D1435

Applied Filters:

Keyword:'D1435'

Showing 1-30 of 7642 results for "D1435" within Papers

Transplant-mediated enhancement of spinal cord GABAergic inhibition reverses paclitaxel-induced mechanical and heat hypersensitivity.

João M Bráz et al.

Pain, 156(6), 1084-1091 (2015-03-12)

Decreased spinal cord GABAergic inhibition is a major contributor to the persistent neuropathic pain that can follow peripheral nerve injury. Recently, we reported that restoring spinal cord GABAergic signaling by intraspinal transplantation of cortical precursors of GABAergic interneurons from the

Exposure to a continuous low dose of tetrachlorodibenzo-p-dioxin impairs the development of the tooth root in lactational rats and alters the function of apical papilla-derived stem cells.

Hao Guo et al.

Archives of oral biology, 60(1), 199-207 (2014-12-03)

Ubiquitous environmental pollutants such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) cause abnormalities in reproduction and development. TCDD inhibits the development of teeth, and its effects depend on its dose and the developmental stage of the tooth. Our aim here was to investigate the

Harmonization of QSAR Best Practices and Molecular Docking Provides an Efficient Virtual Screening Tool for Discovering New G-Quadruplex Ligands.

Daimel Castillo-González et al.

Journal of chemical information and modeling, 55(10), 2094-2110 (2015-09-12)

Telomeres and telomerase are key players in tumorogenesis. Among the various strategies proposed for telomerase inhibition or telomere uncapping, the stabilization of telomeric G-quadruplex (G4) structures is a very promising one. Additionally, G4 stabilizing ligands also act over tumors mediated

Conjugated polymer dots for ultra-stable full-color fluorescence patterning.

Kaiwen Chang et al.

Small (Weinheim an der Bergstrasse, Germany), 10(21), 4270-4275 (2014-07-23)

Stable full-color fluorescence patterning are achieved by multicolor polymer-dot inks. The fluorescent patterns show extraordinary stability upon various treatments, offering a superior combination of bright fluorescence, excellent photostability, chemical resistance, and eco-friendship.

Systematic analysis of BRAF(V600E) melanomas reveals a role for JNK/c-Jun pathway in adaptive resistance to drug-induced apoptosis.

Mohammad Fallahi-Sichani et al.

Molecular systems biology, 11(3), 797-797 (2015-03-31)

Drugs that inhibit RAF/MEK signaling, such as vemurafenib, elicit profound but often temporary anti-tumor responses in patients with BRAF(V) (600E) melanoma. Adaptive responses to RAF/MEK inhibition occur on a timescale of hours to days, involve homeostatic responses that reactivate MAP

Glutathione S-transferase P influences redox and migration pathways in bone marrow.

Jie Zhang et al.

PloS one, 9(9), e107478-e107478 (2014-09-13)

To interrogate why redox homeostasis and glutathione S-transferase P (GSTP) are important in regulating bone marrow cell proliferation and migration, we isolated crude bone marrow, lineage negative and bone marrow derived-dendritic cells (BMDDCs) from both wild type (WT) and knockout

Understanding the self-assembly of Fmoc-phenylalanine to hydrogel formation.

Virender Singh et al.

Soft matter, 11(26), 5353-5364 (2015-06-11)

Hydrogels of low molecular weight molecules are important in biomedical applications. Multiple factors are responsible for hydrogel formation, but their role in governing self-assembly to hydrogel formation is poorly understood. Herein, we report the hydrogel formation of fluorenylmethyloxycarbonyl phenylalanine (FmocF)

Estrogen promotes the survival of human secretory phase endometrial stromal cells via CXCL12/CXCR4 up-regulation-mediated autophagy inhibition.

Jie Mei et al.

Human reproduction (Oxford, England), 30(7), 1677-1689 (2015-05-16)

What mechanism is involved in regulating the autophagy of endometrial stromal cells (ESCs), and does it participate in the pathogenesis of endometriosis? CXCL12 down-regulates secretory phase ESC autophagy. mTOR (mammalian target of rapamycin), the major negative regulator of autophagy, is

Injectable poly(oligoethylene glycol methacrylate)-based hydrogels with tunable phase transition behaviours: physicochemical and biological responses.

Niels M B Smeets et al.

Acta biomaterialia, 10(10), 4143-4155 (2014-06-10)

The potential of poly(oligoethylene glycol methacrylate) (POEGMA) hydrogels with varying thermosensitivities as soft materials for biomedical applications is demonstrated. Hydrogels are prepared from hydrazide and aldehyde functionalized POEGMA precursors, yielding POEGMA hydrogels with a volume phase transition temperature (VPTT) below

In vitro, in vivo and ex vivo characterization of ibrutinib: a potent inhibitor of the efflux function of the transporter MRP1.

Hui Zhang et al.

British journal of pharmacology, 171(24), 5845-5857 (2014-08-29)

The transporter, multidrug resistance protein 1 (MRP1, ABCC1), plays a critical role in the development of multidrug resistance (MDR). Ibrutinib is an inhibitor of Bruton's tyrosine kinase. Here we investigated the reversal effect of ibrutinib on MRP1-mediated MDR. Cytotoxicity was

Apoptotic and neurotoxic actions of 4-para-nonylphenol are accompanied by activation of retinoid X receptor and impairment of classical estrogen receptor signaling.

E Litwa et al.

The Journal of steroid biochemistry and molecular biology, 144 Pt B, 334-347 (2014-08-06)

4-para-Nonylphenol (NP) is a non-ionic surfactant that has widespread and uncontrolled distribution in the environment. Little is known, however, about its actions on neuronal cells during critical developmental periods. This study aimed to investigate the mechanisms underlying the apoptotic and

Co-delivery of natural metabolic inhibitors in a self-microemulsifying drug delivery system for improved oral bioavailability of curcumin.

Alex E Grill et al.

Drug delivery and translational research, 4(4), 344-352 (2014-11-26)

In spite of its well-documented anticancer chemopreventive and therapeutic activity, the clinical development of curcumin has been limited by its poor oral bioavailability. Curcumin has low aqueous solubility and undergoes extensive first pass metabolism following oral dosing. We hypothesized that

MicroRNA-663 activates the canonical Wnt signaling through the adenomatous polyposis coli suppression.

Cheng-gui Miao et al.

Immunology letters, 166(1), 45-54 (2015-06-02)

Rheumatoid arthritis (RA) is a symmetrical polyarticular autoimmune disease of unknown etiology. In this present study, we observed that the adenomatous polyposis coli (APC) expression is down-regulated and the expression of microRNA (miR)-663 increased significantly in synovium from RA patients

β1-Adrenergic blockers exert antioxidant effects, reduce matrix metalloproteinase activity, and improve renovascular hypertension-induced cardiac hypertrophy.

Elen Rizzi et al.

Free radical biology & medicine, 73, 308-317 (2014-06-17)

Hypertension induces left-ventricular hypertrophy (LVH) by mechanisms involving oxidative stress and unbalanced cardiac matrix metalloproteinase (MMP) activity. We hypothesized that β1-adrenergic receptor blockers with antioxidant properties (nebivolol) could reverse hypertension-induced LVH more effectively than conventional β1-blockers (metoprolol) when used at

Effectiveness of localized ultrasound-targeted microbubble destruction with doxorubicin liposomes in H22 mouse hepatocellular carcinoma model.

Fangyu Zhu et al.

Journal of drug targeting, 23(4), 323-334 (2015-01-23)

In order to increase local drug concentration and reduce systemic side effects of liver cancer chemotherapy, it is desirable to develop novel non-invasive technologies for drug targeting, such as ultrasound-targeted microbubble destruction (UTMD). H22 hepatocellular carcinoma (HCC) xenograft transplantation model

Scutellariae radix induces apoptosis in chemoresistant SCC-25 human tongue squamous carcinoma cells.

Byul-Bora Choi et al.

The American journal of Chinese medicine, 43(1), 167-181 (2015-02-03)

Scutellariae radix is one of the most widely used anticancer herbal medicines in several Asian countries, including Korea, Japan, and China. Squamous cell carcinoma (SCC) is one of the most common head and neck carcinomas, which is highly invasive and

H2O2 generated by NADPH oxidase 4 contributes to transient receptor potential vanilloid 1 channel-mediated mechanosensation in the rat kidney.

Chian-Shiung Lin et al.

American journal of physiology. Renal physiology, 309(4), F369-F376 (2015-07-03)

The presence of NADPH oxidase (Nox) in the kidney, especially Nox4, results in H2O2 production, which regulates Na(+) excretion and urine formation. Redox-sensitive transient receptor potential vanilloid 1 channels (TRPV1s) are distributed in mechanosensory fibers of the renal pelvis and

Induction of p53-independent growth inhibition in lung carcinoma cell A549 by gypenosides.

Jung-Sen Liu et al.

Journal of cellular and molecular medicine, 19(7), 1697-1709 (2015-03-18)

The objectives of this study are to investigate antiproliferative effect and mechanisms of bioactive compounds from Gynostemma pentaphyllum (G. pentaphyllum) on lung carcinoma cell A549. Saponins, carotenoids and chlorophylls were extracted and fractionated by column chromatography, and were subjected to high-performance

Viral transduction of the HER2-extracellular domain expands trastuzumab-based photoimmunotherapy for HER2-negative breast cancer cells.

Kyoko Shimoyama et al.

Breast cancer research and treatment, 149(3), 597-605 (2015-01-27)

The prognosis of HER2-positive breast cancer has been improved by trastuzumab therapy, which features high specificity and limited side effects. However, trastuzumab-based therapy has shortcomings. Firstly, HER2-targeted therapy is only applicable to HER2-expressing tumors, which comprise only 20-25% of primary

Insulin like growth factor binding protein 7 (IGFBP7) expression is linked to poor prognosis but may protect from bone disease in multiple myeloma.

Arnold Bolomsky et al.

Journal of hematology & oncology, 8, 10-10 (2015-04-19)

Insulin like growth factor binding protein 7 (IGFBP7) is a secreted protein binding insulin like growth factor 1 (IGF-1), insulin, vascular endothelial growth factor A (VEGFA), and activin A. It antagonizes bone morphogenetic proteins and is involved in the tumour

Prenatal alcohol exposure causes the over-expression of DHAND and EHAND by increasing histone H3K14 acetylation in C57 BL/6 mice.

Weihua Zhang et al.

Toxicology letters, 228(3), 140-146 (2014-05-27)

Prenatal alcohol exposure leads to congenital heart abnormal development, its mechanisms are still unknown. Recent reports have associated alcohol exposure with histone H3 acetylation. In the present study, we have performed the experiments to test the hypothesis that histone H3K14

Threshold Dose of Three Types of Quantum Dots (QDs) Induces Oxidative Stress Triggers DNA Damage and Apoptosis in Mouse Fibroblast L929 Cells.

Ting Zhang et al.

International journal of environmental research and public health, 12(10), 13435-13454 (2015-10-31)

Although it has been reported that fluorescent quantum dots (QDs) have obvious acute toxic effects in vitro, their toxic effects at low doses or threshold doses are still unknown. Therefore, we evaluated the biological histocompatibility and in vitro toxicity of

Identification of AHK2- and AHK3-like cytokinin receptors in Brassica napus reveals two subfamilies of AHK2 orthologues.

Alena Kuderová et al.

Journal of experimental botany, 66(1), 339-353 (2014-10-23)

Cytokinin (CK) signalling is known to play key roles in the regulation of plant growth and development, crop yields, and tolerance to both abiotic stress and pathogen defences, but the mechanisms involved are poorly characterized in dicotyledonous crops. Here the

Functionalized graphene oxide-based thermosensitive hydrogel for magnetic hyperthermia therapy on tumors.

Xiali Zhu et al.

Nanotechnology, 26(36), 365103-365103 (2015-08-21)

A novel locally injectable, biodegradable, and thermo-sensitive hydrogel made from chitosan and β-glycerophosphate salt was prepared. It incorporated polyethylenimine (PEI)-modified super-paramagnetic graphene oxide (GO/IONP/PEI) as a form of minimally invasive treatment of cancer lesions by magnetically induced local hyperthermia. Doxorubicin

Bone regeneration with osteogenically enhanced mesenchymal stem cells and their extracellular matrix proteins.

Bret H Clough et al.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 30(1), 83-94 (2014-08-19)

Although bone has remarkable regenerative capacity, about 10% of long bone fractures and 25% to 40% of vertebral fusion procedures fail to heal. In such instances, a scaffold is employed to bridge the lesion and accommodate osteoprogenitors. Although synthetic bone

Antioxidant inhibition of steady-state reactive oxygen species and cell growth in neuroblastoma.

Yueming Zhu et al.

Surgery, 158(3), 827-836 (2015-06-20)

Reactive oxygen species (ROS) contribute to adult tumorigenesis; however, their roles in pediatric solid tumors are unknown. Here, we sought to define the steady-state ROS levels in neuroblastoma and to examine whether aggressive cellular behavior, which may predict treatment failure

Toll-like receptor 2-dependent extracellular signal-regulated kinase signaling in Mycobacterium tuberculosis-infected macrophages drives anti-inflammatory responses and inhibits Th1 polarization of responding T cells.

Edward T Richardson et al.

Infection and immunity, 83(6), 2242-2254 (2015-03-18)

Mycobacterium tuberculosis survives within macrophages and employs immune evasion mechanisms to persist in the host. Protective T helper type 1 (Th1) responses are induced, and the immune response in most individuals is sufficient to restrict M. tuberculosis to latent infection

Albumin is synthesized in epididymis and aggregates in a high molecular mass glycoprotein complex involved in sperm-egg fertilization.

Kélen Fabíola Arroteia et al.

PloS one, 9(8), e103566-e103566 (2014-08-02)

The epididymis has an important role in the maturation of sperm for fertilization, but little is known about the epididymal molecules involved in sperm modifications during this process. We have previously described the expression pattern for an antigen in epididymal

Probucol Protects Against Asymmetric Dimethylarginine-Induced Apoptosis in the Cultured Human Brain Microvascular Endothelial Cells.

Jiwei Ma et al.

Journal of molecular neuroscience : MN, 57(4), 546-553 (2015-08-10)

Asymmetric dimethylarginine (ADMA) is emerging as a key contributor to endothelial dysfunction. The drug probucol was reported to have an anti-lipid peroxidation effect and improve endothelial dilation function. But little is known about the protective effect of probucol on ADMA-induced

Cytokine responses induced by diesel exhaust particles are suppressed by PAR-2 silencing and antioxidant treatment, and driven by polar and non-polar soluble constituents.

Nicolai Bach et al.

Toxicology letters, 238(2), 72-82 (2015-07-15)

Adsorbed soluble organics seem to be the main drivers of inflammatory responses induced by diesel exhaust particles (DEP). The specific compounds contributing to this process and the cellular mechanisms behind DEP-induced inflammation are not well known. We have assessed pro-inflammatory

Page 1 of 255