clarification filters

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Keyword:'clarification filters'

Showing 1-12 of 12 results for "clarification filters" within Papers

Development of adsorptive hybrid filters to enable two-step purification of biologics.

Nripen Singh et al.

mAbs, 9(2), 350-363 (2016-12-09)

Recent progress in mammalian cell culture process has resulted in significantly increased product titers, but also a substantial increase in process- and product-related impurities. Due to the diverse physicochemical properties of these impurities, there is constant need for new technologies

An effective, simple and low-cost pretreatment for culture clarification in tetanus toxoid production.

Lucía Avila et al.

Preparative biochemistry & biotechnology, 48(9), 808-814 (2018-09-29)

Chemically inactivated tetanus toxin (tetanus toxoid, TT), purified from cultures of a virulent Clostridium tetani strain, is the active pharmaceutical ingredient of anti-tetanus vaccines. Culture clarification for TT production and is usually performed by filtration-based techniques. Final clarification of the

A new simplified clarification approach for lentiviral vectors using diatomaceous earth improves throughput and safe handling.

Jennifer J Labisch et al.

Journal of biotechnology, 326, 11-20 (2020-12-11)

Lentiviral vectors have proven their great potential to serve as a DNA delivery tool for gene modified cell therapy and gene therapy applications. The downstream processing of these vectors is however still a great challenge, particularly because of the low

Adopting primary plastic trickling filters as a solution for enhanced nitrification.

Simon P Wilson et al.

Water environment research : a research publication of the Water Environment Federation, 87(1), 80-87 (2015-01-30)

The wastewater industry is under pressure to optimize performance of sewage treatment works (STW), while simultaneously reducing energy consumption. Using a process configuration selection matrix, this paper explores the practicability of placing a hypothetical cross flow structured plastic media (CFSP)

Immobilization of tomato (Lycopersicon esculentum) pectinmethylesterase in calcium alginate beads and its application in fruit juice clarification.

Pushpa Bogra et al.

Biotechnology letters, 35(11), 1895-1900 (2013-07-25)

Clarity of fruit juices is desirable to maintain an aesthetically pleasing quality and international standards. The most commonly used enzymes in juice industries are pectinases. A partially-purified pectinmethylesterase from tomato was entrapped in calcium alginate beads and used for juice

Influence of an innovative and promising gas clarification process on the quality of stored extra virgin olive oils.

Enrico Valli et al.

Food research international (Ottawa, Ont.), 116, 30-36 (2019-02-06)

Filtration of extra virgin olive oil is a process that may improve preservation of the quality during storage. In the current study, different aliquots of extra virgin olive oils were subjected to filtration with a traditional filter press or an

Lentivirus capture directly from cell culture with Q-functionalised microcapillary film chromatography.

N J Darton et al.

Journal of chromatography. A, 1251, 236-239 (2012-07-10)

A new disposable adsorbent material for fast anion-exchange capture of nano-complexes without prefiltering, clarification or pre-processing of samples was developed based on plastic microcapillary films (MCFs). An MCF containing 19 parallel microcapillaries, each with a mean internal diameter of 142

Impacts on product quality attributes of monoclonal antibodies produced in CHO cell bioreactor cultures during intentional mycoplasma contamination events.

Erica J Fratz-Berilla et al.

Biotechnology and bioengineering, 117(9), 2802-2815 (2020-05-22)

A mycoplasma contamination event in a biomanufacturing facility can result in costly cleanups and potential drug shortages. Mycoplasma may survive in mammalian cell cultures with only subtle changes to the culture and penetrate the standard 0.2-µm filters used in the

Impacts of intentional mycoplasma contamination on CHO cell bioreactor cultures.

Erica J Fratz-Berilla et al.

Biotechnology and bioengineering, 116(12), 3242-3252 (2019-09-04)

Mycoplasma contamination events in biomanufacturing facilities can result in loss of production and costly cleanups. Mycoplasma may survive in mammalian cell cultures with only subtle changes to the culture and may penetrate the 0.2 µm filters often used in the primary

Sensitive methods for evaluation of antibodies for host cell protein analysis and screening of impurities in a vaccine process.

Christine Sund Lundström et al.

Vaccine, 32(24), 2911-2915 (2014-03-19)

Host cell proteins (HCP) should be carefully monitored in vaccine production. To achieve a reliable HCP estimation, a mixture of polyclonal antibodies (pAbs) with broad affinity would be of preference. Sensitive evaluations of the pAbs are therefore of value. Column

Effect of Different Clarification Methods on Volatile Aroma Compound Composition of Virgin Olive Oil.

Karolina Brkić Bubola et al.

Food technology and biotechnology, 57(4), 503-512 (2020-03-04)

This study investigates the effect of industrial scale filtration of fresh monovarietal virgin olive oil from Buža and Istarska bjelica cultivars on their volatiles, total phenols and sensory characteristics, and compares the oil samples clarified by filtration with those clarified

Antibody capture from corn endosperm extracts by packed bed and expanded bed adsorption.

Todd J Menkhaus et al.

Biotechnology progress, 21(2), 473-485 (2005-04-02)

Topical treatments of chronic infections with monoclonal antibodies will require large quantities of antibodies. Because plants have been proven capable of producing multisubunit antibodies and provide for large-scale production, they are likely hosts to enable such applications. Recovery costs must

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