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Showing 1-30 of 108 results for "d3314" within Papers
Wenting Liao et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 122, 109700-109700 (2020-01-10)
Hypoxia induces cardiomyocytes injury, which further triggers the occurrence and development of cardiovascular diseases. There is a paucity of specific treatment options available with proven efficacy. Chinese patented pharmaceutical product Salidroside (Sal) has potent efficacy on treating hypoxic injury. However
Megan Melland-Smith et al.
Autophagy, 11(4), 653-669 (2015-04-09)
Bioactive sphingolipids including ceramides are involved in a variety of pathophysiological processes by regulating cell death and survival. The objective of the current study was to examine ceramide metabolism in preeclampsia, a serious disorder of pregnancy characterized by oxidative stress
Gaurav Ahuja et al.
EMBO reports, 20(4) (2019-03-20)
Cardiac dysfunctions dramatically increase with age. Revealing a currently unknown contributor to cardiac ageing, we report the age-dependent, cardiac-specific accumulation of the lysosphingolipid sphinganine (dihydrosphingosine, DHS) as an evolutionarily conserved hallmark of the aged vertebrate heart. Mechanistically, the DHS-derivative sphinganine-1-phosphate
The UPR Activator ATF6 Responds to Proteotoxic and Lipotoxic Stress by Distinct Mechanisms
Tam AB, et al.
Developmental Cell, 46(3), 327-343 (2018)
Alonso Zavafer et al.
Scientific reports, 10(1), 10360-10360 (2020-06-27)
In plants, pathogen triggered programmed cell death (PCD) is frequently mediated by polar lipid molecules referred as long chain bases (LCBs) or ceramides. PCD interceded by LCBs is a well-organized process where several cell organelles play important roles. In fact
Yang Liu et al.
iScience, 25(7), 104533-104533 (2022-07-06)
Ferroptosis is crucial to the pathology of many neurological diseases. Here, we found pre-treatment with myriocin, an inhibitor of de novo synthesis of sphingolipid, significantly decreased the erastin- or glutamate-induced ferroptosis of HT22 cells without requiring the recovery of intracellular
Jesús Enrique Vizcarra-Olvera et al.
Mycopathologia, 174(3), 247-254 (2012-03-08)
This study was conducted to evaluate the possible protector effect of bentonite and zeolite in Bovans chicks fed a diet containing 59 mg kg(-1) of fumonisin B1 (FB1) during 3 weeks. A total of 200 one-day-old male chicks were treated
Davy Vandenbosch et al.
Antimicrobial agents and chemotherapy, 56(5), 2290-2294 (2012-02-23)
Previous research has shown that 1% to 10% of sessile Candida albicans cells survive treatment with high doses of miconazole (a fungicidal imidazole). In the present study, we investigated the involvement of sphingolipid biosynthetic intermediates in this survival. We observed
Slavica Ribar et al.
Croatian medical journal, 44(2), 165-170 (2003-04-17)
To determine the concentrations and ratios of sphingoid bases, sphinganine and sphingosine, in the serum and urine of healthy individuals, as a basis for the normal value range, which may be useful in the diagnosis of diseases characterized by sphingolipid
New insights into cell death induced by long chain bases in Arabidopsis.
Louise V Michaelson
The New phytologist, 191(4), 909-911 (2011-08-13)
Hyun Joon Kim et al.
Journal of lipid research, 53(8), 1701-1707 (2012-06-05)
The sphingolipids are a diverse family of lipids with important roles in membrane compartmentalization, intracellular signaling, and cell-cell recognition. The central sphingolipid metabolite is ceramide, formed by the transfer of a variable length fatty acid from coenzyme A to a
C F Roff et al.
Developmental neuroscience, 13(4-5), 315-319 (1991-01-01)
Niemann-Pick Type C (NPC) disease is a cholesterol lipidosis resulting from defective postlysosomal cholesterol transport. In normal cells this segment of cholesterol trafficking is inhibited by treatment with either U18666A or imipramine. Other compounds are also capable of blocking postlysosomal
S Ribar et al.
Journal of chromatography. B, Biomedical sciences and applications, 754(2), 511-519 (2001-05-08)
Endemic nephropathy (EN) is a chronic renal disease present as an endemic in Brodska Posavina, Croatia. The aim of the study was to assess the possible role of fumonisins, i.e., mycotoxins produced by Fusarium moniliforme, as causative agents for EN.
Disruption of sphingolipid metabolism augments ceramide-induced autophagy in preeclampsia
Melland-Smith M, et al.
Autophagy, 11(4), 653-669 (2015)
Fiorentina Roviezzo et al.
The Journal of pharmacology and experimental therapeutics, 337(3), 830-837 (2011-03-23)
The sphingosine kinase (SPK)/sphingosine-1-phosphate (S1P) pathway recently has been associated with a variety of inflammatory-based diseases. The majority of these studies have been performed in vitro. Here, we have addressed the relevance of the SPK/S1P pathway in the acute inflammatory
Priyanka Bhadwal et al.
Scientific reports, 10(1), 4668-4668 (2020-03-15)
Perturbations in lipid metabolic pathways to meet the bioenergetic and biosynthetic requirements is a principal characteristic of cancer cells. Sphingolipids (SPLs) are the largest class of bioactive lipids associated to various aspects of tumorigenesis and have been extensively studied in
Mihaela Dragusin et al.
Journal of lipid research, 44(9), 1772-1779 (2003-06-05)
We studied the metabolism of radioactively labeled safingol (l-threo-dihydrosphingosine) in primary cultured neurons, B104 neuroblastoma cells, and Swiss 3T3 fibroblasts, and compared it to that of its natural stereoisomer d-erythro-dihydrosphingosine. Both sphingoid bases are used as biosynthetic precursors for complex
Carol L Fischer et al.
Antimicrobial agents and chemotherapy, 56(3), 1157-1161 (2011-12-14)
There is growing evidence that the role of lipids in innate immunity is more important than previously realized. How lipids interact with bacteria to achieve a level of protection, however, is still poorly understood. To begin to address the mechanisms
Hwang Eui Cho et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1112, 16-23 (2019-03-06)
A simple and specific hydrophilic interaction liquid chromatography-tandem mass spectrometry (HILIC-MS/MS) method was developed for the simultaneous determination of C18-L-threo-sphinganine (safingol, an anti-neoplastic in phase I trials) and its diastereomer, C18-D-erythro-sphinganine (sphinganine), in human plasma. Sample pretreatment involved a protein
Itsuo Murakami et al.
Lipids in health and disease, 10, 150-150 (2011-08-25)
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that regulate lipid and glucose metabolism. PPARα is highly expressed in the liver and controls genes involved in lipid catabolism. We previously reported that synthetic sphingolipid analogs, part of which contains shorter-length
Kuan-Boone Tan et al.
Journal of controlled release : official journal of the Controlled Release Society, 160(2), 290-298 (2011-11-22)
Prognosis of patients with acute myeloid leukemia (AML) remains poor despite the use of first-line induction chemotherapy. Therefore, it is imperative to find effective treatment for AML patients. Safingol is a bioactive sphingolipid which has demonstrated promising in vitro anti-leukemic
Jean-Luc Cacas et al.
Analytical and bioanalytical chemistry, 403(9), 2745-2755 (2012-05-12)
In eukaryotic organisms, sphingolipids are major structural lipids of biological membranes and perform additional essential functions as signalling molecules. While long-chain bases (LCB), the common precursor to all sphingolipid classes, is represented by only one major molecular species in animals
Alexander J Nelson et al.
JCI insight, 5(16) (2020-08-21)
Type 1 diabetes (T1D) is a consequence of autoimmune β cell destruction, but the role of lipids in this process is unknown. We previously reported that activation of Ca2+-independent phospholipase A2β (iPLA2β) modulates polarization of macrophages (MΦ). Hydrolysis of the
Daniel Da Silva et al.
Plant signaling & behavior, 6(5), 736-739 (2011-04-02)
Sphinganine or dihydrosphingosine (d18:0, DHS), one of the most abundant free sphingoid Long Chain Base (LCB) in plants, is known to induce a calcium dependent programmed cell death (PCD) in tobacco BY-2 cells. In addition, we have recently shown that
Daniel Börgel et al.
Metabolic engineering, 14(4), 412-426 (2012-03-28)
The study describes the identification of sphingolipid biosynthesis genes in the non-conventional yeast Pichia ciferrii, the development of tools for its genetic modification as well as their application for metabolic engineering of P. ciferrii with the goal to generate strains
Rong Chen et al.
Diabetologia, 63(9), 1885-1899 (2020-05-10)
Compared with the general population, individuals with diabetes have a higher risk of developing severe acute pancreatitis, a highly debilitating and potentially lethal inflammation of the exocrine pancreas. In this study, we investigated whether 1-deoxysphingolipids, atypical lipids that increase in
Qian Zhou et al.
Journal of ethnopharmacology, 252, 112618-112618 (2020-02-02)
Sini decoction (SND) is a famous Traditional Chinese Medicine (TCM) formula composed of Acontium carmichaeli, Zingiber officinale and Glycyrrhiza uralensis, which is considered as an efficient formula against doxorubicin (DOX)-induced heart failure. But the compatibility mechanism of SND remains unclear.
P Ball et al.
Steroids, 31(2), 249-258 (1978-02-01)
Under the protection of ascorbic acid a 2-hydroxyestrone bovine serum albumin conjugate was prepared containing intact 2-hydroxyestrone as determined by gas chromatographymass spectometry. Using this antigen highely specific antibodies were raised in rabbits. Cross-reactivity for 2-hydroxyestradiol and 2-hydroxyestriol was 26
Yasuko Mikami-Saito et al.
Molecular genetics and metabolism reports, 25, 100674-100674 (2020-11-19)
Newborn screening is a public health care program worldwide to prevent patients from critical illness or conditions. Tandem mass spectrometry allows multiplex, inexpensive, and rapid newborn screening. However, mass spectrometry used for newborn screening to date is not able to
Lili Song et al.
Journal of proteome research, 16(9), 3180-3189 (2017-07-20)
Recently, increasing attention has been paid to diabetic encephalopathy, which is a frequent diabetic complication and affects nearly 30% of diabetics. Because cognitive dysfunction from diabetic encephalopathy might develop into irreversible dementia, early diagnosis and detection of this disease is
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