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Showing 1-30 of 7642 results for "D1435" within Papers
Young-Sang Kim et al.
BMB reports, 47(8), 433-438 (2013-11-30)
Plant sterols have shown potent anti-proliferative effects and apoptosis induction against breast and prostate cancers. However, the effect of sterols against hepatic cancer has not been investigated. In the present study, we assessed whether the stigmasterol isolated from Navicula incerta
M Montazerozohori et al.
Materials science & engineering. C, Materials for biological applications, 55, 462-470 (2015-06-29)
Some new cadmium(II) Schiff base complexes CdLX2 (where X=Cl(-), Br(-), I(-), SCN(-) and N3(-) and L=N,N-bis((E)-3-(4-(dimethylamino)phenyl)allylidene)benzene-1,2-diamine) were synthesized and characterized by elemental analysis, FT-IR, UV-visible, (1)HNMR spectra, and conductivity measurements. Moreover, the structure of the CdLI2 was determined by single
Stephanie A Nguyen et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 20(18), 4894-4903 (2014-08-01)
The current standard of care for glioblastoma (GBM) involves a combination of surgery, radiotherapy, and temozolomide chemotherapy, but this regimen fails to achieve long-term tumor control. Resistance to temozolomide is largely mediated by expression of the DNA repair enzyme MGMT;
Thorbjørn Krejsgaard et al.
Blood, 124(5), 761-770 (2014-06-25)
Patients with cutaneous T-cell lymphoma (CTCL) are frequently colonized with Staphylococcus aureus (SA). Eradication of SA is, importantly, associated with significant clinical improvement, suggesting that SA promotes the disease activity, but the underlying mechanisms remain poorly characterized. Here, we show
Qinghua Zhang et al.
ChemSusChem, 6(4), 593-596 (2013-03-19)
MCC Hammer: Microcrystalline cellulose (MCC) is dissolved and subsequently regenerated in a CO2 -based switchable solvent system, drastically reducing its crystallinity index and thereby its recalcitrance to hydrolysis. Among the investigated systems, based on cheap, widely available chemicals, is one
Natalie Cortes et al.
Life sciences, 122, 42-50 (2014-12-23)
Amaryllidaceae alkaloids exhibit a wide range of physiological effects, of which the acetylcholinesterase (AChE) inhibitory activity is the most relevant. However, scientific evidence related to their neuroprotective effectiveness against glutamate-induced toxicity has been lacking. Thus, the purpose of this study
Ting Wu et al.
Journal of experimental & clinical cancer research : CR, 34, 17-17 (2015-04-19)
Extranodal NK/T-cell lymphoma (ENKL) is an aggressive hematological malignancy associated with Epstein-Barr virus (EBV) infection. It is often resistant to conventional chemotherapy and has a poor prognosis. Icaritin, a compound derived from Chinese herbal medicine, Herba Epimedii, has been reported
Mandana Ghisari et al.
Toxicology and applied pharmacology, 284(3), 292-303 (2015-02-17)
Evidence suggest that exposure to pesticides can interfere with the endocrine system by multiple mechanisms. The endocrine disrupting potential of currently used pesticides in Denmark was analyzed as single compounds and in an equimolar mixture of 5 selected pesticides. The
Hye-Sook Seo et al.
Molecular medicine reports, 12(1), 800-818 (2015-03-18)
Retinoids possess anti-proliferative properties, which suggests that they possess chemopreventive and therapeutic potential against cancer. In the current study, genes modulated by rexinoids (retinoid X receptor (RXR)-pan agonists, LGD1069 and LG100268; and the RXRα agonist, Ro25-7386) were identified using an
Gabriela Torrea et al.
The Journal of antimicrobial chemotherapy, 70(8), 2300-2305 (2015-05-16)
The objective of this study was to evaluate the performance of the BACTEC MGIT960 system to test the susceptibility to bedaquiline for Mycobacterium tuberculosis complex. We determined the quality control (QC) range of bedaquiline using the M. tuberculosis H37Rv reference
Wei Lu et al.
Cancer biology & therapy, 15(9), 1174-1184 (2014-06-12)
Cancer stem cells (CSCs) may contribute to tumor initiation, distant metastasis and chemo-resistance. One of RNA-binding proteins, Quaking (QKI), was reported to be a tumor suppressor. Here we showed that reduced QKI levels were observed in many human oral cancer
Yanzhuo Zhang et al.
Pharmaceutical research, 32(7), 2372-2383 (2015-01-23)
A novel mesoporous carbon/lipid bilayer nanocomposite (MCLN) with a core-shell structure was synthesized and characterized as an oral drug delivery system for poorly water-soluble drugs. The objective of this study was to investigate the potential of MCLN-based formulation to modulate
Katherine Czysz et al.
PloS one, 10(2), e0117689-e0117689 (2015-02-07)
Definitive endoderm (DE) is one of the three germ layers which during in vivo vertebrate development gives rise to a variety of organs including liver, lungs, thyroid and pancreas; consequently efficient in vitro initiation of stem cell differentiation to DE
Katja K Schneider et al.
Neuroreport, 26(4), 186-191 (2015-02-13)
Acetylcholine influences the speed of information processing. We examined the effect of the rs3841324 polymorphism (L/S) and the rs16969968 (G/A) polymorphism on response speed in the Stroop task and the Negative priming task. These polymorphisms are located in the gene
Shi Yue et al.
Journal of immunology (Baltimore, Md. : 1950), 192(11), 5343-5353 (2014-04-29)
Although the role of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) in regulating cell proliferation is well established, its function in immune responses remains to be fully appreciated. In the current study, we analyzed myeloid-specific PTEN function in
Ricardo G Amaral et al.
The Journal of pharmacy and pharmacology, 67(8), 1100-1106 (2015-03-20)
The aim of this study was to investigate the cytotoxic and antitumour effects of the essential oil from the leaves of Mentha x villosa (EOMV) and its main component (rotundifolone). In-vitro cytotoxic activity of the EOMV and rotundifolone was determined
Fattah Sotoodehnejadnematalahi et al.
PloS one, 10(6), e0125799-e0125799 (2015-06-10)
Hypoxia is a hallmark of many pathological tissues. Macrophages accumulate in hypoxic sites and up-regulate a range of hypoxia-inducible genes. The matrix proteoglycan versican has been identified as one such gene, but the mechanisms responsible for hypoxic induction are not
Chien-Min Lin et al.
Drug design, development and therapy, 9, 4709-4717 (2015-09-01)
Decrease of peroxisome proliferator-activated receptors-δ (PPARδ) expression has been observed after spinal cord injury (SCI). Increase of PPARδ may improve the damage in SCI. Telmisartan, the antihypertensive agent, has been mentioned to increase the expression of PPARδ. Thus, we are
Nuria Bonilla et al.
Applied and environmental microbiology, 81(10), 3405-3418 (2015-03-15)
One of the main avocado diseases in southern Spain is white root rot caused by the fungus Rosellinia necatrix Prill. The use of organic soil amendments to enhance the suppressiveness of natural soil is an inviting approach that has successfully
Shuzhen Sun et al.
Liver international : official journal of the International Association for the Study of the Liver, 34(10), 1532-1542 (2014-01-01)
Study on viruses has greatly benefited from visualization of viruses tagged with green fluorescent protein (GFP) in living cells. But GFP tag, as a large inserted fragment, is not suitable for labelling Hepatitis B virus (HBV) that is a compact
Zi-Ming Chen et al.
Fitoterapia, 102, 61-66 (2015-02-24)
Five new triquinane-type sesquiterpenes, antrodins A-E (1-5) and a new gymnomitrane sesquiterpene, antrodin F (6), together with three known compounds 7-9 were isolated from fermentation of Antrodiella albocinnamomea. Their structures were elucidated through extensive spectroscopic methods including 2D NMR and
Wusong Dong et al.
International journal of clinical and experimental pathology, 8(8), 8731-8741 (2015-10-16)
Inflammatory responses are key players in myocardial ischemia/reperfusion (I/R) injury. Our previous studies showed that resveratrol alleviated I/R injury in myocardial I/R animal models, but whether the NALP3 inflammasome pathway contributes to the mechanisms remains to be elucidated. In this
Naveen Kaushal et al.
Journal of immunology (Baltimore, Md. : 1950), 193(7), 3683-3692 (2014-09-05)
Inflammation is a hallmark of inflammatory bowel disease (IBD) that involves macrophages. Given the inverse link between selenium (Se) status and IBD-induced inflammation, our objective was to demonstrate that selenoproteins in macrophages were essential to suppress proinflammatory mediators, in part
B T Paul et al.
Oncogene, 34(23), 3036-3052 (2014-08-19)
Ovarian cancer is the first in mortalities among gynecologic cancers in the United States, often due to late diagnosis and/or acquired platinum-resistant recurrences. This study investigates whether BRCA1-IRIS is a novel treatment target for ovarian cancers and in platinum-resistant recurrences.
Hua Liu et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35(9), 9139-9146 (2014-06-12)
Gastric cancer is the leading cause of cancer death worldwide. Oridonin, a diterpenoid isolated from Rabdosia rubescens, has attracted considerable attention as a potential treatment for gastric cancer based on its anti-tumor effects in many tumor cell lines. However, detailed
Na-Na Wang et al.
International journal of molecular sciences, 16(1), 1266-1292 (2015-01-13)
Polo-like kinase 1 (PLK1) is highly expressed in many cancers and therefore a biomarker of transformation and potential target for the development of cancer-specific small molecule drugs. RO3280 was recently identified as a novel PLK1 inhibitor; however its therapeutic effects
Sonja Aits et al.
Autophagy, 11(8), 1408-1424 (2015-06-27)
Lysosomal membrane permeabilization (LMP) contributes to tissue involution, degenerative diseases, and cancer therapy. Its investigation has, however, been hindered by the lack of sensitive methods. Here, we characterize and validate the detection of galectin puncta at leaky lysosomes as a
Yi Yang et al.
Human vaccines & immunotherapeutics, 11(3), 795-805 (2015-04-04)
The development of an HIV-1 vaccine that is capable of inducing effective and broadly cross-reactive humoral and cellular immune responses remains a challenging task because of the extensive diversity of HIV-1, the difference of virus subtypes (clades) in different geographical
Asha K Patel et al.
Biomaterials, 61, 257-265 (2015-05-26)
Cardiomyocytes from human stem cells have applications in regenerative medicine and can provide models for heart disease and toxicity screening. Soluble components of the culture system such as growth factors within serum and insoluble components such as the substrate on
Xinhui Tian et al.
Scientific reports, 5, 16982-16982 (2015-11-21)
Merrillianoid (1), a racemic neolignan possessing the characteristic benzo-2,7-dioxabicyclo[3.2.1]octane moiety, was isolated from the branches and leaves of Illicium merrillianum. Chiral separation of 1 gave two enantiomers (+)-1 and (-)-1. The structure of 1 was established by comprehensive spectroscopic analysis
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