multipotent cells resident in the bone marrow throughout adulthood which have the capacity to differentiate into cartilage, bone, fat, muscle, and tendon. A number of monoclonal antibodies raised against human MSCs have been shown to react
N Takahashi et al.
Cancer research, 61(21), 7846-7854 (2001-11-03)
Endoglin (EDG; CD105) is a proliferation-associated cell membrane antigen of endothelial cells and is strongly expressed on the tumor-associated angiogenic vascular endothelium. Furthermore, EDG is essential for angiogenesis and a component of the transforming growth factor (TGF)-beta receptor complex. The
Valeria Barresi et al.
Acta neuropathologica, 114(2), 147-156 (2007-06-28)
Microvessel density (MVD) is considered to be a prognostic marker in many tumours. Nevertheless, conflicting results were achieved regarding its prognostic role in meningiomas when it was quantified through pan-endothelial markers such as CD34, CD31 or Factor VIII. In the
Amit Nair et al.
Cellular oncology (Dordrecht), 43(5), 835-845 (2020-05-30)
The current treatment outcomes in cholangiocarcinoma are poor with cure afforded only by surgical extirpation. The efficacy of targeting the tumoural endothelial marker CD105 in cholangiocarcinoma, as a basis for potential microbubble-based treatment, is unknown and was explored here. Tissue
Ivo C J H Post et al.
Xenotransplantation, 20(1), 18-26 (2013-01-26)
Endothelial damage is a critical step in the development of (xeno) transplantation-related and cardiovascular pathology. In humans, the amount of circulating endothelial cells (CEC) correlates to disease intensity and functions as a valuable damage marker. While (xeno) transplantation and cardiovascular
Mirko Adam et al.
European urology, 44(3), 329-336 (2003-08-23)
Induction of angiogenesis is essential for tumor growth and metastasis. The role of angiogenetic factors and corresponding microvessel density in the development of metastasis of nonseminomatous testicular germ cell tumors (NSGCTs) is not clearly defined. Aim of the study was
Yuying Liu et al.
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery, 22(3), 100-103 (2008-05-15)
To explore the expressions of thymidine phosphorylase (TP), midkine (MK) and MVD marked with CD105 antibody in laryngeal squamous cell carcinoma (LSCC) and their clinical significance. The expressions of TP, MK and CD105 in LSCC tissues of 43 cases were
Xiaoling Zhang et al.
Cancer biology & medicine, 17(2), 418-432 (2020-06-27)
Objective: Bevacizumab is a recombinant humanized monoclonal antibody that blocks vascular endothelial growth factor (VEGF) with clear clinical benefits. However, overall survival of some cancer types remains low owing to resistance to bevacizumab therapy. While resistance is commonly ascribed to
Anna Benetti et al.
Cancer research, 68(20), 8626-8634 (2008-10-17)
Hepatocellular carcinoma (HCC) is one of most malignant and aggressive human tumors. Transforming growth factor-beta1 (TGF-beta1) and its coreceptor CD105 have been shown to contribute to HCC malignant progression. TGF-beta1 and CD105 have also been implicated in angiogenesis, but their
Anisha Madhav et al.
Oncogene, 37(32), 4385-4397 (2018-05-03)
Radiation therapy is the primary intervention for nearly half of the patients with localized advanced prostate cancer and standard of care for recurrent disease following surgery. The development of radiation-resistant disease is an obstacle for nearly 30-50% of patients undergoing
Laurence M Wood et al.
Cancer immunology, immunotherapy : CII, 60(7), 931-942 (2011-03-25)
The FDA approval of bevacizumab (Avastin®, Genentech/Roche), a monoclonal antibody raised against human VEGF-A, as second-line therapy for colon and lung carcinoma validated the approach of targeting human tumors with angiogenesis inhibitors. While the VEGF/VEGFR pathway is a viable target
Camila Couto Figueiredo et al.
Histology and histopathology, 34(3), 257-264 (2018-09-13)
A crucial component of the integration between foreign implants and the host is angiogenesis. However, to date, none of the available techniques and/or endothelial markers employed to assess angiogenesis in the implant/host interface seems to be able to highlight vascular
Chenggang Li et al.
Pathobiology : journal of immunopathology, molecular and cellular biology, 73(4), 192-197 (2006-11-23)
This study aims to identify plaque neovascularisation using antibodies to CD31, CD105 and TGFbeta1, and to compare their patterns of expression. Tissue expression of CD31, CD105 and TGFbeta1 was examined immunohistologically in atherosclerotic plaques from 53 patients who had undergone
Megan E Dempsey et al.
Cellular and molecular bioengineering, 14(3), 267-277 (2021-06-11)
Antibodies are an essential research tool for labeling surface proteins but can potentially influence the behavior of proteins and cells to which they bind. Because of this, researchers and clinicians are interested in the persistence of these antibodies, particularly for
M D Safwat et al.
Folia morphologica, 68(3), 144-155 (2009-09-02)
Breast cancer is the leading cause of cancer deaths among women. Results from experimental studies suggest that tumour progression and metastasis in breast cancer are angiogenesis dependant. The College of American Pathologists has stated that further study of quantification of
M Jeziorska
Zeitschrift fur Kardiologie, 90 Suppl 3, 23-26 (2001-05-26)
To investigate the expression and localisation of transforming growth factor betas (TGF beta s) and their receptor CD105 (endoglin) in relation to calcification and bone formation in atherosclerotic lesions of human carotid arteries. The TGF beta family regulates cellular growth
Joshua M Barnett et al.
Investigative ophthalmology & visual science, 55(10), 6490-6498 (2014-08-28)
We investigated endoglin expression in hypoxic microvascular endothelial cells and retinal endoglin expression in rats that develop experimental oxygen-induced retinopathy (OIR). We also tested neutralizing antibodies (Abs) against endoglin (anti-CD105 Ab) and VEGF (anti-VEGF Ab) either alone or in combination
Shruti Chaturvedi et al.
Thrombosis research, 135(1), 102-108 (2014-12-04)
The antiphospholipid syndrome is characterized by venous or arterial thrombosis and/or recurrent fetal loss in the presence of circulating antiphospholipid antibodies. These antibodies cause activation of endothelial and other cell types leading to the release of microparticles with procoagulant and
Sebastian Szubert et al.
Journal of cancer research and clinical oncology, 140(3), 361-369 (2014-01-01)
The primary aim of this paper was to evaluate the expression of extracellular matrix metalloproteinase inducer (EMMPRIN) and its relationship with proangiogenic factors and microvessel density (MVD) in ovarian cancer. The study group included 58 epithelial ovarian cancers (EOCs), 35
Kazumasa Takenaka et al.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 14(8), 1972-1975 (2005-08-17)
Carbonyl reductase (CBR) is a cytosolic NADPH-dependent oxidoreductase metabolizing prostaglandins, steroids, quinines, and anthracycline antibiotics. Many experimental studies have shown that CBR plays important roles in the regulation of tumor progression, but clinical significance of CBR status remains unclear. Thus
Petra Muenzner et al.
Cell host & microbe, 27(5), 793-808 (2020-04-15)
Several pathogens suppress exfoliation, a key defense of epithelia against microbial colonization. Common among these pathogens, exemplified by Neisseria gonorrhoeae, is their ability to bind carcinoembryonic antigen-related cell adhesion molecules (CEACAMs). Gonococcal CEACAM engagement triggers the expression of CD105, which
Aihua Jiang et al.
Investigative ophthalmology & visual science, 50(2), 844-850 (2008-10-22)
The very low-density lipoprotein receptor (VLDLR) knockout (vldlr(-/-)) mouse has been identified as a model for retinal angiomatous proliferation with subretinal neovascularization (SNV) evolving from retinal vessels. The effects of VLDLR on the angiogenic functions of retinal vascular endothelial cells
Patrícia Martins et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 23(9), 2889-2894 (2008-04-10)
Secondary hyperparathyroidism (SHPT) is a common complication of chronic kidney disease. Increased parathyroid hormone (PTH) synthesis and secretion is associated with parathyroid cell hyperplasia. The exact mechanisms involved in parathyroid gland (PTG) hyperplasia are still poorly understood. There is no
Rebeca M Torrente-Rodríguez et al.
Journal of pharmaceutical and biomedical analysis, 129, 288-293 (2016-07-23)
A sensitive and rapid method for the determination of the clinically relevant biomarker human endoglin (CD105) in serum samples is presented, involving a magneto-actuated immunoassay and amperometric detection at disposable screen-printed carbon electrodes (SPCEs). Micro-sized magnetic particles were modified with
Karina B Salgado et al.
Clinical & experimental metastasis, 24(6), 403-410 (2007-06-15)
Brain metastases are linked to poor prognosis. After carcinomas of the lung and breast, malignant melanomas (MM) are the next type of neoplasm with the higher metastatic dissemination involving the central nervous system and that has the worst prognosis after
Kai-Kai Chang et al.
International journal of clinical and experimental pathology, 6(10), 2030-2038 (2013-10-18)
Nonmetastatic gene 23-H1 (NME1, also known as nm23-H1) is a wide-spectrum tumor metastasis suppressor gene that plays an important role in suppressing the proliferation, adhesion and invasion of endometrial stromal cells (ESCs). The present study is undertaken to explore the
Magdalena Białas et al.
Polish journal of pathology : official journal of the Polish Society of Pathologists, 62(4), 236-240 (2012-01-17)
Epithelioid haemangioendothelioma (EH) is a very rare neoplasm. It is assumed that these tumours derive from vascular endothelial cells. The aim of the study was to identify the immunohistochemical profile of tumour cells in lung EH. The unique material consisting
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