CGLDIL

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Showing 1-13 of 13 results for "CGLDIL" within Papers

Phenotypic plasticity of mesenchymal stem cells is crucial for mesangial repair in a model of immunoglobulin light chain-associated mesangial damage

Herrera GA, et al.

Ultrastructural Pathology, 42(3), 262-288 (2018)

Generation, expansion and functional analysis of endothelial cells and pericytes derived from human pluripotent stem cells.

Valeria V Orlova et al.

Nature protocols, 9(6), 1514-1531 (2014-05-31)

Human endothelial cells (ECs) and pericytes are of great interest for research on vascular development and disease, as well as for future therapy. This protocol describes the efficient generation of ECs and pericytes from human pluripotent stem cells (hPSCs) under

Phenotypic plasticity of mesenchymal stem cells is crucial for mesangial repair in a model of immunoglobulin light chain-associated mesangial damage.

Guillermo A Herrera et al.

Ultrastructural pathology, 42(3), 262-288 (2018-04-19)

Mesangiopathies produced by glomerulopathic monoclonal immunoglobulin light chains (GLCs) acting on the glomerular mesangium produce two characteristic lesions: AL-amyloidosis (AL-Am) and light chain deposition disease (LCDD). In both cases, the pathology is centered in the mesangium, where initial and progressive

DHFR silence alleviated the development of liver fibrosis by affecting the crosstalk between hepatic stellate cells and macrophages.

Yu Peng et al.

Journal of cellular and molecular medicine, 25(21), 10049-10060 (2021-10-10)

Liver fibrogenesis is a dynamic cellular and tissue process which has the potential to progress into cirrhosis of even liver cancer and liver failure. The activation of hepatic stellate cells (HSCs) is the central event underlying liver fibrosis. Besides, hepatic

Exosomes from activated hepatic stellate cells contain GLUT1 and PKM2: a role for exosomes in metabolic switch of liver nonparenchymal cells.

Lu Wan et al.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(7), 8530-8542 (2019-04-11)

The mechanism of exosomes derived from activated hepatic stellate cells (HSCs) involved in liver fibrosis is poorly understood. We previously reported that hypoxia-inducible factor 1 (Hif-1) regulated HSC activation, and, therefore, we investigated in current work whether Hif-1 regulates exosome

Mechanisms of M2 Macrophage-Derived Exosomal Long Non-coding RNA PVT1 in Regulating Th17 Cell Response in Experimental Autoimmune Encephalomyelitisa.

Lei Wu et al.

Frontiers in immunology, 11, 1934-1934 (2020-10-06)

Long non-coding RNA (lncRNA) is pivotal for multiple sclerosis (MS), but the potential mechanism of lncRNA PVT1 in MS animal model, experimental autoimmune encephalomyelitis (EAE) still remains unclear. In this study, macrophages were firstly isolated and induced to polarize into

Imaging volumetric dynamics at high speed in mouse and zebrafish brain with confocal light field microscopy.

Zhenkun Zhang et al.

Nature biotechnology, 39(1), 74-83 (2020-08-12)

A detailed understanding of the function of neural networks and how they are supported by a dynamic vascular system requires fast three-dimensional imaging in thick tissues. Here we present confocal light field microscopy, a method that enables fast volumetric imaging

Circulating Exosomal miR-96 as a Novel Biomarker for Radioresistant Non-Small-Cell Lung Cancer.

Qin Zheng et al.

Journal of oncology, 2021, 5893981-5893981 (2021-03-18)

Patients with non-small-cell lung cancer (NSCLC) frequently develop radioresistance, resulting in poor response to radiation and unfavourable prognosis. Early detection of radioresistance hence can guide the adjustment of treatment regimens in time. Exosomes are lipid bilayer-enclosed vesicles with sub-micrometer size

Mitochondrial Fission Promotes the Continued Clearance of Apoptotic Cells by Macrophages.

Ying Wang et al.

Cell, 171(2), 331-345 (2017-09-26)

Clearance of apoptotic cells (ACs) by phagocytes (efferocytosis) prevents post-apoptotic necrosis and dampens inflammation. Defective efferocytosis drives important diseases, including atherosclerosis. For efficient efferocytosis, phagocytes must be able to internalize multiple ACs. We show here that uptake of multiple ACs

Regulation of blood flow in the retinal trilaminar vascular network.

Tess E Kornfield et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(34), 11504-11513 (2014-08-22)

Light stimulation evokes neuronal activity in the retina, resulting in the dilation of retinal blood vessels and increased blood flow. This response, named functional hyperemia, brings oxygen and nutrients to active neurons. However, it remains unclear which vessels mediate functional

Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury.

Arif Yurdagul et al.

Cell metabolism, 31(3), 518-533 (2020-02-01)

Continual efferocytic clearance of apoptotic cells (ACs) by macrophages prevents necrosis and promotes injury resolution. How continual efferocytosis is promoted is not clear. Here, we show that the process is optimized by linking the metabolism of engulfed cargo from initial

Stem Cell-Derived Exosomes as Nanotherapeutics for Autoimmune and Neurodegenerative Disorders.

Milad Riazifar et al.

ACS nano, 13(6), 6670-6688 (2019-05-24)

To dissect therapeutic mechanisms of transplanted stem cells and develop exosome-based nanotherapeutics in treating autoimmune and neurodegenerative diseases, we assessed the effect of exosomes secreted from human mesenchymal stem cells (MSCs) in treating multiple sclerosis using an experimental autoimmune encephalomyelitis

Association of Aβ with ceramide-enriched astrosomes mediates Aβ neurotoxicity.

Ahmed Elsherbini et al.

Acta neuropathologica communications, 8(1), 60-60 (2020-04-30)

Amyloid-β (Aβ) associates with extracellular vesicles termed exosomes. It is not clear whether and how exosomes modulate Aβ neurotoxicity in Alzheimer's disease (AD). We show here that brain tissue and serum from the transgenic mouse model of familial AD (5xFAD)

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