D12384

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Showing 1-30 of 579 results for "D12384" within Papers

The loss of NDRG2 expression improves depressive behavior through increased phosphorylation of GSK3β.

Tomonaga Ichikawa et al.

Cellular signalling, 27(10), 2087-2098 (2015-07-26)

N-myc downstream-regulated gene 2 (NDRG2) is one of the important stress-inducible genes and plays a critical role in negatively regulating PI3K/AKT signaling during hypoxia and inflammation. Through recruitment of PP2A phosphatase, NDRG2 maintains the dephosphorylated status of PTEN to suppress

Glomerular parietal epithelial cells contribute to adult podocyte regeneration in experimental focal segmental glomerulosclerosis.

Diana G Eng et al.

Kidney international, 88(5), 999-1012 (2015-05-21)

As adult podocytes cannot adequately proliferate following depletion in disease states, there has been interest in the potential role of progenitors in podocyte repair and regeneration. To determine whether parietal epithelial cells (PECs) can serve as adult podocyte progenitors following

Histological and electrophysiological analysis of the corticospinal pathway to forelimb motoneurons in common marmosets.

Takahiro Kondo et al.

Neuroscience research, 98, 35-44 (2015-06-21)

Using histological and electrophysiological methods, we identified the neuroanatomical properties of the common marmoset corticospinal tract (CST), which underlies hand/arm motor control. Biotinylated dextran amine (BDA) was injected into the primary motor cortex to anterogradely label CST axons in the

The neurokinin-3 (NK3) and the neurokinin-1 (NK1) receptors are differentially targeted to mesocortical and mesolimbic projection neurons and to neuronal nuclei in the rat ventral tegmental area.

Andrée Lessard et al.

Synapse (New York, N.Y.), 63(6), 484-501 (2009-02-19)

Tonic activation of neurokinin-3 (NK(3)) receptors in dopamine neurons of the ventral tegmental area (VTA) has been implicated in the pathophysiology of schizophrenia. This psychiatric disorder is associated with a dysfunctional activity in VTA projection neurons that can affect cognitive

rPbPga1 from Paracoccidioides brasiliensis Activates Mast Cells and Macrophages via NFkB.

Clarissa Xavier Resende Valim et al.

PLoS neglected tropical diseases, 9(8), e0004032-e0004032 (2015-09-01)

The fungus Paracoccidioides brasiliensis is the leading etiological agent of paracoccidioidomycosis (PCM), a systemic granulomatous disease that typically affects the lungs. Cell wall components of P. brasiliensis interact with host cells and influence the pathogenesis of PCM. In yeast, many

Transgenic Mouse Bioassay: Evidence That Rabbits Are Susceptible to a Variety of Prion Isolates.

Enric Vidal et al.

PLoS pathogens, 11(8), e1004977-e1004977 (2015-08-08)

Interspecies transmission of prions is a well-established phenomenon, both experimentally and under field conditions. Upon passage through new hosts, prion strains have proven their capacity to change their properties and this is a source of strain diversity which needs to

n-Type conjugated oligoquinoline and oligoquinoxaline with triphenylamine endgroups: efficient ambipolar light emitters for device applications.

Hancock JM, et al.

Chemistry of Materials, 18(20), 4924-4932 (2006)

Aging, but not tau pathology, impacts olfactory performances and somatostatin systems in THY-Tau22 mice.

Guillaume Martel et al.

Neurobiology of aging, 36(2), 1013-1028 (2014-12-01)

Somatostatin (SOM) cortical levels decline in Alzheimer's disease (AD) in correlation with cognitive impairment severity, the latter being closely related to the presence of neurofibrillary tangles. Impaired olfaction is another hallmark of AD tightly related to tau pathology in the

E7080 (lenvatinib), a multi-targeted tyrosine kinase inhibitor, demonstrates antitumor activities against colorectal cancer xenografts.

Armin Wiegering et al.

Neoplasia (New York, N.Y.), 16(11), 972-981 (2014-11-27)

Clinical prognosis of metastasized colorectal carcinoma (CRC) is still not at desired levels and novel drugs are needed. Here, we focused on the multi-tyrosine kinase inhibitor E7080 (Lenvatinib) and assessed its therapeutic efficacy against human CRC cell lines in vitro

Immunohistochemical and immunofluorescence procedures for protein analysis.

Kishore Reddy Katikireddy et al.

Methods in molecular biology (Clifton, N.J.), 784, 155-167 (2011-09-08)

Immunohistochemistry (IHC) and immunofluorescence (IF) involve the binding of an antibody to a cellular or tissue antigen of interest and then visualisation of the bound product by fluorescence/with the 3,3'-diaminobenzidine (DAB) chromogen detection system. With increasing numbers of available antibodies

Cervical carcinoma-associated fibroblasts are DNA diploid and do not show evidence for somatic genetic alterations.

Willem Ernst Corver et al.

Cellular oncology (Dordrecht), 34(6), 553-563 (2011-11-02)

Cancer-associated fibroblasts (CAFs) have been recognized as important contributors to cancer development and progression. However, opposing evidence has been published whether CAFs, in addition to epigenetic, also undergo somatic genetic alterations and whether these changes contribute to carcinogenesis and tumour

Effects of chlorpyrifos on in vitro sex steroid production and thyroid follicular development in adult and larval Lake Sturgeon, Acipenser fulvescens.

Catherine Brandt et al.

Chemosphere, 132, 179-187 (2015-04-10)

Chlorpyrifos is a widely used organophosphate pesticide that has previously been shown to enter waterways in biologically relevant concentrations and has the potential to disrupt both thyroid hormone and sex steroid biosynthesis in vertebrates. Because gonadal maturation and larval development

Topical application of Acheflan on rat skin injury accelerates wound healing: a histopathological, immunohistochemical and biochemical study.

Jamila Alessandra Perini et al.

BMC complementary and alternative medicine, 15, 203-203 (2015-07-01)

Dermal wound healing involves a cascade of complex events including angiogenesis and extracellular matrix remodeling. Several groups have focused in the study of the skin wound healing activity of natural products. The phytomedicine Acheflan®, and its main active constituent is

First evidence of molecular characterization of rohu carp Sox2 gene being expressed in proliferating spermatogonial cells.

Swagat Kumar Patra et al.

Theriogenology, 84(2), 268-276 (2015-04-29)

Because little is known about the function of Sox2 (Sry-related box-2) in teleosts, the objective of this study was to clone and characterize Sox2 complementary DNA (cDNA) from the testis of Indian major carp, Labeo rohita (rohu). The full-length cDNA

Inhibition of the Immunoproteasome Subunit LMP7 with ONX 0914 Ameliorates Graft-versus-Host Disease in an MHC-Matched Minor Histocompatibility Antigen-Disparate Murine Model.

Jenny Zilberberg et al.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 21(9), 1555-1564 (2015-06-21)

In the current study we evaluated the effects of immunoproteasome inhibition using ONX 0914 (formerly PR-957) to ameliorate graft-versus-host disease (GVHD). ONX 0914, an LMP7-selective epoxyketone inhibitor of the immunoproteasome, has been shown to reduce cytokine production in activated monocytes

SND-117, a sinomenine bivalent alleviates type II collagen-induced arthritis in mice.

Yu-Ren Zhou et al.

International immunopharmacology, 26(2), 423-431 (2015-04-19)

Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disorder that affects about 1% of the population worldwide. RA is mainly manifested by persistent synovitis and progressive joint destruction. The aim of the present study was to examine the anti-arthritis effects

Dynamics of neuroinflammation in the macrosphere model of arterio-arterial embolic focal ischemia: an approximation to human stroke patterns.

Maureen Walberer et al.

Experimental & translational stroke medicine, 2(1), 22-22 (2010-12-22)

Neuroinflammation evolves as a multi-facetted response to focal cerebral ischemia. It involves activation of resident glia cell populations, recruitment of blood-derived leucocytes as well as humoral responses. Among these processes, phagocyte accumulation has been suggested to be a surrogate marker

Pharmacological inhibition of nicotinamide phosphoribosyltransferase/visfatin enzymatic activity identifies a new inflammatory pathway linked to NAD.

Nathalie Busso et al.

PloS one, 3(5), e2267-e2267 (2008-05-22)

Nicotinamide phosphoribosyltransferase (NAMPT), also known as visfatin, is the rate-limiting enzyme in the salvage pathway of NAD biosynthesis from nicotinamide. Since its expression is upregulated during inflammation, NAMPT represents a novel clinical biomarker in acute lung injury, rheumatoid arthritis, and

Thymosin beta 4 improves dermal burn wound healing via downregulation of receptor of advanced glycation end products in db/db mice.

Sokho Kim et al.

Biochimica et biophysica acta, 1840(12), 3452-3459 (2014-09-18)

The delay of dermal burn wound healing caused by vascular disorders is a critical problem for many diabetic patients. Thymosin β4 (Tβ4), identified by subtractive cloning of endothelial cells on plastic versus basement membrane substrates, has been found to promote

Ceftriaxone prevents and reverses behavioral and neuronal deficits in an MPTP-induced animal model of Parkinson's disease dementia.

Chao-Yu Hsu et al.

Neuropharmacology, 91, 43-56 (2014-12-17)

Glutamatergic hyperactivity plays an important role in the pathophysiology of Parkinson's disease (PD). Ceftriaxone increases expression of glutamate transporter 1 (GLT-1) and affords neuroprotection. This study was aimed at clarifying whether ceftriaxone prevented, or reversed, behavioral and neuronal deficits in

A genetically encoded tag for correlated light and electron microscopy of intact cells, tissues, and organisms.

Xiaokun Shu et al.

PLoS biology, 9(4), e1001041-e1001041 (2011-04-13)

Electron microscopy (EM) achieves the highest spatial resolution in protein localization, but specific protein EM labeling has lacked generally applicable genetically encoded tags for in situ visualization in cells and tissues. Here we introduce "miniSOG" (for mini Singlet Oxygen Generator)

Deep-brain stimulation associates with improved microvascular integrity in the subthalamic nucleus in Parkinson's disease.

Ilse S Pienaar et al.

Neurobiology of disease, 74, 392-405 (2014-12-24)

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has become an accepted treatment for motor symptoms in a subset of Parkinson's disease (PD) patients. The mechanisms why DBS is effective are incompletely understood, but previous studies show that DBS

Different dynamics of aquaporin 4 and glutamate transporter-1 distribution in the perineuronal and perivascular compartments during ischemic stroke.

Laurentiu Mogoanta et al.

Brain pathology (Zurich, Switzerland), 24(5), 475-493 (2014-02-28)

Aquaporin-4 (AQP4) and glutamate transporter-1 (GLT-1) represent the major water and glutamate astrocyte buffering gateways in the brain. Utilizing perilesional ischemic human cortices, we have performed here for the first time an integrative assessment on both AQP4 and GLT-1, and

A stable hydroxide-conducting polymer.

Thomas OD, et al.

Journal of the American Chemical Society, 134(26), 10753-10756 (2012)

Improvement in T helper 1-related immune responses in BALB/c mice immunized with an HIV-1 gag plasmid combined with a chimeric plasmid encoding interleukin-18 and flagellin.

Ya-Lei Chen et al.

Microbiology and immunology, 59(8), 483-494 (2015-06-23)

Both flagellin (fliC) and IL-18 (INF-γ-inducing factor) have been developed as adjuvants for improving immunogenicity in DNA-vaccinated hosts. An HIV-1 gag plasmid encodes a protein harboring broad epitopes for cytotoxic T-lymphocytes. In this study, the immunogenicity of BALB/c mice immunized

Intrinsic neurophysiological properties of hilar ectopic and normotopic dentate granule cells in human temporal lobe epilepsy and a rat model.

A L Althaus et al.

Journal of neurophysiology, 113(4), 1184-1194 (2014-11-28)

Hilar ectopic dentate granule cells (DGCs) are a salient feature of aberrant plasticity in human temporal lobe epilepsy (TLE) and most rodent models of the disease. Recent evidence from rodent TLE models suggests that hilar ectopic DGCs contribute to hyperexcitability

Pigment Epithelium-Derived Factor (PEDF) Expression Induced by EGFRvIII Promotes Self-renewal and Tumor Progression of Glioma Stem Cells.

Jinlong Yin et al.

PLoS biology, 13(5), e1002152-e1002152 (2015-05-21)

Epidermal growth factor receptor variant III (EGFRvIII) has been associated with glioma stemness, but the direct molecular mechanism linking the two is largely unknown. Here, we show that EGFRvIII induces the expression and secretion of pigment epithelium-derived factor (PEDF) via

Complement regulatory protein CD46 protects against choroidal neovascularization in mice.

Valeriy Lyzogubov et al.

The American journal of pathology, 184(9), 2537-2548 (2014-07-16)

Dysregulation of the complement system is increasingly recognized as a contributing factor in age-related macular degeneration. Although the complement regulator CD46 is expressed ubiquitously in humans, in mouse it was previously thought to be expressed only on spermatozoa. We detected

Necrostatin-1 reduces intestinal inflammation and colitis-associated tumorigenesis in mice.

Zhen-Yu Liu et al.

American journal of cancer research, 5(10), 3174-3185 (2015-12-23)

Necroptosis, a novel form of programmed cell death, was recently shown to be strongly associated with intestinal inflammation in mice and in pediatric patients with inflammatory bowel disease (IBD). Persistent inflammation of the colon is an important risk factor for

Quantitative differential proteomics of yeast extracellular matrix: there is more to it than meets the eye.

Fábio Faria-Oliveira et al.

BMC microbiology, 15, 271-271 (2015-11-27)

Saccharomyces cerevisiae multicellular communities are sustained by a scaffolding extracellular matrix, which provides spatial organization, and nutrient and water availability, and ensures group survival. According to this tissue-like biology, the yeast extracellular matrix (yECM) is analogous to the higher Eukaryotes

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