COLLD-RO

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Showing 1-8 of 8 results for "COLLD-RO" within Papers

Endothelial AMPKα1/PRKAA1 exacerbates inflammation in HFD-fed mice.

Qiuhua Yang et al.

British journal of pharmacology, 179(8), 1661-1678 (2021-11-20)

Excess nutrient-induced endothelial cell inflammation is a hallmark of high fat diet (HFD)-induced metabolic syndrome. Pharmacological activation of the protein kinase AMP-activated α1 (PRKAA1) also known as AMPKα1, shows its beneficial effects in many studies of cardiometabolic disorders. However, AMPKα1

Isolation of Infiltrating Leukocytes from Mouse Skin Using Enzymatic Digest and Gradient Separation.

Charles J Benck et al.

Journal of visualized experiments : JoVE, (107)(107), e53638-e53638 (2016-02-11)

Dissociating murine skin into a single cell suspension is essential for downstream cellular analysis such as the characterization of infiltrating immune cells in rodent models of skin inflammation. Here, we describe a protocol for the digestion of mouse skin in

An optimized protocol for the isolation of rare stromal cell populations from the mouse spleen.

Yannick O Alexandre et al.

STAR protocols, 3(4), 101923-101923 (2023-01-04)

Lymphoid tissue stromal cells are important regulators of spleen homeostasis and immune responses. Here, we present an optimized protocol that describes the digestion and enrichment steps for the isolation and analysis of rare populations of stromal cells, including fibroblastic reticular

CD16/32-specific biotinylated 2.4G2 single-chain Fv complexed with avidin-FITC enhances FITC-specific humoral immune response in vivo in a CD16-dependent manner.

Adrienn Angyal et al.

International immunology, 22(2), 71-80 (2009-12-03)

Fcgamma receptors (FcgammaRs) play an essential role in the regulation of immune response due to their ability to bind immune complexes. Activating FcgammaRs may facilitate antigen presentation and dendritic-cell maturation, while in the late phase of the immune response, the

Functional xenobiotic metabolism and efflux transporters in trout hepatocyte spheroid cultures.

Chibuzor Uchea et al.

Toxicology research, 4(2), 494-507 (2015-04-22)

Prediction of xenobiotic fate in fish is important for the regulatory assessment of chemicals under current legislation. Trout hepatocyte spheroids are a promising

Promoting antigen escape from dendritic cell endosomes potentiates anti-tumoral immunity.

Jean-Pierre Bikorimana et al.

Cell reports. Medicine, 3(3), 100534-100534 (2022-05-03)

The cross-presenting capacity of dendritic cells (DCs) can be limited by non-specific degradation during endosome maturation. To bypass this limitation, we present in this study a new Accum-based formulation designed to promote endosome-to-cytosol escape. Treatment of primary DCs with Accum

Age-induced prostaglandin E2 impairs mitochondrial fitness and increases mortality to influenza infection.

Judy Chen et al.

Nature communications, 13(1), 6759-6759 (2022-11-10)

Aging impairs the immune responses to influenza A virus (IAV), resulting in increased mortality to IAV infections in older adults. However, the factors within the aged lung that compromise host defense to IAV remain unknown. Using a murine model and

Low intraprostatic DHT promotes the infiltration of CD8+ T cells in BPH tissues via modulation of CCL5 secretion.

Yu Fan et al.

Mediators of inflammation, 2014, 397815-397815 (2014-05-09)

Clinical studies suggested thatandrogen might be associated with infiltrating T cells in prostate of benign prostatic hyperplasia (BPH) patients, but detail of T-cell subset and mechanism still remained unclear. The present study tested the hypothesis that intraprostatic 5 α -dihydrotestosterone

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