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Showing 1-30 of 41 results for "D1500000" within Papers
Yingying Wen et al.
Journal of chromatography. A, 1368, 18-25 (2014-12-03)
A modified Quick, Easy, Cheap, Effective, Rugged and Safe (QuEChERS) method based on the dispersive solid-phase extraction (dSPE) combined with high performance liquid chromatography (HPLC) was developed for the determination of non-steroidal estrogens in water samples. In this study, graphene
Michel Tournaire et al.
Therapie, 69(1), 101-114 (2014-04-05)
This story, that has been going on for 75 years begins with an infatuation for a "miraculous" drug supposed to, according to a theory and without scientific proof of effectiveness, reduce the pregnancy complications, especially the number of miscarriages. The
Elizabeth Blunt
Holistic nursing practice, 18(4), 187-191 (2004-09-07)
Persons exposed to diethylstilbestrol have higher risks of certain health problems. Nurses have an important role in identifying women who received diethylstilbestrol while pregnant and the children of those pregnancies. Identification of these persons allows for risk analysis and counseling
Whasun Lim et al.
Biochemical and biophysical research communications, 456(1), 355-360 (2014-12-06)
Prostaglandin D2 synthase (PTGDS), also known as a glutathione-independent prostaglandin D synthase, catalyzes prostaglandin H2 to prostaglandin D2 that exhibits functions that include regulation of the central nervous system, contraction/relaxation of smooth muscle and inhibition of platelet aggregation. Gene profiling
Hong Zhang et al.
International journal of clinical pharmacology and therapeutics, 52(5), 407-415 (2014-03-13)
We compared the pharmacokinetic (PK) profiles of diethylstilbestrol orally dissolving film (DES ODF) and DES-capsule as well as assessing the safety, local tolerability, taste, and disintegration time of DES ODF. Twelve healthy male volunteers receiving a single administration of 2.0
Oussama Kebir et al.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 13(2), 84-95 (2011-03-25)
We explored whether in utero DES exposure has produced consistent findings with regard to an increased risk of psychiatric disorders. We reviewed systematically the epidemiological studies investigating a possible association between prenatal DES exposure and risk of psychiatric disorders. We
Luke Y Koong et al.
The Prostate, 74(16), 1589-1603 (2014-09-13)
Diethylstilbestrol (DES) and other pharmaceutical estrogens have been used at ≥ µM concentrations to treat advanced prostate tumors, with successes primarily attributed to indirect hypothalamic-pituitary-testicular axis control mechanisms. However, estrogens also directly affect tumor cells, though the mechanisms involved are
Eri Nakamura et al.
The Journal of steroid biochemistry and molecular biology, 143, 233-239 (2014-04-23)
The ovarian bone morphogenetic protein (BMP) system is a physiological inhibitor of luteinization in growing ovarian follicles. BMP-6, which is expressed in oocytes and granulosa cells of healthy follicles, specifically inhibits FSH actions by suppressing adenylate cyclase activity. In the
[Estrogen therapy--high-dose intravenous diethylstilbestrol diphosphate therapy for advanced or hormone refractory prostate cancer].
Masayuki Nakagawa
Nihon rinsho. Japanese journal of clinical medicine, 60 Suppl 11, 199-204 (2003-02-26)
Satoko Haeno et al.
The Journal of endocrinology, 221(2), 261-272 (2014-03-01)
The synthetic oestrogen diethylstilbestrol (DES), which is known to bind oestrogen receptors (ERs), has been reported to have adverse effects on endocrine homeostasis; however, the molecular mechanisms underlying these effects are poorly understood. In this study, we treated rats with
P L Carmichael et al.
Toxicologic pathology, 29 Suppl, 155-160 (2001-11-07)
The 2-year rodent bioassay has long had a central role in determining whether a compound is carcinogenic. It has recently been suggested that the use of 6-month studies in transgenic mice could reduce costs and animal numbers, without impairing the
A Iparraguirre et al.
Journal of chromatography. A, 1356, 163-170 (2014-07-09)
Membrane-assisted solvent extraction (MASE) coupled to liquid chromatography-triple quadrupole mass spectrometry (LC-MS/MS) was studied for the determination of a variety of emerging and priority compounds in wastewater. Among the target analytes studied certain hormones (estrone (E1), 17β-estradiol (E2), androsterone (ADT)
Diane Lauver et al.
Journal of obstetric, gynecologic, and neonatal nursing : JOGNN, 34(4), 494-499 (2005-07-16)
Although diethylstilbestrol has not been prescribed commonly for more than 25 years, its effects on the health of exposed persons are still important. In this article, we summarize current information about the major health effects of diethylstilbestrol exposure and delineate
John F Couse et al.
Toxicology, 205(1-2), 55-63 (2004-10-02)
It is generally believed that estrogen receptor-dependent and -independent pathways are involved in mediating the developmental effects of the synthetic estrogen, diethylstilbestrol (DES). However, the precise role and extent to which each pathway contributes to the resulting pathologies remains unknown.
Fumiharu Imai et al.
Endocrinology, 155(4), 1436-1444 (2014-01-29)
IL-6 is produced in granulosa cells under normal physiological conditions, including during ovulation. However, the roles of IL-6 in ovarian function, including regulation of LH receptor (LHR) expression in granulosa cells, have not been explored in detail. The aim of
Marina Gorga et al.
Journal of chromatography. A, 1352, 29-37 (2014-06-10)
A novel fully automated method based on dual column switching using turbulent flow chromatography followed by liquid chromatography coupled to tandem mass spectrometry (TFC-LC-MS/MS) was applied for the determination of endocrine disruptors (EDCs) and related compounds in sediment and sewage
Masayuki Iwamune et al.
PloS one, 9(10), e108997-e108997 (2014-10-04)
The 78-kilodalton glucose-regulated protein (GRP78) is a molecular chaperone that assists in protein assembly, folding, and translocation. Recently, our laboratory reported that GRP78 regulates the expression of luteinizing hormone-human chorionic gonadotropin receptor (LHR) in the early stage of corpus luteum
Xiaoxia Mi et al.
Journal of chromatography. A, 1356, 54-63 (2014-07-16)
A method for analyzing 26 types of steroids in egg matrix was developed. The method used liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) in electrospray ionization mode (ESI). The procedure involved extraction with acetonitrile and removal of phospholipids by
Conor C Smith et al.
Molecular pharmacology, 86(4), 390-398 (2014-07-25)
Fast excitatory synaptic transmission that is contingent upon N-methyl d-aspartate receptor (NMDAR) function contributes to core information flow in the central nervous system and to the plasticity of neural circuits that underlie cognition. Hypoactivity of excitatory NMDAR-mediated neurotransmission is hypothesized
Arunoday Bhan et al.
The Journal of steroid biochemistry and molecular biology, 141, 160-170 (2014-02-19)
Antisense transcript, long non-coding RNA HOTAIR is a key player in gene silencing and breast cancer and is transcriptionally regulated by estradiol. Here, we have investigated if HOTAIR expression is misregulated by bisphenol-A (BPA) and diethylstilbestrol (DES). Our findings demonstrate
Douglas S Scherr et al.
The Journal of urology, 170(5), 1703-1708 (2003-10-09)
During the last 2 decades there has been an increase in the number of men with prostate cancer placed on luteinizing hormone releasing hormone (LH-RH) agonist therapy. In addition, the duration of individual therapy has extended from what was once
Pierre-Olivier Bosset et al.
BJU international, 110(11 Pt C), E826-E829 (2012-05-15)
What's known on the subject? and What does the study add? Diethylstilbestrol (DES) has been found to have anti-tumour properties and clinical effectiveness in prostate cancer that is resistant to the first-line hormonal therapy. This review found that low-dose DES
Ke Yuan et al.
Analytica chimica acta, 866, 41-47 (2015-03-04)
In this study, a sample pretreatment method was developed for the determination of 13 endocrine disrupting chemicals (EDCs) in sediment samples based on the combination of subcritical water extraction (SWE) and dispersed liquid-liquid microextraction (DLLME). The subcritical water that provided
Shuji Yamashita
Current pharmaceutical design, 12(12), 1505-1520 (2006-04-14)
Neonatal diethylstilbestrol (DES) exposure elicits a wide range of abnormalities in the female mouse genital tract. This animal model system is suitable for investigating the mechanism of DES syndrome in humans. Accumulated evidence has shown that critical periods in development
A A Bamigboye et al.
The Cochrane database of systematic reviews, (3)(3), CD004353-CD004353 (2003-08-15)
Laboratory evidence in the 1940s demonstrated a positive role of placental hormones in the continuation of pregnancy. It was suggested that diethylstilbestrol was the oestrogen of choice for prevention of miscarriages. Observational studies were carried out with apparently positive results
C P Teixeira et al.
Climacteric : the journal of the International Menopause Society, 17(4), 402-409 (2013-10-26)
To evaluate the effects of soy isoflavone extract in the pro-oxidant/antioxidant balance in the uterus of ovariectomized rats. Twenty 3-month-old adult female Wistar rats were divided into four equal groups: GI: sham-operated (estrous phase); GII: control ovariectomized rats; GIII: ovariectomized
Yuliya Dobrydneva et al.
Journal of cardiovascular pharmacology, 55(5), 522-530 (2010-02-12)
Compounds with the stilbene pharmacophore and other nonsteroidal estrogens have previously been shown to inhibit thrombin-induced elevation of intracellular free calcium ([Ca]i) in human platelets. Thrombin elevates [Ca]i in platelets predominantly by activating a store-operated Ca entry (SOCE) mechanism, probably
Barbara Hammes et al.
Journal of midwifery & women's health, 48(1), 19-29 (2003-02-18)
Diethylstilbestrol (DES) was etiologically linked to clear cell adenocarcinoma of the vagina in 1971. This article reviews on-going research and emerging information relevant to DES-related health risks, thereby enabling women's health care providers to maintain an evidence-based practice for their
Michael Römer et al.
PloS one, 9(5), e97640-e97640 (2014-05-17)
In the area of omics profiling in toxicology, i.e. toxicogenomics, characteristic molecular profiles have previously been incorporated into prediction models for early assessment of a carcinogenic potential and mechanism-based classification of compounds. Traditionally, the biomarker signatures used for model construction
S B Malkowicz
Urology, 58(2 Suppl 1), 108-113 (2001-08-15)
Diethylstilbestrol administration was a classic form of androgen deprivation therapy (ADT) that gradually fell out of favor because of its cardiovascular toxicity, economic disinterest on the part of manufacturers, and the emergence of novel therapeutic agents with a superior safety
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