CRM48665

Applied Filters:

Keyword:'CRM48665'

Showing 1-30 of 128 results for "CRM48665" within Papers

Differential 12-O-Tetradecanoylphorbol-13-acetate-induced activation of rat mammary carcinoma susceptibility Fbxo10 variant promoters via a PKC-AP1 pathway.

Xin Xu et al.

Molecular carcinogenesis, 54(2), 134-147 (2013-09-07)

Rat mammary carcinoma susceptibility 5a1 (Mcs5a1), which is concordant to human MCS5A1 breast cancer risk locus, mediates susceptibility by a non-mammary cell-autonomous mechanism associated with T cell differential expression of F-box protein 10 (Fbxo10). Human FBXO10, an evolutionarily conserved ubiquitin

Oral benzo[a]pyrene: understanding pharmacokinetics, detoxication, and consequences--Cyp1 knockout mouse lines as a paradigm.

Daniel W Nebert et al.

Molecular pharmacology, 84(3), 304-313 (2013-06-14)

Benzo[a]pyrene (BaP) is a prototypical polycyclic aromatic hydrocarbon (PAH); this ubiquitous environmental carcinogenic agent is found in tobacco smoke, charcoal-grilled foods, and PAH-contaminated surfaces of roofs, playgrounds, and highways. Cytochrome P450 1 wild-type, Cyp1a2(-/-), Cyp1b1(-/-), or Cyp1a2/1b1(-/-) knockouts, and mice

Protective action of n-3 fatty acids on benzo[a]pyrene-induced apoptosis through the plasma membrane remodeling-dependent NHE1 pathway.

Béatrice Dendelé et al.

Chemico-biological interactions, 207, 41-51 (2013-11-20)

Plasma membrane is an early target of polycyclic aromatic hydrocarbons (PAH). We previously showed that the PAH prototype, benzo[a]pyrene (B[a]P), triggers apoptosis via DNA damage-induced p53 activation (genotoxic pathway) and via remodeling of the membrane cholesterol-rich microdomains called lipid rafts

High throughput analysis and capture of benzo[a]pyrene using supermacroporous poly(4-vinyl pyridine-co-divinyl benzene) cryogel matrix.

Ankur Gupta et al.

Journal of chromatography. A, 1278, 16-21 (2013-01-23)

A novel supermacroporous cryogel matrix, poly(4-vinyl pyridine-co-divinyl benzene) has been synthesized by free radical polymerization using 4-vinyl pyridine and divinyl benzene as monomers and poly(ethylene glycol) diacrylate as crosslinker. Hydrophobic property of such synthesized matrix allows capture of polyaromatic hydrocarbons

Hypoxia-inducible factor-lα increase is an early and sensitive marker of lung cells responding to benzo[a]pyrene.

Olga Mavrofrydi et al.

Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 31(4), 335-347 (2013-02-12)

Hypoxia inducible factor-1α (HIF-lα) is a central regulator of tumor survival and metastasis, responsible for metabolic adaptation to hypoxic conditions and promotion of angiogenesis. It has been also shown to respond to non-hypoxic stimuli, such as growth factors and moderate

Albumin and hemoglobin adducts of benzo[a]pyrene in humans--analytical methods, exposure assessment, and recommendations for future directions.

Heiko U Käfferlein et al.

Critical reviews in toxicology, 40(2), 126-150 (2010-01-21)

Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in our environment and can cause cancer. Exposure to PAHs can be assessed by protein adduct dosimetry using benzo[a]pyrene (B[a]P) as a model compound. We present an overview of analytical methods to detect B[a]P-

A critical appraisal of intratracheal instillation of benzo[a]pyrene to Syrian golden hamsters as a model in respiratory tract carcinogenesis.

A P Wolterbeek et al.

Cancer letters, 89(1), 107-116 (1995-02-10)

Several experimental models have been developed to study respiratory tract carcinogenesis. The most widely applied in vivo model uses Syrian golden hamsters which receive intratracheal instillations of a suspension of benzo[a]pyrene (B[a]P) particles attached to ferric-oxide (Fe2O3) particles in saline;

Induction and repair of benzo[a]pyrene-DNA adducts in C57BL/6 and BALB/c mice: association with aging and longevity.

M E Boerrigter et al.

Mechanisms of ageing and development, 82(1), 31-50 (1995-07-28)

In this study, we employed the sensitive 32P-postlabeling assay to assess the influence of age on the formation and disappearance of benzo[a]pyrene (B[a]P) DNA adducts in six organs of two different mouse strains with different life spans, C57BL/6ByJ (C57BL/6) and

Genotoxicity of rice bran oil extracted by supercritical CO2 extraction.

Jae-Suk Choi et al.

Biological & pharmaceutical bulletin, 37(12), 1963-1970 (2014-12-03)

Rice bran oil extracted by supercritical CO2 extraction (RB-SCE) reportedly exhibits pharmacological activities such as antioxidant and in vivo hair growth-inducing effects. Such activities raise the possibility of the development of novel hair growth-inducing agents using RB-SCE. The aim of

Benzo[a]pyrene modulation of acute immunologic responses in Red Sea bream pretreated with lipopolysaccharide.

Jun Bo et al.

Environmental toxicology, 29(5), 517-525 (2012-05-23)

The effects of polycyclic aromatic hydrocarbons (PAHs) have been reported to modulate the immune response in aquatic animals, but the collected information of their effects on fish immunity is so far ambiguous. This study demonstrated that Benzo[a]pyrene (BaP) exposure altered

Pleiotropic and epistatic behavior of a ring-hydroxylating oxygenase system in the polycyclic aromatic hydrocarbon metabolic network from Mycobacterium vanbaalenii PYR-1.

Ohgew Kweon et al.

Journal of bacteriology, 196(19), 3503-3515 (2014-07-30)

Despite the considerable knowledge of bacterial high-molecular-weight (HMW) polycyclic aromatic hydrocarbon (PAH) metabolism, the key enzyme(s) and its pleiotropic and epistatic behavior(s) responsible for low-molecular-weight (LMW) PAHs in HMW PAH-metabolic networks remain poorly understood. In this study, a phenotype-based strategy

BFCOD activity in fish cell lines and zebrafish embryos and its modulation by chemical ligands of human aryl hydrocarbon and nuclear receptors.

N Creusot et al.

Environmental science and pollution research international, 22(21), 16393-16404 (2014-12-05)

Assessment of exposure and effect of fish to pharmaceuticals that contaminate aquatic environment is a current major issue in ecotoxicology and there is a need to develop specific biological marker to achieve this goal. Benzyloxy-4-trifluoromethylcoumarin-O-debenzyloxylase (BFCOD) enzymatic activity has been

Derivation of a site-specific assessment criterion for benzo[a]pyrene in red shale at a former coking works.

C Paul Nathanail et al.

Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering, 48(6), 594-603 (2013-02-28)

A former coking works in England is being remediated to enable its redevelopment. We have developed site specific human health risk assessment criteria (SSAC) for benzo[a]pyrene (BaP) based on detailed characterisation of red shale proposed for reuse in an area

Polydopamine-based immobilization of zeolitic imidazolate framework-8 for in-tube solid-phase microextraction.

Juan Zhang et al.

Journal of chromatography. A, 1388, 9-16 (2015-03-03)

Zeolitic imidazolate frameworks (ZIFs), a subfamily of metal-organic frameworks (MOFs), have received considerable attention as a novel porous material for sample preparation due to their fascinating structures and unique properties. Here, we developed a novel bio-inspired polydopamine (PDA) method to

Occurrence, sources, and potential human health risks of polycyclic aromatic hydrocarbons in agricultural soils of the coal production area surrounding Xinzhou, China.

Long Zhao et al.

Ecotoxicology and environmental safety, 108, 120-128 (2014-07-23)

A comprehensive investigation of the levels, distribution patterns, and sources of polycyclic aromatic hydrocarbons (PAHs) in agricultural soils of the coal production area surrounding Xinzhou, China, was conducted, and the potential human health risks associated with the levels observed were

Benzo[a]pyrene sensitizes MCF7 breast cancer cells to induction of G1 arrest by the natural flavonoid eupatorin-5-methyl ether, via activation of cell signaling proteins and CYP1-mediated metabolism.

Vasilis P Androutsopoulos et al.

Toxicology letters, 230(2), 304-313 (2013-09-03)

Eupatorin-5-methyl ether (E5M) is a flavone containing 4 methoxy groups that is present in plants with medicinal activity, whereas luteolin (L) is a polyhydroxylated flavone commonly encountered in dietary products. In the present study we investigated the interaction of the

Single cell gel electrophoresis (SCGE) and Pig-a mutation assay in vivo-tools for genotoxicity testing from a regulatory perspective: a study of benzo[a]pyrene in Ogg1(-/-) mice.

Anne Graupner et al.

Mutation research. Genetic toxicology and environmental mutagenesis, 772, 34-41 (2014-10-14)

The OECD has developed test guidelines (TG) to identify agents with genotoxic effects. The in vivo alkaline single cell gel electrophoresis (SCGE) assay is currently being prepared to become such a TG. The performance of a combined SCGE/Pig-a gene mutation

L-kynurenine/aryl hydrocarbon receptor pathway mediates brain damage after experimental stroke.

María I Cuartero et al.

Circulation, 130(23), 2040-2051 (2014-11-02)

Aryl hydrocarbon receptor (AhR) is a transcription factor that belongs to the basic helix-loop-helix PAS (Per-Arnt-Sim homology domain) family known to mediate the toxic and carcinogenic effects of xenobiotics. Interestingly, AhR is widely expressed in the central nervous system, but

Nanomolar levels of PAHs in extracts from urban air induce MAPK signaling in HepG2 cells.

I W H Jarvis et al.

Toxicology letters, 229(1), 25-32 (2014-06-10)

Polycyclic aromatic hydrocarbons (PAHs) are common environmental pollutants that occur naturally in complex mixtures. Many of the adverse health effects of PAHs including cancer are linked to the activation of intracellular stress response signaling. This study has investigated intracellular MAPK

Neurotoxic effect of subacute benzo(a)pyrene exposure on gene and protein expression in Sprague-Dawley rats.

Shu-qun Cheng et al.

Environmental toxicology and pharmacology, 36(2), 648-658 (2013-07-31)

Benzo(a)pyrene (B[a]P) is an environmental carcinogen that induces tumors in many animal species, but the neurotoxic effects of B[a]P have not been well studied. In the present study, we investigated the effects of subacute exposure to B[a]P in Sprague-Dawley (SD)

Exome-wide mutation profile in benzo[a]pyrene-derived post-stasis and immortal human mammary epithelial cells.

Paul L Severson et al.

Mutation research. Genetic toxicology and environmental mutagenesis, 775-776, 48-54 (2014-12-02)

Genetic mutations are known to drive cancer progression and certain tumors have mutation signatures that reflect exposures to environmental carcinogens. Benzo[a]pyrene (BaP) has a known mutation signature and has proven capable of inducing changes to DNA sequence that drives normal

Distribution and Source of Polycyclic Aromatic Hydrocarbons (PAHs) in Water Dissolved Phase, Suspended Particulate Matter and Sediment from Weihe River in Northwest China.

Yuyun Chen et al.

International journal of environmental research and public health, 12(11), 14148-14163 (2015-11-13)

Weihe River is a typical river located in the arid and semi-arid regions of Northwest China. In this study, the distribution and sources of 16 polycyclic aromatic hydrocarbons (PAHs) in Weihe River were investigated. The concentrations of ∑PAHs ranged from

Differential expression of CYP1A1 and CYP1A2 genes in H4IIE rat hepatoma cells exposed to TCDD and PAHs.

Sonja Kaisarevic et al.

Environmental toxicology and pharmacology, 39(1), 358-368 (2015-01-03)

Rat hepatoma cells H4IIE were treated by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and polycyclic aromatic hydrocarbons (PAHs) (dibenz(a,h)anthracene, benzo(a)pyrene, benz(a)anthracene, chrysene), low-concentration mixtures of PAHs and TCDD, and environmental mixtures contaminated by PAHs and their derivatives. Expression of the gene battery comprising cytochrome

Risk assessment for benzo[a]pyrene.

J F Collins et al.

Regulatory toxicology and pharmacology : RTP, 13(2), 170-184 (1991-04-01)

Benzo[a]pyrene is the most studied carcinogenic polycyclic aromatic hydrocarbon and one of the most potent, and it is often used as a toxicological prototype or surrogate for all carcinogenic polycyclic aromatic hydrocarbons. Quantitative risk assessment of benzo[a]pyrene has been hampered

Sustained induction of cytochrome P4501A1 in human hepatoma cells by co-exposure to benzo[a]pyrene and 7H-dibenzo[c,g]carbazole underlies the synergistic effects on DNA adduct formation.

Alena Gábelová et al.

Toxicology and applied pharmacology, 271(1), 1-12 (2013-05-04)

To gain a deeper insight into the potential interactions between individual aromatic hydrocarbons in a mixture, several benzo[a]pyrene (B[a]P) and 7H-dibenzo[c,g]carbazole (DBC) binary mixtures were studied. The biological activity of the binary mixtures was investigated in the HepG2 and WB-F344

Effects of benzo[a]pyrene on whole cytochrome P450-involved molecular responses in the marine medaka Oryzias melastigma.

Bo-Mi Kim et al.

Aquatic toxicology (Amsterdam, Netherlands), 152, 232-243 (2014-05-06)

Despite being a strong toxicant for aquatic ecosystems, the effect of benzo[a]pyrene (B[a]P) on whole cytochrome P450 (CYP) biotransformation mechanisms has not been deeply investigated in aquatic organisms. To understand the mode of action of B[a]P on CYP molecular responses

CYP1A1 and GSTM1 genotypes affect benzo[a]pyrene DNA adducts in smokers' lung: comparison with aromatic/hydrophobic adduct formation.

Kroum Alexandrov et al.

Carcinogenesis, 23(12), 1969-1977 (2003-01-01)

Benzo[a]pyrene diol epoxide (BPDE)-DNA adducts are involved in the induction of p53 mutations and probably in the causation of human lung cancer associated with cigarette smoking. The ratio between CYP1A1 and GST enzyme activities is a critical determinant of the

Interindividual variation in response to xenobiotic exposure established in precision-cut human liver slices.

Marlon J A Jetten et al.

Toxicology, 323, 61-69 (2014-06-21)

Large differences in toxicity responses occur within the human population. In this study we evaluate whether interindividual variation in baseline enzyme activity (EA)/gene expression (GE) levels in liver predispose for the variation in toxicity responses by assessing dose-response relationships for

Application of the margin-of-exposure (MoE) approach to substances in food that are genotoxic and carcinogenic e.g.: benzo[a]pyrene and polycyclic aromatic hydrocarbons.

Diane Benford et al.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 48 Suppl 1, S42-S48 (2009-10-13)

Benzo[a]pyrene (BaP) and a number of other polycyclic aromatic hydrocarbons (PAH) are mutagenic and are also carcinogenic in rodent bioassays. Oral carcinogenicity data are not available for individual PAH other than BaP, and so BaP has been used as a

Involvement of DNA polymerase β overexpression in the malignant transformation induced by benzo[a]pyrene.

Wei Zhao et al.

Toxicology, 309, 73-80 (2013-05-09)

To explore the relationship between DNA polymerase β (pol β) overexpression and benzo[a]pyrene (BaP) carcinogenesis. Firstly, mouse embryonic fibroblasts that express wild-type level of DNA polymerase β (pol β cell) and high level of pol β (pol β oe cell)

Page 1 of 5